Lori L. Burrows @Dr_Lori_Burrows
microbiologist, McMaster U 🇨🇦 • type IV pili, phages, biofilms, antibiotic resistance • equestrian🐴 • cancer survivor🎗️ burrowslab.ca Hamilton, ON Joined July 2012-
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We should also be thinking how to prevent them, not just treat them. See also my recent piece on prophylaxis for UTIs in PLoS Pathogens journals.plos.org/plospathogens/… @McMasterIIDR @BBS_McMasterU @MacGlobalNexus nytimes.com/2024/04/24/hea…
Called last night at 1am about an almost pan-resistant organism. First time in ages since I've needed to remote in and review all the microbiology at night to formulate a plan. I wonder if the rest of healthcare appreciates how common these organisms are becoming and the
Exploring our views on the impact of Post Translational Modifications elicited by #phage to rapidly finetune #bacteria #metabolism during #infection . Review with @noort_zuit in Current Opinion in #Microbiology : bit.ly/phagePTM #bioinformatics #alphafold #omics
Excellent review article on "The type IVc pilus: just a Tad different" by @gregbwhitfield sciencedirect.com/science/articl…
Happy to highlight our newly posted paper biorxiv.org/content/10.110… We show that P. aeruginosa prophages encode a component of the type IV pilus. This protein, which is homologous to the bacterial FimU protein, can be incorporated into the type IV pilus.
So excited for our latest story on a tunable-spectrum antibiotic to be published. We desperately need microbiome-sparing strategies to treat P. aeruginosa. Amazing effort led by the fantastic @ConnorChain
So excited for our latest story on a tunable-spectrum antibiotic to be published. We desperately need microbiome-sparing strategies to treat P. aeruginosa. Amazing effort led by the fantastic @ConnorChain
Excited to share our latest work on an interesting TLS pathway in bacteria - initiated by MSc @ATetenych and brought over the finish line by newly minted MSc Kristi L, with support from the rest of the team! doi.org/10.1002/pro.49…
A video summary for those of you who do not have time to read our paper on how antibodies interact with type IV pili nature.com/articles/s4146…! 👇 Thanks and congrats again to all collaborators!
Persistence and evolution of Pseudomonas aeruginosa following initiation of highly effective modulator therapy in cystic fibrosis @mbiojournal by @catarmbruster et al from Jennifer Bomberger with @vscooper journals.asm.org/doi/10.1128/mb…
In a bold new approach to #admissions to our MD Program @QueensUHealth, all qualified applicants will have an equal chance of being offered an interview. theglobeandmail.com/canada/article… #innovation #meded #access
Bacteriophages avoid autoimmunity from cognate immune systems as an intrinsic part of their life cycles | Nature Microbiology nature.com/articles/s4156…
🚨Happy to share that our paper "Characterization and genomic analysis of the Lyme disease spirochete bacteriophage ϕBB-1" is now published @PLOSPathogens ! doi.org/10.1371/journa…
🚨Happy to share that our paper "Characterization and genomic analysis of the Lyme disease spirochete bacteriophage ϕBB-1" is now published @PLOSPathogens ! doi.org/10.1371/journa…
Great story - T4P-dependent temperate #phages that encode an alternate version of their own receptor! Prophages express a type IV pilus component to provide anti-phage defence biorxiv.org/content/10.110…
We are happy to announce that the 10th ASM Conference on Biofilms will be held in Portland, Oregon, from Nov 9-13, 2025. We look forward to gathering the biofilm community for what should be a fantastic meeting. See the ASM website for details. asm.org/Events/ASM-Bio…
In vitro development of resistance against antipseudomonal agents: comparison of novel β-lactam/β-lactamase inhibitor combinations and other β-lactam agents | Antimicrobial Agents and Chemotherapy journals.asm.org/doi/10.1128/aa…
Preventive nasal administration of flagellin restores antimicrobial effect of gentamicin and protects against a multidrug-resistant strain of Pseudomonas aeruginosa | Antimicrobial Agents and Chemotherapy journals.asm.org/doi/10.1128/aa…
Quorum-sensing regulation of phenazine production heightens Pseudomonas aeruginosa resistance to ciprofloxacin | Antimicrobial Agents and Chemotherapy journals.asm.org/doi/10.1128/aa…
Antimicrobial resistance currently kills millions of people every year in the world. However, it has become a neglected topic. Over the past 30 years, there has been a severe decrease in the numbers of researchers and published papers in this field. Funding has also plummeted. I…
If you’re a fan of DIY lab equipment, you’ll love the phenotype-o-mat, a customizable DIY 96-well plate imager from @ArcadiaScience that you can now build for only $400 🧵 1/7 protocols.io/view/building-…
Until now, bacterial mRNA stability has been hugely overestimated... Great to see this out in @PNASNews ‼️ Finally, a precise assessment of the global stability of Salmonella RNA transcripts Congrats to @LBarquist @WestermannLab @JoergLab & team
Until now, bacterial mRNA stability has been hugely overestimated... Great to see this out in @PNASNews ‼️ Finally, a precise assessment of the global stability of Salmonella RNA transcripts Congrats to @LBarquist @WestermannLab @JoergLab & team
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@Dr_Lori_Burrows this would make a nice desk object. You guys should map and print one! It’s pretty cool looking.
Here’s the much-requested 3D printed bacterial motor from our study. My 3-year-old thinks it’s a tiara, while some think it’s a lamp shade! I have made the 3D print file available here: 3d.nih.gov/entries/3DPX-0… @NIH3D #Science #STEAM #OpenAccess #3Dprint nature.com/articles/s4156…
Called last night at 1am about an almost pan-resistant organism. First time in ages since I've needed to remote in and review all the microbiology at night to formulate a plan. I wonder if the rest of healthcare appreciates how common these organisms are becoming and the
Richly deserved honor @laahrs! Congratulations !!!
⭐️New Awards Announcement⭐️ Congrats to these brilliant scientists for their bold #basicscience questions, providing insights into regeneration, the origins of life, and prevention of infection & disease. bit.ly/HFAwardees Hear from the #HFScouts who recommended them👇1/
Exploring our views on the impact of Post Translational Modifications elicited by #phage to rapidly finetune #bacteria #metabolism during #infection . Review with @noort_zuit in Current Opinion in #Microbiology : bit.ly/phagePTM #bioinformatics #alphafold #omics
Excellent review article on "The type IVc pilus: just a Tad different" by @gregbwhitfield sciencedirect.com/science/articl…
Another paper from fruitful collaboration with @SoleymaniLab @deb_yamamura @Millerlab_atMac and many others at @McMasterU. Thanks to @zentekltd and @MitacsCanada and @NSERC_CRSNG for the support.
Our paper with @Yingfu8888 uses kinetics profiling, aptamers, and machine learning for detecting viruses. Congrats Payel Sen and Zijie Zhang. Thanks to collaborators @Millerlab_atMac, @deb_yamamura, Bruno Salena and support of @zentekltd. @McMasterIIDR onlinelibrary.wiley.com/doi/10.1002/an…
Super happy to see this out! Thank you to all current and previous @traivio and Glover lab people for making this project possible. An especially big shoutout to my talented co-author Cameron Murray for providing indispensable expertise and insight. 🔬🦠 jbc.org/article/S0021-…
I appreciate the feedback about my interview with @mattgallowaycbc. He covered a lot of ground related to the book. Please let me know what you think. #HealthForAll #booktour cbc.ca/listen/live-ra…
This gives me the nostalgia of the type II secretion system (T2SS). This is exactly where T4P and T2SS diverged. Indeed in case of the T2SS the pilus stopped growing outside but still releases exoproteins. Superb and classic work by the Lisa Craig team at shorturl.at/bsW13
Happy to highlight our newly posted paper biorxiv.org/content/10.110… We show that P. aeruginosa prophages encode a component of the type IV pilus. This protein, which is homologous to the bacterial FimU protein, can be incorporated into the type IV pilus.
A real Twitter thread from AD! Can't believe it. Must be worth a read.
Happy to highlight our newly posted paper biorxiv.org/content/10.110… We show that P. aeruginosa prophages encode a component of the type IV pilus. This protein, which is homologous to the bacterial FimU protein, can be incorporated into the type IV pilus.
I love this stuff! Becomes like putty in boiled water and then stiffens rock hard as it cools. Excellent manual sculpting material and infinitely reusable. Good machinability too. Scraps can be melted together. Takes dyes well too. Cheap.
So excited for our latest story on a tunable-spectrum antibiotic to be published. We desperately need microbiome-sparing strategies to treat P. aeruginosa. Amazing effort led by the fantastic @ConnorChain
OUT NOW 📢: A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting @zgitai1 nature.com/articles/s4156…
Lovering and Sockett labs killing it again. The kiss of death: nature.com/articles/s4146… @IMIBirmingham @UoBbiosciences
@Dr_Lori_Burrows Thanks for the shout-out, Lori!
Excited to share our latest work on an interesting TLS pathway in bacteria - initiated by MSc @ATetenych and brought over the finish line by newly minted MSc Kristi L, with support from the rest of the team! doi.org/10.1002/pro.49…
If you enjoyed this thread, please share the first post and follow me for more content: @JamesLucasIT
Wave after wave. Thousands of snow geese and sandhill cranes are pushing ever northward to their nesting grounds. The sounds! After the relative silence of winter today was overwhelming 😊
We have a winner! Congratulations to @MelSpeagle who was awarded a Canada Graduate Scholarship from @CIHR_IRSC ! 👏👏