Dr. Saskia Popescu @SaskiaPopescu
Infectious disease epidemiologist - Biodefense & Global Health Security | Sr Fellow @CSRisks | Asst Prof @UMmedschool | Affiliate @georgetown_ghss @scharschool medschool.umaryland.edu/profiles/Popes… Arizona, USA Joined March 2009-
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Announcing the GHS2024 Preliminary Program! 🎉 Explore our lineup of thought-provoking events, renowned speakers, and immersive workshops focused on global health security. Join us on this inspiring journey towards a safer world. eur.cvent.me/bGgg5 #GHS2024 #globalhealth
The most concerning element of this discovery is that it points towards widespread, undetected circulation in cattle - in keeping with the latest analysis from @MichaelWorobey, @angie_rasmussen & co. Our @TelGlobalHealth coverage is free to read: telegraph.co.uk/global-health/…
Re-upping this bc it’s important to know what these results mean rather than hitting an immediate panic button. Great thread from Dr. @angie_rasmussen 👇🏻
Re-upping this bc it’s important to know what these results mean rather than hitting an immediate panic button. Great thread from Dr. @angie_rasmussen 👇🏻
Very important to note here that qPCR positives are not the same as "virus particles." It's much easier to detect viral RNA by qPCR than it is to detect infectious virus or intact virus particles (as the article correctly notes). This finding does have some big implications:
Very important to note here that qPCR positives are not the same as "virus particles." It's much easier to detect viral RNA by qPCR than it is to detect infectious virus or intact virus particles (as the article correctly notes). This finding does have some big implications:
So, *preliminary* molecular clock analyses indicate that the time of the most recent common ancestor (TMRCA) of the US cattle flu clade was late December. TMRCA of that clade and the closest relatives in birds, mid-December. If single intro, likely between those rough dates.
Another great thread from Dr. @MichaelWorobey 👇🏻
Another great thread from Dr. @MichaelWorobey 👇🏻
💯 and great insights from Dr. @MichaelWorobey
💯 and great insights from Dr. @MichaelWorobey
This reporting on COVID origins is exceptional and worth people’s time.
This reporting on COVID origins is exceptional and worth people’s time.
For #H5N1 , we must remember that we will only find infections where we look for them. If we test only symptomatic herds or farms with dead animals, we miss important opportunities to prevent spread among animals and to farmworkers. aphis.usda.gov/sites/default/…
Here is a link to 239 consensus genome sequences, assembled by @xrayfoo, from sequencing reads of 2.3.4.4b H5N1 influenza A virus from cattle and other species. github.com/andersen-lab/a…
If confirmed that #H5N1 has been circulating much longer in cows (particularly given reports of asympt + cows), our current surveillance net should be larger, both geographically & temporally (testing, past human illnesses etc). Our case definition should be broader.
If confirmed that #H5N1 has been circulating much longer in cows (particularly given reports of asympt + cows), our current surveillance net should be larger, both geographically & temporally (testing, past human illnesses etc). Our case definition should be broader.
🤩 Applied Biosafety seeks submissions for a Special Issue on Biosafety & Biosecurity for PPP & DURC. Share insights on policy gaps & best practices. Topics cover AI implications, oversight, & more. Join global experts to enhance biosafety management. ☣️ home.liebertpub.com/cfp/biosafety-…
Data gaps and disparities impede outbreak response. Bridging between agencies, reinforcing collaboration, and working with local farmers/industry is vital. SSDD?
Data gaps and disparities impede outbreak response. Bridging between agencies, reinforcing collaboration, and working with local farmers/industry is vital. SSDD?
I know we'll never get it, but one thing I would really love is to hear a Boeing exec's genuine answer to the question, "What did you think was going to happen when the quarterly financials became more important than the planes?" theatlantic.com/ideas/archive/…
Friday, 4/26 @ 12:00 ET | H5N1: Gauging the Current Threat @JenniferNuzzo will moderate a discussion with Dr. Mary-Margaret Fill @TNDeptofHealth, @DrGerryParker @TAMUOneHealth, & @sauer929 @unmc on the potential impact of #H5N1. Register Here: events.brown.edu/event/h5n1
It is really hard to see how it is not a scandal that @USDA has not shared what its own FAQs on the situation indicate are *extensive* viral sequence data on H5N1 in cattle in 8 states. aphis.usda.gov/sites/default/… statnews.com/2024/04/18/h5n…
All of this 👇🏻
Dr Ellie Murray, ScD @EpiEllie
127K Followers 2K Following Epidemiology asst professor @BUSPH |social media ed @amjepi | cohost @casualinfer podcast | Causal inference & public health #epitwitter🇨🇦 insta/🧵:laughing.e
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Dr. Tara C. Smith @aetiology
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Health Nerd @GidMK
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Alex Meshkin, GED @alexmeshkin
33K Followers 4K Following Founder of @FlowHealthHQ Since you keep asking, yes, I am a high school dropout. *I don't proof read my tweets
Edward Nirenberg 🇺.. @ENirenberg
36K Followers 6K Following Views my own, but you can borrow them if you feel so inclined. Anti-disease. Big Nerd Energy. “A homework person.” Fun at parties. Antibody hoarder. he/him
Prof. Akiko Iwasaki @VirusesImmunity
220K Followers 2K Following We study antiviral immunity and viral disease pathogenesis. #COVID19 #longCOVID #vaccines @HHMINEWS @YaleIBIO @YaleMed @YaleCII President of @ImmunologyAAI
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220K Followers 2K Following I cover infectious diseases @statnews. 2020 Polk winner. Nieman '11. She/her. #H5N2 #birdflu #Covid #polio #flu, #RSV. I have not paid for a blue checkmark.
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Megan Ranney MD MPH �.. @meganranney
111K Followers 3K Following I fix problems and promote health 🔸️Dean @YaleSPH🔸️ER doc 🔸️ Cofounder @researchaffirm #ThisIsOurLane🔸️she/hers
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Katelyn Jetelina @dr_kkjetelina
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Barry Hunt - #DavosSa.. @BarryHunt008
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23K Followers 12K Following Evidence-based, equity-oriented tweets. State policies relevant to COVID-19 & economy at @covidpolicies, https://t.co/H3d9KwvQQe. All views are my own.
Dr. Neuro 🏳️�.. @Neurofourier
25K Followers 2K Following (Not active) Infectious disease | Public Health | Global Health | Epidemiology | @ CDC | He/him 🇺🇸 🏳🌈🦠 | Opinion =My own
Mark Furner MP @MarkFurnerrMP
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Levi Call @Levi16464167
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Cathy 🌻🍁🐕.. @ScienceEducated
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J. R. @cellcaller3
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𝙼𝚊𝚢𝚎 𝙼.. @nowmayemusk4
14 Followers 911 Following Bestselling International Author #AWomanMakesAPlan 📖Doctor of Dietetics 👩🎓 Supermodel 😉💃 #ItsGreatToBe75 Agents⬇️
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Patrick W. Marsh @patrickwmarsh
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𝕊𝕖𝕔𝕦𝕝�.. @syedsalman56
2K Followers 4K Following WE, THE PEOPLE OF INDIA, having solemnly resolved to constitute India into a SOVEREIGN SOCIALIST SECULAR DEMOCRATIC State
Dhi_ren412 @DRen41276235
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Rakibul Hassan @Rakibulbond007
94 Followers 5K Following Happiness... Declaration. ROYAL-NAVY ( RN ) Could be Prideful. Dear, HONOURABLE, Her Majesty The QUEEN.... I am Md. Rakibul Hassan. NID-269-2858-521-316-
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Pavel Kasík @kasikp
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Camara @Camara168710568
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Randy Edward @Randyedwad1
96 Followers 676 Following I make medicine sick, TA chart consultant ,a trader.$10k - $100k trader competition. father of two ,love travel coffee and Nyhttps://t.me/futurestradingconnec
Adi Essam Zarei, PhD .. @Dr_AdiZarei
2K Followers 5K Following Microbial immunology | asst. Professor | Researcher | حساب علمي منوع #الصحيح_علمياً #سلسلة_المناعة #تبسيط_المناعة | Sc. Journals Reviewer
eotweets @eotweets
828 Followers 3K Following Life is better with healthy critters, protect your pets from covid, I'm #masking4afuriend Public & planet health, equity, trauma informd tx. #masksinhealthcare
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280 Followers 615 Following Professor of #Chemistry & #Biochemistry, #Enzymologist, #HepC Survivor, #Transplant Recipient & Molecular #Virologist
Blossom R @BlossomR114218
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Joao Monteiro @JMinImmunoland
4K Followers 657 Following 🏳️🌈 🇧🇷 Physician-scientist turned Chief Editor @NatureMedicine. Former Immunology editor @Cell - Opinions are my own. He/him/his
Alex Vaughan (agvaugh.. @agvaughan
469 Followers 3K Following All opinions my own, and I'm as disappointed as you are. Currently: @Meta Prev: @CajalNeuro, @Pymetrics, CSHL, Stanford Also: @[email protected]
(((Wendy Orent))) @WendyOrent
7K Followers 4K Following science writer, anthropologist, PhD, member of plague lovers's society, disease evolution nerd. Author of Plague, Co-author of Biowarrior. #ProVax
Mickster @MikeyMacMick
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The Count @thecountof1
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Dr Effie Greathouse @effiegreathouse
427 Followers 4K Following Freshwater biologist promoting CDC’s & EPA’s scientific consensus that a little fluoride in water fights cavities. Because Alex Jones is wrong about everything.
Marin Sandu @sandumarin8
50 Followers 439 Following BIM Implementatiom in Romania. Standing with Ukraine.
Delaney Sullivan @DelaneyKSull
248 Followers 473 Following UCLA-Caltech MD/PhD student. Stanford '16.
npj @npjanzen
80 Followers 168 Following
Dr Ellie Murray, ScD @EpiEllie
127K Followers 2K Following Epidemiology asst professor @BUSPH |social media ed @amjepi | cohost @casualinfer podcast | Causal inference & public health #epitwitter🇨🇦 insta/🧵:laughing.e
Dr. Angela Rasmussen @angie_rasmussen
454K Followers 8K Following Virologist. PI @VIDOInterVac. Adj Prof @USask BMI. P2 @covarr_net. Jeopardy! loser. Famed for my obnoxious turns of phrase. 🇺🇸in🇨🇦. she/her
Dr. Tara C. Smith @aetiology
123K Followers 6K Following Infectious disease epidemiologist, writer, mom. Antibiotic resistance, zoonotic disease, scicomm, zombies. She/her. Same handle @ bsky
Health Nerd @GidMK
81K Followers 2K Following https://t.co/hkLzdpoOQd Epidemiologist. Writer (Slate, TIME, etc). ' Research fellow at @UoW Host of @senscipod Email [email protected] he/him
Edward Nirenberg 🇺.. @ENirenberg
36K Followers 6K Following Views my own, but you can borrow them if you feel so inclined. Anti-disease. Big Nerd Energy. “A homework person.” Fun at parties. Antibody hoarder. he/him
Prof. Akiko Iwasaki @VirusesImmunity
220K Followers 2K Following We study antiviral immunity and viral disease pathogenesis. #COVID19 #longCOVID #vaccines @HHMINEWS @YaleIBIO @YaleMed @YaleCII President of @ImmunologyAAI
Helen Branswell 🇨�.. @HelenBranswell
220K Followers 2K Following I cover infectious diseases @statnews. 2020 Polk winner. Nieman '11. She/her. #H5N2 #birdflu #Covid #polio #flu, #RSV. I have not paid for a blue checkmark.
Prof Gavin Yamey @gav.. @GYamey
41K Followers 8K Following Professor of Global Health & Public Policy @DukeU. Director, Center for Policy Impact in Global Health. DJ @wxdu. TIME columnist. He/him. Tallest Jew on Earth.
Megan Ranney MD MPH �.. @meganranney
111K Followers 3K Following I fix problems and promote health 🔸️Dean @YaleSPH🔸️ER doc 🔸️ Cofounder @researchaffirm #ThisIsOurLane🔸️she/hers
Abraar Karan @AbraarKaran
68K Followers 975 Following infectious disease doctor, researcher @stanford
Katelyn Jetelina @dr_kkjetelina
62K Followers 1K Following Epidemiologist, educator, professor, world traveller, lover of ice cream and the ocean. Mom of 2 under 2. Publisher of Your Local Epidemiologist
Jeremy Faust MD MS (E.. @jeremyfaust
100K Followers 3K Following ⚕️Health Policy/Public Health @HarvardMed @brighamandwomens @foampodcast. Editor: @medpagetoday. Director: @longwoodchorus ✉️https://t.co/LRwJFLswnB
Dr. Theresa Chapple @Theresa_Chapple
43K Followers 4K Following Public health geek, maternal and child health advocate, social justice seeker, mother of three. Motto- "In God we trust, everyone else must show data"
Rick Bright @RickABright
41K Followers 3K Following Practical, Innovative, Hyper-focused on saving lives. Immunologist, Virologist, Pandemic Nemesis. Posts are mine.
Dr. Julia Raifman @JuliaRaifman
23K Followers 12K Following Evidence-based, equity-oriented tweets. State policies relevant to COVID-19 & economy at @covidpolicies, https://t.co/H3d9KwvQQe. All views are my own.
Dr. Neuro 🏳️�.. @Neurofourier
25K Followers 2K Following (Not active) Infectious disease | Public Health | Global Health | Epidemiology | @ CDC | He/him 🇺🇸 🏳🌈🦠 | Opinion =My own
Michael Mina @michaelmina_lab
220K Followers 1K Following Physician-Scientist, MD,PhD. Immunology, Epidemiology, Infectious disease, Autoimmunity, Biotech, Diagnostics, Math. CSO, CMO. Past: Harvard Faculty. DM’s Open
Linsey Marr https://w.. @linseymarr
67K Followers 127 Following Engineering professor @virginia_tech with expertise in airborne transmission of viruses, air quality, nanotechnology. Avid recreational athlete.
Jeremy Kamil is also .. @macroliter
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Jennifer Nuzzo, DrPH @JenniferNuzzo
50K Followers 2K Following Epidemiology and global health security policy. https://t.co/47uXVOSCLj… Speaking requests: https://t.co/mflNldsXnL
Sarah Newey @sneweyy
7K Followers 3K Following Correspondent for @TelGlobalHealth in Bangkok, previously London. Shortlisted for some awards. Contact me: [email protected]
Joao Monteiro @JMinImmunoland
4K Followers 657 Following 🏳️🌈 🇧🇷 Physician-scientist turned Chief Editor @NatureMedicine. Former Immunology editor @Cell - Opinions are my own. He/him/his
Stephanie M. Lee @stephaniemlee
24K Followers 2K Following Senior writer @Chronicle, writing about scholarship, scholars, and society / [email protected] / on Signal: stephaniemlee.07 / former @BuzzFeedNews
Brian Wasik @BrianRWasik
4K Followers 2K Following Researcher in Virus Tropism and Evolution. Opinions are my own... but should be yours too. Avatar: Joshua Chamberlain. RT = Reverse Transcriptase
Vanessa Lamers, MESc,.. @vlamers
10K Followers 2K Following Here for public health. Passionate about public health infrastructure. Tweets are still mine and do not represent anyone else. Pronouns: she/her
Barbara Del Castello,.. @LifeWithBabs
370 Followers 743 Following Just a Barbie girl, in a #biosec #scidip world | she/her | 🧬 PhD, Genetics | ☣️ 2024 JHU ELBI | Science Policy Interface GFP UNMGCY | views my own
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1K Followers 57 Following I'm a reporter covering NIH and biomedical research policy for Science magazine.
IBBIS @IBBIS_bio
82 Followers 120 Following Safeguarding modern bioscience and biotechnology so it can advance and flourish safely and responsibly.
Luca Trenta @lucatrenta
4K Followers 4K Following Associate Professor in IR @PCS_Swansea. #US foreign policy, #ColdWar, covert action, assassinations, drones. Host of the @ootsproject podcast.
Chris Bakerlee @cwbakerlee
574 Followers 814 Following Biosecurity & Pandemic Preparedness @ OpenPhil. Views my own. To provide feedback or connect re: other concerns: https://t.co/TJr60xLp0C
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Andrew Dowse @andrewedowse
510 Followers 191 Following Director RAND Australia. Opinions are mine and RTs ≠ endorsements.
Victoria Brookes @DrVikiBrookes
2K Followers 3K Following infectious disease epidemiologist #OneHealth; risk assessment, disease modelling... zoonoses, EIDs, global health and social drivers of disease spread
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Health Policy Watch -.. @HealthPolicyW
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Alex Pearlman 💡 @lexikon1
3K Followers 3K Following Words on bioethics, biohacking, health policy. Formerly @petrieflom @medialab @pennmehp @ginkgo. Telling stories about space drugs @vardaspace. Opinions mine.
Women in Global Healt.. @WGHAustralia
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Matt Mason @MattM_RN
1K Followers 3K Following Lecturer in Nursing @usceduau. Infection Prevention, Infectious Disease & Emergency Management. Opinions my own. living on Gubbi Gubbi land.
Magdi Jacobs @magi_jay
48K Followers 5K Following I write about politics, culture, & science for https://t.co/Gti12sLy1c. Bylines in @PostOpinions, @ForeignPolicy, @Slate, @damemagazine, @Alternet. She/her
Sander van der Linden @Sander_vdLinden
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Benjamin Roche @BenRocheGroup
1K Followers 750 Following Research director @ird_fr and Prof at @UNAM_MX. Evolutionary ecology to tackle health issues. @Prezode_Intl co-founder and director of @Eldorado_Intl
GCR Institute @GCRInstitute
2K Followers 202 Following The Global Catastrophic Risk Institute is a think tank that analyzes the risk of catastrophes severe enough to threaten the survival of human civilization.
Richard Cupitt @RichardCupitt
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Jason Matheny @JasonGMatheny
8K Followers 373 Following President and CEO of the @RANDCorporation, a nonprofit, nonpartisan research org that helps improve policy and decisionmaking through research and analysis.
Oklahoma Department o.. @OKWildlifeDept
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Stella Kyriakides @SKyriakidesEU
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Professor Dame Angela.. @uksciencechief
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World Economic Forum @wef
4.5M Followers 962 Following The international organization for public private cooperation. #wef24
Canadian Association .. @CABSACSB
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Marion Messmer @mgmessmer
2K Followers 3K Following Senior Research Fellow @ChathamHouseISR | @DsD_Kings PhD Views my own.
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ASTHO @ASTHO
17K Followers 2K Following ASTHO is the national nonprofit representing the state and territorial #PublicHealth agencies of the U.S., U.S. territories, and D.C. Visit https://t.co/qi5NEsiark.
Newsha Ghaeli @NewshaGhaeli
2K Followers 997 Following cofounder @BiobotAnalytics. prior @MIT @SenseableCity. alum @McGillU @UWaterloo // canadian-iranian in🗽
Kaveh MD, RAD, DAWG @thehouseofpod
19K Followers 2K Following Humor-adjacent pod looking at health/news/culture . Host- Kaveh: Large mammal & GI doctor. Putting the “fun” back in mfunedicine. Listen: https://t.co/uOaIPujH3O
james stout @jamesstout
14K Followers 3K Following hack investigative journalist, actual historian of anti fascist physical culture, aspiring MAMIL, immigrant, director @pascuayaquibike. DM for signal. he/him
Neil Cherian @NeilCherian
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The most concerning element of this discovery is that it points towards widespread, undetected circulation in cattle - in keeping with the latest analysis from @MichaelWorobey, @angie_rasmussen & co. Our @TelGlobalHealth coverage is free to read: telegraph.co.uk/global-health/…
Really nice article by @sneweyy on a fast-moving topic.
The most concerning element of this discovery is that it points towards widespread, undetected circulation in cattle - in keeping with the latest analysis from @MichaelWorobey, @angie_rasmussen & co. Our @TelGlobalHealth coverage is free to read: telegraph.co.uk/global-health/…
@SaskiaPopescu @angie_rasmussen Dr. @angie_rasmussen was awesome during the pandemic. Always providing valuable information without fearmongering or minimizing Covid.
A really important thread on the #H5N1 #birdflu outbreak in cows. Well worth a read.
Very important to note here that qPCR positives are not the same as "virus particles." It's much easier to detect viral RNA by qPCR than it is to detect infectious virus or intact virus particles (as the article correctly notes). This finding does have some big implications:
Still amazing, 4 years later.
1. So much today on the #H5N1 #birdflu story! Just coming up for air. @US_FDA has found genetic evidence of the virus in commercial milk, but so far it sounds like killed virus. More info on where they found it/how prevalent it was would be useful. statnews.com/2024/04/23/h5n…
Very important to note here that qPCR positives are not the same as "virus particles." It's much easier to detect viral RNA by qPCR than it is to detect infectious virus or intact virus particles (as the article correctly notes). This finding does have some big implications:
#Breaking Testing conducted by the FDA on pasteurized commercially purchased milk has found genetic evidence of the H5N1 bird flu virus, the agency confirmed Tuesday. trib.al/5sU2zvO
Tapping the big sign.
National and international responses to the current #H5N1 influenza situation *now* will test the reality and operability of a One Health approach. It’s not just a waste of surveillance, but is also unethical, if govts & institutions fail to appropriately act on that information.
@xrayfoo @flodebarre @LouiseHMoncla @swientist @meera_chand @MOUGK @EvolveDotZoo @stgoldst @stuartjdneil @PeacockFlu @angie_rasmussen @suchard_group @LemeyLab @jepekar @josh__levy @LrnM9 More details to follow, but sincere thanks to scientists @USDA and contributors to @GISAID for making this possible.
Team effort: @xrayfoo @flodebarre Kristian Andersen @LouiseHMoncla @swientist @meera_chand @MOUGK @EvolveDotZoo @stgoldst @stuartjdneil @PeacockFlu Andrew Rambaut @angie_rasmussen David Robertson @suchard_group @LemeyLab @jepekar @josh__levy Joel Wertheim @LrnM9
So, *preliminary* molecular clock analyses indicate that the time of the most recent common ancestor (TMRCA) of the US cattle flu clade was late December. TMRCA of that clade and the closest relatives in birds, mid-December. If single intro, likely between those rough dates.
Still, the caveat here is that there are still some uncertainties about the (meta)data here.
There is just no good reason to think there's an epizootic of mammalian adapted H5N1 in birds.
My understanding is that these bird (and cat) viruses within the "bovine" clade were sampled from farms that had bovine H5N1. So, are the birds on these farms giving this virus to the cattle, or are the cattle giving it to the birds? It is cattle to birds very likely.
@JeremyFarrar For sure. I believe some of this is going on already by @USDA, @USDA_APHIS, @CDCgov but it would be good to know more.
Incredible to have been with @DrTedros @BoehmeCatharina and an incredible @WHO team in Washington DC 🇺🇸 last week. For more see @DrTedros feed. #ProudToBeWHO
OK, I think we're close to decisive evidence that US bovine H5N1 had a single origin from birds, and that when related viruses from birds *have* been found, they are jumps from cattle back into birds. Grackles, blackbirds, chickens all show mammalian adaptation like PB2 M631L.
1/ Evidence from the recently posted #H5N1 genomes that there was a single introduction and subsequent cow-to-cow transmission.
Here's a visual of the US H5N1 "Cattle clade", HA plus two internal genes. Strongly suggests to me there was single origin, at least for these sequences. Possibly in late 2023/early 2024.
Trends for United States
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