Microsystem technologies for accelerating the discovery and translation of immunotherapies
nature.com/articles/s4157…rdcu.be/eGqYy
This new review describes how microsystems can address efficacy, toxicity, predictability and affordability challenges with immunotherapies
For readers interested in CAR-T cell therapies in cancer immunotherapy, this Review in the May issue discusses management of toxicities and reviews druggable targets and cellular engineering strategies to develop safer CAR-T cells nature.com/articles/s4157…rdcu.be/em0rW
Worked on this for a long time and happy to publish what is hopefully just the beginning stages of an interesting sub-field of brain metastasis research! Thank you to @SZhang_Lab, co-authors and labmates🤓🍀🤠
@NDBios@UTSWCancerBiotinyurl.com/yh6wb9wt
New findings from @MITBiology suggest that the control of RNA splicing, a process that is fundamental to gene expression, is more complex than previously known buff.ly/w9RQOfx
In a follow-up of a phase 1 trial of a first generation CAR-T cell therapy in patients with neuroblastoma, 1 patient has had a sustained clinical response for over 18 years without requiring any additional therapy @MDKevinCHLi, @CAGTHouston@bcmhoustonnature.com/articles/s4159…
In a first-in-human phase 1 trial, HER2-specific CAR-macrophages were feasible to manufacture and well tolerated with no dose-limiting toxicities in patients with HER2-overexpressing solid tumors
nature.com/articles/s4159…
Findings from @MITBiology suggest that the control of RNA splicing, a process that is fundamental to gene expression, is more complex than previously known news.mit.edu/2025/mit-biolo…
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