Dylan Noone @DylanNoone3
biochemist - structural biologist - not no one Imperial College, London, UK Joined February 2022-
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Exciting news! We will soon have a 3-year postdoc position open to work on structure-guided design of proteins and peptides to modulate the human immune system. Drop me a message if you’re interested in this project! #postdoc #cryoEM #immunology #hiring
I’m excited to reveal our latest work – the first structure of a pentraxin activating the human immune system! We used cryoEM to image ligand-bound C-reactive protein interacting with the human complement C1 complex. biorxiv.org/content/10.110… #cryoEM #complement #CRP
Finally was able successfully defend my thesis in Leiden! Now officially a docotor. Thanks to @ThomSharp for a fun and productive time. Hopefully our paths will cross again in the future! #LUMC #Leiden #PhD #Complement #Science
Very proud of Dylan Noone’s (@DylanNoone3) paper describing the first structure of a long pentraxin, PTX3, using cryoEM and AlphaFold structure prediction. pnas.org/doi/10.1073/pn… TL;DR - PTX3 scaffolds activating and inhibiting immune system components. 🧵
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Thom Sharp @ThomSharp
703 Followers 153 Following Interfacial scientist working on combining synthetic and structural biology to understand and control the human immune system, guitar/bass player, beer drinker.
Leoni Abendstein @AbendsteinLeoni
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Bristol Biochemistry @BristolBiochem
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EMBL-EBI @emblebi
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Microbiome News @microbiome_news
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466 Followers 547 Following Collaborative UK network seeking to bring together the research & educational aspirations of complement-orientated groups & industry partners throughout the UK
Complement Society @ComplementSoc
486 Followers 238 Following ICS promotes advances of complement R&D through cooperative educational programs, clinical applications, and professional standards in the complement field.
Complement Therapeuti.. @ComplementTx
186 Followers 3 Following Developing the next generation of complement medicines
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Barral Lab @BarralLab
1K Followers 961 Following Immunology group at @TheCrick and @KingsCollegeLon studying unconventional T cells and mechanisms of immune responses to lipids. Run by the lab members.
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200 Followers 109 Following Helmut Ecker Endowed Professor of AMD & Co-Founder - Complement Therapeutics. A British Biochemist in Europe 🇬🇧 🇪🇺 @[email protected]
Monica Olcina @olcina_mm
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Misha Kudryashev 🔬.. @MishaKudryashev
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caroline stefani @cstefani06
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James S Depelteau @Jamiesd
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Dan Watkins @DanielWWatkins
248 Followers 902 Following 🧫 Biochemist🧑🔬 @cytoseek @sciencecreates 🧪 Engineering artificial membrane binding proteins for cancer cell therapy 🧬
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Alvira @alvipur
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Premier League @premierleague
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Ian Collinson @IanofBristol
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ChimeraX @UCSFChimeraX
7K Followers 15 Following UCSF ChimeraX - software for visualizing biomoleculesExciting news! We will soon have a 3-year postdoc position open to work on structure-guided design of proteins and peptides to modulate the human immune system. Drop me a message if you’re interested in this project! #postdoc #cryoEM #immunology #hiring
The Doryen lab are running the Pretty Muddy CRUK Race for Life - do support them if you can! Good luck to the team!! @BubeckLab fundraise.cancerresearchuk.org/team/doryens-t…
Our lab is running the @CR_UK @raceforlife to raise funds and awareness for #breastcancer. 1 in 2 people will get cancer in their lifetime. Thanks to life-saving research I am here to tell my story. Sponsor us through this link. @ImperialSci @CRUKEventsLDN fundraise.cancerresearchuk.org/team/doryens-t…
Your Premier League table after another dramatic weekend 😮💨
More beautiful work from my PhD student @mart_last - this time he's written software to segment cryoET volumes, which will massively improve our throughput for subtomogram averaging! #cryoEM @cryoEM_Papers biorxiv.org/content/10.110…
Our preprint about Ais: streamlining segmentation & particle picking in cryoET datasets is now online! 😊 biorxiv.org/content/10.110… The software is free and lightweight, and tutorials are available via: ais-cryoet.readthedocs.io/en/latest/
A fantastic swan song from @DylanNoone3 as he leaves my lab and starts afresh as a postdoc in London. @BristolBiochem @GW4CryoEM @cryoEM_Papers @LUMC_Leiden
@DylanNoone3 @ThomSharp Congratulations, Dylan!
I’m excited to reveal our latest work – the first structure of a pentraxin activating the human immune system! We used cryoEM to image ligand-bound C-reactive protein interacting with the human complement C1 complex. biorxiv.org/content/10.110… #cryoEM #complement #CRP
Massive congratulations Dylan! A really solid, and entertaining, defence. It was a pleasure having you in my group - I'm sure you'll excel as a postdoc
Finally was able successfully defend my thesis in Leiden! Now officially a docotor. Thanks to @ThomSharp for a fun and productive time. Hopefully our paths will cross again in the future! #LUMC #Leiden #PhD #Complement #Science
Big congratulations @DylanNoone3, now officially a postdoc in the lab!
Massive congratulations Dylan! A really solid, and entertaining, defence. It was a pleasure having you in my group - I'm sure you'll excel as a postdoc
Congratulations @g_bigotti and Andrea Brancaccio @BristolBiochem , and all the other authors. Very pleased to have been involved in a @BristolUni led international and multidisciplinary study concerning the exploitation of innate viral immunity. doi.org/10.1016/j.anti…
We've written a Python module for GPU-accelerated drift correction, called pyGPUreg: github.com/bionanopattern… With this module we can correct the high drift of our cryoscope at a rate of ~125 images per second. Now available on pypi. We hope it is useful to others as well!
Super-resolution fluorescence imaging of cryosamples does not limit achievable resolution in cryoEM biorxiv.org/cgi/content/sh…
Brilliant talk today @BristolBiochem by @ThomSharp (featuring the inimitable @DylanNoone3 !) - beautiful demo of super high-res cryo-CLEM
We've gone stable with release 4.0 of the #RELION software. 🥳🥳🥳 Download it for free from github.com/3dem/relion. #OpenSoftwareAcceleratesScience
Thanks too to @mart_last for working his Blender magic on this image! It shows the bendy PTX3 molecules, with some bound to potential receptors.
To verify this topology, we used class averaging of flexible regions using EMAN2 (thanks @sludtke!)
To understand their structures, we used AlphaFold to predict the rest of the protein #alphafold. AlphaFold struggled on its own, so we seeded it with known tetrameric coiled coils. Bingo! AlphaFold predicted extended coiled coils with proline rich hinge regions.
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