OpenCellCZB @OpenCellCZB

OpenCell is a collaborative proteome-scale project to measure human protein localizations and interactions led by the @LeonettiManuel lab @czbiohub opencell.czbiohub.org San Francisco, CA Joined March 2021

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Marco Hein @marcoyannic.bsky.social @marcoyannic

4 years ago

One of the super useful features of the opencell.czbiohub.org website is that you can look up the cellular copy numbers and concentrations of your favorite proteins - check it out! (even for proteins that aren't among our targets or their interactors)

Manuel Leonetti @LeonettiManuel

4 years ago

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elevyLab @ElevyLab

4 years ago

Check our perspective on the @OpenCellCZB awesome work from @LeonettiManuel "Modules" help interpret biological systems. However, we see in these new data that connectors far outweigh modules in PPI networks! What does that mean? We discuss it: science.org/doi/10.1126/sc…

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Manuel Leonetti @LeonettiManuel

4 years ago

Our paper is out today in @ScienceMagazine, I’m stoked @OpenCellCZB ! Check out opencell.czbiohub.org: CRISPR tagging + 3D live imaging + IP mass spec to map the human proteome. science.org/doi/10.1126/sc… 👇 tweetorial from our 2021 pre-print.

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Chan Zuckerberg Biohub Network @czbiohub

4 years ago

Published today in Science, a team from CZ Biohub and @MPI_Biochem combined genome engineering, confocal live-cell imaging, mass spectrometry, and data science to systematically map the localization and interactions of human proteins. 🧵 science.org/doi/10.1126/sc…

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Meagan Phelan @MeaganPhelan

4 years ago

.#OpenCell from @czbiohub -- results from which are published in @ScienceMagazine today -- is mapping cells one protein at a time, paving a new way to visualize cellular architecture. science.org/doi/full/10.11…. Video: youtube.com/watch?v=6j4fpV…

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OpenCellCZB @OpenCellCZB

4 years ago

Excited to see this update! Cytoself enabled us to quantitatively compare our IP/MS interaction data with our microscopy images (spoiler alert: we showed that if proteins in our library share similar localization patterns, they are more likely than not to directly interact!)

Hirofumi Kobayashi @liilii_tweet

4 years ago

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Chan Zuckerberg Biohub Network @czbiohub

5 years ago

Cellular life is amazingly complex. To find cures for diseases, we must understand the molecular details of how cells and their proteins operate. Visit our new OpenCell website and interactively explore the localization and interactions of human proteins:opencell.czbiohub.org

Manuel Leonetti @LeonettiManuel

5 years ago

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OpenCellCZB @OpenCellCZB

5 years ago

Our first release is live! 🚀 A collaborative effort led by @LeonettiManuel with @labs_mann and @loicaroyer and many others at @czbiohub to build an open-source map of the human proteome. Check it out and let us know what you think! opencell.czbiohub.org