Baric Laboratory @Baric_Lab
Researching #SARSCoV2, SARS-CoV, MERS-CoV, Dengue, Zika, and human norovirus at the University of North Carolina. Shared laboratory account. Chapel Hill, NC Joined April 2018-
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Lots of exciting discussions about antiviral discovery and pandemic preparedness at the READDI symposium last week! @GillingsGlobal @UNC @UNC_Micro_Imm #lovevirology readdi.org/stories/sympos…
Great showing from past and present UNC coronavirologists at #NIDO2023!
Our collaborative universal vaccine study is out in @NatureComms. These ferritin nanoparticle RBD vaccines protect monkeys against #SARS2 #Beta #Delta and protect mice against #SARSCoV and bat CoVs. Led by @David_RMartinez and @aschaefe29 from our group. nature.com/articles/s4146…
Our Post-Acute Sequelae of SARS-CoV-2 (PASC) mouse pathogenesis model paper is out @ScienceTM . This study was led by @KDinnon @SarahRLeist Ethan Fritch and our #lunginstitute collaborators! Also with support from @aschaefe29 and @LisaGralinski #COVID19 science.org/doi/epdf/10.11…
Our #sarbecovirus pathogenesis paper is now out in @mbiojournal . This herculean effort was led by @aschaefe29 @MTFerris with strong support from @SarahRLeist @LisaGralinski @David_RMartinez and our friends from the @Heise_Lab and @msdiamondlab ! journals.asm.org/doi/epub/10.11…
Our study with @scrippsresearch led by @andrabi_raiees and Dennis Burton is finally out in Nature Immunology. Here we define the protective efficacy of RBD mAbs against SARS-related viruses. Congrats to @LPVictorTse @David_RMartinez @aschaefe29 and @LisaGralinski ! @NatImmunol
Our study with @scrippsresearch led by @andrabi_raiees and Dennis Burton is finally out in Nature Immunology. Here we define the protective efficacy of RBD mAbs against SARS-related viruses. Congrats to @LPVictorTse @David_RMartinez @aschaefe29 and @LisaGralinski ! @NatImmunol
We're hiring! We are seeking an experienced virologist to help lead our flavivirus research program. Apply below to join our group at UNC! unc.peopleadmin.com/postings/230078
Fun! #postdocs on #coronavirus #pathogenesis and #antivirals apply here unc.peopleadmin.com/postings/199413
Psyched to share our story about an oral broadly acting #antiviral therapeutic that diminishes #SARSCoV2 disease and works against #MERSCoV too. Heavy lift by @aschaefe29 @David_RMartinez @Baric_Lab @UNCpublichealth @UNCResearch @ScienceTM science.org/doi/10.1126/sc…
Happy to share our @timothysheahan lab study just out in @ScienceTM of an orally bioavailable drug that strongly dampens #SARSCoV2 disease in mice. Let’s stop pandemics before they occur! @aschaefe29 @UNCpublichealth #antivirals science.org/doi/10.1126/sc…
We need more oral #antivirals to treat #COVID19. Here we show nucleoside prodrug therapy can improve #SARSCoV2 disease in mice. @David_RMartinez @aschaefe29 @timothysheahan @UNCResearch @UNCpublichealth @ScienceTM science.org/doi/10.1126/sc…
Florian Krammer @florian_krammer
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3K Followers 368 Following Studies the pathogenesis and evolution of influenza and astroviruses in high risk populations in order to develop better therapiesOur latest universal #coronavirus vaccine work is out in @NatureComms. We used nanoparticle vaccines that elicited broadly neutralizing antibodies in monkeys against #SARS2 variants and protected mice against 🦇 SARS-related CoVs (Brief thread 👇🏼) nature.com/articles/s4146…
I’m eternally grateful to my scientific mentors Sallie Permar and Ralph Baric for their support. I’m also grateful for many unofficial mentors including Beverly Koller, Aravinda de Silva, Tim Sheahan, Dimiter Dimitrov, and Helen Lazear.
TFW you’re not officially a PI yet but your first grant you submit with PI status gets rejected 😂. Onward and upward! Life goes on. #AcademicChatter #AcademicTwitter
Happy to be a part of this study just out in @NatImmunol ! Targeted isolation of diverse human protective broadly neutralizing antibodies against SARS-like viruses @Baric_Lab @UNCpublichealth @andrabi_raiees nature.com/articles/s4159…
After two decades, final annual meeting for @NIAIDNews Systems Approach to Immunity & Inflammation program is today. Great to have been part of this for the past 10 years as part of our multi-site center between @UNC @OHSUKnight @fredhutch @UW
@Heise_Lab (my PhD mentor), @Baric_Lab, @MichaelGaleJr1 (postdoc mentor), Mike Diamond, Bali Pulendran, Rafi Ahmed, @grakoui, Jens Wrammert, and @Vineet321.
Psyched to share our story about an oral broadly acting #antiviral therapeutic that diminishes #SARSCoV2 disease and works against #MERSCoV too. Heavy lift by @aschaefe29 @David_RMartinez @Baric_Lab @UNCpublichealth @UNCResearch @ScienceTM science.org/doi/10.1126/sc…
@EngEongOoi and I wrote a preview piece in @NatImmunol about delaying the second #SARSCoV2 vaccine shot and the nice effect it has on the neutralizing antibody response. Will this lead to higher real world vaccine efficacy? #vaccineswork nature.com/articles/s4159…
Science can be hard. Peer review can be a demoralizing process when the work that you pour your heart and soul into is criticized and torn apart. I like to remember small and big victories. This one is the result of a fun collaboration and teamwork. #AcademicTwitter @ScienceTM
In collaboration with @LisaGralinski @Baric_Lab, we now show select RBD bnAbs can protect against challenge with many diverse SARS-like viruses (Fig. 6).
Vaccine scientists have been chasing variants. Now, they’re seeking a universal coronavirus vaccine. @David_RMartinez @KingLabIPD @WeissmanLab @KayvonModjarrad washingtonpost.com/health/2022/02…
Elated to share that our paper was selected as the cover of @ScienceTM ! Thanks to @aschaefe29 @sophie_gobeil and @Dapeng_LI @PriYam2021 for the collaboration. But the MVP to thank is the artist beneath the cover: @FalconieriV ! science.org/doi/10.1126/sc… @UNCpublichealth
My #sciart based on @Baric_Lab / @David_RMartinez research is on the cover of STM this week! 👇
This week's new issue of Science Translational Medicine has arrived! fcld.ly/a398fam
Joining us in person is coronavirus OG Vineet Menachery (also @Baric_Lab alumnus) telling us about how his group harnessed reverse genetics to understand #SARSCoV2 pathogenesis. @UNCpublichealth @UNC #lovevirology @TheMenacheryLab
Dr. @David_RMartinez spoke with @TheAtlantic about why our relationship with COVID vaccines is just getting started. The short version: We probably will need additional shots—but how many depends on our immune systems, the virus and how often they collide. theatlantic.com/science/archiv…
Unsurprising yet reassuring. T cell immunity remains stable against more divergent variants like #OmicronVirus. While there’s a small decrease in T cell recognition of #Omicron , this is really great news.
Our T cells appear to be ready, willing and able to defend vs Omicron medrxiv.org/content/10.110… CD4+ and CD8+ cells hold up well in people vaccinated or prior Covid
We should invest in universal vaccines for future pandemics and #SARSCoV2 variants. Thanks Jackie Mogensen for covering our #coronavirus vaccine @MotherJones “The Mother of All Vaccines May Be Closer Than You Think” @UNCpublichealth motherjones.com/politics/2021/…
As the omicron variant threatens to wipe out monoclonal antibodies, the U.S. is saving up one that will still work washingtonpost.com/health/2021/12…
As #Omicron cases increase in the US, it will be critical to deploy tools including #mAbs like Sotrovimab. Thanks @Carolynyjohnson for including my comments @washingtonpost We also need an aggressive pursuit of non-spike antiviral drugs. washingtonpost.com/health/2021/12…