Siddhavinayak Rajmane @SiddhvinayakR
Nephrons Mumbai, India Joined February 2022-
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Immune checkpoint inhibitor–associated nephritis —treatment standard 🆓doi.org/10.1093/ndt/gf…
Much needed practical guidelines
Much needed practical guidelines
📢 New in CJASN: pooled analysis of all completed phase 2/3 RCTs in #IgAN 🔹 4 drug classes (steroids, B-cell, complement, non-immunological) 🔹 All ↓ proteinuria ≥30% 🔹 All improved GFR slope 🔹 Biggest benefit: B-cell therapies journals.lww.com/cjasn/abstract…
Managing #Hypertension in #CKD 📊eGFR ≥30: ACEi/ARB+ CCB +T/TL diuretic → add MRA/BB/others if resistant 📊eGFR <30, not dialysis: ACEi/ARB + CCB+ Loop diuretic→ add chlorthalidone/BB/others if resistant ⚡SGLT2i & finerenone as approved 🔗 doi.org/10.1093/ckj/sf… #HTN
The role of the intestinal microbiome in cognitive decline in patients with kidney disease doi.org/10.1093/ndt/gf…
New dietary and pharmacological interventions to limit intestinal phosphorus absorption could be game-changing for patients with CKD seeking a more individualized approach. kidney.pub/KN1708-16 kidney.pub/KN-lifestyle #ASNKidneyNews
🧬 IgA Nephropathy: 4 pathogenic hits, 1 evolving story! 🎯 From B-cell targeting to complement inhibition & novel agents against proteinuria—precision therapies are reshaping outcomes 💊🌟 🔗 doi.org/10.1093/ndt/gf… @NDTsocial #IgAN #Nephrology #GlomerularDisease #CKD #MedX
🫘🙌New promising nephroprotective drugs for CKD doi.org/10.1093/ndt/gf… @NDTsocial @hjanders_hans
Selective endothelin A receptor antagonism in chronic kidney disease: improving clinical application 🔓doi.org/10.1093/ndt/gf…
Proposed update to current treatment paradigm for dysregulated vitamin D metabolism in CKD ca. 2025 from @asnpublications #Nephpearls #CKDMBD 👉 pubmed.ncbi.nlm.nih.gov/40857105/
Combination therapy: an upcoming paradigm to improve kidney and cardiovascular outcomes in chronic kidney disease 🔓doi.org/10.1093/ndt/gf…
Upcoming drug targets for kidney protective effects in chronic kidney disease ➡️This review describes the new and promising treatments for CKD. These therapies hold the potential to slow kidney disease and improve the wellbeing of patients. 🔓doi.org/10.1093/ndt/gf…
🆕🆕 what’s new in Nephrotic Syndrome??? ✅Anti Nephrin/anti-podocin & anti-Kirrel1 antibodies for diagnosis and precision management academic.oup.com/ndt/advance-ar… @NDTsocial @hjanders_hans
Sjögren’s = 5 S’s, but always say GRACIAS before you diagnose ✅ 5 S’s (Inclusion): Salivary biopsy | Serology | Staining | Salivary flow | Schirmer’s ❌ GRACIAS (Exclusion): GvHD | Radiation | AIDS | HCV | IgG4 | Amyloid | Sarcoid 🧠 Easy, elegant, exam-ready. #MedTwitter…
🩸Etiology of Anemia post kidney transplantation doi.org/10.1093/ckj/sf… @CKJsocial
Anti-nephrin, anti-podocin and anti-Kirrel1 antibodies: Biological challenges and clinical implications 🔓doi.org/10.1093/ndt/gf…
The latest 2025 #Hypertension Guidelines are out 📣 #Nephpearls 📌 Use of risk-based thresholds for initiation of BP treatment 📌 BP thresholds and recommendations for treatment and follow-up 📌 Screening for features suggesting secondary hypertension 👉🏼…
Propuesta sobre el manejo de fluidos en personas con sepsis y lesión renal aguda. Esencialmente, nada nuevo. J Crit Care 2025 doi.org/10.1016/j.jcrc…
Now open access in @NDTsocial Anti-nephrin, anti-podocin and anti-Kirrel1 antibodies: Biological challenges and clinical implications 🧐 Clinical implementation of anti-slit diaphragm antibody testing = precision dx and tx in podocytopathies ▶️academic.oup.com/ndt/article/do…
@sciqst @SciReports Reposted with correct ✅ first page Urine sodium (Urine Na) levels post-saline infusion in differentiating non-edematous hyponatremia ca. 2025 from @SciReports #Nephpearls 📌 Administering a saline infusion before measuring Urine Na may improve diagnostic accuracy by…
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