Issac Emmanuel Goh 🇺🇦 @IssacEGoh

Computational Biologist at Newcastle University and visiting scientist at the Sanger institute. 3D bio-printing enthusiast haniffalab.com/team/issac-goh… Joined January 2011

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Johanna Strobl @johanna_strobl

2 years ago

Fantastic study revealing several new functions of the human yolk sac during development, including monocyte-independent production of macrophages! Congratulations @IssacEGoh @BottingRachel @Muzz_Haniffa an co-authors 👏👏👏

Haniffa Lab @HaniffaLab

2 years ago

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Issac Emmanuel Goh 🇺🇦 @IssacEGoh

2 years ago

What a brilliant way to communicate core-concepts of your equations!

alex peysakhovich 🤖 @alex_peys

2 years ago

What a brilliant way to communicate core-concepts of your equations!

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Vitalii Kleshchevnikov, PhD @vitaliikl

2 years ago

IMO this must be done in all comp bio papers. Without annotations, many model explanations in comp bio papers are very hard to follow. When explaining many inputs in the likelihood or many regularisation terms - you need to label what they mean. Easier to read -> more citations.

alex peysakhovich 🤖 @alex_peys

2 years ago

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Haniffa Lab @HaniffaLab

2 years ago

We also identify pre-specified TREM2+P2RY12+ microglia-like cells in the YS (transcriptionally enriched in brain microglia signature) Microglia-like cells have also been observed in pre-natal gonads and skin (@emmamarydann et al & @roserventotomo et al) 📷 by Liz Tuck [6/12]

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Haniffa Lab @HaniffaLab

2 years ago

We observe a pre-AGM accelerated pathway to macrophage differentiation in the YS prior to monocyte emergence (also in iPSC scRNA-seq @ClaraAlsinet et al) Macrophages in the YS post-AGM are from proliferating macrophage pool and monocyte differentiation [5/12]

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Haniffa Lab @HaniffaLab

2 years ago

We find distinct waves of HSPC (red👇) lineage potential for different blood/immune cells before/after AGM contributions to haematopoiesis in YS. Our data are consistent with definitive HSPC predominance over primitive by 8 post conception weeks (@VincenzoCalvan3 et al) [4/12]

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Haniffa Lab @HaniffaLab

2 years ago

We detail haematopoietic stem progenitor (HSPC) emergence from hemogenic endothelium, also observed in iPSC scRNA-seq data (@ClaraAlsinet et al) similar to aorta-gonad-mesonephros (AGM) [3/12]

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Issac Emmanuel Goh 🇺🇦 @IssacEGoh

2 years ago

Our manuscript was just published in Science! Blessed to have co-led with the brilliant @BottingRachel, working with friends and collabs at @HaniffaLab, @sangerinstitute @Cambridge_Uni! Read about how we uncover the first emergence of blood/immune cells in human embryonic life!

Haniffa Lab @HaniffaLab

2 years ago

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Haniffa Lab @HaniffaLab

2 years ago

New in @science! 🎊 Our #Developmental @humancellatlas study (bit.ly/yolk_sac) uses #SingleCell profiling to map the human yolk sac, pivotal for embryonic survival & first prenatal blood and immune cells. Data-portal: bit.ly/YSportal 👈 [1/12] 🎥 by @megumi4952

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Haniffa Lab @HaniffaLab

3 years ago

Probing the haem compartment further, we detail haematopoietic stem progenitor cell (HSPC) emergence from hemogenic endothelium, also observed in public yolk sac iPSC scRNA-seq (@ClaraAlsinet et al rdcu.be/cTfOt) similar to aorto-gonado-mesenephros (AGM) [3/9]

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Haniffa Lab @HaniffaLab

3 years ago

New preprint alert! 📢🥳 Using multiomic profiling of #SingleCell data we integrated and analysed ~180k cells from first trimester human yolk sac (YS) Our investigations recovered cells from the contents, membrane & vitelline duct [see vid below] Here's what we learnt [1/9]👇🏾

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Haniffa Lab @HaniffaLab

3 years ago

Our data are consistent with definitive HSPC predominance over primitive by 8 PCW (@VincenzoCalvan3 et al rdcu.be/cTgFF) We find differential linage potentials before and after AGM contributions to haematopoiesis in YS [4/9]