Jack Van Horn @JackVanHorn8
Professor of Psychology & Data Science at @UVA; #Scientist, #Scholar, #Student; Thinking about the #brain as a #DataScience - way too much; #MRI #EEG #PET jackvanhorn.org Charlottesville, VA Joined June 2021-
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To do this, we modified the Fixel-based analysis technique featured in @MRtrix3 to generate a summed fiber density and cross-section measurement of intra-axonal volume, in aggregate per voxel. This matched historical histological axonal diameter in the corpus callosum! 3/
Working from the principal that neuronal structure constrains function, and building off of classical neuroscientists like Rushton, and Nobel winners Hodgkin & Huxley, we developed an MRI-based metric of conduction velocity, i.e. the speed action potentials travel along axons. 2/
Thrilled to present our latest work on brain microstructure in autism! We developed an estimate of neural conduction velocity from dMRI, revealing for the first time that ASD may involve neurological differences in axonal structure and function. bit.ly/44cyEMF 1/
Moving forward we'll be exploring how ASD behavioral measures are associated with these brain metrics, longitudinal work, and early application before traditional diagnostic tests are able to be performed. Full paper can be found here: doi.org/10.1371/journa… end/
Demyelination, or a high g-ratio, is associated with numerous neurological diseases including #MultipleSclerosis, #autism, #AlzheimersDisease, and more. But measuring g-ratio in tissue sections is normally a tedious, manual job. New software #MyelTracer makes it easy. 3/9
Conduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder . Benjamin T. Newman et al. PLOS ONE. dx.plos.org/10.1371/journa…
#PLOSONE: Conduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism ... dx.plos.org/10.1371/journa…
New research alleging that our brain connections are too slow, & maybe giving teams a chance to 'treat' our autism. A total belief in autism always being a terrible thing, rather than neurodivergence, is required. Er, enjoy... msn.com/en-gb/health/o… and journals.plos.org/plosone/articl…
See you soon!
Conduction Velocity, G-ratio, and Extracellular Water as Microstructural Characteristics of Autism Spectrum Disorder biorxiv.org/content/10.110…
Conduction Velocity, G-ratio, and Extracellular Water as Microstructural Characteristics of Autism Spectrum Disorder dlvr.it/Sskhhw
Researchers @MedicineUVA have discovered a promising new approach for diagnosing Autism. Their technique involves Diffusion MRI, to be able to create models to identify the differences in the brains of those with Autism and without. #neuroscience journals.plos.org/plosone/articl…
Conduction velocity, G-ratio, and extracellular water as microstructural characteristics of autism spectrum disorder journals.plos.org/plosone/articl… #science #neuroscience #conduction #velocity #gratio #water
@NeuroscienceNew Fascinating advancement in neuroimaging for ASD research. Diffusion MRI's capability to map and track microstructural changes is revolutionary in understanding the neuropathology of autism spectrum disorders. For comprehensive reviews and further reading on such topics, consider…
Autism’s Brain Structure Secrets Revealed A new study uses Diffusion MRI to reveal key structural differences in the brains of those with autism, linking brain microstructures with clinical autism scores. This innovative approach could revolutionize autism diagnosis and…
Autism’s Brain Structure Secrets Revealed Researchers pioneered a novel method to investigate the brain structures of individuals with autism spectrum disorder (ASD) using Diffusion MRI. This technique, which tracks the movement of water molecules within the brain, has enabled…
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It is the most densely connected structure in the brain by volume (Torgerson, 2014) - primarily topographic reciprocal connections with the cerebral cortex. 84% input from cortex.
Does human consciousness rely on this tiny wisp of gray matter? Claustrum anatomy and function 🧵
Thank you to all members of the US National Academy of Sciences for this huge honor.
Accepting the first #NASaward of the ceremony, the 2024 Atkinson Prize in Psychological and Cognitive Sciences, is #NASmember Stanislas Dehaene of @Inserm for his groundbreaking work on brain circuitry. #psychology #neuroscience #NAS161 Watch live: ow.ly/qTqX50RqeiM
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Finally, these microstructural findings are related to functional and behavioral outcomes! We found correlations between brain metrics and the Social Communication Questionnaire, especially for conduction velocity. 9/
These differences are profound enough that if we average the values across the WM or cortex, a simple linear classifier (with the controls mentioned previously) can approach a pretty good diagnostic threshold. 8/
We also observed higher extracellular water and lower g-ratio in a number of ROIs, overall suggesting that autism is associated with reduced diameter axonal fibers, causing slower aggregate transmission speeds. This again in agreement with limited histological work by others. 7/
I was very fortunate to have wonderful collaborators in the NIH's Autism Centers of Excellence network, a multi-site effort with age and sex matched participants. We applied these metrics to look for differences between brains of autistic and non-autistic participants. 5/
We combined this with myelin measurements from T1w/T2w ratio, building on @siawooshmn's brilliant work on aggregate g-ratio, and found that we got physiological values close to the 0.6 ideal. Using Rushton's calculations, we could convert these to conduction velocity. 4/
To do this, we modified the Fixel-based analysis technique featured in @MRtrix3 to generate a summed fiber density and cross-section measurement of intra-axonal volume, in aggregate per voxel. This matched historical histological axonal diameter in the corpus callosum! 3/
Working from the principal that neuronal structure constrains function, and building off of classical neuroscientists like Rushton, and Nobel winners Hodgkin & Huxley, we developed an MRI-based metric of conduction velocity, i.e. the speed action potentials travel along axons. 2/
Thrilled to present our latest work on brain microstructure in autism! We developed an estimate of neural conduction velocity from dMRI, revealing for the first time that ASD may involve neurological differences in axonal structure and function. bit.ly/44cyEMF 1/
Moving forward we'll be exploring how ASD behavioral measures are associated with these brain metrics, longitudinal work, and early application before traditional diagnostic tests are able to be performed. Full paper can be found here: doi.org/10.1371/journa… end/
Demyelination, or a high g-ratio, is associated with numerous neurological diseases including #MultipleSclerosis, #autism, #AlzheimersDisease, and more. But measuring g-ratio in tissue sections is normally a tedious, manual job. New software #MyelTracer makes it easy. 3/9
You can’t erase “The Legion”. The standard is already set.
Brain-wide neuron tracing reveals that the mysterious mouse claustrum is highly connected to the rest of the brain. In this extreme example, several neurons wrap their axons entirely around the cortex, forming a crown-like structure. 👑 More: alleninstitute.org/news/scishots-… #SciShots
Miss posting some photos here, so here it goes! 😁 I like taking photos of weird things happening in the brain, but homeostasis (stable equilibrium) is also beautiful! The image shows how microglia (🔵iba1) and neurons (🔴smi32 maker) are interacting. 📸Taken with @zeiss_micro
I am thrilled to share our lab's latest work documenting sex-differences (SD) in P2RY12's regulation of microglial morphology, synapse density and locomotory behavior. This work is our lab's first dive (of hopefully many)into microglial SD led by @OJ_uweru jneuroinflammation.biomedcentral.com/articles/10.11…
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