Fran Aya @FranAya6
MD PhD Medical Oncologist - Melanoma and Skin Cancers @hospitalclinic / Alumnus & Postdoc @CRGenomica Barcelona, España Joined May 2019-
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Q: What could GO WRONG with a major cancer genomics study in which tumours are sequenced to only 15x depth? A: An awful LOT! 😟 Our detailed reanalysis now out in @RSocPublishing: tinyurl.com/RSOSrebuttal 🧵👇 (1/18)
🧬🧬El #melanoma "rompe" genes para resistir a la acción de los fármacos. 🔬La Dra. @nlbigas, del #IRBBarcelona, participa en este estudio liderado por @CRGenomica y publicado en @CellReports. Junto con @idibaps y @VHIR_🤝 📰@larazon_es ➡️shorturl.at/cnovY #IRBScience
☺️☺️ El melanoma ‘rompe’ genes para resistir a la acción de los fármacos agenciasinc.es/Noticias/El-me… via @agencia_sinc
Identifying and targeting these early resistance mechanisms through profound genetic testing in a clinical setting before treatment begins could improve the efficacy of first-line therapies.
Surprisingly, the researchers found evidence of the same genomic deletions in melanomas which hadn’t been treated yet. In other words, melanomas can naturally develop mechanisms that mimic drug resistance, even without exposure to drugs.
"For years, we've known that some patients produce altBRAFs and these help the cancer resist treatment, but we misunderstood the mechanism behind their creation. Knowing that genomic deletions are the cause opens new avenues for developing therapies that could more effectively…
📚 New paper out from the #ValcarcelLab! 🧬⚡️Melanomas resist drugs by ‘breaking’ genes 👉🏿 @CellReports 🔗crg.eu/en/news/melano…
“Melanoma drug resistance is a huge clinical problem because it occurs in almost all BRAF-mutated patients under BRAF/MEK inhibitor therapy and there are few or no therapeutic alternatives. There is an urgent need to understand the many different underlying mechanisms and find…
GÉTICA is passionate about supporting research and dissemination of latest advances in the field of immunotherapy of cancer on #WorldCancerDay
Las vacunas mRNA personalizadas son una estrategia prometedora en cáncer y ya son una realidad (dentro de ensayo clínico) para pacientes con #melanoma resecado en @hospitalclinic (pronto también en carcinoma escamoso cutáneo #CSCC) 👇👇
Las vacunas mRNA personalizadas son una estrategia prometedora en cáncer y ya son una realidad (dentro de ensayo clínico) para pacientes con #melanoma resecado en @hospitalclinic (pronto también en carcinoma escamoso cutáneo #CSCC) 👇👇
Hospital Clínic @hospitalclinic
64K Followers 6K Following Assistència, recerca i docència, la nostra raó de ser - #SomCLÍNICMeritxell Mollà @MeritxellMolla
842 Followers 345 Following Radiation Oncologist. Hospital Clinic Barcelona. Associate Professor at Universitat BarcelonaCentre for Genomic Re.. @CRGenomica
22K Followers 2K Following We are an international biomedical research lab based in Barcelona, a unique and interdisciplinary centre at the forefront of life sciences. We are @icercaASEICA @ASEICAnews
7K Followers 900 Following ASEICA. Asociación Española de Investigación sobre el Cáncer. Spanish Association of Cancer Research. ¡Únete! Join us!: https://t.co/lHs6T4l1XBCarlos Fernandez de L.. @fdezdelarrea
3K Followers 2K Following Hematologist. Myeloma, macroglobulinemia, amyloidosis. Immunotherapy, CAR-T cells. @hospitalclinic @idibaps @UniBarcelona @sloan_kettering alumniPatryk Poliński @PatrykPolinski
318 Followers 678 Following Postdoc at @EMBLBarcelona. Working on unusual forms of splicing.Juanmi Cejalvo @CejalvoM
821 Followers 495 Following Juan M. Cejalvo, MD PhD. Medical Oncologist. Biomedical Research Institute INCLIVA. Hospital Clínico Universitario of Valencia. Board Member of @_SOLTI #BeSOLTIFrancesco Schettini, .. @FrancescoSche20
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2K Followers 2K Following Hematologist at @hospitalclinic / @hematoclinicbcn At-home management, #bmtsm #leusm and #CARTcell. Opinions of my own. Colombian dreamer🇨🇴Victor Gil (MD, PhD) .. @puerroman
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3K Followers 569 Following MD, PhD, Lead Thoracic Oncol. Unit @hospitalclinic, MedOnc, Prof. @unibarcelona, Researcher Transl Genom 🧬 Targeted Therapies @IDIBAPS, @EORTC @GECP_org, #LCSMXavier Hernandez Alia.. @xavier_heal
461 Followers 844 Following @EMBOFellows Postdoctoral Researcher at Nedialkova lab @MPI_Biochem and @gagneurlab | PhD @CRGenomica | Professor col·laborador @UOCesalutTIAN TIAN @vicenttianfr
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927 Followers 698 Following MD, PhD Internista d, Urgències. @HospitalClinic.Agraïda als meus https://t.co/WlWtjgSzFd meu país. Viuria a les Penyes Altes del Moixeró. Runner, Swimmer, Biker i 🎾Izaskun @izaskinha
787 Followers 1K Following #RadiationOncologist #Barcelona. Loca motivada del deporte. Corro, me libera y me hace feliz. Proyecto de ciclista #Pucelana💜Aina Oliver-Caldes @ainitaoliver
460 Followers 449 Following Hematologist at Hospital Universitari Son Espases, Spain. Former hematologist at Hospital Clínic de Barcelona - Focused on CAR-T in multiple myeloma.𝓔𝓿𝓮 @Mum_Eve_
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4 Followers 61 FollowingPaula Sanchez-Somonte @PSanchezSomonte
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363 Followers 203 Following Regulation of mRNA translation by RNA-binding proteins and its implications on melanoma at @CRGenomica ESP/CAT/ENGIsabel Garcia Fructuo.. @IsabelGarciaFr6
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43 Followers 202 Following Scientist doing tech development for spatial omics @EMBLFernanda Hernández G.. @FerHernandezG
86 Followers 74 Following Interstitial Lung Diseases Program | @hospitalclinic BarcelonaCésar A. Rodríguez .. @1969carodriguez
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2 Followers 45 FollowingAleix Prat #Precision.. @prat_aleix
13K Followers 699 Following Head Oncology @hospitalclinic, CoFounder @RevealGenomics, TranslGenomics @IDIBAPS, Prof @UniBarcelona, Team @IOBoncologia, COI https://t.co/HZFOVJKZcdHospital Clínic @hospitalclinic
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351 Followers 426 Following Chemist 👨🔬🧪 PhD Student in Molecular BioScience Programme UAM-IIBm 🧬Arianna Baggiolini @BaggioliniA
846 Followers 845 Following Stem cell and cancer biologist | Group Leader and Assistant Professor at the Institute of Oncology Research (IOR) affiliated to @USI_enFran Supek @FranSupek
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1K Followers 0 Following MSK's precision oncology knowledge base w/ information about the effects & clinical implications of individual cancer gene alterations. Partially FDA-recognizedAlejandroNavarro_MD @ANavarro_MD
563 Followers 514 Following MD | Thoracic Oncology 🫁 | Clinical Trials | SCLC | @hospitalclinic Barcelona 🏥 | From Marcilla (Navarra) 🏡 | @osasuna ⚽ & Gravel 🚲The New Barcelona Pos.. @newbcnpost
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242 Followers 356 FollowingMarta Garcia de Herre.. @MartaGdeH
124 Followers 255 FollowingCuidar al que Cuida @Cuidaralqcuida
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252 Followers 87 Following CGI-Clinics is a project to improve personalised medicine in oncology by optimising the interpretation of genomic data from tumours. Funded by @HorizonEU.Jose M. Adrover @niseto
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659 Followers 332 Following Passionate about biostatistics, oncology clinical trial designs and basketball. Working at @VHIO and @_SOLTIHaass_Melanoma_lab @HaassLab
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75 Followers 81 Following Medical Oncologist & Researcher. Interested in art, melanoma, NET, CRC and BRAF mutations.Samuels - Lab @Samuels_lab
64 Followers 165 Following We aim to shed new light on the complex networks formed in #melanoma, and learn how we can utilize this information to treat melanoma patients @WeizmannScienceNational Brain Tumor .. @NBTStweets
12K Followers 2K Following National Brain Tumor Society (NBTS) is a nonprofit organization committed to finding a cure for brain tumors.Marco Donia @DoniaMarco
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150 Followers 547 Following 👷🏻♂️ Ingeniero Industrial. 🎹 Músico. Amante del 🔑 Marketing, del 🎨 Arte y de la 🧠 Ciencia.Martín Lázaro @mlazqui
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34 Followers 120 Followingrosa alvarez 💚 @rosaalvarezal
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1K Followers 936 Following Somos una agencia de servicios personalizados para healthcare. Nuestro compromiso de 20 años al servicio de la oncología nos avala 💙#oncología #MásQueCongresosLorea Blazquez @BlazquezLorea
299 Followers 241 Following RNA-processing and therapeutics @Biodonostia. Ramon y Cajal and Ikerbasque Research FellowNieves Martinez Lago .. @DraMartinezLago
2K Followers 2K Following MD PhD. Medical Oncologist at University Hospital Complex of Ferrol. Gastrointestinal and endocrine tumors.🚨🚨Publication alert! If you like R-loops, RNA splicing and DNA replication, this article is a must-read. A tour-de-force in the study of SF3B1-mutated MDS led by Michaela Fontenay at @InstitutCochin. 👏👏👏 nature.com/articles/s4146…
Q: What could GO WRONG with a major cancer genomics study in which tumours are sequenced to only 15x depth? A: An awful LOT! 😟 Our detailed reanalysis now out in @RSocPublishing: tinyurl.com/RSOSrebuttal 🧵👇 (1/18)
Avui es graduen les nostres R5, la Dra.Aguado i la Dra.Piedra. Estem molt orgullosos de la vostra evolució aquests 5 anys. Molta sort en la nova etapa que comenceu!!
🤩 Ha sido todo un honor recibir la beca CRIS de Excelencia dotada con 1.25M€ para diseccionar a un nivel sin precedentes los mecanismos moleculares de los #Sarcomas #GIST - y poder avanzar en el tratamiento de nuestros pacientes 🧬💊 🙏🏼 Muchas gracias a la #CRIScontraelcáncer
🔴 Para el Dr. @DrCeSarcoma del @VHIO de Barcelona por el Proyecto CRIS de Sarcomas Gastrointestinales. ➡️ Entrega el Dr. Kevin Harrington, jefe del servicio de Radioterapia e Imagen del @CTI_ICR. #CRIScontraelcáncer #OtraOportunidad #DíaCienciaCRIS24
So happy of being part of this new project!! Covering the needs of young oncologists!
Nace SOLTIyoung - New Generation Breast Un espacio para reconocer las particularidades y desafíos que enfrentan los jóvenes profesionales dedicados al tratamiento del cáncer, especialmente #cancerdemama, para impulsar su desarrollo académico y científico y su rol activo en la…
@FranAya6 @CellReports 👏👏👏 súper!! Congrats Fran!!
🎓¡Enhorabuena a la Dra. @nlbigas, del #IRBBarcelona, por su nombramiento como académica de la @RACiencias! 📜La toma de posesión, contestada por la Dra. @NietoAngela, será el miércoles 24 de abril a las 18:00 h en @NeuroAlc, con su conferencia: 🗣️"El #Cáncer: Un Proceso de…
🦀 El cáncer: un proceso de evolución darwiniana 🎓 Miércoles 24 de abril 18.00h Toma de posesión de la académica Núria López-Bigas, jefa del laboratorio de Genómica Biomédica @IRBBarcelona 🎙️Será contestado en nombre de la Corporación por Ángela Nieto @NietoAngela 🏫@NeuroAlc
@FranAya6 @CellReports 👏🏻👏🏻🙌🏻🙌🏻
@FranAya6 @CellReports Congratulations Fran! Disfruta del fruto de tu esfuerzo👏👏🔝👨🔬
@prat_aleix @FranAya6 @CellReports @hospitalclinic @idibaps @CRGenomica Many congrats @FranAya6! 👏🏻👏🏻👏🏻 it was great to catch up in Sevilla at @InfoGetica CICON meeting
The peer-reviewed version of our study on the evolution of tissue-specific expression across vertebrates and insects is finally published in @NatureEcoEvo ! @FedeMantica @CRGenomica @UPFbiomed nature.com/articles/s4155…
🚨Exciting pre-print from the lab!👉"Pervasive evolution of tissue-specificity of ancestral genes differentially shaped vertebrates and insects". Deep comparative #transcriptomics across #bilateria by @FedeMantica et al @CRGenomica. 👀biorxiv.org/content/10.110…. Summary👇
Todo agradecimiento a @ContraCancerEs es poco: por sus campañas de divulgación y prevención, por el apoyo a tantísimos investigador@s (desde los más jóvenes a los más establecidos)…y desde luego, por su compromiso con las personas afectadas con cáncer. Colaborad con la AECC!
It was a pleasure to present on this complex but facinating aspect of Potency Assays and clinical efficacy! 🫡
Amazing lecture by @ValentinOrtizMD on a very controversial matter. Extra points for the cool memes 😎. #EBMT24
Almost all the #cancermunity lab+2 early career researchers, running @ContraCancerEs @CNIOStopCancer
Genomic deletions explain the generation of alternative BRAF isoforms conferring resistance to MAPK inhibitors in melanoma: Cell Reports cell.com/cell-reports/f…
🧬🧬El #melanoma "rompe" genes para resistir a la acción de los fármacos. 🔬La Dra. @nlbigas, del #IRBBarcelona, participa en este estudio liderado por @CRGenomica y publicado en @CellReports. Junto con @idibaps y @VHIR_🤝 📰@larazon_es ➡️shorturl.at/cnovY #IRBScience
Surprisingly, the researchers found evidence of the same genomic deletions in melanomas which hadn’t been treated yet. In other words, melanomas can naturally develop mechanisms that mimic drug resistance, even without exposure to drugs.
Identifying and targeting these early resistance mechanisms through profound genetic testing in a clinical setting before treatment begins could improve the efficacy of first-line therapies.
This helps the tumour create alternative versions of the protein (altBRAFs) which lack regions targeted by BRAF inhibitors, reactivating the MAPK pathway and making the drugs less effective. The finding was consistent across various lab models and patient tumour samples.