Stephen Goldstein @stgoldst
Evolutionary virology postdoc @ Univ of Utah. Previously Penn Medicine. Coronaviruses and the Wasatch. Salt Lake City, UT Joined March 2013-
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Active surveillance at human-animal interfaces remains the single most important thing we can do to catch spillovers early, imo.
Active surveillance at human-animal interfaces remains the single most important thing we can do to catch spillovers early, imo.
A few thoughts on the role of pigs in the emergence of influenza A virus in mammals. 1. It is simply not the case that movement of flu viruses into non-swine mammal species requires pigs as a "mixing vessel".
A big win, go figure. But I do genuinely appreciate someone skeptical of our work being so forthright about the results on this analysis.
A big win, go figure. But I do genuinely appreciate someone skeptical of our work being so forthright about the results on this analysis.
Nine beavers were found dead over the last few weeks in Summit, Wasatch and Utah counties. Three were tested and found to be positive for a disease called tularemia, which can also affect humans. Learn more: bit.ly/3TRBPEM
Your daily reminder that viruses are material objects without plans or goals (other than to replicate) and certainly without thoughts or maliciousness. Read more about it here: wwnorton.com/books/virology
Tis the season
Thanks to generous funding from the NIH/NHGRI, we will be sequencing the 4th generation of the CEPH/Utah pedigrees starting this year!
On the unprecedented natural experiment in human immunology and viral evolution that was the COVID pandemic, by @HelenBranswell statnews.com/2024/03/28/cov… via @statnews
Congratulations to Zackular lab postdoc, @Marisa_Egan11, on her new position @swarthmore!!! The Egan lab is going to do amazing things and I can’t imagine a better person to educate students on all things microbiology!
Congratulations to Zackular lab postdoc, @Marisa_Egan11, on her new position @swarthmore!!! The Egan lab is going to do amazing things and I can’t imagine a better person to educate students on all things microbiology!
I normally sit this topic out, but I want to amplify this thread. This modeling is very similar to what I was doing in Jan and Feb 2020, and it’s how I knew then that the story of an outbreak starting from the market in Wuhan was consistent with everything we knew then and after.
I normally sit this topic out, but I want to amplify this thread. This modeling is very similar to what I was doing in Jan and Feb 2020, and it’s how I knew then that the story of an outbreak starting from the market in Wuhan was consistent with everything we knew then and after.
Interesting thread (being written right now) that independently investigates the scenarios explored in Pekar22, using simulation code he wrote in-house + sampling under models that differ from what we used, but getting similar results
Interesting thread (being written right now) that independently investigates the scenarios explored in Pekar22, using simulation code he wrote in-house + sampling under models that differ from what we used, but getting similar results
Pekar's simulations said that happens 3% of the time from a single introduction. My code said it was also about 3%. Those double lineage epidemics can be drawn like this:
@jmol3rd @RicketRobin @mikeydoubled We ignore that threat at our peril. Wildlife farming, trade, and trafficking are huge business ($70 billion a year in China before Covid. . Pangolins are the most trafficked animal in the world, but not in trucks labeled "Pangolin": jammed in lorries with other stressed animals
Remember that cryptic lineage from New Jersey with all the Spike mutations? The Spike has a pretty dramatic phenotype when you transfect it. And these are cells with little to no ACE2 or TMPRSS2.
The Lab Leak Hypothesis™ isn't coherent or self-consistent enough to be described as a conspiracy theory. It's not one hypothesis, or one theory. It's a flexible collection of (often mutually incompatible) explanations that share support for a lab leak. 1/2🧵
4 yrs ago JHU brought in a security firm run by former FBI agents to analyze threats I received. Messages from one of these men rose to the top of their concern list. They weren't even about labs! I'm disheartened that this pattern of abusive behavior has continued w/o penalty.
4 yrs ago JHU brought in a security firm run by former FBI agents to analyze threats I received. Messages from one of these men rose to the top of their concern list. They weren't even about labs! I'm disheartened that this pattern of abusive behavior has continued w/o penalty.
Dr. Angela Rasmussen @angie_rasmussen
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973 Followers 22 Following Together for a fair and responsible trail runningSo, as of mid-2019, the lab didn't have a relevant virus, or at least had no sequence worth publishing.
A few thoughts on the role of pigs in the emergence of influenza A virus in mammals. 1. It is simply not the case that movement of flu viruses into non-swine mammal species requires pigs as a "mixing vessel".
A really important thread on the #H5N1 #birdflu outbreak in cows. Well worth a read.
Very important to note here that qPCR positives are not the same as "virus particles." It's much easier to detect viral RNA by qPCR than it is to detect infectious virus or intact virus particles (as the article correctly notes). This finding does have some big implications:
Coming out of twitter semi-retirement here to share this important preprint by @bblarsen1 , @jbloom_lab and colleagues. An absolute tour de force exploring the pandemic potential, and mitigation, of Nipah virus. Brendan was my PhD student...PROUD! biorxiv.org/content/10.110…
Today was an incredible time that involved hiking up Mount Baldy from @Snowbird and then again from @AltaSkiArea. The snow was fantastic and it stayed fairly cool all day and I even skied chalk in Main Chute and powder in Perla’s. 🌷 11/10 Spring Day🪻
This is tonight! Come and join us 👇
Nice to have @HancksLab here for @ihii_utmb seminar series talking about genetic factors in context of antiviral immunity.
Nine beavers were found dead over the last few weeks in Summit, Wasatch and Utah counties. Three were tested and found to be positive for a disease called tularemia, which can also affect humans. Learn more: bit.ly/3TRBPEM
lmao nickels fully off the rails now
It is absolutely abhorrent to doctor images of tweets, but I am shocked that BN has gone so low as to do this to an esteemed female scientist’s tweet calling out lack of diversity in panels. Doing it with my retweet to show “hypocrisy and dishonesty” is beyond the pale. (1/2)
Your daily reminder that viruses are material objects without plans or goals (other than to replicate) and certainly without thoughts or maliciousness. Read more about it here: wwnorton.com/books/virology
It is absolutely abhorrent to doctor images of tweets, but I am shocked that BN has gone so low as to do this to an esteemed female scientist’s tweet calling out lack of diversity in panels. Doing it with my retweet to show “hypocrisy and dishonesty” is beyond the pale. (1/2)
honestly kind of astonishing how every day there's a new low for misconduct from Nickelbright & yet Rutgers continues to be completely silent.
@matthewherper @SaskiaPopescu They are not. He’s made a fake collage of men he dislikes and is using it to attack women he disagrees with and also dislikes.
I really wish @RutgersU would do something about this. This is ridiculous. Does he really have nothing better to do?
It is absolutely abhorrent to doctor images of tweets, but I am shocked that BN has gone so low as to do this to an esteemed female scientist’s tweet calling out lack of diversity in panels. Doing it with my retweet to show “hypocrisy and dishonesty” is beyond the pale. (1/2)
@zeynep @GYamey @AtomsksSanakan @ban_epp_gofroc @MartinWBastard @ggronvall I’m honestly a bit hung up on “cannot be ruled out” as a standard? Like… very little can be ruled out in science! Especially bioscience where everything is stochastic and contextual. Is there more evidence that’s emerged suggesting it’s plausible?
@zeynep @GYamey @AtomsksSanakan @ban_epp_gofroc @MartinWBastard @ggronvall Sure it’s possible! But practically we have a fair bit of support for “not man made” and I’ve yet to see anything for “man made” except that there was in fact a viral research lab in wuhan?
They put the same comment on every slide I made that had anything to do with dates. As far as Rootclaim is concerned, it simply does not matter when covid started, they're sure that it's still a lab leak no matter when it happened.
Congratulations to @Rasmussen_Lab graduate student Marin Habbick, who won the @usask 3MT competition today presenting her work investigating how sex impacts host responses to emerging coronaviruses! 🏆🏆🏆
Feeding poultry litter (=chicken shit) to diary cows does not sound like a very good idea in times of high #H5N1 circulation (also besides the infections risk, it's disgusting). I sound like a broken record: The way we interact with our fellow species is NOT healthy
“Poultry litter” as a potential source of infection of dairy cows in the USA with highly pathogenic avian influenza virus H5N1 cannot be ruled out. In the USA , it is permitted to feed ground-up chicken waste to cattle. #vogelgriep telegraph.co.uk/global-health/…
A case in point. @JamieMetzl did you read it and if so can you explain the difference btw tMRCA and time of emergence in humans? Because they clearly aren’t the same thing.
Another day, another paper that equates the time of an MRCA to the time of emergence in humans. All very tiresome, as is the gushing of the lab leak illiterati who think it is profound and says something useful.