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Jenlith @Jenlithvm

Joined June 2026
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Jenlith retweeted
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Greg O'Gallagher @gregogallagher

a day ago

Tirzepatide may actually slow biological aging. An epigenetic sub-study from Eli Lilly’s SURMOUNT-5 trial, presented at an aging research conference at Harvard, found that all 15 biological aging clocks advanced more slowly than chronological time. Some even moved backward. This is a promising longevity signal. Some of these improvements may come from weight loss and better metabolic health, but researchers are also investigating whether tirzepatide’s direct GLP-1/GIP metabolic actions provide additional benefits. The key is getting the dose right. You don’t want to suppress your appetite so much that you’re chronically undereating, losing muscle, or feeling depleted. Find the lowest effective dose, eat sufficient protein, and lift heavy to preserve muscle. Get those fundamentals right, and tirzepatide could be an incredible tool for both body composition and long-term metabolic health. The anti-aging findings are preliminary, but the potential is exciting.

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