Gregg Fonarow MD @gcfmd
Los Angeles, CA Joined December 2012-
Tweets12K
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Followers13K
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Following178
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LBB Area Pacing vs RV Pacing for AV Block and Preserved Left Ventricular Function: The #LEAP-Block Trial 📍499 patients with #LVEF ≥50% randomized to LBBAP vs #RVP across 14 Chinese hospitals. 📍 Primary endpoint: 2.4% vs 12.5% favoring #LBBAP (P=0.003). 📍 HF events: 3.4% vs 11.3% with LBBAP vs RVP. 📍 LBBAP ⬇️ the 24-month primary endpoint risk (HR 0.37, 95% CI 0.19–0.73), with no significant differences in mortality or device complications. #LEAPBlock #Cardiology #HeartFailure #Pacing jamanetwork.com/journals/jama/… @JAMACardio #JAMA
@docwarsi @hvanspall @SJGreene_md @JavedButler1 @AndrewJSauer @ankeetbhatt @FudimMarat @robmentz @HeartDocSadiya @boback @ATSandhu Management of Patients With Heart Failure at Home After Hospital Discharge (STRONG@HOME) Sponsor University 🏨, Akershus clinicaltrials.gov/study/NCT06576… •Arms: ◦Digital follow-up at home: video consultations + telemonitoring ◦In-person follow-up at an HF outpatient clinic
What actually drives quality of life(QoL) in #HFrEF?Analysis of 2 HFrEF registries finds low KCCQ-QoL score is driven by symptoms &social limitations(effect size 0.48-0.60)less by physical limitations alone(effect size=0.34) Findings held across age & sex ahajournals.org/doi/10.1161/CI…
@docwarsi @dranulala @MinnowWalsh @DCRINews @CaliforniaACC @Drroxmehran @robmentz @DLBHATTMD @HFSA @NMHheartdoc @MKIttlesonMD Potentially can assist with identifying eligibility, contraindications, prior intolerance beyond simple yes/no queries Potentially can assist with digital/remote initiation, titration, monitoring, including labs and patient education (with less need for in person clinic slots)
🫀 Full quadruple GDMT for US HFrEF: 💊 4 generic pills, ~$25/month ➡️ ❤️ ~114K lives saved/year 🏥 ~864K hospitalizations avoided 💰 $16.3Billion net savings ⚠️ Only 18% get all 4 💻 One of the best opportunities in healthcare for AI to improve care, outcomes & cost?
Practical Implementation of Steroidal and Nonsteroidal Mineralocorticoid Receptor Antagonists in the Management of Heart Failure Guideline-directed medical therapy is often underutilized in patients with HF. Consider simultaneous or rapid sequence initiation of a combination therapy for patients with HF with mildly reduced or preserved ejection fraction @mvaduganathan @gcfmd @CMichaelGibson @SJGreene_md @DrMarthaGulati @HFA_President @GianluSava jacc.org/doi/10.1016/j.…
MRAs are effective for #CHF across the entire LVEF spectrum. Guidelines, label indications, & patient comorbidities must be considered when selecting an MRA for GDMT combination therapy regimens. Read the state-of-the-art review in #JACCAdvances! @gcfmd bit.ly/4ss6kCi
💰 The broader annual cost burden of Heart Failure (HF) is projected to reach $858 billion by 2050. Yet, we hold an extraordinarily cost-effective solution in our hands today. See below for more + click here for more insights from our HF STATS 2026 report bit.ly/3ULm2vS
@GlidingOverAll @rblument1 @kewatson @DrMarthaGulati @boback @CBallantyneMD @AnnMarieNavar @HeartDocSadiya @ATSandhu @ericpetersonMD @pnatarajanmd Less expensive full-dose options: Lerochol at $199/mo (monthly by design) Praluent at $225/mo Lipfendra (oral): if you have commercial insurance, Merck's copay card may get it down to $15 Also can try an insurance appeal with risk documentation
@GlidingOverAll @rblument1 @kewatson @DrMarthaGulati @boback @CBallantyneMD @AnnMarieNavar @HeartDocSadiya @ATSandhu @ericpetersonMD @pnatarajanmd Discuss w/ your MD One 140 mg pen a month: in single-dose data, LDL-C fell about 70% by day 15, and about 38% of that drop remained at day 29 It's off-label with no outcomes data, and on a statin it may fade faster Check lipids right before the next dose to see true trough
💊 PCSK9 inhibitors in the US, Oct 2026: 💉 Repatha: ~60%↓LDL | CVOT ✅ | $239/mo 💉 Praluent: ~45–60% | CVOT ✅ | $225/mo 🩺 Leqvio: ~50% | CVOT ⏳ | no DTC 💉 Lerochol: ~56–60% | CVOT ❌ | $199/mo 💊 Lipfendra (oral!): ~56–59% | CVOT ⏳ | $315 list #Lipids
@LipidLover1030 @DrLuizSilva1 @rblument1 @kewatson @DrMarthaGulati @boback @CBallantyneMD @AnnMarieNavar @HeartDocSadiya @ATSandhu @ericpetersonMD @pnatarajanmd There remains a substantial opportunity to improve care and outcomes for those with and at risk for ASCVD
💊Is evolocumab cost-effective before a first MI or stroke? 📊 VESALIUS-CV lifetime model at $3,107/yr ❤️ −0.24 MACE/person ✅ ICER $71,162/QALY; scenarios $20K–$51K 🎯 All below the $120K AHA/ACC threshold ⚠️ Preprint 🔗 doi.org/10.64898/2026.…
@TheLancet “Meanwhile, observational or real-world data are increasingly available for retrospective evaluations, but face inherent, unmeasurable, systematic errors from confounding and selection biases.”
@orion7710 @boback @kewatson @HeartDocSadiya @rblument1 @DrMarthaGulati @texhern @HeartBobH Low vitamin D is associated with many diseases in observational studies Does supplementing help? RCTs say: 🧠 Dementia — no 🔬 Colon polyps — no ☀️ Melanoma — no 🦠 Severe COVID — no 🦴 Bone/fractures — YES, but only in the truly deficient + calcium
Trial after trial, vitamin D supplements keep coming up empty: 💊 VITAL (25,871): no CV benefit 🧬 83,000 across 21 RCTs: null 💀 80 RCTs: no CV benefit 🩺 SIMPLIFIED (2026, dialysis): no ☠️ benefit, HR 0.94 Billions spent on RCTs Still nothing Low D is a marker
@ACCinTouch @MedAxiom What is the @ACCinTouch doing to help address this issue? The 2027 @CMSGov HF ASM quality measures beta-blockers and RASi 💊, but not ARNI, MRA or SGLT2i Those 3 could prevent: ~88K deaths 💔 a year ~746K 🏥 a year Saving $14.1B 💰, at $227/year per patient
Dr. Martha Gulati ♥... @DrMarthaGulati
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Dr. Deepak L. Bhatt @DLBHATTMD
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American College of C... @ACCinTouch
159K Followers 2K Following Official ACC account. Join us to transform cardiovascular care & improve heart health for all. Find us: @JACCJournals @Cardiology Likes/shares ≠ endorsements
Michelle Kittleson MD... @MKIttlesonMD
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SABOURETCardiologist @SABOURETCardio
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水野篤＠心臓の... @atmizu
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Mohamed Hemida, MD @Hemida_MD
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rocky55 @ramazankaya333
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Guadalupe Hernandez @tonyGuadalupeHd
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AdjuCor GmbH @AdjuCorGmbH
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M. Hosein Yazdanpanah... @MHosein_Yp
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Amy Chitta @AmyChitta
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Ahmed Eliwa @AhmedEliwaMDc
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Ahmed Basheer الد�... @abalqaisi
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Dr. Martha Gulati ♥... @DrMarthaGulati
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Andrew J Sauer MD @AndrewJSauer
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Dr. Deepak L. Bhatt @DLBHATTMD
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JACC Journals @JACCJournals
119K Followers 1K Following Official account representing the ACC's #JACCJournals, one of the most widely read & most impactful CV journal programs in the world. @ACCinTouch #JACC
American College of C... @ACCinTouch
159K Followers 2K Following Official ACC account. Join us to transform cardiovascular care & improve heart health for all. Find us: @JACCJournals @Cardiology Likes/shares ≠ endorsements
Michelle Kittleson MD... @MKIttlesonMD
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Anu Lala (Anuradha La... @dranulala
14K Followers 5K Following Mother/wife/daughter. 💜Function cardiologist. @JCardFail Co-EIC. HF Fellowship PD @MountSinaiNYC; #IntegrativeMedicine; in pursuit of more #SelfAwareness
Muthu Vaduganathan @mvaduganathan
10K Followers 506 Following Cardiologist & Trialist @BrighamWomens @harvardmed | AE @JACCJournals | Podcast #DontMissABeat & #HFinFocus | Disclosures: https://t.co/BmQHCNyLml
Harriette Van Spall, ... @hvanspall
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Pradeep Natarajan @pnatarajanmd
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Eric H Yang, MD @datsunian
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Eiran Gorodeski, MD, ... @EiranGorodeski
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Circulation @CircAHA
79K Followers 4K Following RT/follows do not imply endorsement. Bradley A. Maron, MD Editor-in-Chief, Circulation
Robert Harrington @HeartBobH
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Ankeet S. Bhatt, MD, ... @ankeetbhatt
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trailcam @Trail_Cams
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Dipti Itchhaporia, M.... @ditchhaporia
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Andrew P. Ambrosy, MD... @AndrewPAmbrosy
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American Association ... @AAHFN
4K Followers 430 Following The official site of the American Association of Heart Failure Nurses
European Society of C... @ESC_Journals
121K Followers 7K Following Official @ESC_journals account for the most successful family of CV journals. Articles FREE for 24h from time of post. European Society of Cardiology @escardio
HF Collaboratory @hfcollaboratory
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European Society of C... @escardio
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Cardiology Today @CardiologyToday
51K Followers 2K Following The content you need, when you need it.
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California ACC @CaliforniaACC
2K Followers 2K Following The California State Chapter of American College of Cardiology works to prevent cardiovascular diseases and ensure quality care in California.
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134 Followers 6 Following
Karen Joynt Maddox @kejoynt
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American_Stroke @American_Stroke
23K Followers 4K Following The official account of the American Stroke Association, a division of @American_Heart. We're talking about how strokes are preventable, treatable and beatable!
Stroke AHA/ASA @StrokeAHA_ASA
39K Followers 2K Following Stroke publishes peer-reviewed research on cerebral circulation and its diseases. Tweets/RT are not medical advice. RT/follows do not imply endorsement.
EJHF Editor-in-Chief @EJHFEiC
2K Followers 90 Following #EJHF Editor-in-Chief X account. Posts by Professor Michael Böhm and his team. #HFA_ESC #HeartFailure #HF
Sabra Lewsey @docsabe
296 Followers 386 Following
Dhruv Kazi @kardiologykazi
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nancyatheart @NancyatHeart
8K Followers 779 Following CEO of @American_Heart/@American_Stroke, powered by 35 million volunteers, donors and supporters and a #relentlessforce for a world of longer, healthier lives.
Mariell Jessup @MariellJessup
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Circ: Heart Failure @CircHF
8K Followers 474 Following Circulation: Heart Failure is a journal of the American Heart Association. Editor-in-Chief: Nancy Sweitzer, MD, PhD. RT/follows do not imply endorsement.
Paul Heidenreich @paheidenreich
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