Patrick Salisbury @SalisburyNotes

@kate_rouch This is so correct, so ridiculous and so changeable today! There is a better way to approach cancer care and trial/approvals with the sequencing technologies and llm models now available.

What accessing frontier cancer care looks like in 2026: -Go through 1-2 years of standard of care (poison/slash/burn - original poster forgot radiation and hormone suppression). You’re only a good candidate for a vaccine if you are cancer free or have minimal residual disease. -Hire PhDs / Lawyers to fight with your hospital for your tumor tissue, which is likely stored in a way that makes sequencing it hard / impossible -Pay $50K+ to sequence your tumor tissue -Pay $1M+ for a custom immunotherapy / vaccine with no efficacy or safety info -Find an oncologist and medical setting to sponsor this plan, the biotechs that made you the drug can’t administer it and you’ve likely alienated your actual oncologist by now -Hire lawyers: Petition the FDA for an n-1 clinical trial or relocate to Germany (or maybe Montana) to take vaccine series -Take the series. You won’t actually know if it worked (no data) so you monitor all your markers constantly with ctDNA and other testing to search more therapies and to see if the vaccine activated your immune system and worked. There’s a lot of promise here and people who can access frontier cancer care are so fortunate. Every cancer patient wants every chance they can get. But it’s bs to say we’ve solved cancer in 2026.

Mgoes (bio/acc 🤖💉) @m_goes_distance

2 months ago

cancer treatment in 2025: find the tumor, cut it out, poison the rest with chemo, hope the patient survives cancer treatment in 2026: sequence the tumor's DNA, identify the exact mutations driving it, design a treatment built around those mutations specifically, train the

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Man can’t get the drug for brain cancer that might save his life in time because the ethics board at his hospital only meets once a month. Is anyone checking the ethics board for whether stuff like this is behaving ethically?

@RuxandraTeslo @nytimes Thank you @RuxandraTeslo for taking the time to tell our story so thoughtfully

Thank you, @RuxandraTeslo, for telling this story—and for working to improve treatment access and drug development for all patients. We are entering an era of personalized medicine that will transform cancer care, but our regulatory frameworks were not built for it. Will we slow it down, or lead?

Ruxandra Teslo 🧬 @RuxandraTeslo

2 months ago

We are on the cusp of a wave of new therapies for some of the worst diseases. But the world won’t benefit unless the US fixes its drug regulatory system. My new essay for @nytimes, on how slow clinical trials are now the biggest obstacle to curing cancer. nytimes.com/2026/09/04/opi…

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