Congrats to @MarioSuva lab, @TiroshLab, and @ArlottaLab, especially Vamsi and @RChanoch! A GBM cortical organoid model that not only recapitulates the core GBM cancer cell states, but also recapitulates intercellular communication between cancer cells and the TME via EVs! Having…
Congrats to @MarioSuva lab, @TiroshLab, and @ArlottaLab, especially Vamsi and @RChanoch! A GBM cortical organoid model that not only recapitulates the core GBM cancer cell states, but also recapitulates intercellular communication between cancer cells and the TME via EVs! Having…
There's a lot of excitement about foundation models and their ability to learn biology 🧬💻
But current tools for perturbation prediction perform worse than simple linear models! We need more careful benchmarking to make progress.
biorxiv.org/content/10.110…
I’m very happy to share our paper in @CellCellPress on the spatial organization of GBM! bit.ly/4aKDeEp. Check out our tweetorial for a summary of our findings: bit.ly/44e0uZ9. I wanted to share a few additional thoughts on its implications and some future…
Build what you need and use what you build. This is a core philosophy of my research. It shifts the focus away from publishing “papers” to what really matters — impact. This thread unpacks why I think this is a successful approach to science. 1/10 Or see:
perceiving-systems.blog/en/post/build-…
My main postdoc project over the past two years is now published in @CellCellPress. I'm very thankful to my friends and Co-first authors @alissacg@GaliliNoam for this fun journey together and @itaytirosh for his next level mentorship!
My main postdoc project over the past two years is now published in @CellCellPress. I'm very thankful to my friends and Co-first authors @alissacg@GaliliNoam for this fun journey together and @itaytirosh for his next level mentorship!
Excited to share our new paper in @CellCellPress on spatial organization in glioblastoma authors.elsevier.com/c/1izT9L7PXqQI9. We combine spatial transcriptomics (Visium) and proteomics (CODEX) to reveal five-layer organization of cellular states and a role of hypoxia as tissue organizer. 1/
We probably have about 50 plasmids we would like to prep ASAP. What is the most cost and time effective way to get as much of these plasmids prepped as possible?
Inspired by @lpachter and team's exploration of scRNA-seq pipelines, we face similar challenges in scATAC-seq, only magnified! After 5 years of tackling these inconsistencies with my advisor @JunhyongKim , Here is a summary (and some solutions😃) 1/n #Genomics#Bioinformatics
Inspired by @lpachter and team's exploration of scRNA-seq pipelines, we face similar challenges in scATAC-seq, only magnified! After 5 years of tackling these inconsistencies with my advisor @JunhyongKim , Here is a summary (and some solutions😃) 1/n #Genomics#Bioinformatics
6 statistical methods that can be used for A/B Testing (and when to use them).
A/B Testing is a staple of data science and data analyst interviews.
And it's the Number 1 technique that companies benefit from in improving customer revenue.
So here's a 6 of the most common stat…
Our latest out today in @Nature. We profiled 12 million single cells from mouse embryos spanning gastrulation to birth, defined cell type tree from zygote to birth, and unexpectedly found crazy fast changes within first hour of extrauterine life. OA PDF: rdcu.be/dyDAg
Our latest out today in @Nature. We profiled 12 million single cells from mouse embryos spanning gastrulation to birth, defined cell type tree from zygote to birth, and unexpectedly found crazy fast changes within first hour of extrauterine life. OA PDF: rdcu.be/dyDAg
We are overjoyed! Our SPICEMIX paper is being featured on the cover of @NatureGenet! Does it resemble a spatial transcriptome? It looks just like a spice mix! nature.com/ng/volumes/55/…
We are overjoyed! Our SPICEMIX paper is being featured on the cover of @NatureGenet! Does it resemble a spatial transcriptome? It looks just like a spice mix! nature.com/ng/volumes/55/… https://t.co/eJ0InNCYQn
Excited to share our paper in @NatureGenet: SPICEMIX, a joint model of spatial info and gene exp from spatial transcriptome data. Advances upon NMF w/ integration of graphical model, resulting in more meaningful latent reps of cells and spatial metagenes. nature.com/articles/s4158…
Real science:
1. Is not correlated with the amount of funding
2. Progresses slowly, usually taking many years
3. Leads to more questions than it answers
4. Advances when we disengage & in improvisational discussions
5. Is too important a thing to be done in a non-playful way
Want to hear about the latest updates/new techniques in single cell and spatial genomics? Check out my lab's eighth annual Single Cell Genomics Day on March 29. Keynotes from @IdoAmitLab@JD_Buenrostro and Xiaowei Zhuang. Please RT/spread the word! satijalab.org/scgd
Immensely proud to share our four papers on #SingleCell dissection of #Alzheimers Disease coming out in @CellCellPress today, reporting 2.3M #scRNA profiles and 850k #scATAC profiles across 427 post-mortem human brain samples from AD and non-AD donors in a wonderful…
The best ideas don't come from big teams – it only Takes Two To Think! Get a Science Buddy, today's Nature Biotech explains why and how: nature.com/articles/s4158…@ItaiYanai@HHU_de
328 Followers 441 FollowingOrganizational principles of cancer | Lunenfeld-Tanenbaum Research Institute & Assistant Professor, Dept. of Molecular Genetics, University of Toronto
7K Followers 7K FollowingOur mission is to bring context to biology & human health through the power of spatial phenotyping. We are The Spatial Biology Company®. 🧬🥼 #akoyabio
166 Followers 252 FollowingNeurosurgeon in The University of Tokyo. Research fellow working on single-cell sequencing of brain tumors @MGH, @broadinstitute, Suva lab.
1K Followers 747 FollowingPI at Guangzhou Lab.Broad, WEHI, ZJU alumni. working on single-cell/spatial genomics, long-read sequencing. Data nerd. Photographer.
53 Followers 87 FollowingBioinformatician at the Functional Genomics Team @cnag_eu
Associate Lecturer in Bioinformatics @uvic_ucc
https://t.co/qO9rcfRInV
6K Followers 192 FollowingOur lab focuses on genetic changes in cancer and how they contribute to tumorigenesis in the hope of finding therapeutic targets. Tweets from Scott signed -SWL.
7K Followers 2K FollowingAssociate Professor @WeizmannScience . lncRNAs, RNA biology, RNA therapeutics, gene regulation, all wet+dry. Father of 4. Not much time for anything else.
537K Followers 11 FollowingBreaking news and developing stories from the U.S. and around the world. For insights, follow @BNODesk. Hit the subscribe button to support our work.
948 Followers 428 FollowingCurrent postdoc @UCSF with @willowcoyote studying membrane proteins; PhD @stanford developing spatial tools to study breast cancer with @MikeAngeloLab @cncurtis
4.5M Followers 460 FollowingCutting-edge research, news, commentary, and visuals from the Science family of journals. Follow @NewsfromScience for stories from our News team.
2K Followers 243 FollowingTheoretical biophysicist and co-host of the Night Science Podcast with @ItaiYanai (https://t.co/XGWPyKa6jQ
@nightsciencepod).
352K Followers 255 FollowingNature Medicine is a research journal devoted to publishing the latest advances in translational and clinical research for scientists and physicians.
172K Followers 709 FollowingThe funder-researcher collaboration and open-access journal for research in the life and biomedical sciences | @eLifeCommunity
43K Followers 1 FollowingA modern day preprint server powered by $RSC. Incentivizing the open publication of transparent research. Let's accelerate science!
1K Followers 941 FollowingSenior computational scientist in Fishell lab at the Broad Institute and HMS. Ph.D. and B.S. in Bioinformatics. Interests: #SingleCell #MachineLearning #Neuron
7K Followers 2K FollowingLab studying cancer from a stem cell and cell-cell interaction perspective, #cancerstemcells, #glioblastoma, #GBM. Tweets are my own. @DrexelUniv @NIHOxCam alum
22K Followers 230 FollowingFollow Cancer Discovery for high-impact articles and news covering major advances in basic, translational, and clinical cancer research. Published by @AACR.
2K Followers 582 FollowingComputational cell dynamics, bridging computer science and cell biology. Open science, outreach and education. PI @bengurionu since Oct. 2018.
3K Followers 740 FollowingReader @EdinburghUni. Wrote @QuPath & https://t.co/eem8QmCaK8
Views my own, unless I've changed my mind. Then perhaps not even mine.
5K Followers 82 FollowingThe Cai Lab at Caltech. We developed sequential FISH (seqFISH), seqFISH+, MEMOIR, and RNA SPOTs, apply them to study various biological questions.
7K Followers 7K FollowingOur mission is to bring context to biology & human health through the power of spatial phenotyping. We are The Spatial Biology Company®. 🧬🥼 #akoyabio
11K Followers 497 FollowingNow on Bluesky @urialonlab.bsky.social
The Alon lab explores design principles of biological circuits, focusing on systems medicine, ageing and healthspan.
2K Followers 349 FollowingIncoming Assistant Professor @MITdeptofBE and @kochinstitute intramural member. Tom and Joan Steitz RNA Fellow. Postdoc with @RongFan8
33K Followers 1K FollowingCell biologist studying how a heart grows and dies; also Blebbisomes. Associate Professor at Vanderbilt. Married to @gillianhoo.
1K Followers 506 FollowingOur lab at #WeizmannScience focuses on #cancer research using #massSpectrometry based #clinicalProteomics and #Bioinformatics
166 Followers 252 FollowingNeurosurgeon in The University of Tokyo. Research fellow working on single-cell sequencing of brain tumors @MGH, @broadinstitute, Suva lab.
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