Krutika Kuppalli, MD FIDSA @KrutikaKuppalli
ID physician. COVID-19, mpox,emerging infections, global health & pandemic preparedness and response. Tweets are own views. training.npr.org/sources/krutik… Global Citizen Joined March 2019-
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I still remember where I was when this happened. Couldn’t believe the #POTUS recommended that people should inject bleach for #SARSCoV2 - something that can lead to death. After this speech there was an increase in calls to poison centers
I hope we are investing in the development of other therapeutics with another mechanism of action in case resistance to neuraminidase inhibitors occurs
I hope we are investing in the development of other therapeutics with another mechanism of action in case resistance to neuraminidase inhibitors occurs
Great thread by @MichaelWorobey o the US cattle #H5N1 outbreak and where it can be traced to 👇
Great thread by @MichaelWorobey o the US cattle #H5N1 outbreak and where it can be traced to 👇
As we talk about preparedness for #H5N1, does anyone know if companies are working on developing therapeutics. Although neuraminidase inhibitors should work, we should be looking at developing antivirals that have other mechanisms of action in case resistance develops.
This strengthens the argument for screening symptomatic and asymptomatic cattle, mammals and humans (especially those at high risk). If we don’t do this how will we know if #H5N1 evolves and adapts to hosts. After the mistakes of #COVID this is beyond frustrating to see.
Agree with all that @MichaelWorobey says 👇
Agree with all that @MichaelWorobey says 👇
None of this re #H5N1 surprises me - we are reactive when it comes to outbreak response. We need to - strengthen surveillance of symptomatic & asymptomatic animals & close human contacts. - do serological studies in animals & people - have a more robust vaccination strategy
None of this re #H5N1 surprises me - we are reactive when it comes to outbreak response. We need to - strengthen surveillance of symptomatic & asymptomatic animals & close human contacts. - do serological studies in animals & people - have a more robust vaccination strategy
If you are going to get #Botox make sure it’s from a reputable place since it’s #Botulinum toxin which can cause a descending paralysis @CDCgov issues a HAN related to counterfeit/mishandled Botox occurring in 22 people from 11 states. emergency.cdc.gov/han/2024/pdf/c…
Here is a link to 239 consensus genome sequences, assembled by @xrayfoo, from sequencing reads of 2.3.4.4b H5N1 influenza A virus from cattle and other species. github.com/andersen-lab/a…
My old high school - praying that everyone is safe
Nothing good can come from this
Happy Earth Day, everybody! Elmo hopes you are having a sunny day! And if it's not sunny, that's okay. Elmo is sure it will be sunny again soon. ❤️☀️ #EarthDay
Does anyone know if serological studies are being done on #cattle to see if they have evidence of prior infection. I think this is important for us to understand because animals may have had asymptomatic or pauci-symptomatic infection
Listening to @BBCWorld and learning about the #RwandaBill What is going on in the #UK - are you for real?
And they wonder why so many people are leaving #SiliconValley I was born and raised there but the cost of living has become unreasonable
And they wonder why so many people are leaving #SiliconValley I was born and raised there but the cost of living has become unreasonable
We really should be planning for different possible scenarios in relation to #HPAI We need to increase the stockpile of and develop next generation #vaccines so we are ready in the event of a #H5N1 Emergency
Dr. Angela Rasmussen @angie_rasmussen
454K Followers 8K Following Virologist. PI @VIDOInterVac. Adj Prof @USask BMI. P2 @covarr_net. Jeopardy! loser. Famed for my obnoxious turns of phrase. 🇺🇸in🇨🇦. she/herDr Ellie Murray, ScD @EpiEllie
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0 Followers 34 Followingjason lorenz @jasonlorenz14
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22K Followers 592 Following @AledadeACO EVP/CEO Aledade Care Solutions. Former Secretary @NCDHHS, COO/COS @CMSGov. Mother, Wife, Doctor, Music lover.@KrutikaKuppalli Also strengthens need for wastewater & other watershed testing, wearables, air sampling. Highlights importance of surveillance systems independent, but supportive of government efforts that are limited, constrained, and politically controlled. Together, we can build an early…
Sadly, this would not surprise me one bit…
But it looks to me like a strong possiblity that this has been circulating in cattle for months under our noses, even before the first inkling there might be something new in February. This reveals massive gaps in our pathogen surveillance and detection systems.
@RajlabN @0bFuSc8 @USDA @PeacockFlu @LongDesertTrain @HelenBranswell @RickABright @firefoxx66 @LouiseHMoncla @trvrb @KrutikaKuppalli @michaelmina_lab @florian_krammer @jbloom_lab @cmyeaton @MarionKoopmans @MichaelWorobey Also, as @RickABright said, how recent are these samples, where are they from geographically, and are any of them from the same herd (or even same cow)? Or is all that (basic) meta-data now actually on GISAID?
@RajlabN @0bFuSc8 @USDA @PeacockFlu @LongDesertTrain @HelenBranswell @RickABright @firefoxx66 @LouiseHMoncla @trvrb @KrutikaKuppalli @michaelmina_lab @florian_krammer @jbloom_lab @cmyeaton @MarionKoopmans @MichaelWorobey Somewhat reassuring to see little PB2 change from baseline, but since cows ARE actually replicating H5N1, this PB2 already working fine in SOME mammal tissues? Point already raised by @florian_krammer: E627K in the ONE known human case, but not after multiple cow transmissions??
@0bFuSc8 @USDA @PeacockFlu @LongDesertTrain @HelenBranswell @RickABright @firefoxx66 @LouiseHMoncla @trvrb @KrutikaKuppalli @michaelmina_lab @florian_krammer @jbloom_lab @cmyeaton @MarionKoopmans Here is a list of PB2 mutations from the 239 WGS sequences: public.tableau.com/app/profile/ra… (no adaptation signature) Many thanks to @MichaelWorobey et al for the consensus sequences from the 239 WGS runs
Here is a link to 239 consensus genome sequences, assembled by @xrayfoo, from sequencing reads of 2.3.4.4b H5N1 influenza A virus from cattle and other species. github.com/andersen-lab/a…
@KrutikaKuppalli If Covid was a test run, we’re in trouble.
@KrutikaKuppalli @BBCWorld Like the US, we are a divided country yougov.co.uk/topics/politic…. We also suffer growth of the far right, a weak opposition, and many self-serving politicians who repeatedly produce pointless distractions & fake promises, rather than tackling real issues and improving life in the UK
Happy Earth Day, everybody! Elmo hopes you are having a sunny day! And if it's not sunny, that's okay. Elmo is sure it will be sunny again soon. ❤️☀️ #EarthDay
I should clarify: Idaho halted movement of cattle or bison into the state from states that have reported #H5N1 #birdflu in dairy cow herds.
Idaho, which previously halted movement of cattle or bison into the state to try to stop spread of #H5N1 #birdflu in dairy cows, reports another outbreak, it's second. National total of confirmed outbreaks now at 33. (Data USDA's, graph mine) agri.idaho.gov/main/animals/c…
Promed Post - ProMED-mail another notification of what seems to be a psittacosis cluster, also on the rise in europe. promedmail.org/promed-post/
HEADS UP: @USDA #H5N1 sequences are now live on GISAID (239 all at once)! cc @RajlabN @PeacockFlu @LongDesertTrain @HelenBranswell @RickABright @firefoxx66 @LouiseHMoncla @trvrb @KrutikaKuppalli @michaelmina_lab @florian_krammer @jbloom_lab @cmyeaton @MarionKoopmans #HPAI 1/
(1/2) @USDA published 239 genetic sequences of the U.S. H5N1 clade 2.3.4.4b influenza virus from samples associated with the ongoing highly pathogenic avian influenza outbreak in poultry/wild birds...
@florian_krammer @0bFuSc8 @USDA @RajlabN @LongDesertTrain @HelenBranswell @RickABright @firefoxx66 @LouiseHMoncla @trvrb @KrutikaKuppalli @michaelmina_lab @jbloom_lab @cmyeaton @MarionKoopmans the raw sequences are on SRA - very slowly going through them now but having the fastas public would save me a lot of time/effort....
@0bFuSc8 @USDA @RajlabN @PeacockFlu @LongDesertTrain @HelenBranswell @RickABright @firefoxx66 @LouiseHMoncla @trvrb @KrutikaKuppalli @michaelmina_lab @jbloom_lab @cmyeaton @MarionKoopmans Maybe I am too stupid but I don't see any new cattle sequences in GISAID. The latest I find are feline seqs from 4/16/24.
@KrutikaKuppalli This feels like one of those posts that several decades from now might be referenced by historians
Africa intensifies battle against mpox as ‘alarming’ outbreaks continue science.org/content/articl…
Promising news: per @nmpf's CSO, research is underway from @US_FDA & @USDA to eval impact of pasteurization (& other processes) on #H5N1 #HPAI in milk: (Thx @Alexander_Tin) cc: @RickABright @HelenBranswell @thijskuiken @MarionKoopmans @KrutikaKuppalli #AvianFlu 1/
Does pasteurization really kill H5N1 HPAI in milk? @nmpf's Jamie Jonker said recently that answers could come from @US_FDA and @USDA backed studies with land grant universities "We hope that information will be available shortly" tinalexander.github.io/notes/2024/04#…
👆Yet another reason @USDA rly should be submitting #H5N1 sequences from herds in other states/ subsequent dairy cattle detections & these poultry farms to GISAID, so researchers can evaluate cc @RickABright @HelenBranswell @thijskuiken @MarionKoopmans @KrutikaKuppalli #HPAI 5/5