ExplantLab @ExplantLab

An independent research organisation exploring the links between patient genetics & the design, manufacture & performance of medical devices scholar.google.co.uk/citations?user… Joined January 2020

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ExplantLab @ExplantLab

a year ago

We will present latest results of NHS study on genetics+metal ion levels in painful knees @ personalized arthroplasty meeting next month, Chicago. We have 4 UK sites and 2 international actively recruiting, study in set up at 4 others. @markbowditch65 would yr unit be interested?

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ExplantLab @ExplantLab

a year ago

Some nice early results from our Arthrogenex study. Titanium concentrations in patients with nexgen LPS TKRs attending review clinics at 4 to 10 year follow up. Correlation coefficient-0.7, p=0.002 Funding in place for 1750 patients, outcome scores, blood metal ions and genetics.

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Jonathan Pie @JonathanPieNews

a year ago

Bloody immigrants, coming over here, stopping our kids from being stabbed…

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ExplantLab @ExplantLab

a year ago

This will be a really interesting event. @lathamhips will be talking too. Some of the talks will be dynamite. Surgeon, patient, engineering, legal aspects all to be discussed, everyone welcome. And Newcastle is a great place to visit.

British Hip Society @BritishHip

a year ago

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ExplantLab @ExplantLab

a year ago

Our @innovateuk funded @NHS study is showing some important results for patients with #jointreplacements. The “Arthrogenex”study examines #arthroplasty #genetics and explants. It is clear that metal release in TKRs is important. Get in touch if you would like to take part.

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ExplantLab @ExplantLab

a year ago

Nasty looking explanted RP tray revised for pain, tibial bone loss.

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ExplantLab @ExplantLab

a year ago

ncbi.nlm.nih.gov/pmc/articles/P… Another study, another group showing ALVAL rates around 30% in failed #tkrs ALVAL is clearly a major contributor to unexplained pain. When is the orthopaedic community going to start discussing this properly? @EdinburghKnee @KneeUnit @PeltMD @DrLeeRubin

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ExplantLab @ExplantLab

2 years ago

#Unicompartmental knee analysis looking good now. Key findings so far: 1. Volumetric poly wear of explanted unis is 1.5 > than in total #kneearthroplasty (why?!) 2. Backside surfaces show wear (red), rather than the deformation we tend to see with contemporary #TKR

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ExplantLab @ExplantLab

2 years ago

Unexplained pain post #arthroplasty Could it be due to adverse reaction to metal debris? This is determined by metal exposure and genetics. New test available on NHS combines ICPMS metal levels + genotyping. @TweetsOrtho @OrthoTwiter hospital.blood.co.uk/diagnostic-ser…

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ExplantLab @ExplantLab

2 years ago

We’ve just had an #arthroplasty paper put online in @TheKneeJournal, official journal of @baskonline “Aseptic Loosening of the Option Stemmed Tibial Tray in the Zimmer NexGen LPS Total Knee Arthroplasty System.” Below is link for temporary free access authors.elsevier.com/c/1iMP83S6VBC1…

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ExplantLab @ExplantLab

2 years ago

Great example of material loss from tibial tray. The poly insert has even managed to imprint its catalogue number.... Just to emphasise - this is not material/device specific. Do consider ARMD in #totalkneereplacements #arthroplasty with unexplained pain explantlab.com/orthotype-test