Fessl Lab @fessl_lab
Tweeting about science, mostly membrane proteins, molecular machines and single-molecule biophysics. makrokomplex.cz České Budějovice, CZ Joined August 2017-
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Following92
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@hopeneeds and @MitoPereira_GC (now @MRC_MBU) of @LabCollinson and Henley labs @BristolBiochem new paper (1st of a trilogy!) -big thanks to @wellcometrust (including DMCB PhD program) for funding biorxiv.org/content/10.110…
First of my PhD work live on BioRXiV! Just in time for a quick holiday before we get back to work on the next installment! Thanks to co-authors @IanofBristol @MitoPereira_GC and Jeremy Henley! 🥳
First of my PhD work live on BioRXiV! Just in time for a quick holiday before we get back to work on the next installment! Thanks to co-authors @IanofBristol @MitoPereira_GC and Jeremy Henley! 🥳
The adaptation of the NanoLuc-based import assay to mammalian cells was straightforward. Here is the initial report using rPFO permeabilisation.
The adaptation of the NanoLuc-based import assay to mammalian cells was straightforward. Here is the initial report using rPFO permeabilisation. https://t.co/CvgWzsKZBW
Our latest paper is out in PNAS- great collaboration with @VIB_Switch_Lab. Well done all! Several postdoc positions also available in amyloid mechanism and cryoEM- come and join us!
Will's masterpiece is now published: Rate-limiting transport of positively charged arginine residues through the Sec-machinery is integral to the mechanism of protein secretion | eLife elifesciences.org/articles/77586
Really nice review on how peripheral membrane proteins interact with lipids written by @haahr_larsen with input from us. We struggled to finish as there were so many amazing studies that kept coming out!
Will's (@Murmeth @LabCollinson @BristolBiochem) new paper with @DanielWWatkins @RobinCorey1 @sofiaol43489629 and @cooklabuoonz, Kiel Hards (@otago). His magnum opus, literally years in the making towards a mechanism for ATP and PMF-driven protein secretion biorxiv.org/content/10.110…
Latest preprint from @LabCollinson - a two authorship collaboration from @IanofBristol and I. Inside we investigate and speculate on the myriad of interactions the make up the ‘secretosome’ - the hub of bacterial protein translocation, with the Sec Translocon at its core.
Latest preprint from @LabCollinson - a two authorship collaboration from @IanofBristol and I. Inside we investigate and speculate on the myriad of interactions the make up the ‘secretosome’ - the hub of bacterial protein translocation, with the Sec Translocon at its core.
Lovely day and proud to receive an OBE for services to Molecular Biology- ceremony at Windsor Castle
Exciting postdoc available. Come and join us! Apply at jobs.leeds.ac.uk/FBSAS1044
Identification and assessment of cardiolipin interactions with E. coli inner membrane proteins advances.sciencemag.org/content/7/34/e…
Our own Taekjip Ha @taekjip has been elected President of the Biophysical Society. Congratulations TJ! biophysics.org/news-room?ArtM…
Kuwabara, Collinson &co @IanofBristol @LabCollinson @BristolUni @BristolBiochem show that maintenance of complex I by NDUF-11 is essential for mitochondrial function. #openaccess owing to @Co_Biologists's #ReadandPublish consortium agreement with @Jisc: ow.ly/CruY50FySZZ
Engineering an Allosteric Control of Protein Function pubs.acs.org/doi/10.1021/ac…
Our new paper ‘Refined measurement of SecA-driven protein secretion reveals that translocation is indirectly coupled to ATP turnover’ is out now! Some really cool findings inside (see thread). Thanks to @promegauk for their NanoLuc technology! pnas.org/content/early/…
Mini microscope 😁 featuring parabolics and the worlds most improvised stage (soon to be replaced - don’t worry)
The diversity of protein-lipid interactions remains a fascinating topic. This paper from the Sansom group is a nice illustration of how multiple lipids fight with each other to sit next to the big guys. Duncan, Corey & Sansom, PNAS, 2020. doi.org/10.1073/pnas.1… #CG_Martini
Latest mini-review: mostly @LabCollinson centric view of protein transport through the bacterial Sec machinery -including the action of phospholipids in protein secretion and membrane insertion frontiersin.org/articles/10.33…
The dynamic ATP-driven mechanism of bacterial protein translocation, and the critical role of phospholipids @IanofBristol frontiersin.org/articles/10.33…
It took a while, but here it finally is. Great work by @tamar_cs and colleagues! biorxiv.org/content/10.110…
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