Jakob Farnung @jakobfarnung
PostDoc Schulman Lab, MPI Biochemistry; formerly Bode Lab, ETH Zürich Joined September 2019-
Tweets82
-
Followers160
-
Following154
-
Likes163
Excited about mechanistic biology and processes in the cell's nucleus? Join our lab as a post-doctoral researcher! We have a state-of-the-art cryo-EM facility at HMS, a brand-new lab space, and a vibrant community at HMS! DM/email me or check farnunglab.com
Our collaborative AGO2 work with the Bartel lab is published! @AMohamed_98 and @wyppeter used cryo-EM and biochemistry to determine the structure of AGO2 in a slicing competent conformation with a fully paired RNA. Read more about it here: tinyurl.com/AGO2-slicing
Our collaborative AGO2 work with the Bartel lab is published! @AMohamed_98 and @wyppeter used cryo-EM and biochemistry to determine the structure of AGO2 in a slicing competent conformation with a fully paired RNA. Read more about it here: tinyurl.com/AGO2-slicing
Ever wondered how transcription choreographs histone modifications? Our work reveals the basis of co-transcriptional H3K36me3 by SETD2. We visualize how a histone writer coordinates with the transcription machinery! This is the magnus opus of @MarkertJon tinyurl.com/setd2
Congratulations to graduate students @AMohamed_98 from our group and @wyppeter from the Bartel lab on determining the structure of human AGO2 in the slicing conformation. This was a challenging project with many exciting results. Read our preprint to learn more!
Congratulations to graduate students @AMohamed_98 from our group and @wyppeter from the Bartel lab on determining the structure of human AGO2 in the slicing conformation. This was a challenging project with many exciting results. Read our preprint to learn more!
Having a hard time with #CRISPR HDR? Your cells might be fighting against you! TREX1 nuclease, high in some cells, eats up HDR donor templates. Check out our paper in @NatureBiotech for the story & ways to improve HDR. nature.com/articles/s4158… With @karasuerman1 & @J_Maciejowski
AI is accelerating structural biology! 🧬📷 Read my interview in Harvard Medicine News to explore the future of AI-powered research: hms.harvard.edu/news/how-machi…
Published today, our fantastic collaboration with Lindsey James group, @BrianRaught, and Licht Lab. Thanks to the talented David Nie and John Tabor! nature.com/articles/s4158…
New preprint! 🧬🖥️ With the @FrogWalterLab, we created a predictome of nucleosome acidic patch binders using AlphaFold. Our approach identified both known and novel acidic patch interactors, opening new avenues for chromatin research. Check it out: biorxiv.org/content/10.110… (1/3)
Delighted to see our paper out in @NatureComms! We uncovered that alkylamine-tethered molecules recruit FBXO22 for TPD, making it an exciting addition to the TPD toolbox. nature.com/articles/s4146…
Check out the study on the first identified human protein whose stability is regulated via Pro/N-degron and CTLH E3 ligase
Check out the study on the first identified human protein whose stability is regulated via Pro/N-degron and CTLH E3 ligase
Check out our story revealing exciting regulation of the NAD+ biosynthetic enzyme NMNAT1 by the supramolecular CTLH E3 ligase assembly out in @MolecularCell! ➡️cell.com/molecular-cell… Karthik Gottemukkala, @dawafutisherpa, @ArnoAlpi Schulman lab @MPI_Biochem
Would you like a data set of 40,000 reactions for evaluating your reactivity prediction models? We made it, so you don’t have to. 1/10
Synple Chem (@synplechem) and Enamine partner to jointly develop a new chemical space by fueling the world’s largest collection of building blocks provided by Enamine to Synple Chem’s reaction outcome prediction tools. Read full Press Release: bit.ly/3JGtQ9c
🚨Excited to share that our manuscript is now published in @NatureSMB. Using #cryoEM 🔬we obtained multiple snapshots 📷 of the #chaperone-mediated multistep assembly pathway of the human 20S #proteasome. @MPI_Biochem @HarvardCellBio @ASAP_Research nature.com/articles/s4159…
You are a highly talented researcher? The departments of Brenda Schulman and Matthias Mann are looking for you! Check out the #job offer: ❕apply as soon as possible ❕mpg.de/21767203/phd-s… #hiring #jobAlert @labs_mann #ubiquitin #E3ligase #UPS #massspec #structural_biology
Congratulations to twitter less Bonnie Su on her first paper from the lab! Bonnie shows that NELF can bind Pol II in two distinct confrontations that support either pausing or elongation. She did this using actively transcribing complexes. Read it here: authors.elsevier.com/sd/article/S10…
Now out in @MolecularCell! High-resolution structure showing direct ubiquitylation of a #TPD substrate! And much more, check out 👉shorturl.at/jrsBG #cryoEM @MPI_Biochem @UNLV_CoS @StJudeResearch @DanielS20127197 @rajanprabu (1/2)
See how CRLs forge ubiquitin chains on substrates - and degrader-recruited neo-substrate - at high-res! Millisecond polyubiquitylation! #cryoEM #TPD @NatureSMB @MPI_Biochem @UNLV_CoS 👉shorturl.at/eFS68 Related exciting work from @alessiociulli shorturl.at/hNSU5
See cullin-RING E3s forge #ubiquitin chains on substrates and degrader-recruited neo-substrate at high-res! Millisecond polyubiquitylation! #cryoEM #TPD @NatureSMB ❕nature.com/articles/s4159… Also, ... (1/2)

Tessa @Ruvimbochimidzi
9K Followers 4K Following 🦋Bsc Biochemistry (UZ)🦋 CRISPRCas9 Genome editing tool🦋Molecular Biologist 🦋
FannyRobinson @PlEgx800gw45X
181 Followers 2K Following
Vincent Albrecht @_VAlbrecht
112 Followers 128 Following PostDoc @MPI_Biochem in @Labs_Mann | PhD in Biochemistry
Marwa Amer, PhD @MarwaAmerA
359 Followers 3K Following Structural biology, Genomic and Bioinformatics, mother, and like traveling
DanielleMeier @DanielleMe87611
0 Followers 124 Following 📚 Ready to improve your finances? Join our free course and start learning from industry professionals. Make smarter financial choices today! 👇👇
Michelle Parker @Michel1688
285 Followers 2K Following Reliable medical equipment agents – guardians of patient health --As a trusted medical device distributor, we are committed to providing high-quality medical eq
Maria. @MariaHaveforeve
495 Followers 2K Following 🇺🇸🇺🇸🇺🇸I enjoy cooking, reading, yoga, meditation, investing, golfing, hiking, and travelling outside of my home country to discuss life's lessons wi
Cherry @Cherry_niceg
131 Followers 910 Following If you have a dream in your heart, you must stick to it. Don’t give up when you encounter difficulties. Only through repeated tempering can good steel be forged
Hiroshi Imanaga @HiroshiImanaga
315 Followers 1K Following National Hospital Organization Kyushu Medical Center/hematology-oncology/B-cell precurser acute lympholastic leukemia/glucocorticoid/gymnastics/sake/MD, PhD
Danette Daniels @danetteldaniels
1K Followers 610 Following Scientist, biophysics, cell biology, targeted protein degradation, and drug discovery. Adventure athlete, runner, and mountain biker | Opinions are my own
Dhanusha Nalawansha @nalawansha
379 Followers 640 Following Sr. Scientist_Induced proximity platform @Amgen // former postdoc @Yale (Crews Lab). #TPD, #PROTACs, Chemical inducers of Proximity, #Epigenetics, #KRAS
Yuji Kamei @yujikamei
153 Followers 427 Following PhD student in organic chemistry and chemical biology at EPFL @LcsoLab @LCBM_EPFL
Mark A. Nakasone @Mark_A_Nakasone
454 Followers 984 Following US🇺🇸 Researcher (EU🇪🇺 spouse) in Scotland🏴, UK🇬🇧 #ubiquitin
Tycho Mevissen @TychoMevissen
224 Followers 270 Following Postdoc @FrogWalterLab @harvardmed interested in transcription, DNA repair and ubiquitin | former @JCCFund & @EMBO fellow | Alumnus of @MRC_LMB & @Cambridge_Uni
Urja Kuber @UrjaKuber
347 Followers 898 Following Chromatin Biology @EPFL | MSc Biochemistry @uni_tue | Welcome to the contents of my head
Prabhleen kaur @KaurPrabh130
621 Followers 6K Following CSIR-SRF PhD Scholar at IGIB A Science enthusiast aspiring to explore and expand my knowledge in the field of biology.
Annina Denoth @denidenoth
165 Followers 213 Following
Sjoerd van Wijk @sjoerdjlvanwijk
704 Followers 2K Following Group leader @goetheuni, #ubiquitin, #deubiquitinase, #autophagy, #cellfate and #celldeath #basstrombone (views are own)
Juan Manuel Perez Ber... @Juanmabertoldi1
369 Followers 886 Following
Di Yang @DiYang33319166
113 Followers 603 Following
Filiz Kuybu @filizkuybu
84 Followers 519 Following @IMPRS_ML PhD Student in the @Hopfnerlab at @GeneCenter_LMU exploring DNA Repair and cryoEM
Winklhofer Lab @winklhofer_lab
916 Followers 771 Following Dedicated to elucidate mechanisms of #neurodegeneration: #proteostasis, #ubiquitin, #mitochondria
Interact 2025 @Interact2025
13 Followers 87 Following The translational sciences symposium organized for and by young scientists! 🗓 03&04 April 2025 📍 Biomedical Center Munich
jake @mediocre_jake
56 Followers 167 Following 🇲🇾Postdoc WEHI @FelthamLab PhD @BrownLabUNSW #ubiquitin #inflammation #cholesterol 🆕️ 2024 account, past account was deleted - keen to reconnect
Katrin Rittinger @KatrinRittinger
627 Followers 327 Following Structural biologist, amateur photographer. Views are my own.
RaMue @RaMue1304
7 Followers 149 Following
WIMI Biotech @wimi_biotech
1K Followers 8K Following The Chinese name of "WIIMI" is"未米", which means "the future crops". WIMI Service Items: Genetic Transformation & Vector Construction [email protected]
Peter Wang @wyppeter
322 Followers 415 Following PhD candidate, Bartel Lab, MIT/@WhiteheadInst. Biochemical + biophysical principles of protein/RNA mechanisms. MicroRNA/siRNAs & AGO proteins.
Saikat Guria @saikat_orgchm
87 Followers 441 Following PhD student in @ChattopadhyayL1, CBMR Lucknow
Erman KARASU @karasuerman1
82 Followers 136 Following Research Assistant Professor in Cortez Lab, Vanderbilt University.
Moritz Hunkeler @moritzhunkeler
624 Followers 597 Following Instrument Specialist @BioEM_lab @biozentrum @UniBasel. Views are my own.
Society for Medicines... @SocMedRes
620 Followers 2K Following The SMR is a UK charity for all engaged in drug discovery. We organise scientific, & mentoring events. https://t.co/ID41iWlMvG
Sophie @SophieRth98
43 Followers 149 Following PhD at Harvard & LMU, studying #transcription // #BIF PhD Fellow // either shooting 📸 or pipetting 🧪🧬 // website below 👇🏽
Charlotte Crowe @CharlCrowe
1K Followers 1K Following Structural biology PDRA @MichaelJFoxOrg / PhD 2024 @AlessioCiulli @UoDCeTPD 🏴🇬🇧/ MChem 2020 @univofstandrews / originally from Strasbourg 🇫🇷
Karthik Varma Gottemu... @Karthik_G_Varma
21 Followers 47 Following PhD student @MPI_Biochem | Interested in Cell biology and biochemistry 🧬🔬
Cyndi Chua @ChuaCyndi2020
441 Followers 3K Following Commissioning Editor, Frontiers in Bioscience-Landmark (ISSN: 2768-6701, SCIE&PubMed Indexed, IF: 3.3), IMR Press Email: [email protected]
Stamatia (Matina) Chr... @ChristakiMatina
24 Followers 197 Following PhD candidate Sheffield Uni | Working on injury-induced inflammation, DUBs and Osteoarthritis in zebrafish. Funded by Versus Arthritis. Ismail Lab
Samuel Maiwald @SamuelMaiwald
35 Followers 37 Following PhD student in Schulman lab @MPI_biochem @IMPRS_ML, interested in structural biology and ubiquitin system 🔬
Sona Rhee @krisrhee0917
15 Followers 84 Following Protein design, MD simulations, Programming and more
Kun ZANG 坤 @KunZANG2024
50 Followers 433 Following Postdoc at MPIB. Bacterial microcompartment, Phase separation, Protein structure, Rubisco
Tom Snelling @TWSnelling
2K Followers 2K Following Postdoc with Philip Cohen @mrcppu @dundeeuni with an interest in cell signalling and rare diseases!
Abhay Kumar Arya @abhay_arya74860
7 Followers 484 Following
Sara Šepić @sepic_sara
33 Followers 97 Following PhD student at @MPI_Biochem | Interested in biochemistry and structural biology 👩🏼🔬
Vincent Albrecht @_VAlbrecht
112 Followers 128 Following PostDoc @MPI_Biochem in @Labs_Mann | PhD in Biochemistry
Marcin J. Suskiewicz @MSuskiewicz
1K Followers 4K Following Structural biologist and biochemist. CNRS researcher at CBM Orléans. Interested in protein modifications & interactions. Also husband, dad of 2, friend, ☧.
Danette Daniels @danetteldaniels
1K Followers 610 Following Scientist, biophysics, cell biology, targeted protein degradation, and drug discovery. Adventure athlete, runner, and mountain biker | Opinions are my own
Mark A. Nakasone @Mark_A_Nakasone
454 Followers 984 Following US🇺🇸 Researcher (EU🇪🇺 spouse) in Scotland🏴, UK🇬🇧 #ubiquitin
Filiz Kuybu @filizkuybu
84 Followers 519 Following @IMPRS_ML PhD Student in the @Hopfnerlab at @GeneCenter_LMU exploring DNA Repair and cryoEM
Peter Wang @wyppeter
322 Followers 415 Following PhD candidate, Bartel Lab, MIT/@WhiteheadInst. Biochemical + biophysical principles of protein/RNA mechanisms. MicroRNA/siRNAs & AGO proteins.
Moritz Hunkeler @moritzhunkeler
624 Followers 597 Following Instrument Specialist @BioEM_lab @biozentrum @UniBasel. Views are my own.
Sophie @SophieRth98
43 Followers 149 Following PhD at Harvard & LMU, studying #transcription // #BIF PhD Fellow // either shooting 📸 or pipetting 🧪🧬 // website below 👇🏽
Cheryl Arrowsmith @CherylArrowsmi1
965 Followers 25 Following Scientist and Professor @theSGConline, University of Toronto, Princess Margaret Cancer Centre
Charlotte Crowe @CharlCrowe
1K Followers 1K Following Structural biology PDRA @MichaelJFoxOrg / PhD 2024 @AlessioCiulli @UoDCeTPD 🏴🇬🇧/ MChem 2020 @univofstandrews / originally from Strasbourg 🇫🇷
Karthik Varma Gottemu... @Karthik_G_Varma
21 Followers 47 Following PhD student @MPI_Biochem | Interested in Cell biology and biochemistry 🧬🔬
Samuel Maiwald @SamuelMaiwald
35 Followers 37 Following PhD student in Schulman lab @MPI_biochem @IMPRS_ML, interested in structural biology and ubiquitin system 🔬
Eleftheria Papadopoul... @ecpapadopoulou
188 Followers 495 Following @IMPRS_ML PhD student in Schulman lab, @MPI_Biochem 🧪 BIF PhD Fellow 🔬 Interested in Protein Degradation and Molecular Signaling 👩🏻🔬
Brian Liau @brian_b_liau
2K Followers 226 Following Chemical biologist broadly defined. Associate Prof @ Harvard Chemistry and Chemical Biology.
Kun ZANG 坤 @KunZANG2024
50 Followers 433 Following Postdoc at MPIB. Bacterial microcompartment, Phase separation, Protein structure, Rubisco
The Thought Emporium ... @EmporiumThought
12K Followers 116 Following As close to a real mad scientist as you'll find | Youtuber | Researcher
Fischer Lab @fischerlab1
2K Followers 54 Following News and updates from the Eric Fischer Lab, Est. Oct 2015 @DanaFarber @harvardmed | E3 Ligases | Ubiquitin | Degraders | Chemical Biology | Cancer
Shay Laps @Shay_Laps
587 Followers 3K Following Postdoc, Chou's lab, @Stanford University. Former Israel Academy of Sciences Postdoc fellow @IsraelAcademy
Sofia Todesca @SofiaTodesca
209 Followers 672 Following @IMPRS_ML PhD student in Structural Biology at @MPI_Biochem in @LabConti; @unipv MSc in Molecular Biology and Genetics; @Ghislieri_pavia and @Iusspavia alumna
Sara Šepić @sepic_sara
33 Followers 97 Following PhD student at @MPI_Biochem | Interested in biochemistry and structural biology 👩🏼🔬
Tyler Franklin @tylergfranklin
119 Followers 151 Following Postdoctoral scholar studying ubiquitin signalling in the Pruneda lab at OHSU. Previous @Lugerlab undergrad and @NREL tech.
Eric Herrmann @stEricHerrmann
30 Followers 53 Following Postdoc at @TheHurleyLab at the @UCBerkeley. Interested in structural membrane biology.
Jonathan Pruneda @jnpruneda
1K Followers 607 Following Associate Professor at Oregon Health & Science University studying microbial interference in host ubiquitin signaling. Formerly @UWBiochemistry and @MRC_LMB.
Sylvia Varland @SylviaVarland
314 Followers 919 Following Molecular Biologist interested in basic research, protein modifications, functional genomics and molecular medicine. Views are my own.
Laura Helleckes @laurahelleckes
64 Followers 60 Following Eric and Wendy Schmidt AI in Science Postdoctoral fellow at Imperial College London
Di Antonio Research G... @DiAntonioLAB1
2K Followers 484 Following We are a Chemical-Biology group investigating DNA structures and dynamics based at Imperial College Chemistry.
Thomä Lab @LabThoma
2K Followers 346 Following We are a structural biology lab located both at EPFL in Lausanne and at the Friedrich Miescher Institute in Basel.
Malte Gersch @MalteGersch
397 Followers 266 Following Chemical Biologist & Research Groupleader at Max Planck & TU Dortmund. Interested in proteases, ubiquitin, the outdoors and more. https://t.co/NiwEqrr21H
Mikołaj Słabicki @biomiko
1K Followers 482 Following Assistant Professor at MGH Krantz Family Center for Cancer Research, Harvard Medical School, Broad Institute of MIT and Harvard.
Woo Lab @thewoolab
3K Followers 360 Following Official Account for Christina Woo’s Lab @HarvardCCB | chembio, protein mods, chemoproteomics, TPD | Student-run account | tweets by Christina signed CMW
Tatyana Bodrug @BodrugTanya
150 Followers 421 Following 🔬 Postdoc UCSD, I use cryo-em to look at cell signaling. Views are mine.
Catherine Xu @Catherine_k_xu
44 Followers 86 Following @HFSP fellow in @GuckLab at @MPI_Light | alumna of @KnowlesLabCamb at @ChemCambridge
David Krist @DavidTKrist
309 Followers 619 Following Resident @OpNotes @StanfordSurgery, MD @ILLINOISmed, PhD @NUChemistry, aspiring surgeon-scientist, he/him/his
Tarhan Ibrahim @TarhanEI
641 Followers 798 Following Plant Immunity | Hunting ATG8 binders 🔍 | MPMI | @imperialcollege w/ @Tolga_Bzkrt | 🇨🇾
Katherine Reiter @KHReiter
251 Followers 627 Following Senior Scientist • Former @KlevitLab & Matunis Lab • HDX-MS dream team, structural biochemist, ubiquitin enthusiast • Fly fishing damsel 🎣
Mohit @mohitasya
447 Followers 1K Following Team Leader @iDikic2 lab @Proxidrugs Ubiquitin enthusiast with expertise in structural biology
Rachel O Dea @RaRodea16
146 Followers 274 Following PostDoc at the MRC-PPU, Dundee Ubiquitin and friends enthusiast
Leo James' Lab @JamesLab9
982 Followers 240 Following Leo James' lab at MRC LMB in Cambridge, UK. Host-pathogen interactions, immunity to viruses, TRIM proteins and HIV. Account run by lab members.
Arno Alpi @ArnoAlpi
276 Followers 212 Following Cell biologist with keen interest in biochemistry and structural biology. Exploring ubiquitin biology. Love mountaineering
Donghyuk Shin @Donghyuk_Shin_
547 Followers 538 Following Assistant Professor @yonsei_u Trying to Understand Ubiquitin Biochemistry, Molecular Signaling. Formerly @iDikic2 @MPIBP
Luca Stier @LucaStier3
47 Followers 559 Following
Frank Adolf ❄️�... @frank_adolf
248 Followers 679 Following Project Group Leader @MPI_Biochem | Department of Molecular Maschinens and Signaling | Max Planck Institute of Biochemistry
Max Planck Institute ... @MPI_Biochem
10K Followers 400 Following We tweet about our scientists, science and related topics #biochemistry #biophysics #cellbiology #structuralbiology #machinelearning https://t.co/WXiPehYTw8