Alex Plesa @amplesa
Postdoc at @harvardmed and @WyssInstitute in @geochurch's lab | Working on age reversal Joined October 2019-
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1/ Can we find more precise and even safer ways to rejuvenate vision? As a step towards this goal, I am excited to share this preprint of my 1st postdoc work from @JswLab with amazing collaborators, esp. @bruce_ksander! Using functional genomics, we discovered GSTA4 as a key OSK…
In the past thirty years, the number of deaths from cancer has dropped dramatically, resulting in millions of lives saved. Some of this is due to improvements in oncology treatments, including immunotherapy. But most of the effect has little to do with biopharma at all.
New paper @NatureRevCancer on the evolutionary interplay between ageing and cancer 🚨 These are overlapping yet also antagonistic processes. While cancer involves cell proliferation and growth, ageing often involves cellular degeneration and atrophy. Because natural selection…
🧵1/ LBF7 Spain is happening and we're doing something kinda wild: -We’re gathering the smartest people who want to SOLVE AGING -going to a longevity resort in the Spanish mountains -to learn, discuss and ACTUALLY BUILD stuff for 7 days straight Here’s what we’re cooking 👇
Absolutely crazy month for progress in the world of genome instability & DNA repair, especially as pertaining to aging. A few of the most exciting papers, a 🧵:
Excited to introduce evoCAST: a platform for efficient, programmable gene integration in human cells. This work, product of a close collaboration between @liugroup and @SternbergLab, has been such a fun journey to help lead throughout my PhD. Huge thanks to all contributors!
Excited to introduce evoCAST: a platform for efficient, programmable gene integration in human cells. This work, product of a close collaboration between @liugroup and @SternbergLab, has been such a fun journey to help lead throughout my PhD. Huge thanks to all contributors!
Just posted a piece I've wanted to write for a long time. Maximum Lifespan vs. Healthspan (or - why you cannot diet your way to live to 140), a 🧵 Take a look at these two mice, from the famous Baker et al. 2016 Nature paper:
Our work on nucleic acid sensing in live human cells is out 🧬⚫️🟢! Big thanks to @AIMahas @LisaRiedmayr @geochurch ! Make sure to check out Ahmed's thread 👇
Our work on nucleic acid sensing in live human cells is out 🧬⚫️🟢! Big thanks to @AIMahas @LisaRiedmayr @geochurch ! Make sure to check out Ahmed's thread 👇
NIH grants frozen. Discoveries delayed. PhDs pushed out. Academia getting gutted. Innovation must continue. There’s never been a better time for scientists to build startups.
Our genome-scrambling paper is out in @ScienceMagazine 🍳🧬! Huge thanks to everyone at @LeopoldParts and @geochurch labs, especially my amazing collaborator @JonasKoeppel!!!! Many additions to the preprint, so be sure to check out his thread 🧵!! science.org/doi/10.1126/sc…
Our genome-scrambling paper is out in @ScienceMagazine 🍳🧬! Huge thanks to everyone at @LeopoldParts and @geochurch labs, especially my amazing collaborator @JonasKoeppel!!!! Many additions to the preprint, so be sure to check out his thread 🧵!! science.org/doi/10.1126/sc…
I’m delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases @ScienceMagazine! @ferreira_raph_ @LeopoldParts @ProfTomEllis, @geochurch @sangerinstitute science.org/doi/10.1126/sc… Lots of changes from the preprint. A🧵
One of the most important studies for the longevity field was just released last week, and it does not mention aging once. It's about how genome instability is the cause of Huntington's disease. 🧵
1/ 🧵Announcing CORHORT 6 of the Longevity Biotech Fellowship —the most hardcore community of longevity accelerationists! Join 700 members working to SOLVE aging entirely. ⌛️Deadline: Mar 14 Kickoff Retreat: Mar 31 - Apr 4 in Berkeley. 👉Apply: longbiofellowship.org/apply
Now is the time for a bold and audacious UK! The UK invents the future. It's time for scientists to lead and build it here too. 100x more UK scientists are capable of starting civilisation-defining companies. 5050 UK helps them start. Applications are open! The path from…
X community - need your help finding the best med. oncologists + founders working in adv. renal cell carcinoma. My dad’s cancer returned as stage 4 met. to lung + lymph nodes. Please help me make a miracle happen + connect me to the best folks you know in the space! 💙🙏
My review on scRNAseq of diabetic wounds and our evolving understanding of fibroblast heterogeneity was published in this month's issue of @Biomed_MDPI! Grateful for wonderful mentors @LongakerLab mdpi.com/2227-9059/12/1…
We need to think about cancer prevention as a strategy for longevity. Over the past century, there have been hundreds of aging theories. Almost all of them, from information theory to telomeres to programmed aging, share damage to the genome as a central driver.
Two big papers came out recently filling out some big knowledge gaps in genome instability. The first beautifully ties together R-loops with Cockayne syndrome, TC-NER, and transcript length. Why is that a big deal? nature.com/articles/s4146…
1/ 🚨 Excited to share my Postdoc research with @geochurchlab at @harvadmed! Dive into our discoveries on the central dogma of biology, antibiotic resistance, #compbio designs, and #synbio. 🧬🔬 Check our paper: biorxiv.org/content/10.110…
🧬🔬 How can we address the bystander challenge in base editing? Happy to share my first paper from the @geochurch lab! Discover how we're making on-demand genome editing a reality with ultra-precise base editing enzymes coupled with our agRNAs. 🚀🧵👇 biorxiv.org/content/10.110…
Y. Ryan Lu @Y_Ryan_Lu
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Hao Shen | Kou Shizum... @Hao_K_Shen
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