Santhosh Ambika @RenoHemonc
Oncologist/Hematologist- Doing my part to help onc patients. + fintwit Reno, NV Joined November 2016-
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Santhosh Ambika retweeted
🚨 #ESMO25 | Lung Cancer Updates 🚨 Top 10 new molecules shaping the future of #NSCLC & #SCLC 👇 🧬 EGFR × HER3 bispecifics 🧬 DLL3 & T-cell engagers 🧬 Next-gen KRAS & EGFR TKIs 🧬 ADCs with intracranial activity 🧬 Novel IO combos (TLR7/8, KEYMAKER) #OncoTwitter #ESMO2025…
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Santhosh Ambika retweeted
My Top 10 Lung Cancer Abstracts list at #ESMO25 👇
Santhosh Ambika retweeted
Dr Fernando Fervenza on Management of Monoclonal gammopathy of renal significance Why is it so hard to detect clone in PGNMID? Does a clone really exist here? Interesting discussion @GlomCon #GlomConHawaii
Santhosh Ambika retweeted
Case series of tumor lysis syndrome with the bispecific T-cell engager tarlatamab in patients with small cell lung cancer @ClinicalLung. I have not seen this myself, but for various reasons, tarlatamab in #SCLC could be better with lower disease burden. clinical-lung-cancer.com/article/S1525-…
Santhosh Ambika retweeted
There have been several key advances in the past year regarding CAR T-cell immunotherapy in neuro-oncology. 🧠 @StanfordNsurg researchers highlight some significant recent advances: acsjournals.onlinelibrary.wiley.com/doi/10.1002/cn… @OncoAlert @Ravi_Medikonda1 @Matthewabii @Ethan_Schonfeld @MichaelLimMD
Santhosh Ambika retweeted
Looks like a terrific #ESMO25 coming up for $RHHBY: Imbrave-152, Skyscraper-03 (both late-breakers), Skyscaper-07 & Skyscraper-09 all being presented!
Santhosh Ambika retweeted
🧵 DDX41 & Allo-HSCT Outcomes 1️⃣ Patients with deleterious germline DDX41 variants face 🚨 higher risk of severe acute GVHD post-allo-SCT compared to other germline mutations or sporadic cases 2️⃣ Severe aGVHD (stage 3–4): •DDX41: ~38% •CHEK2: 0% •Other HHM: 12% •No HHM: 9%…
Santhosh Ambika retweeted
The 2025 LBCL Guidelines are out ! Fantastic work made by the @EHA_Hematology Cc @c_thieblemont doi.org/10.1002/hem3.7…
Santhosh Ambika retweeted
🧪 Real-world study in uHCC (n=452) 1L 💉 Atezo/Bev vs Durva/Treme → no OS/TTD diff 📊 Median OS ~14m both arms (p=0.66) ⏳ TTD: 4.9m vs 3.9m (p=0.42) ⚖️ Prognosis by Child-Pugh (CP): 🅰️ 19m | 🅱️7 6.1m | 🅱️8/9 5.1m | 🇨 2.0m ➡️ CP class = key prognostic factor 🔗…
Santhosh Ambika retweeted
177Lu-PSMA vs. cabazitaxel in patients with castration-resistant prostate cancer: Real-world efficacy and safety data from the ARON-3 study ejcancer.com/article/S0959-… In this large real-world study(n=568), patients with metastatic castration-resistant #ProstateCancer treated with…
Santhosh Ambika retweeted
Santhosh Ambika retweeted
🚨 New data on asciminib in relapsed/refractory Ph+ ALL & lymphoid blast crisis CML (LBC-CML)! #leusm #ALL Published in Blood Advances (July 2025): doi.org/10.1182/blooda… 1) Dose 200 mg BID 2) 93% previously on ponatinib 27/35 had BCR::ABL1 mutations • 18 with T315I • 8…
Santhosh Ambika retweeted
Looks like #ESMO25 will be amazing for Urologic Oncology, 4 presentations in Presidential Symposium!! Can’t wait to see the data!!
Santhosh Ambika retweeted
Santhosh Ambika retweeted
🧠 APS 2023 Criteria – What’s New? 🔑 Entry Criteria (NEW!) ✅ Clinical event (thrombosis OR pregnancy morbidity) ✅ ≥1 aPL positive within 3 yrs of event 🧪 📊 Weighted Scoring System (NEW!) Each lab + clinical feature gets points → ≥3 = classify APS 🔬 Lab Updates • LAC…
Santhosh Ambika retweeted
🔬 In LS-SCLC, ctDNA status after induction chemo stratifies who benefits from consolidation IO. 🧬 ctDNA(+) → dramatic PFS/OS gain with IO ❌ ctDNA(–) → minimal added benefit Toward biomarker-driven #Immunotherapy & de-escalation. #Oncology #ctDNA #SCLC
Santhosh Ambika retweeted
My Top 10 Breast Cancer Abstracts list at #ESMO25 👇
Santhosh Ambika retweeted
🚀 Proton therapy has long strived for a solid role in oncology. Now, high-quality evidence is emerging. A randomized phase II trial in JAMA Oncology shows proton craniospinal irradiation (pCSI) significantly improves CNS PFS (8.2 vs 2.3 mo) and OS (11.3 vs 4.9 mo) compared…
Santhosh Ambika retweeted
Santhosh Ambika retweeted
What happens if you conjugate the most effective obesity drug (a triple GLP1/GCG/GIP-R agonist) to a potent cholesterol drug (a PCSK9 mAb) – so they're together in the same molecule? We're about to find out...
What happens if you conjugate the most effective obesity drug (a triple GLP1/GCG/GIP-R agonist) to a potent cholesterol drug (a PCSK9 mAb) – so they're together in the same molecule? We're about to find out...
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