Lodgepole Discovery @LodgepoleDisc

High velocity computational and wet-lab services for high performing pharmaceutical and biotechnology teams. Contact us. wwwlodgepolediscovery.com Aurora, Colorado Joined October 2026

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Michael - Protein Thx and Biologics @biocheMichael

10 hours ago

Unboxed my custom MacBook Pro 128 gb and deployed the company brain to it. Claude Code has been really grinding my gears lately. I have to go back to 4.7 to get normal antibody work done. So basically I have to roll back 6-8 months in terms of model quality. This is unacceptable to me considering I pay for a Max subscription. So I’m going to try and go 90%++ local. This is my fully local v0 solution stack to [bio] flags in Claude Code Grok Harness over GLM4.7 pointed at the repo with real tool calling, auto mode, artifact generation, and auto memory. Fed the Claude md to it so we aren’t starting over. Web app TUI supported by Tailscale and Redis so we can authenticate users, brick lost devices, and queue work. And best of all, no bio classifier stopping me

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Lodgepole Discovery @LodgepoleDisc

3 days ago

Let us engineer the cell line for your next minibinder potency assay! Why stop at SPR? There is a lot of ground between SPR and patch clamp electrophysiology assays!

Michael - Protein Thx and Biologics @biocheMichael

3 days ago

You do not need to go straight to patch clamps. Come to Lodgepole Discovery and we will engineer a cell line and test the potency using a Nav1.6 and Cn2 +\- your minibinders in a cell-ELISA. The co-crystal was just solved. Does your minibinder bind to the same epitope as

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Michael - Protein Thx and Biologics @biocheMichael

3 days ago

Proteins in the soluble fraction after lysis Green flags on the first runs! Antigen 1 and 2 scale up expression tomorrow Purify this week on the Go. Assays next week

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Michael - Protein Thx and Biologics @biocheMichael

6 days ago

Lodgepole Discovery (@LodgepoleDisc) is an end to end discovery partner for biotech and Pharma. First set of transformations look great. It’s like riding a bike, after thousands of these in grad school and my post doc it felt so good to just whip this up without much thought or effort. BL21 DE3 for expression under the Lac operon DH5a for high copy DNA replication and isolation Tomorrow overnight cultures Monday we express and miniprep Tuesday purify and by end of week we are cooking up plate assays. You can always tell the strains apart by their colony size. It may look like the DH5s have not grown well but they always have smaller colonies. @LodgepoleDisc

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Lodgepole Discovery @LodgepoleDisc

a week ago

We are live and accepting new customers. Pharma grade Binder design -> Lab testing The team includes ex Regeneron, ex Ginko, and ex Sartorius scientists. We are protein biochemists and cell biologists on a mission. We move fast. Let’s get on a call.

Michael - Protein Thx and Biologics @biocheMichael

a week ago

I’ve spent >>$100k of my own money building this. End to end lab capabilities coming online to support discovery research. New lab space with significantly more bench space. Molecular biology: cloning, libraries, subcloning, mutagenesis Protein expression: E. coli, CHO,

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Lodgepole Discovery @LodgepoleDisc

2 weeks ago

We can be your end to end discovery partner: Design Make Test Iterate, Faster. Contact us today for a discovery call.

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Lodgepole Discovery @LodgepoleDisc

3 weeks ago

Design it. Express it. Purify it. Characterize it. Iterate faster. lodgepolediscovery.com

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Lodgepole Discovery @LodgepoleDisc

3 weeks ago

Lodgepole operates at the intersection of computational protein engineering, automation, and laboratory science; giving clients a single partner for both in silico discovery and hands-on experimental work.