Alzforum @alzforum
A news and information resource website helping scientists advance AD research since 1996. Alzforum doesn’t endorse any specific product or scientific approach. alzforum.org Boston, MA Joined August 2009-
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A new p-Tau212 assay shows promise as a plasma biomarker of #alzheimersdisease, rivaling the performance of p-Tau217. @goteborgsuni ow.ly/kWKk50RktPT
Peptides possess the power to spark propagation of tau fibrils, or to dismantle fibrils entirely. Two studies point to therapeutic strategies for tauopathies. @ucsantabarbara @UCLA ow.ly/fGY750RkjcX
At #ADPD, scientists showcased preclinical efforts to target microglia in AD, by activating TREM2, blocking CD33, and stopping ASC specks. @adpdnet ow.ly/EnVX50Rk9t3
At #ADPD, scientists parsed microglial and astrocytic contributions to AD pathophysiology. Microglia change their tune as disease worsens. @adpdnet ow.ly/3rh850RftJN
Sumoylation influences tau phosphorylation and aggregation, with SUMO1 promoting, and SUMO2 preventing, these processes. #alzheimersdisease @adpdnet @Columbia @MarioNegriIRCCS @UofT ow.ly/87NR50Rfh1v
Microglia expressing the inhibitory receptor LILRB4 laze around plaques in #Alzheimersdisease and amyloidosis mice. An antibody against LILRB4 stirred microglia to engulf Aβ fibrils and lower plaque load. @WUSTL ow.ly/7zvU50RexJh
A p-tau217 antibody reduced tangles and neurodegeneration and improved memory and coordination in mice. It, and another antibody targeting N-terminal tau, restored brain proteostasis to wild-type levels. @xmuchina @UQ_News ow.ly/1CGt50Remw7
Researchers at AD/PD 2024 discussed progress in developing disease-modifying therapies for synucleinopathies. #parkinsonsdisease @adpdnet ow.ly/sPMC50RcMUi
At #ADPD, scientists focused less on how tau travels between cells, and more on what happens after it arrives. Mechanisms include seed triage by an ATPase and vesicular packaging. @adpdnet ow.ly/NWxh50R7Y6s
Punch biopsies measuring the amount of phosphorylated α-synuclein in the skin diagnosed four synucleinopathies with 93 to 100 percent accuracy. @harvardmed ow.ly/rZCt50R6JVH
Researchers at AD/PD 2024 presented new mouse models of CAA and ARIA, and proposed potential biomarkers of the former and treatments for the latter. #alzheimersdisease @Radboud_Uni @UABBarcelona @adpdnet ow.ly/2XZi50R4Cyl
Scientists linked genetic variants to age-related changes in expression of 10,000 genes in different brain cell types and subtypes. One variant increased expression of APOE only in microglia and correlated with worse CAA. #Alzheimersdisease. @Columbia ow.ly/p8xf50R3v0M
MRI shows CSF flowing into the brain by hugging cerebral arteries. It rides their pulses, spreading into cortical tissue along the way. The data supports the existence of a human glymphatic system. @Oslounivsykehus ow.ly/oaJm50R2wN0
ADPD 2024 highlights O-GlcNAcase inhibitors’ push toward Phase 2 trials in tauopathies. Preclinical studies broaden tau immunotherapy strategies. @adpdnet ow.ly/vefn50R0qee
Despite another Phase 3 flop, TauRx leveraged subgroup analyses to claim glimmers of efficacy for the methylene blue derivative, HMTM. @TauRx @adpdnet ow.ly/6ueN50R0eZw
Knocking out TREM1 preserved memory in old wild-type mice and in models of amyloidosis. Myeloid cell and neuron metabolism improved, while microglia remained ramified. @Stanford ow.ly/thnh50QZ5zG
In #multiplesclerosis mice, activated microglia reverse electron flow within their mitochondria, creating oxidative stress. Blocking this eased neurodegeneration. @Cambridge_Uni ow.ly/ncYV50QYg1H
Roche’s follow-up to gantenerumab, trontinemab, cleared plaque in three months without triggering ARIA in a small cohort. #alzheimersdisease ow.ly/kS1k50QUTnk
In APOE4/4 microglia, Aβ triggers a triglyceride synthesis enzyme. Then they accumulate lipid droplets and release something neurotoxic. @Stanford ow.ly/JEGU50QSeiJ
In 12 people with mild cognitive impairment, six months of lamivudine nudged some biomarkers. The drug suppresses retrotransposons. These jumping genes are less methylated in AD. @UTHealthSA ow.ly/yJ6S50QRBhp
Prof. Melissa E. Murr.. @DrNeuroChic
5K Followers 1K Following Translational neuropathologist | Biomarker enthusiast | Hopeful scientist | Scientific Program Committee @HAIconference #AAIC24 | Advisory board #ADPD2025John Lukens @LukensJohnR
11K Followers 3K Following Neuroimmunologist studying MS, autism, Alzheimer's disease, and brain injury at the University of Virginia. Father of two. Fan of Philly sports and US soccer.Celeste Karch @karchlab
4K Followers 364 Following Professor. Washington University School of Medicine. Genomics, stem cell models, molecular mechanisms of AD and other tauopathies. She/her.Rachel Buckley 🐨�.. @bucklr01
5K Followers 2K Following Assistant Professor @ MGH/Harvard Med: sex differences in risk for preclinical AD. K99/R00 and DP2 awardee. Co-PI of @healthybrain_au. Aussie. Twin mumProf Selina Wray @SelinaWray
12K Followers 3K Following Professor of Molecular Neuroscience at UCL Queen Square Institute of Neurology. Barnsley lass. she/her @wraylabUCL @UCLIoNShane Liddelow 🍊 @LiddelowSA
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11K Followers 6K Following Countering deleterious phase transitions in ALS/FTD, PD, AD, and related disorders @Penn @PennMedicine @bb_upenn @BMBGGUPENN @PGGUPenn @PennNGG @CAMBUpennUK Dementia Research .. @UKDRI
13K Followers 1K Following New scientific discoveries, new hope to stop dementia. Founding funders: @The_MRC @alzheimerssoc @AlzResearchUKNat Rev Neurology @NatRevNeurol
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219 Followers 3K Following offer vitamins and supplements https://t.co/6lX91v1au9 https://t.co/zo3V69PMED https://t.co/sQmtttMy3w https://t.co/4AsuEubyqN https://t.co/wNZJnwTH4t https://t.co/QTd4LCNYKe https://t.co/tlG6l5uHd5 https://t.co/P7PbTJ3ntJ 🌱Dr. Madhu Benekareddy @madhurimabr
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4 Followers 40 FollowingAddie Walsh @Addie_E_Walsh
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4 Followers 224 FollowingDilek Kolit @DilekKolit
0 Followers 60 FollowingMiranda Devine @MDevine98128
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21 Followers 94 Following Neuroscience | Fluid biomarkers | Alzheimer's disease Associate Researcher UGOT 🇸🇪Meeting Centres Scotl.. @ScottishMCN
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472 Followers 629 Following Associate Professor, Department of Psychology, Lakehead University; Psychologist, Dilico Anishinabek Family CareCeleste Karch @karchlab
4K Followers 364 Following Professor. Washington University School of Medicine. Genomics, stem cell models, molecular mechanisms of AD and other tauopathies. She/her.Rachel Buckley 🐨�.. @bucklr01
5K Followers 2K Following Assistant Professor @ MGH/Harvard Med: sex differences in risk for preclinical AD. K99/R00 and DP2 awardee. Co-PI of @healthybrain_au. Aussie. Twin mumProf Selina Wray @SelinaWray
12K Followers 3K Following Professor of Molecular Neuroscience at UCL Queen Square Institute of Neurology. Barnsley lass. she/her @wraylabUCL @UCLIoNShane Liddelow 🍊 @LiddelowSA
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8K Followers 4K Following Neuroscientist. Prof @EdinburghUni Group Leader @UKDRI founding editor @BrainComms President @BritishNeuro (you can call me madame president). she/her 🧠 🔬 📚UK Dementia Research .. @UKDRI
13K Followers 1K Following New scientific discoveries, new hope to stop dementia. Founding funders: @The_MRC @alzheimerssoc @AlzResearchUKNat Rev Neurology @NatRevNeurol
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2K Followers 1K Following Neuroimaging Researcher | LMU Munich | Institute for Stroke and Dementia Research | studying tau spreading & resilience in Alzheimer's disease @ISDneuroimagingAdam Smith @BetterResearch
12K Followers 4K Following #Dementia Research at @UCL - creator of Dementia Researcher supporting ECR CareersDavid Gate @DGateLab
3K Followers 2K Following Assistant Professor, Northwestern Neurology. The Gate lab studies the role of the immune system in neurodegenerative diseases.Carlos Cruchaga @ccrugom
1K Followers 339 Following NeuroGenomics and Informatics Center Director. Washington University School of MedicineAD/PD - Advances in S.. @adpdnet
4K Followers 1K Following AD/PD™ 2024: Striving for a better future for all those affected by neurodegenerative diseases. March 5-9, 2024 | Lisbon, Portugal | #ADPD2024Lance Johnson @LJohnsonLab
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3K Followers 361 Following Neuroscience center in Belgium 🔬🧠 Part of @VIBLifeSciences × @KU_Leuven ✨ Discover our research community ➡️ https://t.co/oDhNWj4ixQSalk Institute @salkinstitute
39K Followers 4K Following The Salk Institute for Biological Studies is one of the world's preeminent basic research institutions. Click link below to sign up for our monthly newsletter.C Van Broeckhoven @cvbroeck
2 Followers 17 FollowingAlzheimer's Afternoon.. @AlzAfternoons
859 Followers 2 Following Alzheimer's Afternoons seminar series. Every Tuesday and Thursday 3pm EDT. On Friday we have our Happy hour with two talks from trainees.HenneHolstege @HolstegeHenne
640 Followers 204 Following cognitively healthy centenarians escaped dementia: it’s in their genome! #100plusStudy @AlzheimerAms @amsterdamumc @GeneticAms @AmsNeuroscience https://t.co/o04nvzjb6cThe Rainwater Charita.. @RCFNeuro
885 Followers 422 Following Supporting scientific progress to understand primary tauopathies in neurodegenerative disease research. Visit our website to discover all our funding programs.C. Roy Lin, MD MPH @RoyCLinMD
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6K Followers 2K Following #neuropsychologist #healthequity #SDOH #brainhealth #AD @Columbia. Posts represent my personal views and not those of CUIMCWray Lab @WrayLabUCL
2K Followers 506 Following Research group in the Department of Neurodegenerative Disease @UCLIoN working on Alzheimer's Disease and Frontotemporal Dementia.Maria Carrillo @DrMariaALZ
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23K Followers 10K Following MD; Curator:Medical/Health/Tech; Focus: Aging, Mobility, AgingTech, AgeTech, HealthyAging, AssistiveDevices, AssistiveTechJason Resendez @jason_r_DC
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3K Followers 520 Following NIHR National Director for Dementia Research, Professor Emeritus, and Principal Research Associate at the UCL Queen Square Institute of Neurology.Wes Ashford @wes_ashford
105 Followers 222 Following Stanford Professor, Neuroscientist, Neuropsychiatrist. Longtime leader in Alzheimer's Research.Mychael Lourenco @mvlourenco
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110 Followers 923 Following 🇯🇴🇬🇧 Interested in inherited rare diseases, stem cells and gene editing research @jordanuni_int; @UCL; @IoOECREdinburgh Dementia Pr.. @CenDemPrevent
2K Followers 477 Following A cross-discipline research centre established to understand and tackle risk factors associated with dementia. Directed by Profs Manson, Ritchie and Clarke.Mike Donohue @MikeCDonohue
125 Followers 140 Following Associate Director of Biostatistics at Alzheimer's Therapeutic Research Institute of University of Southern CaliforniaHeather Brown @heatherjyb
18 Followers 74 Following I'm an editor @TheLancetNeuro and I knit whenever I'm able. If I get round to expressing any views here, they will be my own.@alzforum @Alzheimers_NIH @WakeForest Hi @alzforum, NIA has updated its Twitter handle! Please use @NIHAging moving forward so we can see your tweets! 😀
I was asked to contribute to some work summarizing Tau-targeting therapies. I still can not believe how good of a resource @alzforum is. The amount of information is incredible, and all up to date. Can't imagine how many work-hours the collective AD-field owes alzforum.
Always a pleasure to contribute @alzforum 😀 alzforum.org/papers/plasma-…
Preprint describing a coordinated approach by public domain bioinformatics resources curating proteins relevant to Alzheimer Disease content.iospress.com/articles/journ… #Alzheimers @Alzheimers_NIH @aruk @aruknew @UCLgene @imexconsortium @QuickGO_EBI @uniprot @alzforum @complexportal
…and finally, for news and updates on the latest research into dementia, check out: Neurocentral - @Neuro_Central Alzforum - @alzforum Add your suggestions for great accounts in the replies below ⬇️⬇️⬇️
Check out the Alzforum coverage on our recent paper on maintained cognitive health in centenarians. We can learn so much from them! alzforum.org/news/research-…
Amyloid and PET #imaging reveals the pathology driving particular #Alzheimers disease symptoms alzforum.org/news/conferenc… MT @alzforum #neuroscience #dementia @YuHelenYu @RonniLaurie @MairiLicious7 @RodneyClaeys @DrWardBondTV @IrmaRaste @KentSmalley @b_and_s_designs @Neil_ODonnell
The first ever Tau2020 Global Conference was a big success. Thanks to @alzforum for a nice summary.
A new international tau meeting kicked off in Washington, D.C. It aims to cover all tau-related diseases. Researchers reported new genetic variants for progression of progressive supranuclear palsy and Parkinson’s disease. #Tau2020 ow.ly/8sVd50yCdo2
Here is Part 2 of Alzforum’s excellent write-up of the Tau2020 Global Conference.
Scientists have solved the three-dimensional structure of α-synuclein fibrils isolated from diseased human brain. They look different than tau fibrils. @MRC_LMB #Alzforum ow.ly/V19o50yDfmd
Summary & discussion covering our recent work into cognitive maintenance in centenarians ja.ma/2VNefwO. @AlzheimerAms @AmsNeuroscience @VU_FGB @VUamsterdam @HenneHolstege #NinaBeker
Dutch study: If you are still sharp at 100, you’ll stay sharp and healthy some years longer. Such people offer a way to identify protective factors against #alzheimersdisease. #vrijeuniversiteitamsterdam ow.ly/UVqF50yDcwR
It's fantastic to see @alzforum write about our @biorxivpreprint on #alphasynuclein filaments from #MSA brains. The preprint model will only work if their precedence is properly recognized. alzforum.org/news/conferenc…
This is really cool
Scientists have solved the three-dimensional structure of α-synuclein fibrils isolated from diseased human brain. They look different than tau fibrils. @MRC_LMB #Alzforum ow.ly/V19o50yDfmd
Can PET Match Up Areas of Protein Deposit With #Alzheimers Symptoms? Read more at @alzforum: ow.ly/X2cZ50yCGSp #tangles #protein
Cool research identifying the "rhinal cortex" as the location of earliest tau deposits that are easily detectable using PET. Rhinal cortex surrounds the rhinal sulcus - the anterior part of the collateral sulcus that separates the entorhinal cortex from the fusiform gyrus.
Using PET, researchers detect first traces of tau accumulation in the rhinal sulcus, and propose a tau staging scheme. #Tau2020 #Alzforum ow.ly/lcNB50yEeRS
Great summary of tau PET tracer discussions that took place at The Tau2020 Global Conference.
Autopsy data confirms selectivity of different PET ligands for specific forms of tau. New tracers may specifically bind 4R tau and α-synuclein. #Tau2020 #Alzforum ow.ly/ZUFv50yF6Wf
This is very cool research! 👍🏼 #TAU2020 @KosikLab @MGHmapp @ApoEdscvr
Scientists identify a cell-surface receptor, LRP1, that binds tau, facilitating its spread through the brain. #Tau2020 #Alzforum ow.ly/ZVHG50yFWDi
Cool. Rauch found that LRP1 KD totally abolished tau uptake. Without LRP1, the H4 cells were unable to absorb monomers, oligomers, and fibrils of tau. Likewise, when LRP1 was KD in neurons derived from human induced pluripotent stem cells, they also no longer endocytosed Tau”
Scientists identify a cell-surface receptor, LRP1, that binds tau, facilitating its spread through the brain. #Tau2020 #Alzforum ow.ly/ZVHG50yFWDi
Behold the First Human α-Synuclein CryoEM Fibril Structure alzforum.org/news/conferenc… @alzforum
I always enjoyed the #Alzheimers mutations diagrams of @alzforum. Glad to see the update!
Alzforum unveils upgraded mutation diagram of key #Alzheimer’s protein APP. ow.ly/P3KR50yc52Q