Kirill Martemyanov Lab @KLabGPCR
GPCRs in neural circuit function scripps.edu/martemyanov Jupiter, FL Joined May 2019-
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We found that endogenous ligand for GPR139 is opioid peptide dynorphin. With this, GPR139 may not be an orphan any more but the 5th opioid receptor. Heavy lift by talented Xiaona Li with great thanks to all who contributed! nature.com/articles/s4146…
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We have innovated design of templates for CRISPR/Cas9 editing which allows efficient introduction of epitope tags in vivo. It is a simple hack which we hope to be broadly useful. Work by talented graduate student Chuanping Zhao. nature.com/articles/s4146…
Kirill Martemyanov Lab retweeted
The ON/OFF dichotomy is fundamental to visual processing. In a new study led by Flori Soto, we identify a conserved molecular mechanism establishing the OFF pathway. rdcu.be/eikoa
Kirill Martemyanov Lab retweeted
Our latest on GPCR function in the brain. We report that glutamate receptor mGlu4 needs to be properly positioned at synapses of cholinergic interneurons in NAc by cell adhesion molecule ELFN1 to regulate opioid reward. pnas.org/doi/epub/10.10…
A popular FDA-approved drug to treat hypertension, hydralazine works, at least in part, by modulating RGS proteins! Honored to be a part of a collaborative team led by @MegaMatthewsLab! biorxiv.org/content/10.110…
Excited to share our latest on ELFN1 mechanisms, a dysfunction of which leads to a devastating neurodevelopmental disorder. Swan song of @GPCRHenry. #GPCR , #Elfn1, @jbiolchem sciencedirect.com/science/articl…
Kirill Martemyanov Lab retweeted
Happy to introduce DeFrND: designer peptide scaffolds to enable detergent-free reconstitution of membrane proteins with native lipids into nanodiscs for biochemical and structural studies. Let me know if you would like to try it. biorxiv.org/content/10.110…
An amazing paper- a treat to read! Can't be more proud of former postdocs doing awesome science! Go Brian Muntean! pnas.org/doi/10.1073/pn…
Kirill Martemyanov Lab retweeted
As shown recently a single point mutation in G protein alpha subunit yields a stable complex without the use of stabilizing nanobodies! nature.com/articles/s4146…
Spot on!
Soluble GPCRs! Check it out! Congrats @befcorreia ! nature.com/articles/s4158…
This is a must read masterclass in sensory circuit dissection and really cool behavioral adaptation!
This is a must read masterclass in sensory circuit dissection and really cool behavioral adaptation!
Frizzled receptors are so cool. Consolidated model of GPCR realm with scaffolding signalosome.
Frizzled receptors are so cool. Consolidated model of GPCR realm with scaffolding signalosome.
This is an amazing progress! Breathtaking structure and a cool model!
This is a phenomenal paper! Very easy to read and advance is mesmerizing. Highly recommend to folks interested in orphan receptors and their role in totally new biology.
This is a phenomenal paper! Very easy to read and advance is mesmerizing. Highly recommend to folks interested in orphan receptors and their role in totally new biology.
Welcome, Ezgi @ezgi_hsuleyman ! Looking forward to working with you!
Welcome, Ezgi @ezgi_hsuleyman ! Looking forward to working with you!
Kirill Martemyanov Lab retweeted
@jbiolchem symposium @ASBMB meeting kicked off by @ChiefEditorJBC , and composed by three outstanding talks by editors and scientists @HenrikDohlman @DrBrianStrahl @KLabGPCR.
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