Circular Vision @CircVisionH2020
Circular Vision is a European H2020 project. Our goal is to explore the new opportunities circular DNA creates in early diagnosis and monitoring of disease. circularvision.org Joined March 2023-
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Want to examine circular DNA from circular DNA enrichment or whole genome long-read sequencing? Check out the article on the bioinformatic tool, CReSIL, academic.oup.com/bib/article/23… #eccDNA #H2020
Today we read an article by BHRI from Spain, called "Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter" to be published soon. Stay tuned and check out our research at circularvision.org/published-by-c… #Biomarker #eccDNA #H2020
Proteins that activate other proteins, (called proprotein convertases), may be a treatment target for colon cancer. Preventing them from working, decreases colon cancer stem cell growth and survival. Check it out at, mdpi.com/2072-6694/14/5… #ColonCancer #H2020
Pigs are well studied in biomedical research, but little is known of the variation between individual cells of which genes are active or not. Check out the single cell transcriptome atlas of 20 different kinds of tissues, nature.com/articles/s4146… #H2020
How does #epigenetics, the alteration of which genes are active or not, contribute to the development of malignant melanoma? What about diagnosis and treatment? Check out the article at, mdpi.com/1422-0067/23/3… #Research #Cancer #H2020
In the CIRCULAR VISION project, we have explored the biology of circular DNA, and how we can potentially exploit it, creating essential methods and tools for circular DNA research. Check it out at, circularvision.org/published-by-c… #eccDNA #H2020
How does circular extrachromosomal DNA (ecDNA) contribute to higher activity of cancer genes? Check out the @Nature article we read today at, nature.com/articles/s4158… #CancerResearch #ecDNA
#DidYouKnow that when mitotic cells divide successfully, the chromosomes are split evenly, but for circular DNA, more may end up in one cell, affecting the cell evolution and function? sciencedirect.com/science/articl… #eccDNA #H2020
We had our 7th and final consortium meeting in Rome, Italy on 29/2-1/3, 2024. Many thanks to Lorenza Putignani from Ospedale Pediatrico Bambino Gesù for hosting, and thank you to all consortium members for a great project. See the gallery! circularvision.org/rome #H2020
#Immune cells and #tumor cells compete for food in the tumor #microenvironment, and tumor cells can alter their metabolism to their advantage. Check out the review on the genome scale modeling studying this, mdpi.com/2072-6694/13/1… #H2020
The CIRCULAR VISION project has created circular DNA technologies for visualization, purification, sequencing and analysis. Check out our research at, circularvision.org/published-by-c… #Research #Technology #eccDNA #H2020
How does extrachromosomal DNA (ecDNA) drive cancer and how can we treat cancers driven by ecDNA? Check out the preprint we read today at, ncbi.nlm.nih.gov/pmc/articles/P… #Cancer #ecDNA
How can fundamental research be commercialized to benefit patients? Listen to Prof. Birgitte Regenberg @regenberg_lab interview Prof. Paul Mischel @mischellab, part 3/3. Check out the podcast at, circularvision.org/podcasts #CancerResearch #eccDNA #ecDNA #H2020
The majority of circular DNA is also mitochondrial DNA (mtDNA). To look at the circular DNA that carry biomarkers and affect cancer development, CRISPR-Cas9 can be used to cut mtDNA. Check out the article at, ncbi.nlm.nih.gov/pmc/articles/P… #eccDNA #H2020
New methods of screening for prostate cancer are desperately needed, as current methods lead to overdiagnosis and long term adverse effects. Epigenetic markers may be the answer, mdpi.com/1422-0067/24/1… #ProstateCancer #Screening #Epigenetics #H2020
Why can cancers quickly develop resistance to treatments? Listen to Prof. Birgitte Regenberg @regenberg_lab interview Prof. Paul Mischel @mischellab, part 2/3. Check out the podcast at, circularvision.org/podcasts #CancerResearch #eccDNA #ecDNA #H2020
How is cell free DNA and circular DNA connected to Inflammatory Bowel Disease and how can it be used for personalized medicine? Check out the review at, ncbi.nlm.nih.gov/pmc/articles/P… #IBD #eccDNA #cfDNA #H2020
Today we read an article about how our DNA, when shattered, can be reassembled incorrectly and lead to changes in size and structure found in most human cancers. Check it out at, nature.com/articles/s4158… and see more on our website. #Research #eccDNA
Why is circular DNA central to cancer research? Listen to Prof. Birgitte Regenberg @regenberg_lab interview Prof. Paul Mischel @mischellab, part 1/3. Check out the podcast at, circularvision.org/podcasts #CancerResearch #eccDNA #ecDNA #H2020
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