Feng Zhang @zhangf

Engineer and molecular biologist. Curious about the world and optimistic to make it better. zlab.bio Cambridge, MA Joined April 2015

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281
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54K
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270

Sajith Wickramasekara @sajithw

3 weeks ago

Long time lurker, breaking a decade of silence to share an essay on what I've learned from scientists about making medicines (spoiler: it's hard) and why the future looks bright (also spoiler: AI) 🧵

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Feng Zhang @zhangf

3 weeks ago

Deeply saddened by the loss of David Baltimore - a mentor, role model, and scientific giant who shaped so many of us. Most memorably, I was sitting next to David, a month after I started as a baby Assistant Professor, when I learned about CRISPR. His kindness and wisdom will be…

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Joseph Kreitz @kreitz_joseph

2 months ago

Check out our new paper, out today in @NatureBiotech! We present SPEAR, a modular system for biomolecular cargo delivery with bacterial "nanosyringes". Thanks to my advisor, @zhangf, and amazing undergraduate (now graduate) student @vicy_ang nature.com/articles/s4158…

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Huan Edmonds @GraceKC

3 months ago

Can we use RNA to insert kilobases of DNA into the human genome, opening up a new way to engineer cells or treat disease? Excited to share our latest work turning a retrotransposon (a “jumping gene” with an RNA intermediate) from songbirds into a genome editing tool. 🧵 (1/7)

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Shai Zilberzwige-Tal @zilberzwige

7 months ago

RNA-guided systems span kingdoms, from bacterial immunity to eukaryotic gene regulation. How did they evolve? We traced the origins of CRISPR-Cas13 and identified its likely ancestor: an RNA-based toxin-antitoxin (TA) system. Here’s what we uncovered: cell.com/cell/fulltext/… 1/8

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Han Altae-Tran @altaetran

7 months ago

#CRISPR revolutionized medicine, but where did its RNA-guided mechanisms come from? Using #AI, we unearthed new Cas13s and found they evolved from toxin-antitoxins, revealing how nature created these amazing reprogrammable molecules. Discover the recipe: doi.org/10.1016/j.cell…

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Feng Zhang @zhangf

9 months ago

Congratulations to @rumya_r @mircoscopy @DStrebinger @blake_lash @cyrusbiotech and colleagues on an exciting study combining AI and protein engineering to minimize the immunogenicity of Cas9 and Cas12a nucleases. These approaches have the potential to improve the safety and…

Rumya @rumya_r

9 months ago

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Feng Zhang @zhangf

9 months ago

Happy 2025=1^3+2^3+3^3+4^3+5^3+6^3+7^3+8^3+9^3 and many new discoveries!

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Patrick Hsu @pdhsu

11 months ago

Today we report Evo, a generalist foundation model for biology, on the cover of @ScienceMagazine. Trained on billions of DNA nucleotides, Evo was designed to capture two key aspects of biology: the multi-modality of the central dogma and the multi-scale nature of evolution.

Science Magazine @ScienceMagazine

11 months ago

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Feng Zhang @zhangf

a year ago

Excited to see our team’s work on Fanzor now published in @CellCellPress! Amazing effort by @Peiyu_Xu_ and the entire team in uncovering the structural diversity and DNA cutting mechanisms of Fanzor. Proud of everyone involved! Onward to more discoveries. 🚀…

Peiyu Xu @Peiyu_Xu_

a year ago

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Feng Zhang @zhangf

a year ago

Nature is amazing! Congratulations to @maxewilkinson and team on a beautiful study revealing a clever way that bacteria defend against viruses. Check out Max’s posts for more detail! doi.org/10.1126/scienc…

Max Wilkinson @maxewilkinson

a year ago

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Feng Zhang @zhangf

a year ago

Congratulations to all of the graduates during this commencement season! Wishing you all a creative and fulfilling future! "What you follow with your heart will indeed come back to make your life much richer."