Jean M Hebert @Replacing_Aging
Neurogeneticist, Prof @Einsteinmed, Founder BE Therapeutics. Engineering brain tissue to restore and preserve cognitive function. hebertlab.einsteinmedneuroscience.org Bronx, NY Joined May 2020-
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2nd pig kidney transplant in a living person. Some key differences with this one: -Donor pig has just 1 edit -Pig's thymus gland was also transplanted -Patient also got a heart pump Here's my coverage for @WIRED: wired.com/story/combined…
(6/6) All that combined led me to a sobering realization that we barely know any intervention that reliably extends mice's lifespan. Now, I don't want to be overly pessimistic - we at least have something that worked in ITP, but I believe it's important to have realistic…
1/ Is there a credible plan to solve aging in our lifetimes? A plausible series of steps from where we are today, to a post-aging future? We looked, but we couldn’t find one. So we decided to build one. ↗️ See V1 of the Roadmap: longbiofellowship.org/roadmap
Best discourse on beating aging imho: "Mark Hamalainen | A Coherent, Executable Plan to Achieve Unlimited Healthy Lifespan" @MarkHamalainen @realNathanCheng @foresightinst foresight.org/summary/mark-h…
1/ Announcing COHORT 3 of the Longevity Biotech Fellowship! ❤️🚀 Join the revolution to end aging - and get to work building a future where death and decline are optional. Apply now: longbiofellowship.org/apply ⏳Deadline: Dec 31, Kickoff: Jan 18 ❄️
Excited to share initial press release @BlueRockTx on promising results of Phase 1 trial in 12 PD patients bit.ly/3JCKneG. A major milestone on a 20+ year journey. Amazing leadership by @TabarViviane, @MSKCancerCenter & @BlueRockTx (@bigosi, Mark Tomishima & many more).
Excited to share initial press release @BlueRockTx on promising results of Phase 1 trial in 12 PD patients bit.ly/3JCKneG. A major milestone on a 20+ year journey. Amazing leadership by @TabarViviane, @MSKCancerCenter & @BlueRockTx (@bigosi, Mark Tomishima & many more).
"Walking naturally after spinal cord injury using a brain–spine interface". pubmed.ncbi.nlm.nih.gov/37225984/ Not perfect, but a key step in the right direction. I imagine it won't be long before we can bypass complete spinal cord severing to restore a brain's motor control over the body.
Another early step toward brain tissue repair and replacement. Thank you, team! doi.org/10.3390/bioeng… Still a lot of work ahead. Looking forward to the challenge!
This is at the top of the Cell paper. But it's a huge overstatement: the only ageing being driven backward *is* of the epigenome! They didn't reverse any physiological ageing at all. Are you just allowed to put anything you like in the "Highlights" with zero oversight?
Another study showing that eliminating senescent cells is detrimental - this time in the lungs of mice. It's a recurring theme, and clearly senescent cells play physiological roles. As the authors note, it raises questions about therapies aimed at controlling cell senescence.
Another study showing that eliminating senescent cells is detrimental - this time in the lungs of mice. It's a recurring theme, and clearly senescent cells play physiological roles. As the authors note, it raises questions about therapies aimed at controlling cell senescence.
Do longevity drugs retard ageing in mammals? Or do they have ageing-independent benefits - e.g., reducing cancer? Even for rapamycin, I don’t think an antiageing effect has been well established. What is the best evidence that a longevity drug delays mammalian ageing?
It is not the rodent research, folks. It is the humans looking for simple answers and “stories” publishable in CNS mags that is slowing down progress
1/ Announcing the Longevity Biotech Fellowship (LBF)! A nonprofit org and community with the mission to: 🌱 Grow the Longevity Biotech Community 💪 Maximize our Members' Impact 🚀 & Break Bottlenecks to Progress Apply now at longbiofellowship.org! (First cohort Jan 2023)
A perspective worth reading: nature.com/articles/s4358…
Yet another good example supporting the potential of neural precursors for repairing or replacing damaged brain tissue: pubmed.ncbi.nlm.nih.gov/36224417/
More of this please pubmed.ncbi.nlm.nih.gov/35762203/
@LifeNoggin @LifespanNews @Replacing_Aging 🤗👴🏼🔜👨🏻🦱🙏🤞
Mainstream discussion of lab grown organs. Applications start with curing life-threatening diseases, of course, but inevitably (and not mentioned) can be used to replace age-deteriorated organs. cnn.com/2022/06/10/hea…
Nathan S. Cheng think.. @realNathanCheng
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3K Followers 388 Following Founder (raised $20M VC + sold to public co, now bootstrapping) | mobility & immigration | health & longevity | 🇯🇵 | dancing | 🌎 w/@adamgries + 👧🏻👶🏻@KristerKauppi @mkaeberlein @OptispanPodcast @OraBiomedical Krister, while I agree with your assessment, I must remind that we need to choose wisely how to spend our time and resources. And while I agree that we can learn many new things about mice from additional calorie restriction studies, what are the chances it will translate into…
@BasedBeffJezos @Replacing_Aging working on brain cell replacement once you need fresh brain cells vitadao.com/projects/be-th…
.@Replacing_Aging is one of my favorite longevity researchers in the field. One of the slides he showed today at the @vita_dao Zuzalu conference made me think of something @kaimicahmills said: “We will resolve aging but it won’t be pretty” Save our brains Jean!
I recently had the opportunity to attend the @LongevityGlobal event in New York, where I engaged in discussions on the topic of longevity. It was fascinating to explore various perspectives and approaches towards achieving a long and healthy life.
This is at the top of the Cell paper. But it's a huge overstatement: the only ageing being driven backward *is* of the epigenome! They didn't reverse any physiological ageing at all. Are you just allowed to put anything you like in the "Highlights" with zero oversight?
Another study showing that eliminating senescent cells is detrimental - this time in the lungs of mice. It's a recurring theme, and clearly senescent cells play physiological roles. As the authors note, it raises questions about therapies aimed at controlling cell senescence.
Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression ahajournals.org/doi/10.1161/CI…
You are not and will never be your emulation, no matter how strongly Kurzweil tries to convince you otherwise. Reject mind uploading, embrace radical life extension.
Wondering if small molecule research holds the #longevity field back. They are the lowest hanging fruits to get small effects on health- & lifespan extension. Experiments are uncomplicated and unsophisticated allowing academics to publish quickly. Seems to stifle innovation🫤
If we agree that an individual’s life has inherent value, whether they are young or old, then it makes sense to want to preserve that life. - Jean Hébert (Replacing Aging, 2020) @Replacing_Aging
Do longevity drugs retard ageing in mammals? Or do they have ageing-independent benefits - e.g., reducing cancer? Even for rapamycin, I don’t think an antiageing effect has been well established. What is the best evidence that a longevity drug delays mammalian ageing?
@Replacing_Aging time to get going on the sequel! ✍🏻
By sheer coincidence I seem to be working on this tech tree project which is attempting to build a map of the longevity space. My original goal was to try to get an accurate map of where we should be going. The best way to do this is actually to include wrong pathways as well
They’re going to saw a person’s chest open, cut their heart out, and suture that one in. But many NIH grant reviewers apparently believe intracranial AAV injections lack translational potential bc they’re too invasive
Join us this Sunday at 2pm EST in collab with @vita_dao as Jellyfish filmmakers chat with neuroscientist Jean Hebert (@Replacing_Aging) about the power of movies and media to impact public perception on Longevity 🎥🔬🧬 discord.gg/tnpRGnPT?event…
Anunciamos o novo lançamento da NTZ: "Substituindo o envelhecimento", a versão em português do livro "Replacing Aging" de Jean Hébert. Vejam a entrevista completa com o autor com legendas em português: youtu.be/edZpZrn7ihE
@LifeNoggin @LifespanNews @Replacing_Aging 🤗👴🏼🔜👨🏻🦱🙏🤞
@Replacing_Aging I imagined this day would come . The power of our minds are now pushing dreams becoming a reality . Thanks for posting ! Go science 🧪
Bioprinted ear grown from the patient's own cells. Before similar technology was used for bone implant by @EpiBoneInc news.cornell.edu/stories/2022/0…
@yesbutmostlyno Many things LOOK like programmed aging, but they can't be: pubmed.ncbi.nlm.nih.gov/25902458/ Similarly, "hyperfunction theory" is simply modern-language antagonistic pleiotropy: pubmed.ncbi.nlm.nih.gov/33784821/ pubmed.ncbi.nlm.nih.gov/33784825/ For full texts email [email protected] (not gmail)