Stephan Hammer @Stephan_Hammer
biocatalysis, organic synthesis & directed evolution @unibielefeld @CeBiTec uni-bielefeld.de/stephan-hammer Joined October 2016-
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Molecular Basis for Chemoselectivity Control in Oxidations of Internal Aryl-Alkenes Catalyzed by Laboratory Evolved P450s (S. C. Hammer, M. Garcia-Borras et al.) @Stephan_Hammer, @MarcGBQ, @IQCCUdG, @UdGRecerca #openaccess onlinelibrary.wiley.com/doi/10.1002/cb…
🙏 for the highlight! @ChemEurope
🙏 for the highlight! @ChemEurope
Join us! We are looking for a new team member (PhD student) with strong background in organic chemistry. Organic chemistry meets #DirectedEvolution Highly interdisciplinary & passionate research group 🙏RETWEET (We want to recruit internationally) uni-bielefeld.hr4you.org/job/view/3249/…
🙏 for the highlight @ChemBioChem @KaiSchuelke @MarcGBQ
🙏 for the highlight @ChemBioChem @KaiSchuelke @MarcGBQ
Orders of magnitude higher activity, for multiple substrate, in a single enzyme engineering step? Efficient transferase engineering for SAM analog synthesis ... towards selective alkylation with engineered enzymes @KaiSchuelke @MarcGBQ #FOR5596 doi.org/10.1002/cbic.2…
Controlling carbocation rearrangements with a catalyst can be very challenging. Find out now in @angew_chem how engineered enzymes control the acid-catalyzed isomerization of pinene. onlinelibrary.wiley.com/doi/abs/10.100…
Great collection! Our article was collaborative work with @Stephan_Hammer and @EnzymeNicoCorn.
Great collection! Our article was collaborative work with @Stephan_Hammer and @EnzymeNicoCorn.
Our research unit "Exploiting the potential of S-adenosylmethionine-dependent enzyme chemistry" #FOR5596 led by @andexerlab will be funded by @dfg_public. Looking forward to work with @Stephan_Hammer, @SeebeckLab, @barra_lena, @BORRAS & X-less colleagues. dfg.de/en/service/pre…
Happy to see our latest work highlighted in Synfacts. Thank you @thiemechemistry and @ListLaboratory thieme-connect.com/products/ejour…
Another new #cytochromeP450 function! With #enzymes and #directedevolution, and some very clever intuition and analysis, we can push the #chemistry of the biological world into whole new and useful realms. Congrats @Stephan_Hammer and @MarcGBQ .
Another new #cytochromeP450 function! With #enzymes and #directedevolution, and some very clever intuition and analysis, we can push the #chemistry of the biological world into whole new and useful realms. Congrats @Stephan_Hammer and @MarcGBQ .
Enzymes for aerobic arylalkene to ketone oxidation now in @NatureCatalysis. Incl. #directedevolution, detailed mechanistic studies, carbocations, protein dynamics and application in synthesis. Great teamwork with @MarcGBQ @unibielefeld @IQCCUdG @CeBiTec nature.com/articles/s4192…
Please to share this collaborative work with the @Stephan_Hammer and @EnzymeNicoCorn. We directly compare a halide methyltransferase (HMT) and a methionine adenosyltransferase (MAT) to access SAM analogues and explore their utility in cascade reactions with methyltransferases.
Please to share this collaborative work with the @Stephan_Hammer and @EnzymeNicoCorn. We directly compare a halide methyltransferase (HMT) and a methionine adenosyltransferase (MAT) to access SAM analogues and explore their utility in cascade reactions with methyltransferases.
We are hiring a postdoc to work with us on an exciting research project in collaboration with BASF SE. #biocatalysis #proteinengineering 🙏 retweet uni-bielefeld.hr4you.org/job/view/2329/…
Please check out these alkene methylations to modify natural terpenes (using an engineered enzyme). Now in @angew_chem onlinelibrary.wiley.com/doi/10.1002/an…
Very cool!
Wow, new work from @Stephan_Hammer. #enzymes #directedevolution!
Wow, new work from @Stephan_Hammer. #enzymes #directedevolution!
Chiral alcohols from simple alkenes and water? See our newest work now in @angew_chem. Directed evolution of a styrene hydratase. Huge congrats 🎉 to Matúš Gajdoš, @PipeOspi and team. Thanks to Martin Engqvist #directedevolution @CeBiTec onlinelibrary.wiley.com/doi/10.1002/an…
Thanks for the highlight and the support. This is work mainly from @KaiSchuelke and @PipeOspi
Thanks for the highlight and the support. This is work mainly from @KaiSchuelke and @PipeOspi
Selective Biocatalytic N-Methylation of Unsaturated Heterocycles (Hammer) @MarcGBQ @Stephan_Hammer #openaccess thanks to #projektDEAL onlinelibrary.wiley.com/doi/10.1002/an…
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338 Followers 423 Following Deciphering and building metabolic pathways since 2016
@Stephan_Hammer Thanks, Stephan! Also congratulations on your new HMT paper! We studied it and thoroughly enjoyed it
We publish our second paper on pyridoxal biocatalysis in Nature: We repurposed PLP-dependent threonine aldolases to catalyze radical C-C coupling reactions that are not known in either organic chemistry or enzymology: nature.com/articles/s4158…
Molecular Basis for Chemoselectivity Control in Oxidations of Internal Aryl-Alkenes Catalyzed by Laboratory Evolved P450s (S. C. Hammer, M. Garcia-Borras et al.) @Stephan_Hammer, @MarcGBQ, @IQCCUdG, @UdGRecerca #openaccess onlinelibrary.wiley.com/doi/10.1002/cb…
Congrats to the team & especially the senior authors @SebBarthel and Luca Brenker. I hope Nicole is not too sad about the LC-MS bashing (: @erblabs @simone_giaveri @nitinbohra3
I am very happy to share our pre-print on the prototyping of a complex enzyme cascade (the CETCH cycle) using in vitro transcription-based (ROSALIND) biosensors. Thanks to everybody involved. We are looking forward to your feedback! @erblabs doi.org/10.1101/2024.0…
Previously @ChemRxiv, the final version of this study is now out in @NatureComms. doi.org/10.1038/s41467… This naturally occurring "non-native" nucleoside has been sitting right under noses for a long time.
So ... the natural purine nucleosides are NOT all N9-ribosides? doi.org/10.26434/chemr…
A unique cuticular hydrocarbon from the springtail Heteromurus nitidus. This new terpene type, a prenylated geranylated diterpene, highlights differences between Collembola and more advanced insects. See our article in J Nat Prod. doi.org/10.1021/acs.jn…
Our paper on evolved nonheme Fe enzyme ACCO for stereoselective fluorine atom transfer is online at Nature Synthesis: nature.com/articles/s4416…
Check out our last work, in collaboration with Sarah Barry, on CFAS enzymes for stereoselective cyclopropane synthesis! #biocatalysis @UCLChemistry #sustainablechemistry onlinelibrary.wiley.com/doi/abs/10.100…
So happy to see this work finally out after a long journey! @UCLChemistry @UCLEast
Check out our last work, in collaboration with Sarah Barry, on CFAS enzymes for stereoselective cyclopropane synthesis! #biocatalysis @UCLChemistry #sustainablechemistry onlinelibrary.wiley.com/doi/abs/10.100…
I am deeply grateful to @dreyfusfndn for this esteemed recognition. My sincere thanks to all current and former members of our team for their dedication and hard work, which have made this possible.
Congratulations to Dr. Xiongyi Huang (@xiongyih), @JohnsHopkins, for being named a 2024 Camille Dreyfus Teacher-Scholar! @JHUChemistry #DreyfusAwards
Our second paper on the excited flavoproteins triggered single-electron transfer biocatalysis is online @angew_chem, please check out onlinelibrary.wiley.com/doi/abs/10.100…
We are looking for two #postdocs to join us: 1) @ERC_Research funded position in the context of RNA origami, cryoEM, synthetic cells, directed evolution; 2) A position in the excellence cluster @Cluster3DMM2O at the interface of chemistry & biology. Please share and get in touch!
Happy to share the final version of our work describing computational filters for selecting functional ML-generated enzymes in @NatureBiotech! This was a distributed and remote collab with @TrichomeDoctor @Xiaozhi_Fu and other members of @AZelezniak's group. Global Science!
Our computational filter for enriching functional AI-generated enzymes is finally out. nature.com/articles/s4158… Many thanks to @TrichomeDoctor @KevinKaichuang @Xiaozhi_Fu et al. for the fantastic collaboration!
Take a look at our latest work just published in @NatureCatalysis . We have developed a general platform for the desaturative synthesis of aminated heteroaromatics. nature.com/articles/s4192…
We would like to congratulate @HagedoornLeon and @Caroline_E_Paul on their recent appointments as associate professor @tudelft
Super happy to receive this award 🎉! Huge thanks to my wonderful group, the selection committee and the supportive environment @EuroMedChem @NCCR_Catalysis @ZHAW Looking forward to presenting our science at the EFMC-ISMC conference in Rome! efmc.info/prizes
Our Pick of the Week, published #OpenAccess in @ChemBioChem by @MarcGBQ, @KaiSchuelke, @Stephan_Hammer and team at @unibielefeld: "Efficient Transferase Engineering for SAM Analog Synthesis from Iodoalkanes" ow.ly/m1te50Rinso
Efficient Transferase Engineering for SAM Analog Synthesis from Iodoalkanes (Stephan C. Hammer et al.) @Stephan_Hammer #openaccess onlinelibrary.wiley.com/doi/10.1002/cb…
We have a PhD position opening for a candidate with demonstrated experience in electrochemistry. We are aiming to immobilize various metalloenzymes for small molecule activation. See for example: pubs.acs.org/doi/ful
A comprehensive guide to asymmetric radical chemistry in EREDs, from postdoc alum Dr. Haigen Fu (now professor at the Institute of Medical Biotechnology, Chinese Academy of Medical Sciences)! Out now in Acc. Chem. Res. @ACSPublications. Congrats, Haigen! pubs.acs.org/doi/full/10.10…
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