André Mansinho @Andr3_M
Oncology Clinical Director @ START Lisbon Portugal Joined September 2009-
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Following376
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How can combos work with ADCs? Great talk by @DrTFriedlander at @ASCO #GU25 @yekeduz_emre @BradMcG04 @DrChoueiri @DanaFarber_GU @DanaFarber
Safety and clinical activity of BMS-986365 (CC-94676), a dual androgen receptor ligand-directed degrader and antagonist, in heavily pretreated patients with metastatic castration-resistant prostate cancer sciencedirect.com/science/articl…
We’re thrilled to announce that Dr. Chris Takimoto has joined START as our CMO! With 250+ early-phase oncology trials led and a proven track record in drug development, Chris will be a key driver in advancing our mission. Welcome, Chris! startresearch.com/the-start-cent…
Nectin-4 is the target for Enfortumab Vedotin and is widely expressed in UC (median 275/300) . EV302 is 1st randomised trial to explore its relationship with response. IHC results show no clear relationship between Nectin-4 and outcome (RR,PFS,OS) or PD-L1 #ESMO2024
🚨 Exciting Update! 🚨 Our new EVITA (EV Ineligible criTeriA) criteria for identifying patients ineligible for the EV/Pembro combo in #metastaticurothelialcarcinoma has just been published in @EUplatinum!!!! This breakthrough could significantly reshape daily clinical practice!…
Interesting work of @sogug1 led by S. Vázquez and O. Fernández. Efficacy of atezolizumab + radiotherapy in muscle-invasive bladder cancer. 100% pathologic complete response and favorable safety profile. #atezobladderpreserve #asco24
🔥 📰 Hot of the press: sharing our work on HRR testing for prostate cancer using US database. Most mCRPC still don't get HRR testing. +pts being tested earlier. Race, age, insurance, low socioecon st, outside academia⏩ low testing @neerajaiims @montypal @DrRanaMcKay @CParkMD
Biomarker data from adjuvant ipi/nivo vs placebo study in renal cancer shows circulating Kidney injury marker-1(KIM-1), which is over expressed & prognostic in RCC #AACR24, maybe important (along with PD-L1) in response to ipi/nivo. Patient selection for adjuvant IO is important
Fantastic meeting at Canary Islands (III Edition Trending Topics in GU Cancers) organized by @g_develasco @Uro_Oncologist Great discussions, interactions and fantastic atmosphere! Congrasts!! @Uromigos
Modified of @Uromigos are the combos the future of non clear cell RCC? @g_develasco @Uro_Oncologist
Modified of @Uromigos are the combos the future of non clear cell RCC? @g_develasco @Uro_Oncologist https://t.co/0Ly0rNaq2A
Comments on my personal top 5 #GI24 abstracts (2/4): 2. CHECKMATE 8HW Ipi + Nivo versus Chemotherapy as 1L treatment of MSI-H/dMMR colorectal cancer: ⬆️PFS (5.9 mo vs NR, HR 0.21) AMAZING PFS graphic @OncoAlert 1/
Late 2023 drop of CYPIDES, a Ph I/II trial of a CYP11A1 inhibitor (ODM-208) that blocks steroid synthesis & is very active in AR mutant #prostatecancer - 53% PSA RR in ARPI-Rx pts. Major S/E: adrenal insufficiency Provides a strong platform for coming OMAHA trials @Merck
JUST IN (and finally...): Pembrolizumab hits OVERALL SURVIVAL in KYN-564 adjuvant study in Kidney Cancer!!! The time has finally come... via @BusinessWire @DanaFarber_GU @tompowles1 @OncoAlert @OncBrothers @OncLive @TargetedOnc @urotoday @Uromigos @ALLIANCE_org @eaonc @SWOG…
Enfortumab vedotin & Pembrolizumab improving PFS & OS by 55% & 53% respectively compared to platinum based chemo in 1st line UC (+avelumab in 30%). Chemo has not been beaten before (despite multiple efforts). RR and CR of 68% & 29% is hard to beat. DOR not reached (1/3)#ESMO2023
Un honor compartir mesa sobre #carcinomaurotelial avanzado / Uma honra compartilhar uma mesa sobre #carcinomaurotelial avançado Synergy2 @PedroASMadeira @Andr3_M OvidioFernandez @sogug1 @SociedadeSpo
Livestream sessions for #UromigosLive 2023: 1st line bladder cancer @DrRosenbergMSK @MattGalsky @shilpaonc, @tompowles1 and 1st line RCC with @brian_rini, Drs. Atkins and McDermott. UROMIGOS cup Semi-finals and Final. Livestream links to follow and on Uromigos.org!
Oligometastatic Bladder Cancer: Defining a Novel Entity buff.ly/3LW8C8y @Chrislabaki1 @eddy_saad @DrChoueiri @OncoBellmunt #bladdercancer

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Isabel Pereira @IsabelMORP
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cancercalc @cancer_calc
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Alfonso Gómez de Lia... @Uro_Oncologist
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Karine Martins da Tri... @karinemtrindad
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