Kelvin Lau always @klausenhauser on ☁️ 🪡 🐘 @klausenhauser
🇨🇦🇭🇰👨🔬@ protein production and structure facility 🇨🇭Equally #proteins #plants #transit #cats #politics. My views here orcid.org/0000-0002-9040… Geneva/Lausanne/Toronto/Vancouver Joined February 2010-
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people: "scientific fraud has consequences!!!" the consequences:
Love these stories to add on to the standard Mol Biol slides in courses.
Love these stories to add on to the standard Mol Biol slides in courses.
About a month ago I suggested a plasmid cloning experiment and said it will be "the easiest, simplest cloning you'll ever do". You can predict the broad strokes of what happened next, but the details are kind of amusing (in retrospect)... 1/n
We are looking for a postdoc excited about structural biology of protein-RNA complexes. We have interesting research questions, high-end facilities and a great network of collaborators. Join my awesome team @BNITM_de @CssbHamburg #structuralbiologyrocks jobrxiv.org/job/bernhard-n…
How is it that a Swiss-made drug can cost $6,000 in the US, $3,000 in Switzerland, and $1,000 in South Africa? Check out the full version of our video explaining the quirks and rules of drug pricing when it goes live on YouTube on Thursday. buff.ly/3UwAwwD
WHAT % OF YOUR TARGET BIOMOLECULES ARE YOU REALLY IMAGING? The *labeling efficiency* of your experiment is extremely important for image quality and quantitative results in super-resolution! Super excited about our new article in @naturemethods! 🤩 nature.com/articles/s4159…
Exciting news! Our latest preprint is out, showcasing the work of Nicolas Flaugnatti on T6SS & capsule in Acinetobacter baumannii. Congratulations Nico! 🍾🥳 🧵below .... 1/x Capsular Polysaccharide Restrains Type VI Secretion in Acinetobacter baumannii biorxiv.org/content/10.110…
In Australia we have a computational thinking competition for kids each year called Bebras. You get a certificate if you get all of them right. Here's one of the "easy" level questions for children in grade 3. GPT 4 got it wrong.
Cost-of-living adjustment: SNSF increases salary bands for staff working on its projects. The rise takes effect retroactively as of 1 January 2024. sohub.io/mbzv
Love this flex of casually breaking all biologics IP.
Love this flex of casually breaking all biologics IP.
Interested in trying LEA proteins on your own samples for cryo-EM air-water-interface protection? Our plasmid for RvLEAMshort is now available on addgene! addgene.org/218122/
Interested in trying LEA proteins on your own samples for cryo-EM air-water-interface protection? Our plasmid for RvLEAMshort is now available on addgene! addgene.org/218122/
Check out our pre-print describing a CCHFV glycoprotein complex in the pre-fusion conformation! We used several engineering tricks to design our final construct, GP38-GnH-DS-Gc. Great collaborative effort, led by graduate student @Eliza4Science! biorxiv.org/cgi/content/sh…
We have released a major update to pLM-BLAST, a remote homology detection method based on representations from protein language models such as ProtT5. Check it out on @mpitoolkit (toolkit.tuebingen.mpg.de/tools/plmblast) and GitHub (github.com/labstructbioin…) & see below 🧵 for details!
The best discussions at conferences happen informally during social events. This is why I’m not a fan of online conferences. I have a meeting today with the same people I was chatting with last night. It will be interesting to see which interaction is more insightful.
I think we really are underselling how cooked Facebook is. This is a 17,000 member group called "Facebook complaints center" made up of people that post like they recently got a concussion
Great honor to publish and be part of @NatureChemistry May issue with Prof. Norman Metanis in News & Views article about STATE-OF-THE-ART synthetic folding of disulfide-rich peptides and proteins nature.com/articles/s4155…
Time for the annual workshop “Scientific Writing Academic Papers.” On the importance of orthogonal replication. Watch the video at kamounlab.medium.com/dont-perish-a-…
I am pleased to announce the conclusion of the Protein Design Games Winter 2024, hosted by RosettaCon and sponsored by Liberum Biotech! Five teams competed head to head to design the best TEV protease, only one came out on top!!! rosettacommons.blogspot.com/2024/04/winter… liberumbio.com/PDG24.htm
Paper out: Gene encoded nanoparticles (GEMs) with 180 GFPs are cool tools to track in cells. GEMs reveal biophysical basis of infection, too. Using GPI-anchored nanobody receptors over 6 logs of affinity shows that adhesion energy alone explains uptake! rdcu.be/dFddO
Andreas Boland @BolandLab_GE
4K Followers 3K Following https://t.co/RfDg6e8gDU Biochemistry and Structural Biology @UNIGEnews; views are my own 🇩🇪 🇨🇭 🇬🇧 RT ≠ endorsementMisha Kudryashev 🔬.. @MishaKudryashev
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24K Followers 8K Following Amateur 🌿 Biologist • Aspiring 🌺 Designer Researcher at Binomica Labs • Degreeless Heathen • Petunia Breeder • Open Lab Notebook: https://t.co/umYTLluuuwBasil Greber @BJ_Greber
5K Followers 1K Following Structural Biologist: #CryoEM #Transcription #DNArepair. MRC career development fellow/team leader at @ICR_London. Views my own. @[email protected]Brady Johnston @bradyajohnston
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5K Followers 5K Following Structural Biology Facility Manager @ImperialCollege. Expect protein crystallography🧬💎🎇, Boardgames♟️, D&D🎲, MTG🧙, and birds called Nori and Kili 🦜🦜Jeremy Kamil is also .. @macroliter
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13K Followers 2K Following Protein and coffee lover, father of two, professor of biophysics and sudo scientist at the #LinderstrømLang Centre for Protein Science 🇩🇰 Same usr @ 🦋Tristan Croll @CrollTristan
4K Followers 479 Following Principal Scientist at Altos Labs. Making data-based macromolecular modelling faster, more accurate and a bit more fun. Devoted husband and father.EMDB - EMPIAR @EBI @EMDB_EMPIAR
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36 Followers 279 FollowingSjors Scheres @SjorsScheres
15K Followers 658 Following Joint Head of Struct. Studies @MRC_LMB #RELION, #cryoEM, #amyloids, #OpenScience All opinions my own. Same name on https://t.co/7ZvFwboaIY and https://t.co/DCRukHhSh7cryoEM Papers @cryoEM_Papers
13K Followers 0 Following I'm a bot that surveys the cryoEM literature for you! Operated by @fredericpoitev1 & @CorneliusGati, adapted from PaperBots twitter app developed by @fxcoudertTamir Gonen 🎗️ @gonenlab
6K Followers 530 Following Professor @UCLA School of Medicine @HHMINEWS Investigator; Membrane proteins; #cryoEM; crystallography; #MicroED; #firstgen; Opinions my own. 👋👋👋🎗️Andreas Boland @BolandLab_GE
4K Followers 3K Following https://t.co/RfDg6e8gDU Biochemistry and Structural Biology @UNIGEnews; views are my own 🇩🇪 🇨🇭 🇬🇧 RT ≠ endorsementMisha Kudryashev 🔬.. @MishaKudryashev
4K Followers 971 Following Group Leader at the Max Delbruck Center for Molecular Medicine @MDC_Berlin Professor in Charité – Universitätsmedizin Berlin Science / Biophysics / Cryo-EMSebastian S. Cocioba�.. @ATinyGreenCell
24K Followers 8K Following Amateur 🌿 Biologist • Aspiring 🌺 Designer Researcher at Binomica Labs • Degreeless Heathen • Petunia Breeder • Open Lab Notebook: https://t.co/umYTLluuuwBasil Greber @BJ_Greber
5K Followers 1K Following Structural Biologist: #CryoEM #Transcription #DNArepair. MRC career development fellow/team leader at @ICR_London. Views my own. @[email protected]Brady Johnston @bradyajohnston
15K Followers 2K Following structural biologist, scientific animator, creator of #MolecularNodes, he/him #rstats #b3d mstd: [email protected] bsky: @bradyajohnston.bsky.socialStructura Biotechnolo.. @structurabio
5K Followers 449 Following Algorithms, Software and Systems for Cryo-EM. Makers of CryoSPARC.とりさん @biochem_fan
6K Followers 4K Following とりさん。学問(≠研究)を楽しむ程度の能力。 生合成経路・天然物化学・酵素反応機構・構造生物学・プログラミングが好き。言語や古典文学にも手を出したり。ただの下手の横好き。 科学におけるオープンソース・オープンデータ原理主義者。 言うまでもなく、全ては個人の意見・感想です。 注意:持病のため気分の波あり。鬱発言多しDavid Dranow, Clone m.. @GntlmnScientist
2K Followers 497 Following he/him, Jewish, retired PhD candidate, habitual x-ray crystallographer, recovering electron microscopist, native Californian, views expressed here are my ownSam Horrell 🗿 @DrHorrell
5K Followers 5K Following Structural Biology Facility Manager @ImperialCollege. Expect protein crystallography🧬💎🎇, Boardgames♟️, D&D🎲, MTG🧙, and birds called Nori and Kili 🦜🦜Jeremy Kamil is also .. @macroliter
25K Followers 5K Following He, him. CMV virologist exploring how viruses exploit glycoimmune checkpoints #Glycotime | Loves 🥾 🏔️ 🏕️| Y'all on Bluesky or Threads? Linktree below ⬇️Lucrezia Catapano @lulu_catapano
1K Followers 892 Following Postdoctoral Scientist in Computational Structural Biology @MRC_LMB. Macromolecular refinement| Coot and Moorhen developer| Blender 3D |Coot tutorials| She/HerKelly Nguyen @KellyTHD_Nguyen
5K Followers 1K Following Group Leader @MRC_LMB /Structural Biologist/Biochemist. Amateur baker in free time #RNAworld #spliceosome #telomerase #telomeres #cryoEM #XraycrystallographySergey Ovchinnikov �.. @sokrypton
12K Followers 3K Following Scientist, Assistant Professor @MITBiology, #FirstGen, ProteinBERTologistDimitry Tegunov @DTegunov
4K Followers 664 Following Mostly #cryoEM-related tweets. Group leader at a biotech company. Views expressed are strictly my own.swissinfo.ch @swissinfo_en
45K Followers 340 Following International Service of the Swiss Broadcasting Corporation. 📧 [email protected]neoplants @neoplants
531 Followers 1 Following The first generation of plant systems bioengineered to fight air pollution.Ryan Cross the Scienc.. @RLCscienceboss
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16K Followers 17K Following Earth resilience, tipping behavior, nonlinear thinking, stability analysis, climate change, photosynthesis, soil respiration, tree mortality, Fulbright ScholarOpen Collective Europ.. @OC_Europe
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472 Followers 204 Following postdoc - designing proteins at Dana-Farber/Harvard Medical School | formerly, evolutionary biochemistry at Max PIanck Institute in MarburgGeorg Hochberg @KaHochberg
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3K Followers 50 Following rebalancing the planet’s carbon cycle using the power of plants 🌱💪Leonardo Ferreira @enhancerleo
3K Followers 5K Following Molecular immunologist. Human genome engineer. Deconstructing the immune system to achieve immune tolerance in type 1 diabetes and transplantation.Jack Zhang Lab @zhang_lab
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473 Followers 248 Following PhD student @EPFL 🇨🇭 | ML & computational biology 🤖🧬⚛️Stephen Buckley @St_Buckley
72 Followers 669 Following PhD candidate at the LPDI lab in EPFL; interested in all things proteins.Steve McGuire @sfmcguire79
20K Followers 2K Following Paul & Karen Levy Fellow in Campus Freedom @goACTA. Writings in @WSJ, @nypost, @Newsweek, @FoxNews, @RCPolitics, etc. Opinions are my own. RT ≠ endorsement.WBF DEFR EAER @DefrWbf
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2K Followers 485 Following Prof. @Materials_EPFL and Physics. President-elect of @EPFL, starting 01.01.2025 This is my personal account.Alex Colville @AlexJColville
3K Followers 432 Following General Partner at @age1vc extending healthy lifespan. PhD alum of @Thomas_Rando @stanfordmedPekka Kallioniemi @P_Kallioniemi
146K Followers 2K Following Creator of #vatniksoup and The Soup Central. Inquiries to [email protected]Old Toronto Series @oldTOseries
18K Followers 244 Following Twitter account for the Old Toronto Series. Make sure to also check out @oldcanadaseries. run by: @morgan_c_ross. Want to support? “Buy me a coffee!” click ⬇️Aidan Grosas @AidanGrosas
501 Followers 1K Following Research Fellow at the ARC Training Centre for Cryo-Electron Microscopy of Membrane Proteins, Molecular Horizons, UOWNathan Benaich @nathanbenaich
51K Followers 32K Following solo member of investment staff @airstreet, brewing ambition @airstreetcafe, next token predictor @airstreetpressJinwoo Leem @ideasbyjin
959 Followers 582 Following Director of ML @alchemabtx prev: @benevolent_ai, @OPIGlets. Antibodies, LLMs, protein structure prediction, neuro, onco. 🇨🇦🇬🇧🇰🇷 Tweets=my views.Gourav Arora @gourav_arora_g
2K Followers 3K Following PhD candidate in Coupland's group @mpipz_cologne , rePLANT @MSCActions fellow. Previously @IITRoorkee @IISERPUNE @UnivofDelhi @dubotanyMiles Graham @miles_a_graham
95 Followers 196 Following DPhil student in Cellular Structural Biology @ Oxford. Using cryo-EM, cryo-ET & cryo-FIB/SEM. Currently @GroupZhang and @eBIC_Diamond. Previously @TBharat_lab.Shuhan @shuhan_paint
105 Followers 511 Following PhD student advised by Peter Murray @pjmurray_lab and Ralf Jungmann @JungmannLab @MPI_Biochem @IMPRS_LS. Excited about #immunology and #imaging.Daniel Hoces @DanielHoces
339 Followers 596 Following Postdoc @Stanford. Engineering immune cells to fight cancer. Ph.D. @ETH_en | M.D. @CayetanoHeredia 🇵🇪 🇨🇭Helena Keller @helenarkeller
365 Followers 1K Following PhD candidate @DukovicLab | nanocrystal-enzyme photocatalysis | ultrafast spectroscopy | EPR | co-organizer @NiNC_Seminar | gardening | she/her 🇺🇸/🇦🇹FriedaLeesch @FriedaLeesch
418 Followers 897 Following PhD student in the @PauliGroup 🐟 at the @IMPvienna, exploring the intricacies of translation regulation & ribosome dormancy in the egg🧬🥚@klausenhauser Fair But most of the narrative now about being a scientist is that nothing can ever go off the rails Don't get those 2 or 3 Cell/Science/Nature papers out of your PhD and a K99 as a postdoc? Go off yourself. You failed When really, if you're being consistently useful, it works
Much hoopla about the improvements to the field and seats at the Roger’s Centre (nee Skydome). I assume that there will be improvements outside too. But in the years leading up to this how much does it cost to put a cost of paint on this?
@gaghyogi49 looks like the ship that's chasing them from one of the early S5 trailers, so we're probably not done with the Breen
@jrkelly yes, but having been there building some of the first automated synthesis & screening automation platforms, the scientists that were best at experimental design & data analysis were also some of the best hands in the lab. skilled in the art means all facets of the art.
@PolesWires It’s not a maintenance issue. Those planters have no where for roots to grow. It’s like a smallish concrete pot that they are planted in. Streetscape trees like that all die after a year or two. It’s a bad way to plant trees.
Love these asphalt planters. Toronto optimism at a start of a project replaced by resignation that maintenance is too much for this city.
Yay! Three years after @raoult_didier @Pr_Chabriere_E and @IHU_Marseille filed a complaint against me for harassment and blackmail, the Marseille Procureur tells me today they could not find any grounds for criminal prosecution.
@wanderer_jasnah Man, ~20 years ago I remember one of the grad students in the lab I was a summer student in mentioning that a potential postdoc position interview they had with Tessier-Lavigne lab had all the wrong vibes.
people: "scientific fraud has consequences!!!" the consequences:
Former Stanford president Marc Tessier-Lavigne, who resigned following an investigation, has left the university for "biotech’s new AI mega-startup." endpts.com/marc-tessier-l…
@klausenhauser lol. This is a great story. I am currently obsessed with plasmids.
@david_kochman It's also a bit of a lesson as to why clonal re-isolation and test-digests are not a bad idea despite how much faster and better current commercial services are.
@david_kochman If it was done through primordium or plasmidsaurus I think their method only gives back the consensus highest abundance species. That's both good and a bit of a curse
About a month ago I suggested a plasmid cloning experiment and said it will be "the easiest, simplest cloning you'll ever do". You can predict the broad strokes of what happened next, but the details are kind of amusing (in retrospect)... 1/n
A great thread on why ever cloner probably should learn some "real" E. coli genetics.
We got the parent plasmid from a collection and verified by whole-plasmid Nanopore sequencing that it had the correct yeast gene. The plan was to digest with a restriction enzyme to excise an unwanted antibiotic resistance marker, then dilute and ligate. Easy-peasy, right? 2/n
@e_zyko I'll inquire. PDB hesitates to add to PDB files info that does not come from author, although it does calculate some properties from coordinates (e.g. secondary structure). But it could provide other files that include additional information (like SIFTs).
RCSB scientific advisory board meeting tomorrow. 5- character ligand codes already in use. Longer pdb codes soon. Anything you want me to discuss with pdb leadership?
Some Bristolian weeds for your amusement
We are looking for a postdoc excited about structural biology of protein-RNA complexes. We have interesting research questions, high-end facilities and a great network of collaborators. Join my awesome team @BNITM_de @CssbHamburg #structuralbiologyrocks jobrxiv.org/job/bernhard-n…
@dancvg Yeah, Hong Kong has some great parks. It's also surrounded by mountains, most of which are undeveloped.