Harmala Alkaloids Identify Ayahausca Intoxication in a Urine Drug Screen 1/5 doi.org/10.1093/jat/bk…
BACKGROUND: Ayahausca is an ethnobotanical drink of South America and the compound dimethyltryptamine (DMT) is primarily responsible for the #hallucinogenic effects. DMT has a short half-life and its detection in urinary drug screens is chal... 2/5
lenging. We investigate a simple alternate approach to detect #ayahuasca consumption by relying on other constituents of the drink, the β-carboline harmala alkaloids.METHODS: Three commercially sourced harmala alkaloids were characterized an... 3/5
d added to a non-targeted high-resolution mass spectrometry urine drug screening method. All analyses were performed on a Waters Xevo G2-XS LC-QTof, in positive electrospray ionization mode. The mass detector was operated in MSE mode and da... 4/5