Brian Wasik @BrianRWasik
Researcher in Virus Tropism and Evolution. Opinions are my own... but should be yours too. Avatar: Joshua Chamberlain. RT = Reverse Transcriptase scholar.google.com/citations?user… Ithaca, NY, USA Joined November 2012-
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What’s going on here? FDA is broadening surveillance of milk for fragments of DNA from DEAD virus as way to find which dairy farms have outbreaks not detected by USDA. When viruses are killed by pasteurization harmless fragments of DNA is always detectable washingtonpost.com/health/2024/04…
So, *preliminary* molecular clock analyses indicate that the time of the most recent common ancestor (TMRCA) of the US cattle flu clade was late December. TMRCA of that clade and the closest relatives in birds, mid-December. If single intro, likely between those rough dates.
1. So much today on the #H5N1 #birdflu story! Just coming up for air. @US_FDA has found genetic evidence of the virus in commercial milk, but so far it sounds like killed virus. More info on where they found it/how prevalent it was would be useful. statnews.com/2024/04/23/h5n…
With all due respect to the hard work of these reporters... someone have a gift link? Obvious discrepancy with article title and I want to understand the full context before commenting.
With all due respect to the hard work of these reporters... someone have a gift link? Obvious discrepancy with article title and I want to understand the full context before commenting.
OK, I think we're close to decisive evidence that US bovine H5N1 had a single origin from birds, and that when related viruses from birds *have* been found, they are jumps from cattle back into birds. Grackles, blackbirds, chickens all show mammalian adaptation like PB2 M631L.
<commensal fermenter enters apartment to see all his family and friends with serious looks> Hey, what are you all doing here... oh...
<commensal fermenter enters apartment to see all his family and friends with serious looks> Hey, what are you all doing here... oh...
My prior is 'spillovers are common, outbreaks are rare.' But I want to know if MRCA in 2.3.4.4b to cattle were genetically 'primed' for this particular host spill. Also, ecologically: what happened in winter 23/24 to prime spill, did panhandle fires in Feb exacerbate outbreak?
My prior is 'spillovers are common, outbreaks are rare.' But I want to know if MRCA in 2.3.4.4b to cattle were genetically 'primed' for this particular host spill. Also, ecologically: what happened in winter 23/24 to prime spill, did panhandle fires in Feb exacerbate outbreak?
There are so many layers to this anti-vaccine nonsense. And at the core is the pathologizing of our neurodiverse loved ones. It is shameful. 🩵
Here's a visual of the US H5N1 "Cattle clade", HA plus two internal genes. Strongly suggests to me there was single origin, at least for these sequences. Possibly in late 2023/early 2024.
Scary Triangles xkcd.com/2923
Here is a link to 239 consensus genome sequences, assembled by @xrayfoo, from sequencing reads of 2.3.4.4b H5N1 influenza A virus from cattle and other species. github.com/andersen-lab/a…
Thrilled to share another chapter of my PhD work w/ @VirusesImmunity where we repurposed neomycin to elicit immunological protection against respiratory viral infection and transmission!! (1/3)
Thrilled to share another chapter of my PhD work w/ @VirusesImmunity where we repurposed neomycin to elicit immunological protection against respiratory viral infection and transmission!! (1/3)
Edward Nirenberg 🇺.. @ENirenberg
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5K Followers 607 Following Laboratory of Lymphocyte Dynamics at @RockefellerUniv. Opinions are Gabriel’s own. @victora.bsky.socialPasteurization kills influenza viruses. What is being detected is remnants of RNA, the genetic material from the dead virus. These dead fragments of RNA pose no human health risk; we consume them all the time in food. FDA is culturing the milk just to be certain there’s no live…
@mattyglesias Rafael Yglesias? The New York screenwriter?
Legendary work on the part of @xrayfoo who assembled these genomes and play key role in molecular clock analyses.
.@chrislhayes: On April 23, 2020, Trump suggested you could combat the coronavirus by injecting disinfectant into your body, or by shining UV light inside various orifices— all while thousands of people were dying a day. So, are you better off now than you were 4 years ago?
Very important to note here that qPCR positives are not the same as "virus particles." It's much easier to detect viral RNA by qPCR than it is to detect infectious virus or intact virus particles (as the article correctly notes). This finding does have some big implications:
#Breaking Testing conducted by the FDA on pasteurized commercially purchased milk has found genetic evidence of the H5N1 bird flu virus, the agency confirmed Tuesday. trib.al/5sU2zvO
We know that if you don't want an outbreak to become an epidemic or a pandemic, it needs to be contained quickly. This news further shows that it has neither been contained and there is no evident rush to do so. This is both alarming and profoundly depressing.
5+. I'm not attributing this to malice, incompetence, territorialism, bureaucracy, or anything else, but it's very clear that this apparent lack of transparency and urgency to share these relevant data are greatly harming both the US and global capacity to respond.
Paula is top 10 nicest, funniest people I’ve ever met. One of the best weeks of my life was writing with her on an awards show. Just a nexus of joy.
One of my comedy idols Paula Pell is having a moment with Girls5eva so it’s important we revisit this incredible bit
@angie_rasmussen @MichaelWorobey netherlands also considering retrospective cattle testing
really wanna dunk on xaira but tbh they *could* actually do some cool stuff odds are still against (as always) but de novo antibody design seems like the clearest route for AI to improve drug dev
Well, if there's anything this man knows, it's how to tell the difference between legal and barely legal
This case against Trump is so laughably weak. So basically Michael Cohen wanted to act like a big shot and did some slimy (but probably not illegal) things with *gasp* the National Inquirer. This is a pop culture / politics / tv crime drama mad lib, not a lawful prosecution.
OK, I think we're close to decisive evidence that US bovine H5N1 had a single origin from birds, and that when related viruses from birds *have* been found, they are jumps from cattle back into birds. Grackles, blackbirds, chickens all show mammalian adaptation like PB2 M631L.
Ok i thought this was a Golden Girls quote
Blanche: "Spoiler alert. There's nothing wrong with trying to influence an election."
Team Trump was personally placing articles in The Enquirer accusing @tedcruz of infidelity. Will the world's saddest cuck actually stand up for himself and his family this time? I think we know the answer...
More Enquirer headline exhibits slamming Cruz: "TED CRUZ SEX SCANDAL — 5 SECRET MISTRESSES" "DONALD TRUMP BLASTS TED CRUZ'S DAD FOR PHOTO WITH JFK ASSASSIN" Pecker gives the backstory of these, from circa spring 2016.
This sounds tough to overcome, but in fairness Trump was later able to repair his relationship with his former opponents by never apologizing for this in any way
Pecker on negative stories about Trump's opponents: Michael Cohen would call me and say we would like you to run an article on a certain person...and then Cohen would send me a piece on Ted Cruz, for example, and the Enquirer would embellish it from there.” B/c Cohen wasn't a…
A reminder that @tedcruz enthusiastically endorsed Trump and backs him to this day notwithstanding Trump, Cohen, and Pecker’s vile smears of Cruz’s wife, Heidi, and his father, Rafael. He is an opportunist at the expense of his family.
Today, fmr National Enquirer publisher David Pecker on unfounded stories about @tedcruz: Cohen would call him to plant story & mag "would embellish it from there." At the time, Cruz: "Smear that has come from Donald Trump & his henchman...all of which started with Donald Trump."
Great work from @MichaelWorobey @xrayfoo , et al. to generate consensus sequences from the USDA raw sequence data released by the USDA. Lots more analysis is needed, as well as information on cattle movement but sequences seem consistent with a single source introduction
Here is a link to 239 consensus genome sequences, assembled by @xrayfoo, from sequencing reads of 2.3.4.4b H5N1 influenza A virus from cattle and other species. github.com/andersen-lab/a…
Not so many fans of the spirit of the law over the letter, hunh?
Happy Passover to everyone else celebrating in my traditional manner: by eating only fast food for a week
There's this idea that Trump's trial are helping him, but the polling over the last month says that is hogwash. Biden's gaining in the polls, & those paying attention to the trials favor Biden over Trump by a clear margin.