Yuri Deigin @ydeigin
Vitalist and longevity biotech entrepreneur developing epigenetic rejuvenation gene therapies since 2017 | DRASTIC cofounder https://t.co/jpRBlDRMg1 |🇺🇦🇨🇦 linkedin.com/in/yurideigin/ Toronto, Canada Joined November 2010-
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Oh yes, I do. I remember it quite well.
I think the part of DEFUSE that talks about searching for SARS-like viruses with existing furin cleavage sites and creating new ones "where mismatches occur" is a hastily adapted previous research proposal from Ralph Baric to do the same for MERS-like viruses. Here's why: The…
I think the part of DEFUSE that talks about searching for SARS-like viruses with existing furin cleavage sites and creating new ones "where mismatches occur" is a hastily adapted previous research proposal from Ralph Baric to do the same for MERS-like viruses. Here's why: The… https://t.co/ClcrJM8e0u
@tgof137 @slatestarcodex If someone at WIV, on the lookout for furin cleavage sites in SARS-like viruses as per DEFUSE, was now starting a deep dive into S1/S2 cleavage of SARS-like viruses as a determinant of species and tissue tropism, as well as ADE — as they were already doing at WIV with MERS in…
“It is ludicrous to interpret two mutations as proof of distinct spillovers. This hypothesis of two early spillovers is demolished by a very recent paper which concluded All of them may have evolved from one common ancestor” — Simon Wain-Hobson biosafetynow.substack.com/p/why-words-ma…
The extreme similarities b/w the virus DEFUSE applicants applied in 2018 to create and the SARS2 virus which appeared the following year in Wuhan cannot logically be a coincidence. Excellent new piece by @ydeigin w/ important insights re #COVID19 origins. yurideigin.medium.com/sars-cov-2-is-…
People ask: What are the chances SARS-CoV-2 emerged near a lab specializing in SARS-like viruses? A more precise question might be: What are the chances SARS-CoV-2 emerged near the lab looking for SARS 2.0?
People ask: What are the chances SARS-CoV-2 emerged near a lab specializing in SARS-like viruses? A more precise question might be: What are the chances SARS-CoV-2 emerged near the lab looking for SARS 2.0?
😮 This is so cool: “RNA polymerase II, which is responsible for mRNA transcription in eukaryotes, is also derived from the ancestors of modern giant viruses. In total, our results support a model of eukaryogenesis in which complex cells emerged from a genomic chimera of Asgard…
“Why use an insertion to create an FCS rather than point mutations?” say lab leak critics. One reason could be to align the new FCS with the MERS FCS, which is 4 residues shorter at the S1/S2 junction. The MERS FCS could also be the inspiration behind the leading proline in PRRA.
“Why use an insertion to create an FCS rather than point mutations?” say lab leak critics. One reason could be to align the new FCS with the MERS FCS, which is 4 residues shorter at the S1/S2 junction. The MERS FCS could also be the inspiration behind the leading proline in PRRA.
Alina Chan @Ayjchan
72K Followers 563 Following Scientific Advisor at Broad Institute of MIT & Harvard 🧬 Co-author of VIRAL: the search for the origin of Covid-19 📖 A dangerous young investigator 🕵🏻♀
Richard H. Ebright @R_H_Ebright
70K Followers 283 Following Board of Governors Professor of Chemistry and Chemical Biology @RutgersU @BiosafetyNow
Alex Washburne @WashburneAlex
30K Followers 3K Following Deaf guy, great listener! Princeton PhD Math/Stats/Bio/Finance Opinions my own 👌🤓
Jamie Metzl @JamieMetzl
63K Followers 14K Following https://t.co/M3eSpDEAUu Founder • Futurist • #Superconvergence #HackingDarwin #EternalSonata author • @AtlanticCouncil • Fmr NSC, State, UN, @WHO adv committee
Matt Ridley @mattwridley
128K Followers 3K Following Biologist | Author of Red Queen, Genome, Rational Optimist, and Viral: The Search for the #OriginOfCovid: https://t.co/wHGfoouaqx
Charles Rixey, MA MBA.. @CharlesRixey
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Emily Kopp @emilyakopp
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Paul D. Thacker @thackerpd
44K Followers 1K Following Journalist; Former Investigator U.S. Senate; Former Safra Ethics Center, Harvard. https://t.co/aD6NkYzjqM
Walter M Chesnut @Parsifaler
79K Followers 3K Following WHAT IS, IS. My research is funded by donation only. Please consider supporting my work. At: https://t.co/Hb8pYRMFxA. Or via PayPal at https://t.co/D4ah3zh0Hh
Gilles Demaneuf @gdemaneuf
7K Followers 1K Following Pointy Head. Opinions, analyses and views expressed are purely mine and should not in any way be characterised as representing any institution or company.
bad_stats 🕜💵�.. @thebadstats
35K Followers 339 Following making IDW content accessible to those with average IQs and below
@mbalter — investig.. @mbalter
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Louis R Nemzer @BiophysicsFL
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Igor Chudov @ichudov
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Nacho @CaseCowboy_
135 Followers 451 Following La realidad era algo que existía en pequeños pedazos, moviéndose rápidamente y sin conexión. No había límites claros entre lo real y lo simulado
Is Ollvera🎭 @Artemisa031
48 Followers 167 Following 🤨 😁 ❤️ Cualquier momento es perfecto para aprender algo nuevo. ¬¬🌝🌝🌝🪐🌠⭐🌟
Pherekydes @Pherekydez
154 Followers 1K Following “But who prays for Satan? Who, in eighteen centuries, has had the common humanity to pray for the one sinner that needed it most?”
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Anna Bonno @Annabonno
335 Followers 881 Following When the whole world is running towards a cliff, he who is running in the opposite direction appears to have lost his mind.
Wesley @Zwarte_Eland
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195 Followers 398 Following Master Communication Policy, City University, London, Non-conformist, 💙🖤, The truth lies in the 👀 o/t beholder, cui bono? ☮️
Miss 🦋 Anouk V. @MissV1989
3K Followers 3K Following Alle generalisaties zijn onjuist, ook deze. 😁💛💚 Retweet betekent niet altijd goedkeuren! 💜 is ook in gebruik als bewaarfunctie!
Kinsey Kat @KinseyKat1
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RexesRule 😺 @CatsRule2023
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Alicia S @Alies_mag_ook
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413 Followers 3K Following | Tweets = my personal opinion | Retweets, Likes and Follows =/= endorsements |
Djae @Djae62525626
1K Followers 5K Following Still working on our dreams for our family and country, with His grace.💖👨👨👧👧💖🇱🇷💖✝️💖🌎💖MAGA💖
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大江 @osupwAMGXUUNR9R
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merlijn @Merlijn46
4K Followers 5K Following vrouw! rechtvaardigheid/ bewustzijn/ economie/ kunst/spiritualiseren geldstroom/vrijheid/humor! tweet op persoonlijke titel/geen tweedeling/tegen dwang
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2K Followers 3K Following 💃🏻Tegen de wind ingaan bleek gaandeweg het leven toch niet te werken. De windrichting kan ik niet veranderen. Wel zeilen bijzetten waar dat passend is :)💃🏻
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1K Followers 2K Following Tweets in Nederlands, English, Deutsch, Français.
Alina Chan @Ayjchan
72K Followers 563 Following Scientific Advisor at Broad Institute of MIT & Harvard 🧬 Co-author of VIRAL: the search for the origin of Covid-19 📖 A dangerous young investigator 🕵🏻♀
Richard H. Ebright @R_H_Ebright
70K Followers 283 Following Board of Governors Professor of Chemistry and Chemical Biology @RutgersU @BiosafetyNow
Alex Washburne @WashburneAlex
30K Followers 3K Following Deaf guy, great listener! Princeton PhD Math/Stats/Bio/Finance Opinions my own 👌🤓
Jamie Metzl @JamieMetzl
63K Followers 14K Following https://t.co/M3eSpDEAUu Founder • Futurist • #Superconvergence #HackingDarwin #EternalSonata author • @AtlanticCouncil • Fmr NSC, State, UN, @WHO adv committee
Matt Ridley @mattwridley
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Charles Rixey, MA MBA.. @CharlesRixey
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44K Followers 1K Following Journalist; Former Investigator U.S. Senate; Former Safra Ethics Center, Harvard. https://t.co/aD6NkYzjqM
Prof Francois Balloux @BallouxFrancois
148K Followers 1K Following Director @UGI_at_UCL. Interest in Infectious disease epidemiology, pathogen genomics and global health
Gilles Demaneuf @gdemaneuf
7K Followers 1K Following Pointy Head. Opinions, analyses and views expressed are purely mine and should not in any way be characterised as representing any institution or company.
bad_stats 🕜💵�.. @thebadstats
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Louis R Nemzer @BiophysicsFL
4K Followers 3K Following Professor at Nova Southeastern University. Antibiotic Resistance, Agent-Based Models, Seizure Prediction, Information Entropy of DNA
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Agingdoc⭐David Barz.. @agingdoc1
31K Followers 100 Following Health & longevity coaching at:👉https://t.co/XWGLGiSPyZ Longevity, health, aging, diet, exercise, evidence, healthspan, lifespan, rapamycin, geroscience🚫advice⚕️
Monali C. Rahalkar @MonaRahalkar
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Tony VanDongen @tony_vandongen
5K Followers 759 Following Truth and time have a funny way of catching up with each other. YouTube channel: https://t.co/KpmIIwJI4o
Brack Lab @BrackLab
4K Followers 946 Following Scientist interested in aging, stem cells and tissue repair at UCSF. Co-founder of Arrive: Develop treatments for age-related diseases. views are my own.
Ambrosia Path - Longe.. @ambrosiapath
234 Followers 163 Following Reporting the latest longevity news and interviews Subscribe to our weekly newsletter to get the latest longevity news in your inbox. Join 2,354+ subscribers
Ryan Hisner @LongDesertTrain
22K Followers 838 Following Teacher "Be ruthless with systems and be kind to people." Michael Brooks, 1983-2020
farbood — e/acc @farbood
20K Followers 2K Following Founded Grockit backed by Benchmark (acq. by Kaplan) Biohacking for 25 years. I live to build (myself and companies)
Yan Granat — e/imm @yangranat
2K Followers 3K Following @SayForeverOrg campaigner | #longevity activist | immortalist, transhumanist, vitalist | e/imm — enlightened immortalism | #death_is_unacceptable
Danila Immortalist @DanilaImmortal
2K Followers 4K Following Longevity Maximalist | Transhumanist | Vitalist ⠀⠀⠀ Those who stand against us fall #SayForever!
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24K Followers 340 Following Husband, father, scientist, athlete (sort of), CEO, recovering academic. Passionate about helping people and companion animals live longer, healthier lives.
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992 Followers 106 Following Longevity activist and software engineering lead. CTO at @GeroSense. Co-Founder of @SayForeverOrg.
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527 Followers 254 Following brains, body, emotions, ai. ceo/co-founder @handl_ai (yc w20) - data extraction from documents by ai+humans; @flocktory(acquired '17)
Marc Johnson @SolidEvidence
31K Followers 132 Following Molecular virologist, Professor, sewage sage and wastewater wizard.
Cᴀʟɪʙʀᴇ Oʙs�.. @CalibreObscura
196K Followers 699 Following Was a Arms Research & Occasional Effortposter. Interested in MENA/Asia NSAGs
Lulu Cheng Meservey @lulumeservey
79K Followers 2K Following “Meservey isn’t your typical flack.” -The Information. Founder of ROSTRA. Ex-Activision and Substack. TrailRunner cofounder. Writing https://t.co/4xKo7wQTQo
denisa lepadatu @denisalepadatu_
38 Followers 69 Following Longevity | writer | searching for infinity🏙️
Adrian Kaniewski🌎�.. @KaniewskiAdrian
20K Followers 22K Following Health🍀Longevity🍀Life extension🍀Progress Subscribe my You Tube channel👇
Jenna Harris, PhD @molbiomarie
464 Followers 627 Following women’s health and longevity @athena_DAO_ ⭐️DeSci and biotech ⭐️ alum @BrandeisU @GeorgiaStateU ⭐️ views are my own
Nick Davidov @Nick_Davidov
15K Followers 1K Following investor and serial founder in AI/ML/CV space. co-founder DVC - backing repeat founders. e/acc, go OSS
Michael Davidson MD @mdavidsonmd
4K Followers 1K Following Professor, Director of the Lipid Clinic, The University of Chicago. International Expert and Author on Lipidology.
Niklas Anzinger 📍 .. @NiklasAnzinger
3K Followers 2K Following Founder of Infinita VC & Vitalia | Building a longevity bio/acc zone | Based in @Prosperahn | Host of the "Stranded Technologies Podcast"
Alexander Fedintsev @afedintsev
40 Followers 15 Following Anti-aging researcher, proposed 10th hallmark of aging. Expert in the aging of extracellular matrix, machine learning and hardcore biohacking
Dan Zurek @DanZurek_
7K Followers 1K Following GTM | Advisor | Investor @shimacapital, https://t.co/sbxDtJfJCG, @swellvc
Toronto Longevity Res.. @tlrc_info
98 Followers 14 Following community + jclub for longevity and regenerative medicine research 🧬
Courtney Hudson-Paz @c_hudpaz
404 Followers 408 Following Passionately Curious | Founder of @Time_Initiative | MBL Biology of Aging course manager @biologyofaging | Biology of Aging PhD graduate @buckinstitute
Max the VC 👨�.. @mreiffy
19K Followers 4K Following Geek 🤓 | VC 🦄 @ IDC Ventures | Attorney ⚖️ Investing at Series A in US, LatAm, and Europe 🌎 Building something awesome? Don’t be shy 🔗👇
Lonis @_Lonis_
6K Followers 1K Following Founder Godmode. Uneducated. Founded @deworkxyz, depict ai (YC S20). Send me anonymous feedback: https://t.co/byObIgwnLd
Alexey Kadet @Alexey_Kadet
232 Followers 195 Following Chief Business Officer at Gero | Targeting root causes of age-related diseases
Justin Olshavsky @olshav
2K Followers 2K Following GP and Founder of Bio+Health Fund @pioneer_fund VC // Prev founded Voyage Bio (YC S19), acq by Penumbra (NYSE:PEN) // MechE & BioE @ucberkeley @ucsf @clemson
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404 Followers 742 Following PostDoc at Institute of Functional Epigenetics @HelmholtzMunich | Interested in Chromatin Biology, Histone Modifications and Mass Spec
Jim Edwards @Jim_Edwards
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timour kosters @timourxyz
3K Followers 2K Following building @joinedgecity | 🏡 Zuzalu 🌱 @seedclubvc 🐉 @hydraventures_ | ex founder / investor / runescape woodcutter
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348 Followers 94 Following
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258 Followers 939 Following 🤡🎪 or 🏥💊 Genetics & Philosophy |Start Up in Stealth| Researching at @SickKids & @UHN | Ajmera Transplant Center | @UofT | Thoughts be my own
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595 Followers 310 Following Memoirs of a gweisha | Core, Dealflow Steward @vita_dao | Prev: COO @lab_dao | @beondeck | Interested in the intersection of politics, philosophy & science
@emilyakopp Your work has been phenomenal, thank you. Geographic coincidence is striking. But another under-appreciated coincidence is temporal coincidence. Of all the thousands of years mankind has been encountering wildlife, why 2019? Is it just a coincidence the outbreak was just a few…
The extreme similarities b/w the virus DEFUSE applicants applied in 2018 to create and the SARS2 virus which appeared the following year in Wuhan cannot logically be a coincidence. Excellent new piece by @ydeigin w/ important insights re #COVID19 origins. yurideigin.medium.com/sars-cov-2-is-…
excellent summary on SARS2 related strains, WIV sampling and FCS design by @ydeigin! yurideigin.medium.com/sars-cov-2-is-… The only part I disagree with is the closing statement: "while we do not yet have certainty in any particular Covid origin scenario". Here, I'm with @R_H_Ebright👇
@ydeigin 1/ As you point out, the 2015 Baric-Shi work on MERS-HKU4 (and similar work by Whittaker et al) led them to realize that spike cleavage is at least as important as receptor binding, *at least for MERS-like viruses*. But it's puzzling that the 2005 Nunberg et al paper...
People ask: What are the chances SARS-CoV-2 emerged near a lab specializing in SARS-like viruses? A more precise question might be: What are the chances SARS-CoV-2 emerged near the lab looking for SARS 2.0?
4 years after my first Medium article on Covid origins, I wrote another one. In it, I make the case that SARS-CoV-2 is precisely the virus WIV was hunting for in 2019. yurideigin.medium.com/sars-cov-2-is-… Below is a thread on the key points:
@ydeigin Fascinating thread. I think Baric's interest in SARSr-CoVs with 10-25% divergence in spike goes back to 2015 or earlier. And he has referred to the upper limits ("highly variable") as "book-ends", for instance in his briefing to Congress in early 2020.
@ydeigin A very nice and detailed work indeed, summarising everything! Congratulations and will love to read the Medium article.. Just read your long thread.
Hercules level effort.
97/ Until then, we can keep debating about raccoon dogs, pangolins, and stuffy Mahjong rooms at the Huanan Seafood Market. /END (phew)
Really excellent work by @ydeigin pulling together all the sources.
Excited to share my new position as a Program Manager @ARPA_H . It’s been an incredible journey in academia at the @CRM and @ucsfmskcenter @UCSFAging where I had the pleasure of working with incredible scientists. I look forward to everything we will achieve in aging/longevity!
Something I like about biotech is that we don't have to think as hard to find a "user need" (as we'd have in SaaS). We know people want to live longer healthier lives already, the hard part is actually making that possible. So we can focus almost purely on R&D.
Daszak also confirms that EcoHealth and Wuhan Institute of Virology "have 15,000 samples in freezers in Wuhan, and could do the full genomes of the 700+ CoVs we've identified," contradicting his previous false claim that EcoHealth/WIV had published all of the CoVs they…
🚨BREAKING🚨 @EcoHealthNYC President Dr. Peter Daszak CONFIRMS whistleblower allegations that Dr. David Morens — a top advisor to Dr. Fauci — used Gmail to hide COVID-19 information. We are beginning the process to secure Dr. Morens's public testimony. washingtonexaminer.com/policy/healthc…
Repair Biotechnologies has announced findings from early research suggesting that its technology can quickly stop the advancement of atherosclerosis. lifespan.io/news/new-gene-… By Steve Hill #ClinicalTrials #nanoparticles #aging #rejuvenation #HeartAttack #stroke
@tgof137 @arguablywrong @nizzaneela @slatestarcodex You failed to indicate that you had altered the image in your slide in the Rootclaim debate youtube.com/watch?v=Y1vaoo… 1:20:25
After visiting a few start-ups the last couple of weeks, I'm reasonably convinced we're on the verge of cracking cryonics and preserving bodies AND brains in new ways.
30 years ago today, we lost the wonderful Kurt Cobain 🕊️ Truly one of a kind.
Pig kidney transplant recipient "leaves the hospital" and goes home. Now that is something we havent heard before in xenotransplant. Could this go from radical to normal? bbc.com/news/world-us-…
Solving aging means little if that doesn't include brain aging! Retro is going deeper into CNS territory, we just hired a Head of CNS! Reach out if brain rejuvenation is of interest! :)
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