Filippo Montemurro @FilippoMontemu1
Senior Medical Director, F. Hoffmann La Roche Basel, Switzerland Joined November 2018-
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Important update of the ABC trials. With 6.9y of follow up, adjuvant AC-T had a small RFI benefit over TC, restricted to triple-negative tumors. No OS benefit by adding anthracyclines, but a major increase in leukemias (7 vs 1) & non-BC deaths (62 vs 34). ascopubs.org/doi/10.1200/JC…
The quantification of ctDNA is being studied for several indications, including monitoring of disease progression. In this preliminary report (n=19), ctDNA appeared useful and complementary to Ca15.3 to track MBC progression. Follow @ESMO_Open for more! esmoopen.com/article/S2059-…
The quantification of ctDNA is being studied for several indications, including monitoring of disease progression. In this preliminary report (n=19), ctDNA appeared useful and complementary to Ca15.3 to track MBC progression. Follow @ESMO_Open for more! esmoopen.com/article/S2059-… https://t.co/tTFPPPq4tX
It’s great to see colleagues advocating for longer and better lives for patients with cancer, which is totally aligned with our philosophy. Great to see @TheLancet make it their cover. This should be printed and pasted on the walls of all cancer centers!
Molecular profiling of longitudinal plasma samples characterizes mechanisms of resistance to PARPi in MBC with BRCA1, BRCA2 or PALB2 mutations: 🔹BRCA1/2 reversion mutations were most prevalent 🔹LOF mutations in TP53BP1, RIF1 or PAXIP1 less frequent annalsofoncology.org/article/S0923-… #bcsm
Oncologists have been pursuing NACT as a platform to increase the cure rate in EBC for decades. CREATE-X succeeded, and the rest is history...National trends in neoadjuvant chemotherapy utilization in patients with early-stage node-negative triple- pubmed.ncbi.nlm.nih.gov/37864105/
A "must read" for the practicing medical oncologist, once again stressing the importance of adequate follow-up procedures in prem. BC patients on OFS Selection of appropriate biomarkers to monitor effectiveness of ovarian function suppression'.. pubmed.ncbi.nlm.nih.gov/38242892/
Biomarkers of anti CD19 CART cell efficacy: CD19 , naive T cells : + , glycolytic activity, immunosuppressive microenvironment : -
Biomarkers of anti CD19 CART cell efficacy: CD19 , naive T cells : + , glycolytic activity, immunosuppressive microenvironment : - https://t.co/XzxbDeEoyw
This yearly installment is always much awaited!
Optimising first-line subtyping-based therapy in triple-negative breast cancer (FUTURE-SUPER): a multi-cohort, rand… pubmed.ncbi.nlm.nih.gov/38211606/ Very nice, subtype adapted, clinical trial with intriguing results
One of those "must read papers" The future of the global clinical trial ecosystem: a vision from the first WHO Global Clinical Trials Forum - The Lancet thelancet.com/journals/lance…
Outstanding and innovative work of @StefiMorganti @JCO_ASCO @ASCO @LaStatale @IEOufficiale Prevalence, Dynamics, and Prognostic Role of Clonal Hematopoiesis of Indeterminate Potential in Patients With Breast Cancer | Journal of Clinical Oncology ascopubs.org/doi/10.1200/JC…
A super @Raffa_Casolino flying high 🧨🧨🧨
A super @Raffa_Casolino flying high 🧨🧨🧨
New germline genetic testing guidelines: All women with breast cancer diagnosis under the age of 65 should be offered germline genetic testing. They don’t need to meet any additional criteria. Thank you @ASCO for the opportunity to draft these guidelines. ascopubs.org/doi/full/10.12…
Menarini and Insilico Medicine enter exclusive license agreement for the development of the KAT6 inhibitor ISM5043. Data presented at #SABCS23 showed antitumor activity with ISM5043 as monotherapy or combined with ET in ER+ BC xenograft mouse models. prnewswire.com/news-releases/…
Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials Local recurrence with neoadjuvant chemotherapy vs adjuvant, RR 1.37 (1.17-1.61)
Correlation of HER2 Protein Level with mRNA Level Quantified by RNAscope in Breast Cancer pubmed.ncbi.nlm.nih.gov/38135153/ Does messenger RNA convey...the right message across the range of HER2-protein expression?
@bozovicspa @drsarahsam @nlinmd Agree that T-DXd works best— yet @FilippoMontemu1 et al. have shown some pretty encouraging intracranial activity with T-DM1 as well, with nearly 50% IC-ORR among patients with HER2+ active brain mets in KAMILLA! annalsofoncology.org/article/S0923-…
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One of the most impactful aspects about ADCs is their remarkable intracranial activity, seen with T-DM1 & T-DXd. No data is however available with Trop2 ADCs. Happy to have worked with @drsarahsam & @nlinmd at the ph2 DATO-Base trial of Dato-DXd for brain mets, now open at DFCI!
One of the most impactful aspects about ADCs is their remarkable intracranial activity, seen with T-DM1 & T-DXd. No data is however available with Trop2 ADCs. Happy to have worked with @drsarahsam & @nlinmd at the ph2 DATO-Base trial of Dato-DXd for brain mets, now open at DFCI!
Paolo Tarantino @PTarantinoMD
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14K Followers 454 Following Associate Professor at @UniGenova & Medical Oncologist at @SanMartino_Ge. Chair of @myESMO YOC. #BreastCancer #Fertility. Big fan of @sampdoria & @giroditalia.Aleix Prat #Precision.. @prat_aleix
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546 Followers 1K Following MD, PhD. Radiation oncologist at Fudan University Shanghai Cancer Center, China. ESMO YOC, ASCO Editorial, IASLC ART #esophagus #lung #radiation T/RT = my ownTiffany Gowen @pfccdirector
862 Followers 4K Following Healthcare professional passionate in the "the power of partnerships" to improve and enhance #patient- and family-centered care. #PFCC #LungCancer #Healthequity@madeintheUSA @madeintheUSA0
191 Followers 2K FollowingSociety for Immunothe.. @sitcancer
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2 Followers 54 FollowingMalak Munir @MalakMunirMD
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2 Followers 1K Following Biotech I It wasn't brains that brought me here; I assure you that.BCnewswire @bc_newswire
63 Followers 232 Following Stay abreast of the latest research and news as we race for a breast cancer cure. Peer-reviewed and credible insights delivered in plain English.𝐂𝐡𝐚𝐧𝐝�.. @CParkMD
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26 Followers 46 FollowingTiziana Latiano @latiano_titty
22 Followers 111 FollowingJean Rivera Irizarry,.. @JeanKRivera
346 Followers 416 Following Senior Biotech Equity Research Associate, Bloomberg Intelligence → Views my own ≠ recommendations to buy/hold/sellPaolo Tarantino @PTarantinoMD
22K Followers 536 Following Medical Oncologist, Research Fellow @DanaFarber | @Harvard | PhD @LaStatale. SoMe Editor @ESMO_Open. Interested in breast oncology, HER2, ADCs & good music.Matteo Lambertini, MD.. @matteolambe
14K Followers 454 Following Associate Professor at @UniGenova & Medical Oncologist at @SanMartino_Ge. Chair of @myESMO YOC. #BreastCancer #Fertility. Big fan of @sampdoria & @giroditalia.Aleix Prat #Precision.. @prat_aleix
13K Followers 699 Following Head Oncology @hospitalclinic, CoFounder @RevealGenomics, TranslGenomics @IDIBAPS, Prof @UniBarcelona, Team @IOBoncologia, COI https://t.co/HZFOVJKZcdErika Hamilton, MD @ErikaHamilton9
15K Followers 3K Following Med Onc, Director of Breast Cancer Research Program @ Sarah Cannon Research Institute #bcsm #WomenInMedicine Wife, Mom to 2 girls, tweets are mine.Vivek Subbiah, MD @VivekSubbiah
34K Followers 2K Following Chief, Early-Phase Drug Development|@SarahCannonDocs #Oncologist, #Phase1trials, #PrecisionMedicine. Tweets=My own.Toni Choueiri, MD @DrChoueiri
36K Followers 480 Following Senior Executive & Chief GU Cancers @DanaFarber; Prof Medicine @HarvardMed; 2021 Giants of Cancer Award ⚽ lover; 🚲@PanMass, seen on @msnbc @cnn @TODAYshow @GMAMaurizio Scaltriti @ScaltritiLab
38K Followers 340 Following VP Translational Medicine, Early Oncology, AstraZeneca. Previous Associate Director of Translational Science at MSKCC. Co-founder of https://t.co/sf253Xny69.FabriceAndre @FAndreMD
14K Followers 518 Following Head of Research Division of @GustaveRoussy , @myesmo President ElectHope Rugo @hoperugo
9K Followers 545 FollowingSara Tolaney @stolaney1
10K Followers 621 Following Chief, Division of Breast Oncology @DanaFarber Tennis fan Mother of two teenage girlsStephanie Graff, MD, .. @DrSGraff
19K Followers 4K Following Director Breast Oncology, Lifespan Cancer Institute, Legorreta Cancer Center Brown Univ | Medical Advisor @drloveresearch | #bcsm #clinicaltrials | Views MineFrancesco Schettini, .. @FrancescoSche20
1K Followers 398 Following Medical Oncologist @hospitalclinic, Post-Doc Researcher @IDIBAPS, @EACRnews ambassador. #HRposbreastcancer #intrinsicsubtypes #biomarkerdevelopment #HER2low.ESMO - Eur. Oncology @myESMO
75K Followers 873 Following The European Society for Medical Oncology (ESMO) is a reference organisation for cancer education and information, supporting the oncology community’s work.Angela Toss @angela_toss
1K Followers 276 Following MD, PhD Oncologist from Modena (Italy) 🇮🇹 involved in Breast Cancer Care and BRCA-related Malignancies 🧬Dana-Farber’s Breas.. @DFCI_BreastOnc
4K Followers 334 Following Patient-centered care, clinical trials & translational research on breast cancer @DanaFarber and @HarvardMed. Appts: 877-442-3324, Clinical trials: 877-338-7425Icro Meattini @Icro_Meattini
2K Followers 425 Following Professor, Florence University, Italy. Radiation/Clinical Oncologist. Head, Breast Unit at Florence Univ Hospital. Father. Opinions are my own. RT not endorse.Evandro de Azambuja, .. @E_de_Azambuja
4K Followers 933 Following Evandro de Azambuja, Breast cancer specialist @JulesBordet. ESMO Director of Membership 2023-2024. BSMO President 2023-2026.Mark Lewis @marklewismd
88K Followers 39K Following Director, GI Oncology, @Intermountain. Interests: neuroendocrine tumors, cancer syndromes, empathy (even had a Whipple myself). Tweets my own.Elisa Agostinetto @ElisaAgostinett
3K Followers 2K Following MD, Medical Oncologist🇮🇹•Research Physician at @JulesBordet Institute in Brussels🇧🇪 Great interest in #BreastCancer and #ImmunoOncologyRebecca Shatsky, MD @Dr_RShatsky
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8 Followers 51 FollowingEllen Willcox @WillcoxEllen
220 Followers 1K Following Global Oncology Talent Scout, AstraZeneca Pharmaceuticalssenthil kumar @esenthil84
168 Followers 2K Followingsilke gillessen @Silke_Gillessen
2K Followers 1K Following Medical Oncologist, Oncology Institute of Southern Switzerland, views are minesaverio cinieri @saverio_cinieri
57 Followers 74 Followinggiovanna pecoraro @giovanna55701
55 Followers 138 Following 🧬🩺 Oncology resident focusing on GU cancersSam Fazeli @SamFazeli8
2K Followers 374 Following Director of Research, Global Industries, Bloomberg Intelligence. Views my own. Not recommending buy/hold/sell.Ana Go @GoAnaGo
44 Followers 125 Following Medical Oncologist. Breast & Gynae tumors at HRU-HVV Málaga 👩🏼⚕️👩🏼🏫🦀🥊Akash Maniam, MD 🇺.. @ManiamAkash
7K Followers 4K Following Ardent supporter of Ukraine & decolonisation. 🇹🇹 born, 🇬🇧 based. MD, MBA. Focus- Ukraine, Geopolitics,History, Disinfo. Speak 🇩🇪 🇺🇦Gabriella Pravettoni @GPravettoni
572 Followers 544 Following Head of the #PsychoOncology Division @IEOufficiale | Full Professor of Psychology of #DecisionMaking & Head of the Oncology and Hemato-oncology Dept. @LaStataleIlaria Colombo @Ilaria_Colombo_
282 Followers 289 Following Medical Oncologist, MD. Drug Development and Gyne Cancer. Oncology Institute of Southern Switzerland (IOSI)Carlos Garcia-Etienne @cgarciaetienne
117 Followers 174 Following Breast Surgical Oncology & Oncoplastic Surgery, Italy; MSKCC alumni, SSO committee member. Views are my ownCamila Bragança Xavi.. @CamilaBragancaX
1K Followers 1K Following MedicalOncologist & PhD student @hsiriolibanes • Young @SBOC_Oncologia • @ASCOTECAG @ASCO • @JIPOEditors • ICT Fellow @MDAndersonNews • Translational research🧬Dr. Cathy Eng @CathyEngMD
11K Followers 4K Following Co-Director/Co-Leader GI Oncology Research; Exec Direc Young Adult Cancers Program; Co-Chair, NCI GI Steering Committee; and Director for Strategic RelationsAndrea Boutros @boutrosand
740 Followers 748 Following Medical Doctor & Oncology Resident @SanMartino_Ge & @MelanomaAus #Melanoma & Skin Cancer, Immunotherapy | 🇮🇹🇪🇬🇦🇺🇫🇷Dr Sarah Sammons @drsarahsam
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95 Followers 884 Following Oncologist MD / médecin spécialiste en Oncologie médicaleBitcoinminetrix Team @bitcoinmineot
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1K Followers 457 Following Assistant professor & medical oncologist at the Ohio State University, immuno-oncology fan, trialist, Melanoma & cutaneous malignanciesRoger Velasco @rooogerthat
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9 Followers 38 FollowingAndrea D'Arienzo @an_darienzo
42 Followers 73 Following Medical Doctor. Oncology resident, Fed II Univ Naples.Nicola Normanno @NicolaNormanno
284 Followers 178 FollowingMirko Bellotti @MirkoBellotti8
23 Followers 106 Following Banking and finance student, soccer player, gamer, TVseries addict.Said Abdul Hamid Saad.. @DrAbdulHamid786
2K Followers 3K Following 6th Year Medical Studen/🩺❤. Education 📖 is the most powerful weapon you can use to change the world. Our hope is progressive and prosperous Afghanistan 🇦🇫Gavin Preston, M.D. @GavinPrestonMD
89K Followers 98K Following Author of the upcoming book: "The Managed Care Blues: A doctor's journey, a broken system, real solutions." Retired physician. Willing to be wrong. Trumpeter.Charles Swanton @CharlesSwanton
15K Followers 818 Following Francis Crick Institute and UCL Hospitals @CR_UK Cancer Evolution and Genome Instability Lung Oncologist Air Pollution and Drug Resistance Fair Weather 🚴Natalia Nunes @nccnunes
79 Followers 519 Following médica oncologista, interessada em câncer de mama e cuidados paliativos. Tenta fugir da realidade do Brasil com memes do Twitter e vídeos de gatinhosross bussa @rossibuss
615 Followers 2K Following ingegnere/contadino/lettore in ordine sparso... nuorese in trasferta💚💙... co-founder di @fattoria20 e di #lavocedellepiante 🌱🌿🌳#bionicarmgirl di default 🦾Fabiana Napolitano @md_napolitano
91 Followers 134 Following Oncology Specialist 🩺 Federico II Univ Naples MD, PhD student 🔬Filipa Lynce, MD, FAS.. @FilipaLynce
1K Followers 500 Following Breast Oncologist @ Dana-Farber Cancer Institute. Director, Dana Farber IBC Program. DFCI Center for BRCA and related genes. Alliance EO. Tweets are my own.Marco Ventin @MVentinMD
224 Followers 452 Following Incoming PGY-1 @DeptSurgeryCS | Postdoc @CedarsSinai @MGHSurgery Ferrone Lab | MD @uniud | Interested in HPB Surgery, Cancer Immunology & ImmunotherapyFotios Loupakis @fotiosloupakis
421 Followers 415 FollowingCristina @krikrisel
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131 Followers 202 Following Medical Oncology Fellow at ICESP- FMUSP - São Paulo, BrazilAmeish Govindarajan, .. @AGovindarajanMD
1K Followers 4K Following Current HPM Fellow @MSKCancerCenter I Former Postdoc @CityOffHope I Interested in the Intersection of Heme/Onc & HPM I Opinions are my own. I #SuppOncDimitrios Varvaras MD.. @MdVarvaras
507 Followers 961 Following Oncoplastic and Reconstructive Breast Surgeon Director Breast Center - Tiberia Hospital GVM Care & ResearchCarmine Valenza @ValenzaCarmine
549 Followers 729 Following Medical Oncology Fellow, European Institute of Oncology (@IEOufficiale), MilanWes Wilson @WesleyWilson
9K Followers 5K Following Tumour Immunologist & Pulmonary Oncology @PennMedicine , Bioinformation, Perpetual Hockey Player, #SciComm #cancer Editor @SciSeeker, Host @TumorTalkMario Mancino🇮🇹 @mmancino78
51 Followers 358 Following Papà, Ricercatore, Papà, Marito e Papà. La 🇮🇹 nel nome non ha alcun significato politico: un segno di nostalgia dopo tanti anni lontano dalla mia terra.Nonclinical safety and PK for 14 vedotin ADCs: - Tissue expression of the targeted antigen rarely correlated with dose-limiting toxicity - Consistency in highest tolerated doses - Consistency of nonclinical PK Must read preclinical 📄 @MCT_AACR!!! aacrjournals.org/mct/article/do…
⭐️My first time inside @GustaveRoussy in Paris France, 🇫🇷 ⭐️Such an honor to meet & get a tour of all the amazing facilities with the only & only @FAndreMD on the day of the major announcement that he was awarded the Giants of Cancer Award 👏🏼🎉@ASCO #ASCO24 @OncLive !…
This. Physicians are people too - we have families. We explain to our kids why we are on call and rounding on Easter (my most recent example), but also owe them a life and experiences outside of our clinic/hospital. Doesn't mean we are any less committed to our patients.
Yesterday, I asked social media for some tips on an upcoming family trip to Europe. In return, I received a very disappointing comment and had to respond. Please stop treating our healthcare professionals like this. 🎤⏬ #healthcare
Such a blast to catch up with my stellar mentor and dear friend @curijoey! Always impressed by the impact he’s had on the lives of patients and of dozens of #CuriglianoLab mentees, many of which are now pursuing brilliant careers in Italy, USA, France, Spain and beyond. #JSMO24
The Molecular Twin artificial-intelligence platform integrates multi-omic data to predict outcomes for pancreatic adenocarcinoma patients @NatureCancer nature.com/articles/s4301…
Important update of the ABC trials. With 6.9y of follow up, adjuvant AC-T had a small RFI benefit over TC, restricted to triple-negative tumors. No OS benefit by adding anthracyclines, but a major increase in leukemias (7 vs 1) & non-BC deaths (62 vs 34). ascopubs.org/doi/10.1200/JC…
📰 Cancer : la révolution des nouveaux traitements, notamment à @GustaveRoussy. Un article à découvrir dans @lobs 👉 nouvelobs.com/societe/202402…
The quantification of ctDNA is being studied for several indications, including monitoring of disease progression. In this preliminary report (n=19), ctDNA appeared useful and complementary to Ca15.3 to track MBC progression. Follow @ESMO_Open for more! esmoopen.com/article/S2059-…
What is the value of monitoring disease progression for metastatic breast cancer with ctDNA (vs Ca15.3)? In this new @ESMO_Open article, Martens et al found a complementary value for ctDNA and Ca15.3 monitoring, with high PPV to predict disease progression esmoopen.com/article/S2059-…
Nectin4 ampl predict response to enfortumab vedotin in mUC (ORR 96% ampl vs 32% not ampl). Common alteration, also found in breast & lung cancer. Very interesting when you think that HER2 ampl predicts the activity of HER2 ADCs and some data exists also for Trop2 ampl and SG.
NECTIN4 amplification predicts response to Enfortumab vedotin in mUC! It occurs frequently across solid tumors (app. 25% of mUC)➡️potential tumor-agnostic biomarker for NECTIN4-targeting therapies! Happy to share our poster K17 @ASCO #GU24! @Markuseckstein3 @OncoAlert @urotoday
The anti-nectin4 ADC enfortumab vedotin granted FDA accelerated approval for pretreated urothelial carcinoma The conjugate has shown impressive activity in pretreated UC both in monotherapy and IO combo @OncoAlert
It’s great to see colleagues advocating for longer and better lives for patients with cancer, which is totally aligned with our philosophy. Great to see @TheLancet make it their cover. This should be printed and pasted on the walls of all cancer centers!
Congratulations @prat_aleix ! So well deserved!!
Our CSO & co-founder, @prat_aleix received the National Research Award "Doctores Diz Pintado" His exceptional work, including our groundbreaking test #HER2DX, has earned him this prestigious honor. Read about his achievements! 👉🏻 ow.ly/aFFX50QuMxr #precisiononcology
I bet this will be the most cited article of 2024. Cancer statistics,2024! @drdonsdizon @AmericanCancer @ASCO @OncoAlert acsjournals.onlinelibrary.wiley.com/doi/epdf/10.33…
The largest #WGS study reveals myriad actionable alterations for 33 #cancer types, but logistical, technical and economic challenges must be overcome before this approach can be standard of care. News & Views from @MarkARubin1, Dilara Akhoundova @unibern nature.com/articles/s4159…
New📄Pregnancy After Breast Cancer in Young BRCA Carriers: An International Hospital-Based Cohort Study just published in @JAMA_current. @AnnPartridgeMD @matteolambe @ElisaAgostinett @dimeglio_anto @kevinpunie @angela_toss @MIgnatiadis @KathrynRuddyMD pubmed.ncbi.nlm.nih.gov/38059899/
Our study on pregnancy after #BreastCancer in young #BRCA carriers made it to the first @JAMA_current issue of 2024...what a great way to start the year! @OncoAlert @UniGenova @SanMartino_Ge @AnnPartridgeMD @BlondeauxEva #bcsm Link to the full article: jamanetwork.com/journals/jama/…
A super @Raffa_Casolino flying high 🧨🧨🧨
New! Although #GenomicTests can lead to better outcomes in #CancerCare by informing #CancerRisk, prognosis, and therapeutic selection, they remain underutilized in routine #CancerCare. Find practical guidance from authors at acsjournals.onlinelibrary.wiley.com/doi/full/10.33… @OncoAlert @MeliD32
New germline genetic testing guidelines: All women with breast cancer diagnosis under the age of 65 should be offered germline genetic testing. They don’t need to meet any additional criteria. Thank you @ASCO for the opportunity to draft these guidelines. ascopubs.org/doi/full/10.12…