ClaytonLab @lab_clayton
Studying pathogens that hide out in macrophages to escape killer immune responses Clayton-lab.org UMass ChaMed School, Worcester Joined August 2021-
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Hey macrophage mafia — ectopic expression of TFs in macrophages and then RNAseq…can anyone think of any datasets in this space? I found a few studies with qPCR and small # targets but no omics. Especially curious about TFs associated with tissue resident MFs.
Our new study suggests that #centenarians (those who live >100 yrs) have elite immune systems that may function to avert disease and promote #longevity! @CReM_Boston @BUMedicine @The_BMC @DowreyTodd medicalxpress.com/news/2023-03-c…
Congratulations Dr. Ysasi!!!! Another phenomenal defense from @DrGJMurphy Lab
It turns out that the non-neutralizing antibody response to Epstein-Barr virus is vastly different from what we have seen for HIV and other pathogens: journals.plos.org/plospathogens/… #ITHF #EBV #SystemsSerology @ragoninstitute @ithf
It’s live! @OwenKLeddy brings to life what was just a dream idea a few years ago, combining bacterial genetics, mass spec, phagosome biology, and much more to help inform how we think about antigen presentation of Mtb peptides in human cells!
Proud and excited to share our paper on the different capacities for IgG subclass to prevent HIV transmission which is now online! science.org/doi/10.1126/sc… The overarching message is that broadly neutralizing antibodies can drive innate immunity to help prevent HIV transmission.
This amazing work represents Jacqueline Brady's PhD project. I'm so incredibly proud of her efforts! Also, many thanks to everyone in the lab that helped make this happen with a lot of hard work, as well as our excellent collaborators in the Ackerman lab at Dartmouth!
REACH is focused on HIV, but there are other benefits to bringing scientists together. The first collab between @AwesomeJonesLab and @PaulBieniasz: Inhibition of major histocompatibility complex-I antigen presentation by sarbecovirus ORF7a proteins biorxiv.org/content/10.110…
Having a blast at the NIH Martin Delaney REACH Collaboratory Annual Meeting. Learned many stimulating thoughts, synergies & collaboration ideas for HIV cure! See John Frater's talk here. Thanks to the excellent leadership & vision of Brad Jones & Marina Caskey. @REACHforthecure
For the MGH/Ragon Institute press release, please see here: ragoninstitute.org/latest-news/sa…
Vectored ImmunoProphylaxis (VIP) produces broadly neutralizing antibody (VRC07) in humans! I'm incredibly proud to have been able to participate in the development of VIP from the very beginning and am excited to see where this goes next! nature.com/articles/s4159…
Researchers used #HIV proviral landscape analysis in different T cell subsets. They found that expression of Nef (an HIV protein), both from intact and defective proviruses, promotes immune evasion from CD8+ T cell killing. bit.ly/3DS34qH #HIVcure
Transcriptionally active HIV-infected cells survive, proliferate & persist as the loud minority and the key barrier to cure. Check out @CellCellPress: EinKauf/Lichterfeld developed novel PRIPseq summarized in our Preview @JACollora bit.ly/3nK8kpd bit.ly/3Ap9fR9
We are looking to recruit new techs to join the lab and help us engineer immunity against SARS-CoV-2 and HIV infection! If you are passionate about virology and immunology and want to be part of creating the next-generation of interventions please apply! partners.taleo.net/careersection/…
Check out our latest work published today as cover story in @ScienceMagazine! High-speed image-enabled cell sorting (ICS) isolates cells with complex spatial phenotypes, led by @LarsMSteinmetz, @CuylenLab & @BDBiosciences science.org/doi/10.1126/sc… 1/9
"Individuals who received three doses of mRNA vaccine had very significant neutralization against the Omicron variant.” @BalazsLab @wilfredo_nk @CellCellPress news.harvard.edu/gazette/story/…
So is this the future? The next variant may still surprise us. Based on a case we characterized of extensive SARS-CoV-2 evolution in one individual who could not clear the virus because of HIV advanced disease immune suppression, just published: sciencedirect.com/science/articl…
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