BLOG: As #AntibioticResistance spreads, NIAID-supported researchers are studying new ways of using older antibiotics to treat #bacterial infections. In a new study, researchers from @DukeU are testing the safety of #fosfomycin when delivered via IV. bit.ly/Fosfomycin
Just had coffee with a friend and biotech CEO. They’re moving operations out of the Bay Area and California entirely, decamping for sites back East, eg RTP.
It’s gotten to the point where you have to be a Pharma or enjoy setting cash on fire to operate a lab in the Bay Area.
#Biotech companies raised $16.8 billion in #venturecapital in 2018 compared to $12.1 billion in 2017. Additionally, the average amount per round of financing was 42 percent more than in 2017.
fiercebiotech.com/special-report…
Fascinating paper on changes in levels of mGlu5 in PTSD linked to suicidal thoughts. Potential biomarker and pathway for treatment. pnas.org/content/early/…
Fierce competition among biosimilar manufacturers in China, India and South Korea means they are outcompting Western biosimilar manufacturers in low-income markets go.nature.com/2PWYnmd
Antibiotic mechanisms are revealed by a white-box machine-learning approach that integrates biochemical screening and metabolic network modeling. #NBThighlightbit.ly/2HcX4eV
BLOG: NIAID scientists have discovered how tissue protects 💪 itself from damage by unwanted #inflammation in response to a small, innocuous injury, such as the death of a single cell: bit.ly/MacrophageCloa…
“Everyone agrees that there is an absolute need for new antibiotics but there is no sustainable market,” @IFPMA’s Thomas Cueni warns on the growing threat of antimicrobial resistance. buff.ly/2LeTpmf
.@deevybee urges researchers to rein in the four horsemen of the reproducibility apocalypse: publication bias, low statistical power, P-value hacking and HARKing. go.nature.com/2L0zWpr
Two new studies report the first cryo-EM structures of a GABAA receptor in a physiological conformation and in complex with various drugs. These structures could provide the basis for future structure-based drug discovery. go.nature.com/2QD9wY7@RaduAricescu and @MRC_LMB
Researchers develop a method to investigate how bacteria respond to starvation and to identify which proteins bind to the “magic spot” — ppGpp. Explore in 3D at RCSB PDB: rcsb.org/structure/6CZFnews.mit.edu/2018/mit-biolo…
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