George W Sledge MD @GeorgeSledge51
Ancillary Clinical Professor of Medicine, Stanford University; breast cancer doc and Chief Medical Officer, Caris Life Sciences Joined August 2013-
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George W Sledge MD retweeted
Long Road Home: The Continuing Journey of Metastatic Disease. Co-authored by @GeorgeSledge51. Read the full article. bit.ly/3R4m8g6
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Long Road Home: The Continuing Journey of Metastatic Disease. asco.altmetric.com/details/199033… Please see, and I hope enjoy, my new JCO OP editorial on where we sit with metastatic cancer.
George W Sledge MD retweeted
Ian Krop named section chief of Medical Oncology and Hematology and deputy director for Clinical Affairs for @YaleCancer cancerletter.com/in-brief/20260…
George W Sledge MD retweeted
Every ASCO has some hidden pearls. One that I had the luck to attend was a presentation by Gil Shamai on the discordance between AI prediction and standard path features — wonderfully discussed by David Rimm. Highly recommended. “AI errors are not bugs, but rather features”
George W Sledge MD retweeted
A care model led by Manali Patel, MD, MPH, a Stanford thoracic oncologist, demonstrated that trained lay health staff can improve patient experiences, reduce emergency department visits, and lower overall #healthcare costs. ow.ly/4xlG50YW66U
@ConquerCancerFd A giant of our field, as well as being one of the kindest, most decent human beings I have ever known.
George W Sledge MD retweeted
🧠 #SABCS25: #AI models outperformed standard tools for predicting distant recurrence in patients with early-stage #BreastCancer, enabling more individualized risk assessment and treatment decision guidance. 👨⚕️ @jsparano | Eleftherios Mamounas, MD 🔗 ascopost.com/news/december-…
George W Sledge MD retweeted
Possible mechanisms of resistance to T-DXd in breast cancer patients using real-world data and multiomic profiling ⬆️ABCC1 and ⬇️ERBB2 showed ⬇️OS, in line with previous works on T-DXd. Presented at #SABCS24, now published on @Nature_NPJ by @GeorgeSledge51 et al. (link below)
@thenasheffect @ConquerCancerFd @ASCO @BurrisSkip @jrgralow @ASCOPres Congrats to Rafeh. Well done.
George W Sledge MD retweeted
A Real-World Experience in Pan-Tumor Testing for HER2 IHC in More Than 65 000 Solid Tumors jamanetwork.com/journals/jamao… Trastuzumab deruxtecan-nxki (T-DXd) received tumor-agnostic FDA approval in April 2024 for adults with unresectable or metastatic HER2-positive (IHC 3+) solid tumors lacking other treatment options, based on responses seen across three DESTINY trials. This prompted widespread HER2 IHC testing across tumor types, leading to the first large-scale report on real-world HER2 IHC 3+ prevalence using standardized interpretation criteria. Among over 65,000 tested patients, HER2 IHC 3+ rates varied widely by cancer type, with #BladderCancer showing the highest prevalence (13.9%), while others—like gliomas, sarcomas, #ProstateCancer, and kidney cancers—had minimal or no expression. These findings suggest universal HER2 testing may not be necessary for all solid tumors, and a more targeted approach—initiating HER2 IHC only after identifying ERBB2 amplification or overexpression via comprehensive genomic profiling—could reduce unnecessary testing while optimizing workflow and cost-efficiency. Dave Bryant Rebecca Feldman Farah Abdulla Daniel Magee Jennifer R. Ribeiro Matthew Oberley Milan Radovich David Spetzler @carisls @GeorgeSledge51
@TNBCFoundation @HayleyDinerman What a champion for women with TNBC. And what a great supporter for the researchers trying to end this scourge. Hayley, we owe you a great debt for your tireless work.
@carisls Our paper is the first broad view of tissue agnostic indications based on a large, solid dataset. We need to rethink what “tissue agnostic “ means, and how we approach tissue agnostic approvals.
George W Sledge MD retweeted
Caris has published a 295,000+ patient study revealing variable efficacy among cancers for patients treated with tissue-agnostic drugs and uncovering the potential for expanding approvals to other drugs in the same class. Learn more: ow.ly/Ii5x50VlbqJ
George W Sledge MD retweeted
@PamelaKunzMD @YaleMed @YaleCancer @ericwiner @ROYHERBST Congratulations and well deserved.
George W Sledge MD retweeted
Caris Chief Scientific Officer Milan Radovich, PhD, shares insights on how Caris Assure sets a new benchmark in #liquidbiopsy profiling. Join us in transforming patient care through innovative solutions: ow.ly/4LGf50TVt28
George W Sledge MD retweeted
This week, we highlighted two recent collaborative publications by researchers, including @EHeath4100, @KelseyAPoorman, @JoanneXiu, @SamuelKareffMD, @marshalj23, @saikatbib, @Marindoc, @jpshen_md and others published in @BrJCancer and @CRC_AACR. bit.ly/3zlVK8H.
@VanAllenLab Hello, 1960 calling and it’s looking for its technology.
@PTarantinoMD Underpowered trial is my guess
Paolo Tarantino @PTarantinoMD
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Tatiana Prowell, MD @tmprowell
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Jame Abraham, MD, FAC... @jamecancerdoc
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Anjali B @AnjaliB2402
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Traci King @TraciKingMD
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Paolo Tarantino @PTarantinoMD
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Erika Hamilton, MD, F... @ErikaHamilton9
20K Followers 3K Following Chief Development Officer & Director of Breast Cancer Research @ Sarah Cannon Research Institute| Wife | Mom| Tweets are My Own #BCSM, COI @ link.
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12K Followers 572 Following
Stephanie Graff, MD, ... @DrSGraff
22K Followers 4K Following Director Breast Oncology, Brown University Health | Assoc Prof Legorreta Cancer Center Brown Univ | Views Mine | https://t.co/WVUQaIHeKn | COI ⬇
Tatiana Prowell, MD @tmprowell
60K Followers 9K Following Oncologist serving people w/ #cancer in #MedEd #SciComm & #bcsm. Past ASCO Ed Chair. Cofounder @HCWvsHunger. #LongCovid. Team hope/good trouble/go high. No FCOI
Rebecca Shatsky, MD @Dr_RShatsky
16K Followers 1K Following Professor of Medicine. Breast medical oncology team leader @UCSD specializing in young patients, TNBC, Lobular, metaplastic and precision/personalized oncology
Harold J. Burstein, M... @DrHBurstein
15K Followers 574 Following Breast cancer specialist and professor @DanaFarber Cancer Institute and @HarvardMed. Tweets are my own and not medical advice. COI disclosure: no COI.
Toni Choueiri, MD @DrChoueiri
46K Followers 341 Following Chief GU Cancers @DanaFarber II Prof Medicine @HarvardMed II ⚽ lover II @PanMass 🚲rider.
Sara Tolaney @stolaney1
13K Followers 635 Following Chief, Division of Breast Oncology @DanaFarber Tennis fan Mother of two teenage girls
SABCS @SABCSSanAntonio
16K Followers 702 Following An international scientific symposium for interaction and exchange among basic scientists and clinicians in breast cancer
Vivek Subbiah, MD @VivekSubbiah
41K Followers 2K Following Drug Development| Precision Oncology| Tissue-Agnostic Precision Medicine #Oncologist, #Phase1trials, #PrecisionMedicine. Tweets=My own.
FabriceAndre @FAndreMD
15K Followers 500 Following Head of Research Division of @GustaveRoussy , @myesmo President
Naoto T Ueno, MD, PhD @teamoncology
15K Followers 1K Following Director, NCI-designated University of Hawai’i Cancer Center @UHCancerCenter, Breast Med Onc. Cancer Survivor. https://t.co/uqfgfoIHL3
Dana-Farber’s Breas... @DFCI_BreastOnc
8K Followers 480 Following Patient-centered care, clinical trials & translational research on breast cancer @DanaFarber and @HarvardMed. Appts: 877-442-3324, Clinical trials: 877-338-7425
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42K Followers 138 Following 🌐 Worldwide oncology professionals network | Run by oncologists, for colleagues | All tumor types | Non-profit 🚨 We are #OncoAlert | Oncology360°
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Eleonora Teplinsky, M... @drteplinsky
4K Followers 1K Following Breast & gyn med onc @valleyhealthnj. Opinions my own. Host of INTERLUDE podcast. 📗 BEYOND THE PINK (2026). Patient education on Instagram.
Stephen V Liu, MD @StephenVLiu
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World Health Organiza... @WHO
12.7M Followers 2K Following We are the @UN’s health agency working for #HealthForAll Always check our latest tweets for updated advice/information.
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Dr. Michael Gnant @MichaelGnant
1K Followers 295 Following Surgeon. Physician Scientist. Clinical Trials. @MedUni_Wien @ABCSGVienna. Arzt. Chirurg. Dad. Streben nach Weisheit. Cogito ergo sum. Tweets&opinions are mine.
Janice Cowden @JaniceTNBCmets
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Annals of Oncology @Annals_Oncology
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858 Followers 482 Following Mamma, Professoressa Associata in Oncologia Medica, portatemi in montagna e sarò felice.
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Emanuela Ferraro, MD @EmaFer_90
655 Followers 557 Following Medical Oncologist, Breast Cancer 🎗️ #bcsm clinical research fellow @MSKCancerCenter__ Cats lover🐾__southern soul 🇮🇹🌶️
Alessandra Gennari MD... @ALEDIGNUS12
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Elisa Agostinetto @ElisaAgostinett
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Rafeh Naqash, MD, FAS... @thenasheffect
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Aditya Bardia, MD @dradityabardia
4K Followers 134 Following Medical Oncologist, UCLA. Passionate about accelerating innovative research and fostering academic mentorship to improve patient outcomes.
Sangeetha Reddy @smreddymd
784 Followers 149 Following Breast cancer medical oncologist, translational researcher and clinical trialist with focus on immunotherapy and the tumor microenvironment
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1K Followers 260 Following
YaleBreastCancer @YaleBreast
1K Followers 1K Following @yalecancer. Director @maryam_lustberg Co Director @greenuprachel Chief Research Directors @QinYan1 #LajosPusztai
SWOG Cancer Research ... @SWOG
15K Followers 1K Following SWOG Cancer Research Network runs publicly funded clinical trials that have saved 3 million+ years of life. Founded by the National Cancer Institute in 1956.You might like
Harold J. Burstein, M...
@DrHBurstein
15K Followers
Joseph A. Sparano, MD
@jsparano
2K Followers
FabriceAndre
@FAndreMD
15K Followers
Hope Rugo
@hoperugo
12K Followers
Erika Hamilton, MD, F...
@ErikaHamilton9
20K Followers
Matteo Lambertini, MD...
@matteolambe
19K Followers
SABCS
@SABCSSanAntonio
16K Followers
Erica Mayer
@elmayermd
4K Followers
Ann Partridge MD, MPH
@AnnPartridgeMD
4K Followers
Elizabeth A. Mittendo...
@ASCOPres
10K Followers
Sara Tolaney
@stolaney1
13K Followers
Rebecca Shatsky, MD
@Dr_RShatsky
16K Followers
Stephanie Graff, MD, ...
@DrSGraff
22K Followers
Julie Gralow
@jrgralow
11K Followers
Antonio Giordano, MD ...
@antgiorda
4K Followers