Yungan TAO @YG_TAO
Radiation Oncologist, Gustave Roussy Cancer Campus President-Elect GORTEC - French Head and Neck Oncology Radiotherapy Group Paris Joined October 2016-
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📰 Les dernières avancées dans le traitement des cancers ORL. Du 15 au 20 septembre, la campagne « Make-Sense, Prendre le cancer à la gorge » se déploie sur différents canaux pour sensibiliser aux cancers ORL, qui touchent chaque année 15 000 nouveaux patients en France. À…
🧪#ASCO2025 In-Depth! Dr @YG_TAO on KEYNOTE-412: ✔️ Pembro + CRT: 5y EFS 55% vs 47% ✔️CPS ≥20 = best results 🎥 Watch now bit.ly/4mLvOXR #MediMix #HNSCC #PDL1 #ImmunoCRT
Pembrolizumab (before surgery and during post-operative radiotherapy + after RT) approved in CPS>=1 resectable LA-HNSCC fda.gov/drugs/resource…
Hot of the press @IJROBP: Role of SABR in oligometastatic head and neck cancer: a GORTEC randomized trial Full text here: doi.org/10.1016/j.ijro…
GORTEC announces that the NIVOPOSTOP study (NCT03576417) met its primary endpoint of Disease-Free survival (DFS) across all comers high risk resected HNSCC. Combined with KN689 this represents the 2nd positive IO trial in the postop setting. prnewswire.com/news-releases/…
GORTEC announces that the NIVOPOSTOP study (NCT03576417) met its primary endpoint of Disease-Free survival (DFS) across all comers high risk resected HNSCC. Combined with KN689 this represents the 2nd positive IO trial in the postop setting. prnewswire.com/news-releases/…
Honored to contribute as co-PI to our Phase 3 trial NIVOPOSTOP GORTEC 2018-01 evaluating nivolumab in addition to post-operative concurrent CRT for resected HR LAHNSCC pts, which met its primary endpoint of DFS across all comers. @PBlanchardMD @GustaveRoussy
Why are Western pharmaCos licensing so many Chinese drugs lately? Is China going to do all our drug discovery in the future? My thoughts in a new post. This post has languished in drafts for a while, but the Merck+Hansoh deal motivated me to finish it up atelfo.github.io/2024/12/20/wil…
KN689 is the 1st +ve trial IO (+surgery -RT) in LA-HNSCC, neoadjuvant role PD-1 probably essential, but we should not ignore CONCOMITANT use of pembro during post-OP (C)RT. Waiting for GORTEC Nivo-postOP results to clarify definitely neoadjuvant role.
KN689 is the 1st +ve trial IO (+surgery -RT) in LA-HNSCC, neoadjuvant role PD-1 probably essential, but we should not ignore CONCOMITANT use of pembro during post-OP (C)RT. Waiting for GORTEC Nivo-postOP results to clarify definitely neoadjuvant role.
KN689 positive, Neoadjuvant pembrolizumab 2 cycles before surgery improved EFS compared to surgery in LA-HNSCC! @PBlanchardMD @DrMLChua
Toripalimab, anti-PD-1 of TopAlliance finally approved by EMA for 1L R/M nasophayrgeal cancer and also 1L esophageal SCC. @PBlanchardMD @DrMLChua
Wrapped another great interview with @YG_TAO of @GustaveRoussy who walked us through data from the final analysis of the phase 3 GORTEC 2017-01 REACH trial of avelumab plus cetuximab/RT vs SOCs in patients with LA-SCCHN. More from @myESMO #ESMO24 here: onclive.com/conference/esm…
Thank you @DrMLChua , surely synergy Avelumab+cetuximab on distant control, and a little + tox during RT. Difficult to say no synergy anti-PD-1 (PD-L1) + cDDP, waiting for long-term outcome KeyNote-412 next ASCO. Still KeyNote-689 and GORTEC 2018-01 Nivo-postOP very soon
Thank you @DrMLChua , surely synergy Avelumab+cetuximab on distant control, and a little + tox during RT. Difficult to say no synergy anti-PD-1 (PD-L1) + cDDP, waiting for long-term outcome KeyNote-412 next ASCO. Still KeyNote-689 and GORTEC 2018-01 Nivo-postOP very soon
Innovative GORTEC trial at #ESMO2024: prophylactic neck #radiotherapy replaced by IO durvalumab. Low rate of neck relapse BUT frail population with high toxicity and lots of early death (may have underestimated the true risk of nodal relapse). Congrats @JoelCastelli & team
OS result of keynote A18 confirmed the benefit of pembrolizumab when combining with concurrent chemo- radiotherapy, in contrast to our negative results of IO + RT in HNSCC @PBlanchardMD @DrMLChua
Big PFS gain with HR 0.51 in favor of Ivonescimab (AK112) vs Pembro 1L NSCLC compared with HR 0.78 in LEAP-007 Pembrolizumab +/- Lenvatinib, could we expect OS gain? Hope AK112 also in HNSCC @PBlanchardMD
Big PFS gain with HR 0.51 in favor of Ivonescimab (AK112) vs Pembro 1L NSCLC compared with HR 0.78 in LEAP-007 Pembrolizumab +/- Lenvatinib, could we expect OS gain? Hope AK112 also in HNSCC @PBlanchardMD
Another disappointing result of combination IO and RT, even with SBRT... While huge benefit in phase 2 trial. Similar situation as Trilynx with IAPi in LA-HNSCC. @PBlanchardMD @BenjaminBesseMD
Another disappointing result of combination IO and RT, even with SBRT... While huge benefit in phase 2 trial. Similar situation as Trilynx with IAPi in LA-HNSCC. @PBlanchardMD @BenjaminBesseMD
Totally agree, OS similar, it is possible to use the osimertinib later without OS loss.
Totally agree, OS similar, it is possible to use the osimertinib later without OS loss.
Bispecific PD-1/VEGF antibody Ivonescimab (AK112) showed better PFS than pembrolizumab in 1L NSCLC TPS>=1, first head-to-head trial vs anti-PD-1 ICI, waiting for OS result. Trial with AK112 in HNSCC expected. @dplanchard @PBlanchardMD
Bispecific PD-1/VEGF antibody Ivonescimab (AK112) showed better PFS than pembrolizumab in 1L NSCLC TPS>=1, first head-to-head trial vs anti-PD-1 ICI, waiting for OS result. Trial with AK112 in HNSCC expected. @dplanchard @PBlanchardMD
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