Jacob Trefethen @JacobTref
Program officer @open_phil, science jacobtrefethen.com San Francisco, CA Joined June 2015-
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For the final post of 🥳PATENT DATA WEEK🥳 it's the all-things considered, definitive post on patents as a way to measure innovation. Synthesizing the rest of the week's posts, and discussing ways people use to extract more signal from patents. newthingsunderthesun.com/pub/6skgk0ij/r…
Proud to support, exciting discoveries from the @icipe team in Kenya What a neat little microbe. Found in the wild, gets transmitted from mother mosquito to child and between mates, and seems to block transmission of the malaria parasite. More to explore.. imagine if it works...
Proud to support, exciting discoveries from the @icipe team in Kenya What a neat little microbe. Found in the wild, gets transmitted from mother mosquito to child and between mates, and seems to block transmission of the malaria parasite. More to explore.. imagine if it works...
Here's the post, with plenty of additional context for the questions included atelfo.github.io/2024/04/01/bio…
I thought I knew what this post was going to be about. I’ve been to a million conferences and more recently felt like it is a lot of time to set aside (especially if it’s the same people over and over). But Jacob makes a fun point here about using them to focus efforts to…
I thought I knew what this post was going to be about. I’ve been to a million conferences and more recently felt like it is a lot of time to set aside (especially if it’s the same people over and over). But Jacob makes a fun point here about using them to focus efforts to…
Just posted our 2023 annual review: openphilanthropy.org/research/our-p… It's been a rollercoaster couple of years, but I'm proud of our team and excited about the year ahead.
Come work with us! IFP is currently hiring for: - Chief of Staff - Data Fellow - Biotechnology Fellow - Senior Biotechnology Fellow ifp.org/come-work-with…
A great write-up of Product Development Partnerships and how they bring to market high-impact technologies at a fraction of the cost of traditional pathways. Thank you @JacobTref for featuring @IVIHeadquarters as a successful example of accelerating #vaccines for global health!
A great write-up of Product Development Partnerships and how they bring to market high-impact technologies at a fraction of the cost of traditional pathways. Thank you @JacobTref for featuring @IVIHeadquarters as a successful example of accelerating #vaccines for global health!
Fascinating read from @JacobTref on institutional experiments in non-profit drug development via PDPs. Also love seeing funders talk more openly and candidly about their ideas
Fascinating read from @JacobTref on institutional experiments in non-profit drug development via PDPs. Also love seeing funders talk more openly and candidly about their ideas
Next post: there is much to learn from the last 28 years of Product Development Partnerships, on how to organise research and develop public goods. For example - that PDPs exist! A dozen institutions few people have heard of, quietly marching to results: blog.jacobtrefethen.com/reinventing-re…
1/ 🚨 Launching the Talent Mobility Fund 🚨 Talent is distributed equally but opportunity is not. The Talent Mobility Fund is on a mission to fix this. 🧵
Great summary of Priority Review Vouchers, an effective policy tool that costs the USG exactly $0, and incentivizes R&D that otherwise suffers from low profitability/market failures
Great summary of Priority Review Vouchers, an effective policy tool that costs the USG exactly $0, and incentivizes R&D that otherwise suffers from low profitability/market failures
Next blog post: want to make drugs to benefit people in lower income countries, but don’t know how to finance the clinical trials? Tell investors you’ll win a Priority Review Voucher if you succeed: blog.jacobtrefethen.com/how-to-make-10…
Economics of innovation has long highlighted that markets do not necessarily direct R&D to areas with highest social value. Pretty vivid illustration of that point here. blog.jacobtrefethen.com/10-technologie…
True We CAN save millions of lives through technologies, vaccines and treatments to things that kill lots of people But we're not organized for it We could be. Operation Warp Speed was one example But we see OWS as a one-off, not as model for solving big scientific problems
True We CAN save millions of lives through technologies, vaccines and treatments to things that kill lots of people But we're not organized for it We could be. Operation Warp Speed was one example But we see OWS as a one-off, not as model for solving big scientific problems
striking table and call for funding: blog.jacobtrefethen.com/10-technologie…
"Half of these problems rarely affect rich people, so there is not much money supporting product development. With an extra $10 billion over 10 years I’m pretty sure we’d get to 5 or 6 of the 10 on the list, and millions of unnecessary deaths would be prevented." @JacobTref
Alexander Berger @albrgr
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Peter Wildeford @peterwildeford
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Stefan Schubert @StefanFSchubert
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David Manheim @davidmanheim
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Ollie Base @Ollie_Base
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Lauren Gilbert @notanastronomer
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Caleb Watney @calebwatney
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Saloni @salonium
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Bruno Carballa Smicho.. @BrunoCarballa
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223 Followers 1K Following Znížiť prepad hlasov/nereprezentovaných voličov pod volebným kvórom (CZ 19% SK 28%) znížením volebného kvóra či systém prenosného hlasu strán.
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Russ @RussellWeigley
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Molamin drammeh ✝�.. @DarboeFakk90452
141 Followers 4K Following The Lord makes poor and makes rich; he brings low and he exalts.
Cameron Dockum @came_doc
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Charlie Higgs @CharlieHig47726
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27 Followers 206 Following
3 beloved squirrels i.. @ty19454
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Beaulah Rehmann @BeaulahRehm
63 Followers 5K Following
Hauke Hillebrandt @Ha_uke
328 Followers 1K Following Former researcher at @Harvard @UCL @CGDev @CentreforEA and Founder of https://t.co/hgikUchI9b https://t.co/RjW7rjb4IC
Aaidah Cedeno @CedeAaid
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iAsjey @iAsjey
66 Followers 197 Following Product Designer at @theloopcraft • “The design is not just what it looks like and feels like. The design is how it works” — Steve Jobs 
Calvin McCarter @CalvinMccarter
419 Followers 1K Following AI + biology. Views not always my own, but never more than my own. Occasional notes at https://t.co/KmxL03ZcAR.
Tim Fist @fiiiiiist
740 Followers 426 Following Senior Tech Fellow @IFP. Senior Adjunct Fellow @CNASdc. AI & compute policy, science, innovation.
Tim Hwang @timhwang
18K Followers 1K Following for me, the action is the juice / letter: https://t.co/Taapwkm4wM / proprietor: https://t.co/LR6pUYuhsU / co-founder: https://t.co/8AtNLBdZI6
Alison Munson @munson.. @MunsonAlison
3K Followers 5K Following Ecologist (forest and urban); exploring plant traits and soil carbon stabilization. Semi-retired prof. Writer. Personal tweets.
Celia Loreaux @CeliLorea
44 Followers 5K Following
icipe @icipe
9K Followers 3K Following International Centre of Insect Physiology and Ecology (icipe). #Africa's only institution dedicated to research on #insects and other arthropods. #OneHealth
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2 Followers 2K Following
Stuart Strand @stuartestrand
463 Followers 770 Following Environmental engineer using GMO plants to fight pollution: indoor air, N2Oreductase, CROPS, bioremediation, WWTPs, soils. Opinions mine. 60 yrs bike commuting.
Preeta @preeta_sarada
305 Followers 2K Following PhD in Molecular and Cell Biology | Oncology | Medical Strategy and Communication #WomeninSTEM #WomeninScience
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Max Görlitz @max_goerlitz
44 Followers 180 Following Biosecurity research | currently Genomic Medicine @UniofOxford | previously @medialab
Scott Gleim @sgleim
883 Followers 4K Following Biomedical researcher, data scientist, doting father. 🧬🐍
Alexander Berger @albrgr
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Matthew Yglesias @mattyglesias
542K Followers 2K Following Slow Boring, cohosting https://t.co/wxUj3JFSFf, Bloomberg columnist
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Qualy the lightbulb @QualyThe
7K Followers 320 Following Official Unofficial EA mascot. I'm here to make friends and maximise utility, and I'm all out of neglected altruistic opportunities
Michael Nielsen @michael_nielsen
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Noah Smith 🐇🇺�.. @Noahpinion
322K Followers 1K Following Writes about economics, posts about rabbits. For serious opinions/analysis, read my blog: https://t.co/KfUxUlCYPz
Miles Brundage @Miles_Brundage
43K Followers 10K Following Policy research at @openai. I mostly tweet about AI, animals, and sci-fi. He/him. Views my own.
Tessa Alexanian @tessafyi
2K Followers 515 Following let's make nice things with biology 🌱 screening synthesis @IBBIS_bio, advising @AsimovPress 🌱 former safety officer @iGEM, robot whisperer @Zymergen (she)
Hannah Ritchie @_HannahRitchie
85K Followers 1K Following Deputy Editor @OurWorldinData / Researcher at @UniofOxford / Honorary Fellow at @EdinburghUni @EdCentreCC / Not the End of the World: https://t.co/FoINhggvoR
Max Roser @MaxCRoser
287K Followers 1K Following Data to understand global problems and research to make progress against them. Founder of @OurWorldInData / Professor at @UniofOxford's @BlavatnikSchool
Cate Hall @catehall
19K Followers 273 Following executive director @ Astera | born lucky | leave me anonymous feedback: https://t.co/9RtcgMyTHP How to be More Agentic: https://t.co/O3eJsrzTYW
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3.4M Followers 2K Following New Book, On The Edge, August 13: https://t.co/WeCLEOd4Be
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2K Followers 5K Following Currently: MD Student @UTHealthSA Former: Associate @BCG, Clinical Trials @MDAndersonNews, External R&D @Celgene, Summer Associate, @Lux_Capital. Views my own.
Mark Symes @mdsymes
390 Followers 76 Following Programme Director @ARIA_Research. Professor of Electrochemistry and Electrochemical Technology at the University of Glasgow.
Manjari Narayan | Sub.. @NeuroStats
6K Followers 6K Following Antedisciplinary Scientist. Feedback welcome at https://t.co/wR1ooEvxzP @StanfordMed | PhD@RiceU_ECE | BS@ECEILLINOIS
Tom @TomScriba
2K Followers 234 Following Prof. in immunology and vaccinology of tuberculosis at Univ. of Cape Town, @uct_news. Deputy Director, @satvi_uct. Views my own
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88K Followers 39K Following Director, GI Oncology, @Intermountain. Interests: neuroendocrine tumors, cancer syndromes, empathy (even had a Whipple myself). Tweets my own.
Tim Hwang @timhwang
18K Followers 1K Following for me, the action is the juice / letter: https://t.co/Taapwkm4wM / proprietor: https://t.co/LR6pUYuhsU / co-founder: https://t.co/8AtNLBdZI6
Eliver Ghosn @EliverGhosn
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Amy Nice @AmyMNice
381 Followers 36 Following Distinguished Immigration Counsel @IFP, trying to make the immigration system we're stuck with work better
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Ronny Fernandez 🔍�.. @RatOrthodox
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Jordan Dworkin @jddwor
591 Followers 389 Following Metasciencing @scientistsorg. Formerly neuroimaging methods and biostatistics @ColumbiaPsych and @Penn_SIVE
Plane Jane Spaghetti @the_planejane
43K Followers 311 Following The Mandalorian, the Terminator, the One and Mostly. Rupaul’s Drag Race Season 16 🌟
Will Owens @willovvens
287 Followers 87 Following Grad student @MITBiology working on immunology, computational + systems bio. Formerly SynBio @OctantBio. Florida man. Read my website for full sentences.
Mubanga Kalimamukwent.. @UtushimiTwandi
527 Followers 205 Following OBLIGATIONS TO THE WOUNDED @UPittPress THE MOURNING BIRD @JacanaMedia Ed @UbwaliLitMag | @doeklitmag | @ShenandoahWLU MMF Scholar Rep @PontasAgency PhDing
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242 Followers 349 Following Physician @StanfordDeptMed, Fellow @JHSPH_CHS and @IFP
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563 Followers 497 Following Postdoc @UWproteindesign | @CHADNANO alum | De novo protein designs for programmable self-assembly | Colloidal crystal engineering with DNA
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162 Followers 235 Following PhD student @uwgenome | @JShendure lab| single cell genomics, developmental biology | she/her
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637 Followers 270 Following @UWproteindesign Baker & King labs | @Harvard alum | interested in novel nanomaterials and machine learning | views my own
Ian Haydon @ichaydon
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271 Followers 569 Following Erwin Schrödinger Postdoctoral Fellow in the Baker lab at the Institute for Protein Design, University of Washington
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Steven Tong @syctong
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58 Followers 64 Following
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166 Followers 168 Following
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Richard Fuisz @richardfuisz
2K Followers 782 Following Asking biotechnology (politely) to do useful things. | Future House, Arcadia Science, Templa Nucleics.
I think about this blog post from @JacobTref a lot: "Some technologies are more important than others – indeed, some are life or death. Technological progress is not a mystical force that delivers the most important ones first. Some problems are hard to solve, and won't make…
@calebwatney @JacobTref Stroke doesn't have that - it's just a hard technical challenge to create a drug that is IV and simultaneously reperfuses brain w/o increasing risk for bleeding. Hence the focus on devices / procedures to do that.
@calebwatney @JacobTref More generally, all the other ones on the list have a clear reason why investment in development of them is low - externalities and generally a poor environment for ID R&D investment.
@calebwatney @JacobTref Jacob mentions thrombolysis, which is obviously the big one, but anti-platelet drugs also help treat stroke once its already happened - so insert aspirin, clopidogrel, ticragrelor, etc.
Sometimes when it’s too hard to figure out how to make everyone happy, you have to have two weddings and two wedding dresses (lessons: elope but still buy both dresses)
What did your wedding dress look like? First dress I tried on and I kept comparing every other one for the next several hours to that trainnnnn
In the words of Imagine Dragons “It’s Time” news.mit.edu/2024/circadian…
The funny thing is, it's not even clear that's the lede(!) Another endosymbiotic event is, I think, clearly more important. But that seems maybe a little less clear(?)
A eukaryote that fixes nitrogen(!): newscenter.lbl.gov/2024/04/17/sci…
@michael_nielsen the Beinecke
I'm excited to share share job opportunities to partner with me to shape Open Phil's aid policy work. Please apply by May 12th! (1/3)
L F G !!!
Love this program goal. COVID made clear that we have not done much to improve the built environment for airborne diseases (open windows/put on masks was the same advice 100 years ago). Can we do for air what we did for water, and build a new subfield of R&D.
Love this program goal. COVID made clear that we have not done much to improve the built environment for airborne diseases (open windows/put on masks was the same advice 100 years ago). Can we do for air what we did for water, and build a new subfield of R&D.
BREATHE easy. Our new program aims to revolutionize public health by transforming a building’s ability to eliminate indoor air threats. arpa-h.gov/news-and-event…
BREATHE easy. Our new program aims to revolutionize public health by transforming a building’s ability to eliminate indoor air threats. arpa-h.gov/news-and-event…
I enjoyed this thread on Erdos as "a [largely pre-internet] network between mathematicians, acting as a human computer" who was restructuring expert attention, matching mathematicians to problems and each other:
Investigating the collaborative mathematical practice of Paul Erdős mathematics as a social activity mathshistory.st-andrews.ac.uk/BSHM/Rekvenyi_…
Investigating the collaborative mathematical practice of Paul Erdős mathematics as a social activity mathshistory.st-andrews.ac.uk/BSHM/Rekvenyi_…
Recently @seemaychou and I did a mini tour of Japan (Tokyo and Okinawa) giving talks about @ArcadiaScience. It was so much fun!
@Willyintheworld @Atelfo @JacobTref @Atelfo would love to meet! Just recently moved to SF to work with @withpowerhq on solutions for trial recruitment after my time Amgen
Protip for undergrads interested in getting their feet wet into biotech: scan your university's Technology Transfer Office (TTO) for cool projects! Every school has one. It's where researchers post their filed patents that they want a company to form around and use.
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