Studying the fiery science of inflammation from bench to bedside || #inflammation #celldeath #pain || Driven by all members of the lab - Science Hard!Joined April 2021
30+ years after caspases were found to be interleukin-1 converting enzymes (ICE), the first caspase-cytokine structure is revealed. We identify caspase-4 as a specific pro-IL-18 converting enzyme and describe the CryoEM structure of this enzyme-substrate interaction.
Many kids wait months for a viable liver donation. By investigating the molecular mechanisms involved in cell death that can affect organ transplants, #SKResearch in @Nature hopes to increase the pool of suitable donor organs for children & adults.
Read ➡️bit.ly/443gPOQ
So happy to share our #NINJ1 pre-print on Biorxiv reveling NINJ1 rings acting as cookie cutters to mediate plasma membrane rupture. Congrats to all authors @BobbyHollings@LabSteinberg@JazlynBorges
So happy to share our #NINJ1 pre-print on Biorxiv reveling NINJ1 rings acting as cookie cutters to mediate plasma membrane rupture. Congrats to all authors @BobbyHollings@LabSteinberg@JazlynBorges https://t.co/sRde7nnO0Y
We are excited to share NINJ1 structure and mechanism on BioRxiv that suggest NINJ1 dissolves membranes as a "Ninja" cookie cutter to complete lytic cell death. biorxiv.org/content/10.110… by Liron David and Bobby Hollingdworth @LironDavid2@BobbyHollings
Teaching us how to die.
The incomparable Vishva Dixit describes his years-long exploration of cell death, many of which established the field.
Highly recommend.
@dixitvishva@genentechscience.org/doi/10.1126/sc…
Stopping cells from lysing after they die prevents liver disease. Dixit et al describe an antibody that prevents NINJ1 from rupturing dead cells, with therapeutic potential. Kudos to the authors on this important discovery.
@dixitvishva@genentechnature.com/articles/s4158…
3K Followers 4K FollowingProf at Baker, Uni of Melb and Monash Immunology. Research haematopoiesis in cardiovascular disease, obesity, diabetes, inflammatory diseases.
140 Followers 1K FollowingScholar at Sant’Anna School of Advanced Studies @SantAnnaPisa, Med student at @UniPisa, Italy. Amgen Scholar at @Cambridge_uni 2023. He/Him
127 Followers 206 FollowingMD
Aspiring Pediatric Surgeon-Scientist 🧫🔬🥼 Graduate Student (MSc) @UofT @SickKids Toronto and Resident in Pediatric Surgery @UKL_Leipzig
85 Followers 546 FollowingPostdoc @CWRU @CWRUSOM | #cryoEM #cryoET of viral/cellular membrane proteins | 👀 for future in structure based therapeutics | RT ≠ en
469 Followers 570 FollowingLooking at immune cell mechanobiology under the microscope.
Assistant professor, Department of Molecular Biology and Biochemistry @SFU | #newPI #firstgen
4 Followers 55 FollowingPh.D. candidate in molecular inflammation in the MYCOVIR-group at CEMIR @NTNU. Exploring interactions between M.tb. and the complement system in macrophages.
810 Followers 3K FollowingPhD Food Microbiology candidate at UAEU studying the bioactivities, rheology, and impact on gut microbiome of EPS of Lactic Acid Bacteria. Manchester United❤️
314 Followers 211 FollowingPh.D. Candidate in Virology at @harvardmed | Member of @jkagan1 lab at Boston Children's Hospital | Interest in Innate Immunity, Cell Biology, Synthetic Biology
950 Followers 815 FollowingProfessor, Dad, and Cell Biologist who likes to think about lysosomes, phagosomes, and phosphoinositides. For 202x: more books, gym, and games, less TV/internet
844 Followers 447 Following🇮🇪🇺🇸🇨🇦 peds anaesthetist, mitigated sceptic, helpless Arsenal fan, father of 3 awesome little people, views my own @sickkidsnews #olchc #crumlin
422 Followers 123 FollowingProfessor and Director of #CEMIR @NTNUikom @NTNU. Host-pathogen interactions, cell biology, innate immunity, #tuberculosis. Views are my own
229 Followers 2K FollowingPICU professor Escola Paulista Medicina #HEAL_Update Health Science Study Group#LAPSCI #saveseptckids #federalsepsisPICUinvestigators #Brazil
80 Followers 211 FollowingEarly career researcher exploring mammalian cellular uptake pathways and host-pathogen interactions, with a focus on disease mechanisms.
127 Followers 206 FollowingMD
Aspiring Pediatric Surgeon-Scientist 🧫🔬🥼 Graduate Student (MSc) @UofT @SickKids Toronto and Resident in Pediatric Surgery @UKL_Leipzig
5K Followers 173 FollowingAsa and Patricia Springer Professor of Structural Biology @ Harvard Medical School and Boston Children’s Hospital. #immunology #structure_biology
152K Followers 1K FollowingCell Press partners with scientists across all disciplines to publish and share work that will inspire future directions in research. #ScienceThatInspires
314 Followers 211 FollowingPh.D. Candidate in Virology at @harvardmed | Member of @jkagan1 lab at Boston Children's Hospital | Interest in Innate Immunity, Cell Biology, Synthetic Biology
4K Followers 2K FollowingVice Dean, Strategy and Operations, Professor @uoftmedicine. Past President American Pediatric Society, Nephrologist & Senior Scientist @SickKidsNews
106 Followers 76 FollowingCore Facility within the SickKids Research Institute providing #computational expertise, #HPC resources, #Bioinformatics analysis & #MachineLearning consulting
80 Followers 211 FollowingEarly career researcher exploring mammalian cellular uptake pathways and host-pathogen interactions, with a focus on disease mechanisms.
950 Followers 815 FollowingProfessor, Dad, and Cell Biologist who likes to think about lysosomes, phagosomes, and phosphoinositides. For 202x: more books, gym, and games, less TV/internet
844 Followers 447 Following🇮🇪🇺🇸🇨🇦 peds anaesthetist, mitigated sceptic, helpless Arsenal fan, father of 3 awesome little people, views my own @sickkidsnews #olchc #crumlin
422 Followers 123 FollowingProfessor and Director of #CEMIR @NTNUikom @NTNU. Host-pathogen interactions, cell biology, innate immunity, #tuberculosis. Views are my own
2K Followers 332 FollowingProf. Petr Broz lab @unil Innate Immunity Host-pathogen interaction #inflammasome #celldeath Account run by lab members. RT is not endorsement.
3K Followers 74 FollowingVishva Dixit has made many contributions to biomedicine and his early work on apoptosis is prominent in introductory textbooks of Biology.
748 Followers 322 FollowingThe Department of Anesthesia and Pain Medicine at The Hospital for Sick Children @SickKidsNews @UofTanesthesia #PedsAnes #PedsPain
417 Followers 205 FollowingStudying Pulmonary Hypertension, Inflammation, and Cell Death | Dr. Neil Goldenberg @SickKidsNews @SKAnesthesia @UofTAnesthesia @PhysiologyUofT