Paul Young @DogICUma
ICU doctor, clinical researcher, kite-surfer, bad wing foiler #FOAMed #TEAMtrial #MegaROX @CritCareUnimelb wellingtonicu.com Wellington, NZ Joined May 2013-
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This is the 350th publication from our ICU. Details on this and all other studies we have been involved with can always be found on our Publications website here: wellingtonicu.com/PubResPres/Pub…
the Japanese team reached a milestone of 500 participants @MegaROXtrial (now 501)🇯🇵 - thank you, patients, families, and the whole ICU staff at Wakayama Med, Yokohama City uni, Nagoya uni, Fukuyama hosp, and @Jikei_ICU 💐
the Japanese team reached a milestone of 500 participants @MegaROXtrial (now 501)🇯🇵 - thank you, patients, families, and the whole ICU staff at Wakayama Med, Yokohama City uni, Nagoya uni, Fukuyama hosp, and @Jikei_ICU 💐
Having reviewed a few of these (and without giving too much away), I can say there are practice-changing results here. Worldwide practice in critical care will be changed by what is presented at #CCR24
Having reviewed a few of these (and without giving too much away), I can say there are practice-changing results here. Worldwide practice in critical care will be changed by what is presented at #CCR24
The 23000th patient was enrolled into the @MegaROXtrial at Dunedin Hospital at 350am this morning NZ time. The next interim analysis occurs when we get to 24000 (which will likely be in the next 30 days)
The @MegaROXtrial will reach 23000 recruited patients in the next 24 hours.
Daniel Kahneman, who changed psychology and economics forever, dies at 90. Thanks for everything. We remember him in 10 great quotes:
Effect of automated titration of oxygen on time spent in a prescribed SpO2 target range sciencedirect.com/science/articl…
This is actually the bottom line. The risk of adverse events is MUCH higher in the intervention group.
This is actually the bottom line. The risk of adverse events is MUCH higher in the intervention group.
Individualized Treatment Effects of O2 Targets in Mechanically Ventilated Critically Ill Adults just presented by @kevingbuell at #ISICEM24 and published in @JAMA_current ➡️ O2 targets that are individualized using machine-learning analyses of RCTs may reduce mortality for…
New paper. A glimpse at future of medicine (I reckon) Individualized Treatment Effects of Oxygen Targets in Critically Ill Adults jamanetwork.com/journals/jama/…
Nice editorial from Derek Angus to accompany our new paper. Gives a shout out to the @MegaROXtrial and the @UKRoxTrial too. Personalized Oxygen Supplementation jamanetwork.com/journals/jama/…
We have 4 new positions for doctors interested in obtaining critical care experience: a 12 month rotation through 3 specialties - 6 months in ICU, 3 months in ED & 3 months in Anaesthesia. All are in Wellington Regional Hospital. Details here: capitalhealth.careercentre.net.nz/Job/Critical-C…
Second is a paper in the CJA: Public perception of participation in low-risk clinical trials in critical care using waived consent: a Canadian national survey link.springer.com/article/10.100…
We have 2 new publications this week. First is a letter to the NEJM: Inhaled Amikacin to Prevent Ventilator-Associated Pneumonia nejm.org/doi/10.1056/NE…
It happened. Just before midnight last night NZ time, patient 22000 was enrolled into the @MegaROXtrial at Nepal Mediciti Hospital. In the 7 hours since then, another 18 patients have been enrolled. Incredible effort from a great global team.
The @MegaROXtrial now has 21960 patients recruited. Patient 22000 should be recruited just in time for this week's @anzicsctg meeting in Noosa
𝙟𝙤𝙨𝙝 𝙛.. @PulmCrit
62K Followers 548 Following zentensivist 😷 FOAMite 🌊 diuresis jedi 💦 leader of the rebel alliance ⚔️ resuscitationist 💉 humanist 😢 writer with aweful speling 😬 no COI 💰Cliff Reid @cliffreid
42K Followers 3K Following EM/ICM/PHEM doc. LOVE learning + teaching. I work in the sky above Sydney, have the attention span of a bullet, + often have days that are like cartoons #FOAMedSegun Olusanya (He/Hi.. @iceman_ex
19K Followers 3K Following Husband to @monanniecakes| Intensivist @nhsbartshealth| Ultrascoundrel |#FOAMed|@thosewecarry|@ics_updates|@wicsbottomline|@esicm|@tea_empathynhs| 🇳🇬Alex Psirides @psirides
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55K Followers 916 Following The leading critical care evidence dissemination platform. Website, newsletter, blog, book, podcast, livestream & meeting. #CCR24 June 12-14Critical Concepts @critconcepts
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3 Followers 154 Following Zac 26 yo. Anesthesia & intensive medicine resident doctor 💉cliffication @cliffified
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2 Followers 360 FollowingSimona Trenchevska @TrenchSimona
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11 Followers 148 Following𝙟𝙤𝙨𝙝 𝙛.. @PulmCrit
62K Followers 548 Following zentensivist 😷 FOAMite 🌊 diuresis jedi 💦 leader of the rebel alliance ⚔️ resuscitationist 💉 humanist 😢 writer with aweful speling 😬 no COI 💰Intensive Care Medici.. @yourICM
71K Followers 156 Following International peer-reviewed medical journal for all involved in Intensive Care #FOAMed #FOAMcc 🖋 Write https://t.co/j4p0oZF5XA 📨 Submit https://t.co/BJMsQ4rNz3Cliff Reid @cliffreid
42K Followers 3K Following EM/ICM/PHEM doc. LOVE learning + teaching. I work in the sky above Sydney, have the attention span of a bullet, + often have days that are like cartoons #FOAMedAlex Psirides @psirides
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12K Followers 1K Following Consultant ICM/Anaes @KingsCritCare PhD candidate @KCLDocStudies @KingsCollegeLon Editor @WICSBottomLine Views my own.Anders Perner @AndersPerner
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55K Followers 750 Following Critical Care is an international open access journal that publishes articles in all areas of intensive care and emergency medicine.Tommaso Scquizzato, M.. @tscquizzato
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2K Followers 515 Following Intensivist at The Alfred Hospital, Chair ANZICS Centre for Outcome & Resource Evaluation,robyn whittaker @rawegd
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22K Followers 826 Following Intensivist Anesthesiologist Past President European Society of Intensive Care Medicine ESICM Leadership Data Science 🇮🇹 🇬🇧 🇪🇺 my own personal tweetsMega-ROX @MegaROXtrial
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3K Followers 53 Following SCI indexed, Impact Factor 5.5, International peer-reviewed research in #Anesthesia #CriticalCare #ICU #Pain #PeriOpMedRashan Haniffa @rhaniffa
621 Followers 555 Following ICU and anaes Dr, researcher, improver. @EdinUni_CIR @uclh KDUHospital Sri Lanka, @MORUBKKColin @barco030
1K Followers 839 Following 💉💉💉💉 Cotton wool hater. Onychophagist. Can be a bit sweary. Here for the lolz. Ko tākuta ahau. He mōwai māku. He/him.ANZICS Clinical Trial.. @anzicsctg
1K Followers 83 Following Improving outcomes of intensive care patients and their families by fostering an exceptional, collaborative research community.Robert Arntfield @arntfield
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3K Followers 142 Following The Health Research Council of New Zealand (HRC): Supporting excellent research to improve the health and wellbeing of all New Zealanders.Wellington ICU @WellingtonICU
3K Followers 41 Following We are the 24-bed tertiary Intensive Care Unit in Wellington. We provide critical care to over a million people in the middle of New Zealand.This is the 350th publication from our ICU. Details on this and all other studies we have been involved with can always be found on our Publications website here: wellingtonicu.com/PubResPres/Pub…
the Japanese team reached a milestone of 500 participants @MegaROXtrial (now 501)🇯🇵 - thank you, patients, families, and the whole ICU staff at Wakayama Med, Yokohama City uni, Nagoya uni, Fukuyama hosp, and @Jikei_ICU 💐
The 23000th patient was enrolled into the @MegaROXtrial at Dunedin Hospital at 350am this morning NZ time. The next interim analysis occurs when we get to 24000 (which will likely be in the next 30 days)
@AbbateAntonio everything started with @maxdulac 8y ago stating ‘a conservative protocol for oxygen therapy vs conventional therapy resulted in lower ICU mortality’ pubmed.ncbi.nlm.nih.gov/27706466/ but final answer will be given by @DogICUma #megaroxtrial of 40,000 patient (23,000 already enrolled)
@DogICUma @Michelle_ICU We will be able to answer some important questions about adverse events during mobilisation in @TEAMtrialICU in our next publication. There are likely patients at higher risk than others.
@DogICUma This is 100% true and we need better reporting across all trials to report per patient events. Our next paper from @TEAMtrialICU on heterogeneity of treatment effect from the MEGA Study will help identify patients who EM may benefit versus harm. Stay tuned!
Individualized Treatment Effects of O2 Targets in Mechanically Ventilated Critically Ill Adults just presented by @kevingbuell at #ISICEM24 and published in @JAMA_current ➡️ O2 targets that are individualized using machine-learning analyses of RCTs may reduce mortality for…
@DogICUma I share many points here. Nice reading
@DogICUma Really well written Paul. Food for thought.
Recombinant alkaline phosphatase in sepsis-associated #AKI in #ICU, REVIVAL trial 💉no improved survival 🫘may reduce major adverse kidney events 🔓rdcu.be/dvT09 With editorial: intervention target & end points potential reasons for “failure”? 🔓rdcu.be/dvTxk
Wowser Extraordinary work from the central & global teams
Welcome to 2024. The @MegaROXtrial starts the year with 19823 participants recruited from 🇧🇷 🇨🇦 🇮🇹 🇲🇾 🇳🇵 🇮🇳 🇵🇰 🇯🇵🇰🇼🇴🇲 🇦🇺🇳🇿🇮🇪
Are you looking for interesting manuscripts for your Journal Clubs in critically ill patients? Here are 14 ideas: ➡️All RCTs ➡️All published in 2023, ➡️all @NEJM Half of them with stat significant differences in primary endpoint (or mortality) In order of importance 1/15
@DogICUma I would come with you on my paddleboard to see the dolphins any day!
We have a new publication in JAMA Neurology: Hypothermia vs Normothermia in Patients With Cardiac Arrest and Nonshockable Rhythm - a Meta-Analysis jamanetwork.com/journals/jaman…
@DogICUma Ah yes I remember that stage of having teenagers. It does pass, meanwhile keep doing the things you enjoy.
VASOPRESSIN! A short thread on this medication & its various uses... with a homemade infographic summarizing its pharmacokinetics, indications & adverse effects! #FOAMed @MSharifpourMD @drjohnm @aroradrn @srrezaie @EMSwami @CriticalCareNow @GoodishIntent @Wilkinsonjonny @msiuba
SO close to 50% recruited! @chodgsonANZICRC @anzicsctg
We have reached a major milestone in the @MegaROXtrial Patient number 19000 was just enrolled at Gosford Hospital in Australia! Woo hoo
Why can’t the govt debate the facts of the matter when it comes to #smokefree?
During the interview with Minister Chris Bishop, we challenged the assertion made by him and PM Chris Luxon that under the previous govt's plans Northland would have only one tobacco retailer. In fact, the maximum allowed number would have been 35 health.govt.nz/publication/ma…
"What about patients that receive a large amount of fluids?" has been a frequent question after large trials on balanced solutions versus saline for critically ill. Bear with me (+)
Fluids in #ICU? Analysis of BaSICS trial 🫧 pt characteristics explain less of use variance vs enrolling site 🫧volume & effects of BS mostly interact in #sepsis: benefit of BS in pts receiving more fluid or enrolled in sites using higher volumes found 🖇️bit.ly/46NOygx
@DogICUma Thanks Paul. Hopefully this will provide some useful insight.
@DogICUma Never has a more accurate statement been posted on this medium :-)