McClintock Bio @McClintockBio
Hard work pays off Joined July 2021-
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Directed Evolution of Antibodies with Doug Chapnick @ChapnickDoug Excited to have a conversation with Doug, the Co-Founder & CEO of BioLoomics @bioloomics. A platform company using directed evolution to discover antibody therapeutics. Combining synbio, ML, and imaging
Let the Best Drug Win with Errik Anderson youtu.be/lZl9GwhOyYs Errik is the CEO and Founder of Alloy Therapeutics. Founded in 2017, Alloy democratizes access to drug discovery platforms and services. In our conversation, we discuss Alloy's product offering and story
Scientist Stories: James Crowe, The Human Immune System youtube.com/watch?v=jufvId…
Alexion @AlexionPharma: - Founded in 1992 by Leonard Bell & Stephen Squinto - To drug complement & ending up pioneering a new business model in rare disease drug development - Developing Soliris into a blockbuster medicine first in PNH - Acquired by AstraZeneca from $39B in 2021
Scientist Stories: Jim Allison, Pioneering Immunotherapies youtube.com/watch?v=e4tBQ3…
Massively parallel base editing to map variant effects in human hematopoiesis led by Jorge Martin-Rufino @jmartinrufino from the Vijay Sankaran @bloodgenes lab
"I think there are similarities between science and music. I mean, in both you try to build a team that works. Each person has its own contribution and their own part of the overall work to do." - Jim Allison, Nobel Prize winner for inventing cancer immunotherapies
"I think it’s important to embrace your own unique perspective on science. [Most] impactful discoveries come when people can view a problem in a new way or bring a technique or expertise into a field where they haven’t been before." - Emily Balskus, Pioneer in chemical biology
In situ architecture of the ER–mitochondria encounter structure led by Michael Wozny @michael_wozny from the Wanda Kukulski @KukulskiWanda lab
CalFluors: A Universal Motif for Fluorogenic Azide Probes across the Visible Spectrum led by Peyton Shieh @Peyton_Shieh from the Carolyn Bertozzi @CarolynBertozzi lab
Remix Therapeutics @RemixThera: - Founded in 2019 by Peter Smith & Kevin Bitterman - To develop small molecules that modulate RNA processing with its multi-omic REMaster platform - Expanding the universe of druggable targets to treat cancer, CNS disorders, rare diseases & more
TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer led by Matthew Park @MatthewD_Park from the Miriam Merad @MiriamMerad lab
Tu Youyou is a chemist who won the Nobel Prize in 2015 for the discovery of artemisinin A medicine that has saved millions of lives for the treatment of malaria. All starting from ancient Chinese texts to screen >2K traditional recipes & ~380 extracts
Greetings from a #Sinaloa cornfield that is protected by @Provivitm #pheromones. This is a project ten years in the making, and now in the hands of farmers who want to reduce #insecticides and protect #biodiversity. @pedroslcoelho @ProviviMx
#Chemists in Stockholm! @GRCPres came to see all the fabulous women scientists the @GordonConf have celebrated over the years.
Value investing in life sciences - axial.substack.com/p/value-invest… 1. Find margins of safety 2. Strong owners 3. Growing moats enabled by new technologies and transactions 4. Less dilution 5. Misunderstood business models 6. Undervalued technology 7. A winning franchise 8. Monopolistic
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2 Followers 476 Following Life itself is a journey, we are all worthy and should strive to travel to different lives.Ali Farmsworth @farmsworth75609
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2K Followers 2K Following Neuroscientist @NeuroGeneva from Madagascar 🇲🇬. Interested in psychiatric disorders, reward, motor learning and cerebellum.Yun ZHU @zhuyun93
159 Followers 979 Following Patch-clamper, Social Behavior, 🐁USV, Photometry, Miniscope # Observation and introspectionSungho Hong @sungho_hong_
170 Followers 408 Following Computational neuroscientist 👨🏻💻🧠 @ Institute for Basic Science 🇰🇷, neuron enthusiast trying to understand networks, cerebellum, SCN.Ben Zarov @BenZarov
314 Followers 1K Following All mirth and no matter. The personal is political. Pundits have more pun. Neuroscientist-in-training, all thoughts are personal opinions.Peter @PeterBitterMan
394 Followers 1K Following Funemployed start-up, seeking places to drink, eat & travel - Eat & Drink localJuan Pablo @JuanPablo_64
99 Followers 843 Following Lic. en ciencias físicas - 空手道🥋 - See you space cowboyRoby joon @19robyg62
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339 Followers 2K Following In a world of arrogant arseholes, I aspire to be a humble prickKopa @Kopa66378031
221 Followers 1K FollowingDan Graham @DanGrahamMD
1K Followers 806 Following General Pathologist at Clinical Labs of Hawaii / Interest in BST, H&N, GU, GYN, HemeLeadership Sculptor G.. @LeadSculpt
5K Followers 5K Following #DevelopingRandDLeaders: Our mission is to turn the needle in research in a humanising direction.Sarah H. Shahmoradian @ShahmoraLab
1K Followers 694 Following Assistant Professor @ UTSW Medical Center. Dissecting the brain with electrons. Engineering new tools for cellular cryoET. #ScienceForAll 🛠️⚙️🧠❄️⚛️🔬🤖Katerina Akassoglou @AkassoglouLab
3K Followers 2K Following We investigate neurovascular mechanisms of inflammation, neurodegeneration & neurorepair. Professor @GladstoneInst @UCSF #FirstGen #fibrinogen #MS #ADEddy Albarran @albarran_neuro
2K Followers 2K Following Neuro Postdoc at Columbia | Costa lab Simons Junior Fellow + Helen Hay Whitney PhD at Stanford | Shatz and Ding labs🇺🇦 Dr. Stefanie.. @StefanieRobel
2K Followers 2K Following Author: Writing a book for research teams. Associate Professor Neuroscience. Helping PIs to create low-stress lab & mentoring systems @Glia_LeadershipPetteri Heino (Xeon/C.. @CloudHeino
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242 Followers 492 Following AvH postdoctoral fellow @Bach_Lab|Ph.D. @iiscbangalore| Alumni @RKMRC, Narendrapur| Alumni @RKMVCC, RaharaIndila Dora @indila_dora
132 Followers 329 Following I’m a Buddhist adept, mother of a boy, TCM student, and former model.Thompson Lab U of Ida.. @ThompsonUIdaho
199 Followers 366 Following Brand new synthetic inorganic/organometallic lab at @UIdaho.Christos Constantinid.. @c_constan
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811 Followers 5K Following Studied Looking Down A Microscope at Massey University Views expressed are NOT my own, so I cannot accept any responsibility for them.Hemanth Kumar @hemanthkmr8455
14 Followers 111 Following Research Scholar @ University of Hyderabad, Inorganic Nanomaterials for electrochemical water splitting, sensors, CO2 reduction and N2 reductionDrx__Vitamins @Drx__Vitamin_B
167 Followers 2K Following Registered Pharmacist. Practice makes a Man Perfect.Symposium for YouNg C.. @ForChemists
284 Followers 251 Following A young and interactive space to share pictures, experiences, ideas, collaborations and results born within the framework of the SYNC conference.Chmielarz Research Gr.. @Chmielarz_Group
2K Followers 2K Following 🇵🇱 🇺🇲 🇮🇹 Chmielarz Research Group at the Rzeszow University of Technology.Photo4Chem @Photo4Chem
394 Followers 357 Following Photo4Chem provides technological solutions in the field of apparatus and devices for 3D printing. The start-up also provides innovative research services.Maria Chiara di Grego.. @MariaChiaradiG4
409 Followers 770 Following Assistant Professor at Sapienza University, Rome @TheLittleGroup1 Previously at the van der Boom group, Weizmann Institute. Topics: Crystals & Soft matterviral rawat @viralrawat
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2K Followers 5K FollowingPaweł Chmielarz @Pawel_Chmielarz
3K Followers 2K Following Head of Department of Physical Chemistry Full Professor at Rzeszow University of Technology Chmielarz Research Group @Chmielarz_Group 🇵🇱 🇺🇲 🇮🇹Arsha choudhary @ArshaChoudhary
151 Followers 242 Following Grad Student at @ChemistryUIUC | Fataftah Labganesh upreti @GaneshGchm
302 Followers 871 Following Senior research fellow Indian Institute of Technology Kanpur Photoredox catalysis Organic ChemistAshis Das @ashisdas283
406 Followers 1K Following BSc RKMRC Narendrapur, Kolkata 🇮🇳 MSc IITK India 🇮🇳 PhD at Ecole Polytechnique federale de Lausanne Switzerland 🇨🇭 Senior Scientist Pharmaron, UK 🇬🇧Directed Evolution of Antibodies with Doug Chapnick @ChapnickDoug Excited to have a conversation with Doug, the Co-Founder & CEO of BioLoomics @bioloomics. A platform company using directed evolution to discover antibody therapeutics. Combining synbio, ML, and imaging
Differential vectorial operators for a vectorial function F = F(x, y, z) and a scalar function 𝜑 = 𝜑(x, y, z):
Let the Best Drug Win with Errik Anderson youtu.be/lZl9GwhOyYs Errik is the CEO and Founder of Alloy Therapeutics. Founded in 2017, Alloy democratizes access to drug discovery platforms and services. In our conversation, we discuss Alloy's product offering and story
Eric and I wrote a preview of the consortium paper by Sam Sober and colleagues on the Myomatrix array, a powerful new device for motor unit recordings. Check out the paper by Chung, Zia et al.! elifesciences.org/articles/94764
1/N Excited to share the lab’s first preprint on neural population dynamics in motor cortex and spinal motoneurons during locomotion! This project was led by Eric Kirk, an outstanding postdoc in the lab. Thread … biorxiv.org/content/10.110…
"I was taught that the immune system was incapable of recognizing cancer because cancers are comprised almost entirely of the same substances as normal tissues. The immune system is trained to avoid attacking ‘self’." - Edgar Engleman
Looking at clinical phase transitions from 2011-2020, it becomes abundantly clear that monoclonal antibodies (and maybe biologics in general) have a huge advantage over other drug modalities
hC Bioscience: - Founded in 2021 to develop tRNA-based therapeutics - With its PTCX (Patch) platform using engineered tRNAs to recognize nonsense mutations in mRNA - Suppressing them by inserting an amino acid where it is needed, restoring the protein to full length and function
Scientist Stories: James Crowe, The Human Immune System youtube.com/watch?v=jufvId…
Proteomics is filling out the picture of biology after ~2 decades of the genomic era Moore’s-like law advances in LC/MS as well as single-cell proteomics is leading to a more biochemically sound understanding of proteins across all scales from organs/tissues to cells
"[Science is like a Thanksgiving feast.] It all looks so good, that I always put too much on my plate." - Peter Schultz, Pioneering combinatorial chemistry, molecular evolution, and expanding the genetic code & current CEO of Scripps
Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase enzymes to include non-α-amino acids in vitro and in vivo led by Riley Fricke from the Alanna Schepartz @AlannaSchepartz @schepartzlab lab
Scientist Stories: Florian Büttner, Machine Learning in Oncology youtube.com/watch?v=eyrRFD…
Alexion @AlexionPharma: - Founded in 1992 by Leonard Bell & Stephen Squinto - To drug complement & ending up pioneering a new business model in rare disease drug development - Developing Soliris into a blockbuster medicine first in PNH - Acquired by AstraZeneca from $39B in 2021
"We only go forward not with treatments that will make it a little bit better but with treatments that will transform their lives." - Leonard Bell, Co-Founder of Alexion alongside Stephen Squinto (left)
Peptide-mediated delivery of CRISPR enzymes for the efficient editing of primary human lymphocytes led by Dana Foss @dv_foss from the Ross Wilson @RossWilsonLab lab
Scientist Stories: Jim Allison, Pioneering Immunotherapies youtube.com/watch?v=e4tBQ3…
Abcam @abcam: - Founded in 1998 by Jonathan Milner with Tony Kouzarides & David Cleevely to build an online registry of antibodies reagents - With >100K products in their catalog - Expanding to immunoassays and therapeutic products - Now generating over $400M in annual revenue