Min Dai @artofbiology
Fishell lab postdoc at the Harvard Medical School/Broad Institute. Ph.D. and B.S. in Bioinformatics. Interests: #SingleCell #MachineLearning #Neuron genecell.github.io Cambridge, MA Joined April 2017-
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The Fishell lab fishelllab.hms.harvard.edu @GordFishell at the Broad Institute @broadinstitute is hiring a computational associate. You will work with scRNAseq, scATACseq, spatial transcriptomics and more to learn about interneuron and developmental neurobiology! Please DM me/RT!
It makes sense that this benchmarking prefers Harmony, because the correction vectors for the low-dim in Harmony are the same for each sub-cluster, so the original cluster structure will be preserved. In other words, the correction for Harmony is cluster-wise correction.
It makes sense that this benchmarking prefers Harmony, because the correction vectors for the low-dim in Harmony are the same for each sub-cluster, so the original cluster structure will be preserved. In other words, the correction for Harmony is cluster-wise correction.
The low-rank hypothesis of complex systems | Nature Physics @NaturePhysics nature.com/articles/s4156…
Did you know that Mary Beth Hatten (@khats97) was the first woman to be named head of a laboratory at Rockefeller? Watch her discuss her life and work in this interview from our #oralhistory project. youtube.com/watch?v=kXDu3e…
The first time for me to see a QR-code in the main figures😃 | Multiple parallel cell lineages in the developing mammalian cerebral cortex @ScienceAdvances science.org/doi/10.1126/sc…
#cshlsysbio Excellent talks at the Cold Spring Harbor Systems Biology meeting! Let’s chat if you are interested in multiomic data integration, cell type-specific manipulation using enhancer-AAV, and synthetic enhancer design!
Awesome works! Highlighting the value and the beauty of critical thinking and logical experimental design.
Awesome works! Highlighting the value and the beauty of critical thinking and logical experimental design.
When I see the same combination of transcription factors in different tissues, I see the beauty of biology and the art of gene expression regulation.
... plus the removal of doublets and low-quality cells during cell quality control
... plus the removal of doublets and low-quality cells during cell quality control
By providing Drosophila with CpG islands inserted into genomes, will there be DNA methylation enzymes after many generations?🤔
By providing Drosophila with CpG islands inserted into genomes, will there be DNA methylation enzymes after many generations?🤔
Curious about whether GPT-4 could actually fill the tax forms @OpenAI ✍️😁
An evolutionary perspective on complex neuropsychiatric disease | Perspective | Neuron @NeuroCellPress cell.com/neuron/fulltex…
Rewriting regulatory DNA to dissect and reprogram gene expression | from Jesse Engreitz Lab @jengreitz | bioRxiv biorxiv.org/content/10.110…
Method of the Year 2023🥳by Nature Methods @naturemethods
Method of the Year 2023🥳by Nature Methods @naturemethods
Two works using combinatorial indexing-based scRNAseq to profile whole embryo- or individual-scale for zebrafish across developmental stages or mutant mouse embryos were published on Nature today 1. Mutant embryo: nature.com/articles/s4158… 2. Zebrafish dev: nature.com/articles/s4158…
An encyclopedia of enhancer-gene regulatory interactions in the human genome | bioRxiv biorxiv.org/content/10.110…
Functional genomics and systems biology in human neuroscience | Perspective by Prof. Genevieve Konopka @KonopkaLab and Prof. Aparna Bhaduri @BhaduriLab | Nature nature.com/articles/s4158…
The proteomic landscape of synaptic diversity across brain regions and cell types | Cell | from Prof. Erin M. Schuman's Lab cell.com/action/showPdf…
That’s true. Thinking like a cell is important. The cell also doesn’t look up the UMAP to recognize each other.
That’s true. Thinking like a cell is important. The cell also doesn’t look up the UMAP to recognize each other.
Look forward to the DNA-TF interaction modeling! | Performance and structural coverage of the latest, in-development AlphaFold model storage.googleapis.com/deepmind-media…
Ming "Tommy" Tang @tangming2005
31K Followers 2K Following Director of computational biology. On my way to helping 1 million people learn bioinformatics. Educator, Biotech, single cell. Also talks about leadership.Itai Yanai 💔 @ItaiYanai
24K Followers 2K Following Professor at the NYU School of Medicine. Co-host of the 'Night Science Podcast' https://t.co/Sy1rcWXGLz @nightsciencepodOded Rechavi @OdedRechavi
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10K Followers 955 Following Sc/St-Omics pro-aficionado. Knowledge sharing is my thing. Views, opinions and comments are my own and do not represent those of my employer. Like/RT ≠ endorseRamon Massoni Badosa @rmassonix
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1K Followers 732 Following 🇵🇸 Neuroscientist | Assistant Professor @KAUST_News. Neural circuit development and learning. Layer 1 afficionado. Views are my ownBo Xia @BoXia7
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24K Followers 2K Following Professor at the NYU School of Medicine. Co-host of the 'Night Science Podcast' https://t.co/Sy1rcWXGLz @nightsciencepodOded Rechavi @OdedRechavi
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141K Followers 1K Following Nature Methods publishes cutting-edge methods, tools, analyses, resources, reviews, news and commentary, supporting life sciences research. Tweets by editors.bioRxiv @biorxivpreprint
128K Followers 23 Following The non-profit preprint server for the life sciencesLior Pachter @lpachter
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7K Followers 498 Following Head of Data Science at Hale Center for Pancreatic Cancer | Group leader @DanaFarber @Harvard | We ❤️ genomics, evolution & LLMs | PhD @eth | 🇷🇴🇸🇪🇨🇭🇺🇸bioRxiv Genomics @biorxiv_genomic
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633 Followers 1K Following Alumni @vsicmb, @kaymtye lab & @mbhavana10 lab |interested in neuroscience of decision making and everything interdisciplinary |looking for a PhD!!Maximiliano José Nig.. @MaxNigro_Neuro
3K Followers 3K Following Associate Professor @KISNeuro #NigroLab; Biogeography of cortical circuits; Biologist looking at neurons with birdwatcher's eyes; @maxnigro.bsky.socialTyler Ekins @tyler_ekins
260 Followers 397 Following Postdoc at University of Michigan studying psychedelic neurophysiologyTomàs Montserrat Ayu.. @tmontsay
45 Followers 79 Following Bioinformatician on the Functional Genomics Team @cnag_eu Associate Lecturer in Bioinformatics @uvic_ucc https://t.co/qO9rcfRInVRuth Raichur @RuthRaichur
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173 Followers 139 Following PhD student at UT Southwestern Medical Center 🇺🇦We welcome Julio Saez-Rodriguez @JulioSaezRod as our new Head of Research! Associate Director for EMBL-EBI Services Jo McEntyre @jomcentyre has been promoted to Deputy Director of EMBL-EBI & Rolf Apweiler is stepping back to Associate Director as he looks towards retirement.
@GordFishell @nyulangone behind every great man....
Happy birthday to the late Claude Shannon, whose compression equation is how you’re here right now: bit.ly/1RoxfHu (credit: Gizmodo)
Congratulations, Gord!!
Congratulations Gordon Fishell of @harvardmed, newly inducted #NASmember! #NAS161 #neurobiology #neuroscience
My very close friend @schierlab Alex waited three years after being elected to the NAS in 2020, saying he would get inducted to the national Academy of science when I do. Here I am with him and Moses Chao. Three amigos who started back in the Skirball Institute @nyulangone ♥️
Congratulations Gordon Fishell of @harvardmed, newly inducted #NASmember! #NAS161 #neurobiology #neuroscience
I am extremely honored to have been selected and grateful beyond words for the support of the @americanacad and its membership. This is truly a celebration of the passion and dedicated effort of all the students, postdocs and scholars that I have the privilege to work with every…
Congratulations to HSCRB Chair Paola Arlotta for being elected to @americanacad! @ArlottaLab amacad.org/news/2024-memb…
Nice correlation between massively parallel reporter assays (MPRAs) and mouse enhancer assays and great neurodev enhancer catalog. Great work and collaboration from @michaelkosicki, @DianneLaboy, @LenPennacchio and many others. biorxiv.org/content/10.110…
Thrilled to be starting my PhD in the BCMB program at @WeillCornellGS this fall! Grateful for the incredible mentorship at @insitubiology (@immunoliugy, @hattaca, @AndyRusss + others) and @TexasScience; couldn't have done it without their support. Excited for the journey ahead!
Deeply saddened by the passing of Lubert Stryer, father of FRET, pioneer of DNA and peptide microarrays, author of the famous Biochemistry textbook used across the world. Many may not know that he was also an extremely generous supporter of the arts and deeply passionate about…
A fabulous day reconnecting with Azim Surani’s alumni yesterday… 40 years to the day since imprinting was discovered Spectacular science on show and superfun bar ‘discussions’. And those shades😎!!
Did you know that Mary Beth Hatten (@khats97) was the first woman to be named head of a laboratory at Rockefeller? Watch her discuss her life and work in this interview from our #oralhistory project. youtube.com/watch?v=kXDu3e…
Excited to announce that our study "Spatial enhancer activation influences inhibitory neuron identity" is now online in Nature Neuroscience nature.com/articles/s4159… Big thanks to the Winkelmann (@HelmholtzMunich @TU_Muenchen) & Torres (@CNIC_CARDIO) labs for the collaboration! 1/7
In this preprint biorxiv.org/content/10.110… with @Sindri_e we compared seven widely used methods for batch correction of single cell RNA-seq data. We found that all but one of the methods introduce batch effects when there are none. 1/N
Why can RNA only be linear or circular? It can be branched! We made multi-tailed mRNA, and we had fun! Here is our story led by brilliant graduate student @HongyuChenChem: rdcu.be/dB7ck and his cartoon illustration👇@ChemistryMIT @broadinstitute
Thrilled to see our work on chemically and topologically engineered mRNA online! Using a chemo-enzymatic approach, we introduced multiple end-modified polyA tails on a single mRNA to boost its stability and translatability overtime. nature.com/articles/s4158…
Determination of single-molecule loading rate during mechanotransduction in cell adhesion | Science science.org/doi/10.1126/sc…
Our preprint characterizing mouse developmental Enhancer—Promoter interactions by @Czx17943830 is out today @NatureGenet rdcu.be/dBRPu See also a complementary study on fly Enhancer—Promoter interactions from @Eileen_Furlong nature.com/articles/s4158…
How important is Enhancer—Promoter physical proximity for developmental gene activation? Happy to share our work led by postdoc Zhuoxin Chen @Czx17943830 where we systematically address this question in vivo. (1/n) biorxiv.org/content/10.110…
How does the competence of GABAergic progenitors change in time? It depends on whether you're looking at maturation or differentiation! Check out our new preprint: doi.org/10.1101/2024.0… Big shoutout to the amazing contributors, esp. @YanaKotlyarenk1 @annrosebright8, Flo, Diana!
Our most recent work is now published at @NatureGenet. Epigenetic variation impacts individual differences in the transcriptional response to influenza infection. Great collab with @guilbourque lab and huge congrats to the lead author @katiearacena. Link: shorturl.at/bcdBP
Potentiated synapses