Sayed ali @Drsayedali

💢 “They were children playing with kites. They were just sitting there playing. They are killing children.” Israeli forces shot 10-year-old Palestinian girl Amal Abu Khater in the back, killing her instantly as she sat eating lunch inside her displaced family’s tent in western Khan Younis, southern Gaza, on Monday. Amal had just returned from memorizing the Quran and performing the Dhuhr prayer, her family told Drop Site. “There were people who felt safe, sitting in their tents. It’s supposed to be a safe area, and it is full of displaced people,” Amal’s relative Hassan Abu Khater told Drop Site’s Mohamed Ahmed. “What did she do to deserve to be killed? She was sitting and eating sweets... What sin did this little girl commit?” Amal’s grandmother, Samira Abu Khater said. Eight Palestinians, including two children, have been killed in Israeli attacks across Gaza since dawn Monday. “They fire indiscriminately,” Samira said. 🎥 Footage from Drop Site contributor Mohamed Ahmed.

🔸كيف تقرأ منحنى (Kaplan-Meier Curve) في دراسات البقاء ؟ #احصاء وهو أحد أهم الأدوات الإحصائية في الطب وعلم الأورام لتحليل البقاء على قيد الحياة (Survival Analysis) هذا الإنفوجرافيك تعليمي ويشرح النقاط المهمة في النتائج ، مثالي للطلاب، الأطباء، والباحثين في علم الأورام والإحصاء الطبي. يمكنك استخدامه مباشرة في العروض التقديمية أو المقالات العلمية. النقاط الرئيسية في الصورة: 1. أين يبدأ انفصال المنحنيات؟ (Where do the curves separate?) •انفصال مبكر: يعني أن تأثير العلاج يظهر بسرعة. •انفصال متأخر: يعني تأخير الفائدة (شائع جداً في العلاج المناعي - Immunotherapy). 2. ما مدى كبر الانفصال؟ (How large is the separation?) •كلما زاد البعد العمودي بين المنحنى التجريبي (Experimental) و منحنى الكنترول (Control)، زادت الفائدة المطلقة absolute effect للعلاج. •ملاحظة مهمة: نسبة الخطر (Hazard Ratio - HR) لا تعادل الفائدة المطلقة. 3. هل يحدث تقاطع بين المنحنيات؟ (Is there crossing of curves?) •التقاطع قد يشير إلى: ◦تأخير تأثير العلاج. ◦اختلاف في خصائص المرضى (Heterogeneous population). ◦اختلال في فرضية المخاطر (Proportional Hazards). •في هذه الحالة يجب تفسير HR بحذر شديد. 4. ابحث عن (Plateau) •ذيل طويل مستقيم (flat tail) يعني: ◦سيطرة طويلة الأمد على المرض. ◦وجود ناجين طويلي الأمد (Long-term survivors). •هذا الشكل شائع جداً في العلاجات المناعية. 5. تحقق من متوسط البقاء (Median Survival) •ارسم خطاً أفقياً عند 50%. •حيث يتقاطع كل منحنى مع هذا الخط = المتوسط (Median Overall Survival أو Median PFS). •في المثال: ◦العلاج التجريبي = 36 شهراً ◦الكونترول = 20 شهراً 6. دائماً تحقق من “العدد المعرض للخطر” (Number at risk) •الأرقام في الجدول أسفل المنحنى تُظهر كم مريضاً ما زالوا تحت المتابعة في كل نقطة زمنية. •عندما تصبح الأرقام صغيرة جداً في نهاية المنحنى → التقديرات غير موثوقة. 7. ما معنى علامات الرقابة (Censoring marks +)؟ •علامة “+” تعني أن المريض تمت “رقابته” (Censored)، أي غادر الدراسة دون حدوث الحدث (مثل الوفاة أو التقدم). •الأسباب: ◦انتهاء الدراسة قبل حدوث الحدث. ◦فقدان المتابعة. ◦سحب الموافقة. •كثرة علامات الرقابة في النهاية = زيادة عدم اليقين في التقديرات المتأخرة. الخلاصة : عندما تنظر إلى منحنى Kaplan-Meier: 1-انظر إلى مكان وكمية الانفصال. 2-تحقق من وجود Plateau أم لا. 3- اقرأ الـ Median. 4- تأكد من الأرقام في الجدول السفلي. 5- لاحظ علامات + وتأثيرها على الموثوقية. وبس شكراً 🙏

1/2 KN905 Enfortumab Vedotin + Pembro continues to transform bladder cancer in spectacle fashion. In cisplatin ineligible operable disease it beats cystectomy with EFS HR 0.4, OS HR 0.5. pCR of 57% is much ⬆️ than anything before #ESMO25 pCR> 50% questions unselected surgery

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MATTERHORN: Perioperative Durvalumab in Gastric and Gastroesophageal Junction Cancer nejm.org/doi/full/10.10…

OptiTROP-Lung03 published on @bmj_latest: sacituzumab tirumotecan (sac-TMT) versus docetaxel for previously treated EGFR-mutated advanced NSCLC sac-TMT vs docetaxel ORR: 45% vs 16% PFS: 6.9 vs 2.8 months OS: NR, HR=0.49 (data also presented at #ASCO25) bmj.com/content/389/bm…

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Rechallenge with immune-checkpoint inhibitors in patients with advanced-stage lung cancer 💥Excellent Review👇 nature.com/articles/s4157…

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I’ve seen the silhouettes of so many people—so many children—burning alive, that I can’t look at fire anymore without feeling sick to my stomach. WE MUST STOP THIS MASSACRE. May the Palestinians forgive us.

Retrospective study of neoadjuvant immunotherapy for 112 pts with stage III borderline resectable NSCLC @JAMAOnc. Included stage III with T4 and/or N2/3 NSCLC and 75% underwent surgery with 29% pCR, 42.2% MPR, mEFS 52.6m. Impressive to note that all N3 achieved ypN0.

VIDEO | Above, the film of The Pianist, which recreates the segregation of Jews in the Nazi ghetto of Warsaw, where they were forbidden to pass through the streets, 1943. Below, the Zionist ghetto in the West Bank, where Palestinians are segregated and forbidden to pass through the streets, 2025.

Bloody Blinken. For the rest of their lives, Biden administration officials will be reminded that the blood of tens of thousands of Palestinian men, women, and children is on their hands. Thank you to the activists for raising your voices against this evil regime.

No more words needed

They killed his family members, burned down his hospital, murdered patients. Dr Hussam Abu Safiyeh in his last photo prior to abduction confronting the tanks of the enemy. Have you ever seen courage like this? Have you ever seen cowardice and cruelty like that of the enemy?

BREAKING: Kamal Adwan Hospital is now burned down, staff and patients brutally undressed and forced to leave. Israeli fascism! Dr. Mads

Stories like the Israeli commander breaking the bones of a 4 year old Palestinian child with bare hands, are a confirmation that not only the Israeli army is ROTTEN to the core, but so are all governments that allow these sickening crimes to be normalized.

Haaretz.com @haaretzcom

2 years ago

"The encounter with such dangerous attitudes, which has become more normal in our society, was traumatic for me ... I discharged myself from reserve duty with a psychiatrist's help," said a female reservist who served at the Sde Teiman detention facility haaretz.com/opinion/2024-1…

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“lsraeI kiIIs men women and children and they don’t receive a single sanction. Not a single sanction to stop” - Australian politician Max Chandler-Mather

Synopsis of a year spent denouncing a genocide that all 192 States together could not halt. What an utter disgrace.

Double Down News @DoubleDownNews

2 years ago

Act Now. Stop The Genocide @FranceskAlbs

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Jewish-American orthopedic surgeon Dr. Mark Perlmutter testifies that Israeli snipers deliberately target Palestinian children, often in the head and chest. Dr. Perlmutter traveled to Gaza as part of a medical humanitarian mission earlier this year.

Likely raped to death. A doctor. A stellar surgeon. The embodiment of Palestinian ethics. Likely raped to death. The racism of Western media who are not covering this, and Western politicians who are not denouncing this, together with the thousand other testimonies and allegations of rape and other forms of mistreatment and torture that Palestinians have suffered in Israeli jails, is absolutely sickening.