Thrilled to announce the release of our new preprint. Here we show how fast synaptic inhibition adapts to the level of cortical activity and demonstrate why this could be an important feature of how cortical networks process information. biorxiv.org/content/10.110…
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By establishing in vivo perforated patch-clamp recordings and combining the results with computational modelling, we hope to bring a new perspective on how fast GABA-A receptor-mediated synaptic inhibition operates in the cortex.
@RichBur Amazing. Out of curiosity, what's the success rate for a perf patch recording in awake?