Ghosal Lab @GhosalLab
Genome instability in cancer and premature aging syndromes Omaha, NE Joined June 2022-
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BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
We recapitulated transcription-coupled repair in frog egg extracts and showed that STK19 couples stalled RNAPII to repair. Tour de force by @TychoMevissen (seeking PI positions, grab him if you can!), and key contribution from Lucas Farnung and team. biorxiv.org/content/10.110…
Most happy to share our work on characterising ARIP4 (aka RAD54L2) as a R-loop helicase that promotes AR-dependent (and most likely non-AR as well) transcription. science.org/doi/10.1126/sc…
Check out our latest publication where we developed SEC-seq – a new technology that captures and measures single-cell protein secretion coupled with mRNA transcriptomes published in Nature Nanotechnology! nature.com/articles/s4156… 1/2
🚨Hot off the press! Check out my thesis work, out today in Molecular Cancer Research. 👩🏼🔬 USP1 Expression Driven by EWS::FLI1 Transcription Factor Stabilizes Survivin and Mitigates Replication Stress in Ewing Sarcoma aacrjournals.org/mcr/article/21…
Our paper is out, Bravo and thanks to all the contributors!!👏👏 Take home: after DSB induction, gH2AX domains self-segregate to form a new chromatin compartment, in which some DDR genes also physically relocate to potentiate their expression. rdcu.be/doT6W
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2023 #NobelPrize in Chemistry to Moungi G. Bawendi, Louis E. Brus and Alexei I. Ekimov “for the discovery and synthesis of quantum dots.”
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2023 #NobelPrize in Physics to Pierre Agostini, Ferenc Krausz and Anne L’Huillier “for experimental methods that generate attosecond pulses of light for the study of electron dynamics in matter.”
“Ten years ago I was kicked out and forced to retire.” Our new medicine laureate Katalin Karikó (@kkariko) told us how much it means to be awarded the Nobel Prize after a scientific career that has been full of challenges. Ten years ago, Karikó was still doing all her…
The discoveries by Katalin Karikó and Drew Weissman – awarded the 2023 #NobelPrize in Physiology or Medicine – were critical for developing effective mRNA vaccines against COVID-19 during the pandemic that began in early 2020. Through their groundbreaking findings, this year’s…
Article on how DNA repair alters the epigenome to erase youthful information and drive aging, and how to reset the system #informationtheoryofaging tinyurl.com/yf4d4zy8
David Holden's hand-written notes when he designed signature tagged mutagenesis, which revolutionised molecular genetics #stm @CBRB_Imperial @ImperialInfect
On September 22, the White House will convene leaders in the childhood cancer community to focus on ways to share data, accelerate trials, support families, and generate solutions as we advance progress against this disease. whitehouse.gov/cancermoonshot… #CCAM #Data4ChildhoodCancer
Proud to be a part of the new paper from the Buckley lab describing the role of the E3 ligase FBX021 in AML. Great work by current and former @UNMC_GCBA students Kasidy Dobish and Karli Wittorf! nature.com/articles/s4137….
The Symposium kicked off with opening statements and a panel discussion about Public-Private Collaborations to Improve Pediatric Cancer Prevention and Outcomes in Nebraska. Thank you to our esteemed panel, including Governor Jim Pillen, for their thoughts and leadership.

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