An elegant optogenetics tool streamlines research into inflammasomes, researchers elucidate how the inflammatory cytokine TNF-alpha reprograms the metabolism of T cells, and more in this week’s issue of #ScienceSignaling. scim.ag/6HG

The new issue of #ScienceSignaling is out! Researchers discover how cellular “storehouses” for iron can trigger liver inflammation, our weekly Editors’ Choice piece discusses new findings on lipid droplets and neurotoxicity, and more. scim.ag/6rW

Don’t miss this week’s new issue of #ScienceSignaling! An experimental compound sensitizes stubborn prostate cancers to DNA damage, researchers illustrate how a host transcription factor enables influenza to escape the immune system, and more. scim.ag/6x8

This week’s new issue of #ScienceSignaling has arrived! Scientists decode the biological and molecular impacts of cocaine addiction in the brain, a new study in zebrafish casts light on Wnt proteins and their receptors, and more. scim.ag/6Cy

Don’t miss this week’s new issue of #ScienceSignaling! Researchers discover how muscle cells in mice replenish their lipid stores and recover after exercise, a new study demystifies the signaling properties of an orphan chemokine, and more. scim.ag/6hh

New issue of #ScienceSignaling Research illustrates how protein-laden vesicles from the “architects of cancer pathogenesis” shape the tumor microenvironment, the phospholipid PI4P can enhance the activation of the key immune mediator STING, and more. scim.ag/6bZ

The new issue of #ScienceSignaling has arrived! Research illustrates how protein packages from the “architects of cancer pathogenesis” shape the tumor microenvironment, a phospholipid helps activate a key modulator of the immune system, and more. scim.ag/6bL

A brake on the cell cycle offers a new target in breast cancer cells, researchers characterize the protein-protein interactions that determine the performance of anticancer CAR T cells, and more in this week’s new issue of #ScienceSignaling. scim.ag/66D

This week’s new issue of #ScienceSignaling is out now! Researchers delineate how the pyroptosis of T cells may drive rheumatoid arthritis, a second-generation AKT degrader suppresses breast cancer cells better than its predecessors, and more. scim.ag/61i

This week’s issue of #ScienceSignaling has arrived! Experiments demystify the phenomenon of biased signaling by an important regulator of physiology, a study shows how specific locations within cells can shape biased signaling, and more. Read more: scim.ag/5Rd

A more faithful mouse model could facilitate therapeutic research into a rare autoimmune disorder, fusion proteins aim to enhance lipid signaling and endothelial function in blood vessels, and more in this week’s new issue of #ScienceSignaling. scim.ag/5Wl

This week’s new issue of #ScienceSignaling is out now! Researchers delineate how the inflammatory death of T cells may drive rheumatoid arthritis, a second-generation degrader effectively suppresses breast cancer cells, and more. scim.ag/61a

New research unveils a protein complex that enables mitochondria to move within slender, long neurons, a negative feedback mechanism keeps T cells from becoming overstimulated, and more in this week’s new issue of #ScienceSignaling. scim.ag/5Mn

This week’s new issue of #ScienceSignaling has arrived! Discoveries about the nature of inflammasomes could inform research into inflammatory conditions, a study illustrates how protein competition enables the growth of cellular “antennae,” and more. scim.ag/5Cl

Don’t miss this week’s issue of #ScienceSignaling! A flexible antibody platform could empower research of a ubiquitous signaling process, research reveals how enzymes called small GTPases shape how neurons respond to growth cues, and more. scim.ag/5xj

An alcohol-processing enzyme also helps the immune system to suppress invading viruses, a new Review spotlights the emerging role of NF-kappaB in inflammatory bowel disease, and more in this week’s new issue of #ScienceSignaling. scim.ag/5sh

The #commensal #bacteria #Fusobacterium can promote the migration of #PancreaticCancer #cells, according to a 2022 #ScienceSignaling #study highlighting the growing importance of the tumor #microbiome in #cancer progression and #therapeutic #research. doi.org/10.1126/scisig…

The first #ScienceSignaling issue of 2024 has arrived! Researchers dissect how seedlings respond to light and spread their leaves, a study probes the TAO(K3) of T cells, an Editorial discusses the bright future of basic biology research in India, and more. scim.ag/5nF

Each week, we recognize our #ScienceSignaling board members. Today, we thank Dr. Erica Herzog at Yale University (medicine.yale.edu/profile/erica_…), who shares with us her expertise on pulmonary fibrosis, inflammation, and tissue engineering. @YaleMed

This week’s new issue of #ScienceSignaling has arrived! Mutational experiments decode genetic drivers of an aggressive hereditary gastric cancer, an experimental compound suppresses inflammation from coronaviruses while maintaining immunity, and more. scim.ag/5fx