Sri Kosuri @srikosuri
Cofounder & CEO, @octantbio - srikosuri on Threads octant.bio Berkeley, CA Joined June 2009-
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It pains me to see facile critiques of GWAS on here from our clinical/biostats friends while the many actually good reasons to be critical of GWAS get little attention. So here's a thread on what GWAS does, what critics get wrong, and where GWAS is genuinely still lacking. 🧵:
Very excited to share our new MPRA study on rare variants and cancer somatic mutations in the 3' UTR. Really proud of my former students @ting_fu_21 and @kofiamoah435 for spearheading this effort. Great collaboration with @srikosuri and team. nature.com/articles/s4146…
Excited to share @taraneh_z's preprint: A complete map of specificity encoding for a partially fuzzy protein interaction biorxiv.org/content/10.110…
Introducing OpenBioLLM-Llama3-70B & 8B: The most capable openly available Medical-domain LLMs to date! 🩺💊🧬 Outperforms industry giants like GPT-4, Gemini, Meditron-70B, Med-PaLM-1, and Med-PaLM-2 in the biomedical domain. 🏥📈 🌟 OpenBioLLM-70B delivers SOTA performance,…
Some of you know I've spent the past ~20 years looking for ways to apply #AgingBiology to improve health (dramatically). Five years ago, what I've learned drove me to start @GordianBio with @leportfr, as a way to cut through biological complexity. Today we're starting to share…
Some of you know I've spent the past ~20 years looking for ways to apply #AgingBiology to improve health (dramatically). Five years ago, what I've learned drove me to start @GordianBio with @leportfr, as a way to cut through biological complexity. Today we're starting to share…
I remember the Knicks being on the wrong end of a sequence like this at the hands of Reggie Miller. It’s nice to be on the winning end now!
I remember the Knicks being on the wrong end of a sequence like this at the hands of Reggie Miller. It’s nice to be on the winning end now!
Oh man. New Acquired pod drop. Excited to have some travel upcoming to get a chance to listen to this.
Oh man. New Acquired pod drop. Excited to have some travel upcoming to get a chance to listen to this.
Awesome to see compounds start on our nanogram synthesis platform make their way over the months to kilogram-scale synthesis from our partners at @WuXi_AppTec. Trillion-fold scale difference.
Do the mutations that drive evolution improve many traits or few? How might this change over the course of evolution? Excited to share our new work exploring these questions in the first 2 steps of adaptation w/ @liyuping927 @gsherloc @PetrovADmitri 🧵1/n biorxiv.org/content/10.110…
My latest story is about how a very old and very cheap drug has been quietly revolutionizing bone-marrow transplants. (1/3)
This is so cool! Synthetic G protein-coupled receptors for programmable sensing and control of cell behavior biorxiv.org/content/10.110…
Something literally everyone said at the time, and yet ….
Something literally everyone said at the time, and yet ….
“Chemists Invent Drugs and Drugs Save Lives”
“Chemists Invent Drugs and Drugs Save Lives”
Gloves stay on in lab, but they come off for our board game club on Wednesdays! Happy National Board Game Day!
How to pick a problem. Today in @CellCellPress. 1/53 cell.com/cell/fulltext/…
Lior Pachter @lpachter
44K Followers 2K Following Bren Professor of Computational Biology @caltech. Blog at https://t.co/FFQzhEsmhi. Tweets represent my views, not my employer's. #methodsmatter
Jake Wintermute 🪵 @SynBio1
11K Followers 353 Following Developer evangelist @ginkgo stay humble biodesigners
Sebastian S. Cocioba�.. @ATinyGreenCell
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Arjun Raj @arjunrajlab
25K Followers 2K Following Just another LLM. Tweets do not necessarily reflect the views of people in my lab or even my own views last week. https://t.co/fZAnUCqd12
Niko McCarty 🧫 @NikoMcCarty
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Patrick Hsu @pdhsu
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Anshul Kundaje (anshu.. @anshulkundaje
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Elliot Hershberg @ElliotHershberg
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Kevin K. Yang 楊凱�.. @KevinKaichuang
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Vega Shah @dr_alphalyrae
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Mo Khalil @MoKhalilLab
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Sergey Ovchinnikov �.. @sokrypton
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dybugq9tq8taeke @40i20nr4o9qrek
6 Followers 768 Following We first transfer USDT to you TRC20, you return 90% to BEP20, you get 10% , 2K per day Our co hv a large amt of USDT need to from TRC20 convert to BEP20 network
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∞ @Info7777info
3 Followers 136 Following 도의나 예의를 정확한 계약서 없이 강조하는 것들은 전부 사기꾼이다 계약서를 쓰지 않은 상태에서 거짓말은 딱히 별 신경 안 씁니다. 진실이여도 별 신경 안 써요 제 일 아니에요 : ) 알아서 잘 하실거에요 그냥 아무거나 다 올려요 진짜일지 가짜일지 몰라요 알아서 판단 부탁드려요 : )
Ben Braun @BenSBraun
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Sachin Gaur 🇮🇳 @_SachinGaur
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Tarek Elsayed | طا�.. @Tarekelsayed889
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12th World Biomateria.. @2024Wbc
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Sky Walker🇺🇸�.. @SkyWalk708
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44K Followers 2K Following Bren Professor of Computational Biology @caltech. Blog at https://t.co/FFQzhEsmhi. Tweets represent my views, not my employer's. #methodsmatter
Jake Wintermute 🪵 @SynBio1
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Arjun Raj @arjunrajlab
25K Followers 2K Following Just another LLM. Tweets do not necessarily reflect the views of people in my lab or even my own views last week. https://t.co/fZAnUCqd12
Niko McCarty 🧫 @NikoMcCarty
23K Followers 861 Following Writing and editing stories about scientific progress, especially in biology. Founding Editor @AsimovPress Head of Creative @AsimovBio
Patrick Hsu @pdhsu
30K Followers 3K Following co-founder @ArcInstitute, @BerkeleyBioE professor | researcher & investor in genome editing, biotech, AI | 🇨🇦 @harvard @broadinstitute @editasmed, Fast Grants
Tom Ellis @ProfTomEllis
23K Followers 602 Following Synthetic Biology & Synthetic Genomics @ Imperial College London and the Sanger Institute. Bilingual in English and DNA. Also at https://t.co/f2Na2PES8R
Anshul Kundaje (anshu.. @anshulkundaje
22K Followers 2K Following Genomics, Machine Learning, Statistics, Big Data and Football (Soccer, GGMU). Post: @anshulkundaje, Threads: anshulkundaje
Elliot Hershberg @ElliotHershberg
11K Followers 924 Following Genomics @Stanford, writing https://t.co/3XO8B8H4yG, writing/investing @notboringco
Kevin K. Yang 楊凱�.. @KevinKaichuang
16K Followers 5K Following Senior Researcher in BioML @MSFTResearch (@MSRNE). He/him/他. 🇹🇼
Vega Shah @dr_alphalyrae
12K Followers 3K Following life sciences software 🧬 product strategy 👩🏻💻 writer & futurist 🚀 previously scientist at @JGI, @UW & @UCBerkeley 👩🏻🔬 views are all mine ✨
Mo Khalil @MoKhalilLab
8K Followers 2K Following Prof. @ Boston University and Wyss Institute. Understanding the natural world by building a synthetic one. website: https://t.co/PyjGQRHoUy
Michael Baym @baym
22K Followers 2K Following Microbiology, evolution, applied math, molecular biotech. Associate Professor @HarvardDBMI. “The scholarship… is nearly non-existent.” -Reviewer 3
Michael C. Jewett @MichaelCJewett
7K Followers 483 Following Professor of Bioengineering, Stanford University
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27K Followers 763 Following Entrepreneur. Investor. Happy warrior. Founder @fiftyyears. ❤️ climate, bio, deeptech. Helping great scientists become great founders is my jam.
Jason Kelly @jrkelly
24K Followers 1K Following Co-founder and CEO at Ginkgo Bioworks ($DNA)🧬 Chair of US National Security Commission on Emerging Biotechnology 🇺🇸
Sergey Ovchinnikov �.. @sokrypton
12K Followers 3K Following Scientist, Assistant Professor @MITBiology, #FirstGen, ProteinBERTologist
Prachee Avasthi @PracheeAC
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Anne Carpenter, PhD @DrAnneCarpenter
22K Followers 2K Following Discovery in images. Enthralled by science. 5 kids. She. SAB Recursion, Quiver. Founder SyzOnc. https://t.co/CQCHnSAc9M
Fyodor Urnov @UrnovFyodor
15K Followers 533 Following Gene editor + Professor of Molecular Therapeutics @berkeleyMCB + Director of @igisci @danahercorp Beacon for CRISPR Cures.
Synple Chem @synplechem
903 Followers 3K Following Our mission is to provide easy to use, safe, efficiency-enhancing solutions that represent the future of organic synthesis.
Taraneh @taraneh_z
265 Followers 867 Following Postdoc in the Lehner lab @CRGenomica, PhD @UofT. Interested in evolution of disordered protein regions and too many other things. She/her.
Gordian Biotechnology @GordianBio
830 Followers 74 Following Our mission is to cure age-related disease by moving successful therapeutics toward clinical trials within months, not years. #CreatingTime
Francisco LePort @leportfr
243 Followers 181 Following creating time for all of us by curing age related diseases
Barbara Cheifet @BCheifet
39 Followers 59 Following Chief Editor @naturebiotech, running and science fanatic All views my own.
Stanley Hsieh @Stanley_TH
544 Followers 320 Following Biotech innovator & Genomics AI wizard by day @Xaira_Thera. Proud Shiba aficionado by night.
Phil Leung @definitelyphil
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475 Followers 205 Following postdoc - designing proteins at Dana-Farber/Harvard Medical School | formerly, evolutionary biochemistry at Max PIanck Institute in Marburg
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379 Followers 609 Following @ucberkeley Chemical Biology PhD candidate in @GroupFrancis, @uwmadison Biochem/Spanish grad. Protein engineering & drug delivery.
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Sarah Zhang @sarahzhang
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Biology Deconstructed @BiologyMusings
321 Followers 251 Following Numbers geek with a knack for biology! Follow for data-driven tales that won't induce yawns.
Andrew Gao @itsandrewgao
25K Followers 2K Following techno optimist! currently: @nomic_ai @stanford; prev @LangChainAI; Z Fellow 🇺🇸
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424 Followers 2K Following Dropping science like Galileo dropped the orange. Director DS @Atomwise, ex-DS @Zymergen, @grandroundsinc, PhD @UPennGCB
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Eric Nguyen @exnx
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605 Followers 372 Following Investor at 8VC. Supporter of people who make things.
Leah Sibener @LeahSibener
744 Followers 1K Following Investing and building the future of biotech @ https://t.co/9b7mTQ2q8z Prev: Founder @3tbio, PhD in Immunology @Stanford, Biophysics @JohnsHopkins
Katalin Kariko @kkariko
70K Followers 263 Following I am a scientist, working on the therapeutic use of in vitro transcribed mRNA.
Cee Cee Schnugg @ceeceeboom
2K Followers 2K Following 1st check for deep tech @Astra (NASDAQ: ASTR) @Planet (NYSE: PL) @MammothBioSci @GalileoHealth @SwarmInternet (@SpaceX) @faunabio @gotoimpulse Ex: @iendeavorsIt pains me to see facile critiques of GWAS on here from our clinical/biostats friends while the many actually good reasons to be critical of GWAS get little attention. So here's a thread on what GWAS does, what critics get wrong, and where GWAS is genuinely still lacking. 🧵:
Interesting new multiparameter optimization metric from BMS for identifying compounds with improved permeability, reduced efflux, and better Kpu,u. pubs.acs.org/doi/10.1021/ac…
First paper from the lab! Work with @Xinjun90 and led by super talented former @qbio_usc student @TessaFerrari. Stay tuned for a thread summarizing results.
Towards Simulation Optimization: An Examination of the Impact of Scaling on Coalescent and Forward Simulations biorxiv.org/cgi/content/sh… #biorxiv_evobio
@gracexiao99 @srikosuri @ting_fu_21 @kofiamoah435 congratulations, we build large cell trees from scRNA-seq from blood of healthy people and data does recover a big fraction of 3' and 5' UTR SNVs so if you do scRNA-seq let us know and we can build the trees to represent the somatic mutation burden in your samples, including…
@gracexiao99 @ting_fu_21 @kofiamoah435 @srikosuri Congrats!
@gracexiao99 @ting_fu_21 @kofiamoah435 @srikosuri Congrats, Grace! See you in September in Suzhou:)
Very excited to share our new MPRA study on rare variants and cancer somatic mutations in the 3' UTR. Really proud of my former students @ting_fu_21 and @kofiamoah435 for spearheading this effort. Great collaboration with @srikosuri and team. nature.com/articles/s4146…
@arjunrajlab @wc_ratcliff I think it's part of the broader shift in how people perceive the purpose of grad school. I started in 2014 and the general message for the last decade has been that the academic trajectory is an outlier and most people expect industry jobs
NIH stipends for grad students and postdocs increased: nih.gov/news-events/ne… Not as much as recommended by the advisory committee, but a start. The committee had many good recommendations to improve the postdoc experience: acd.od.nih.gov/documents/pres…
Exclusive first look inside @Extropic_AI, pioneers of thermodynamic AI compute, on episode 41 of S³
We went from learning DNA is the molecule of heredity (1952) to sequencing a virus, transmitting it across an ocean, and synthesizing a functional vaccine before the virus even made it there in 68 years There is only tech stagnation if you have a very narrow knowledge of tech
The next time someone gaslights you that tech stagnation isn’t real, send them this tweet:
Let’s go
40 weeks, 40 documentaries. Let's go build the future.
Thinking about Mary Lasker’s words during this morning’s workout. “If you think research is expensive, try disease” @LaskerFDN @NCIResearchCtr
Very happy to share what I've been working on in Barcelona with @BenLehner ! We made many (>400k) mutations in a disordered peptide and the globular domain it interacts with to gain a comprehensive map of how specificity is encoded in a partially fuzzy protein interaction (1/n)
Excited to share @taraneh_z's preprint: A complete map of specificity encoding for a partially fuzzy protein interaction biorxiv.org/content/10.110…
Excited to share @taraneh_z's preprint: A complete map of specificity encoding for a partially fuzzy protein interaction biorxiv.org/content/10.110…
Introducing OpenBioLLM-Llama3-70B & 8B: The most capable openly available Medical-domain LLMs to date! 🩺💊🧬 Outperforms industry giants like GPT-4, Gemini, Meditron-70B, Med-PaLM-1, and Med-PaLM-2 in the biomedical domain. 🏥📈 🌟 OpenBioLLM-70B delivers SOTA performance,…
Shouldn’t aging be part of drug discovery for diseases of aging? gordian.bio/blog/introduci… Gordian exists to move therapeutic testing from plastic wells and young mice into a living environment with all the complexity present in patients with age-related disease. We’re now…
Some of you know I've spent the past ~20 years looking for ways to apply #AgingBiology to improve health (dramatically). Five years ago, what I've learned drove me to start @GordianBio with @leportfr, as a way to cut through biological complexity. Today we're starting to share…
Shouldn’t aging be part of drug discovery for diseases of aging? gordian.bio/blog/introduci… Gordian exists to move therapeutic testing from plastic wells and young mice into a living environment with all the complexity present in patients with age-related disease. We’re now…
Derek Lowe wrote a column on AI & Xaira Therapeutics & substantial bet their team & investors are making "that AI techniques can somehow transform drug discovery." He explained why he believes other AI for drug disc companies haven't been successful yet: science.org/content/blog-p…
"the most badly needed improvements in drug discovery are in the exact areas that are most resistant to AI & machine learning techniques. By which I mean target selection & predictive toxicology. Uncountable billions of dollars and years of work have been torched by not (in the…
Derek Lowe wrote a column on AI & Xaira Therapeutics & substantial bet their team & investors are making "that AI techniques can somehow transform drug discovery." He explained why he believes other AI for drug disc companies haven't been successful yet: science.org/content/blog-p…
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