Sasha Gusev @SashaGusevPosts
Statistical geneticist. Associate Prof at @DanaFarber | @harvardmed | @DFCIPopSci gusevlab.org Joined January 2023-
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Two new chapters from my open-access textbook in human population genetics are now online: - Population structure: I. Ancestry estimation - Population structure: II. More about admixture web.stanford.edu/group/pritchar…
Two new chapters from my open-access textbook in human population genetics are now online: - Population structure: I. Ancestry estimation - Population structure: II. More about admixture web.stanford.edu/group/pritchar…
I think it is good for universities to spell out which protest regulations will/won't be enforced by the police, and for student protestors to work this into their cost/benefit math for civil disobedience. That way neither side is surprised. Unclear if this happened at Columbia.
First time I am advertising my consulting, but I make diagrams and computationally reproducible R figures for research projects. If you want a custom diagram or figure, contact me at: [email protected]
Interesting study looking at how common education polygenic scores modify the effect of rare developmental delay genes. Given that the EA PGS is actually 2/3rds dynastic environment (or stratification), this suggests that environment could be a substantial compensatory force.
Interesting study looking at how common education polygenic scores modify the effect of rare developmental delay genes. Given that the EA PGS is actually 2/3rds dynastic environment (or stratification), this suggests that environment could be a substantial compensatory force.
I had two postdoc mentors bail from the grant-funded science career. One to Big Pharma due to desire to be closer to helping people with health problems. One to NIH Program, presumably due to being exhausted from the grant chase.
6/ A significant and clinically meaningful OS benefit was observed with adjuvant pembro vs placebo: HR 0.62; 95% CI 0.44-0.87; P = 0.005 At 48 months: 91% of pts receiving pembro were still alive vs 86% with placebo (5% absolute benefit)
Happy to share my latest preprint from @nmancuso_ lab. We introduce SuShiE (Sum of Shared Single Effect) model to perform multi-ancestry SNP fine-mapping for molecular traits (e.g., mRNA and Protein). (1/n) medrxiv.org/content/10.110…
Published today, our reasons for optimism that success rates in drug discovery can be improved by picking the right targets using human genetics: nature.com/articles/s4158… I break the key findings down panel by panel in this thread: x.com/cureffi/status…
Published today, our reasons for optimism that success rates in drug discovery can be improved by picking the right targets using human genetics: nature.com/articles/s4158… I break the key findings down panel by panel in this thread: x.com/cureffi/status… https://t.co/k6g7paLMdA
People say the gut microbiome is related to how you respond to food. Our series of randomized N-of-1 trials will try to sort out individual responses from individuals' responsiveness in terms of postprandial glycemia. Feedback welcome! medrxiv.org/content/10.110…
"our analysis also found multiple significant interactions between PGS and vPGS, suggesting that the non-additive and GxE components related to PGSs could impact prediction accuracy"
"our analysis also found multiple significant interactions between PGS and vPGS, suggesting that the non-additive and GxE components related to PGSs could impact prediction accuracy"
Happy to share paper Efficient storage and regression computation for population-scale genome sequencing studies biorxiv.org/content/10.110…
"caQTLs and haQTLs capture regulatory variations not associated with eQTLs and explain ∼49% of the functionally annotated GWAS loci" Been clear for a while that accessibility & histone marks provide more info for explaining & fine mapping GWAS loci than expression. 1/
"caQTLs and haQTLs capture regulatory variations not associated with eQTLs and explain ∼49% of the functionally annotated GWAS loci" Been clear for a while that accessibility & histone marks provide more info for explaining & fine mapping GWAS loci than expression. 1/
💯 to this conclusion (and the rest of the piece). DIY microbiome hackers have an opportunity to demonstrate a more nimble clinical trial process and are instead choosing the path of wellness scams. But there's still time to change course.
💯 to this conclusion (and the rest of the piece). DIY microbiome hackers have an opportunity to demonstrate a more nimble clinical trial process and are instead choosing the path of wellness scams. But there's still time to change course. https://t.co/KP2CXw4kZW
Prediction of tumor origin in cancers of unknown primary origin with cytology-based deep learning nature.com/articles/s4159…
I discussed the data behind the recent anti-cavity Lumina treatment. TLDR: while the approach looks promising and self-experimentation is cool, most of the direct data comes from small studies in rats and well... most humans are not rats. writingruxandrabio.com/p/on-lumina-an… What's more, I…
New episode (928), with Dr. Charles Roseman (@EvoRoseman): The #evolution of complex Traits, Hereditarianism, and understanding sex. #Anthropology #Biology #Science YouTube: youtu.be/5Usuozf02xs Podcast: bit.ly/4azHI0J
#GWAS can be affected by confounding; @AlexTISYoung explores a @carl_veller @Graham_Coop #PLOSBiology study which asks how different sources of confounding affect GWASs & whether family-based designs offer a solution. Primer plos.io/3UeYyfC Paper plos.io/3Qmu2hF
How did this large study debunk the spurious link of acetominophen/tylenol to autism? The same way that most spurious associations with behavioral traits get deubunked, with SIBLING CONTROLS!
How did this large study debunk the spurious link of acetominophen/tylenol to autism? The same way that most spurious associations with behavioral traits get deubunked, with SIBLING CONTROLS!
Lucas 💛🤍💜�.. @SpikeShroom
161 Followers 456 Following I am God | BLM | 22 | 🏳️⚧️ they/them | 🇧🇴/🇺🇲 | FREE PALESTINE 🇵🇸
good measure @fivefights
334 Followers 2K Following 🌹 pressed down, shaken together, running over 🌹 writer @fromlowwater
. @aliactest
5 Followers 176 Following
Muzaffer Kal @🏡 �.. @MuzafferKal_
1K Followers 5K Following Chips: ASIC, FPGA. CV/ML. Duck pictures by the lake. Some bread making. He/They [email protected] @mkal.bsky.social threads.net@muzafferkal_
Himel Mallick, PhD, F.. @Mallick_Himel
732 Followers 529 Following 🧬 Tenure-track PI @Cornell @WCMPopHealthSci | ASA Fellow | Reverse translational discovery research w/ #Bayes + #AI + #ML + #Omics #DataScience | Tweets=my own
Isil Erbasol Serbes @ieserbes
203 Followers 516 Following Bioinformatics MS.c. student at @UoB (second MS) | Molecular Genetics Ph.D. alum at Uni Bremen (2018) | Passionate about ML and Data Analysis🧬👩💻
D'Anthony @d_in_bridge
2K Followers 5K Following Information+Connections=Knowledge -Les Temps Modernes-
Abdul-Aziz Carter @aziz_carter
2K Followers 5K Following Cornerstone leadership Academy Alumni & University of Dar es salaam & INTP personality
14kal456 @14kal45693590
0 Followers 162 Following
Devon Main @Devinmain
646 Followers 3K Following PhD candidate at the Centre for Ecological Genomics and Wildlife Conservation. Dwarf chameleon phylogenomics. Cycling coach @MTraincoaching & cyclist
Emma Dyer @EmmaChancellor
133 Followers 279 Following Computational Biologist, PhD Candidate @HarvardChanSPH | @UChicago ‘21 AB, '23 MS at @lab_pearson, XCTF 🏃♀️
Fatto fiasco @fattofiasco
5 Followers 253 Following
Kumail Alhamoud @KumailAlhamoud
395 Followers 288 Following PhD student @MIT_CSAIL and @AIHealthMIT. Prev: MS @KaustVision and BS @Cornell. 🇸🇦
Isaac F. López-Moyad.. @IsaacLopezMoyad
494 Followers 2K Following Scientist interested in chromatin+cancer+blood+🤏🏻immunology. Sciencing @AnjanaRaoLab. 🚴🏻♂️🚣🏻🏊🏻♂️ when not 👨🏻🔬👨🏻💻. 🇲🇽 🌈 🗣EN/ES/emoji.
Jack Lawrence @JackMLawrence
3K Followers 1K Following Doing PhD on pancreatic cancer | Care about research integrity, free speech, democracy | Troublemaker | “Well-trained in the dark arts” - Pierre Kory
Degin @DeginUser
61 Followers 199 Following Student majoring in history, classics, and european studies.
haareblond @HaareBlond
175 Followers 897 Following *summons u* Not aligned GpuPoor not opensource't geymer. "All the rizz fell out :c" "I’ve never died before not even once" "I tossed a brick j-just" age 22
Chris Labaki @Chrislabaki1
830 Followers 932 Following PGY-1 @BIDMC_IM | Research Associate @DanaFarber | via @DanaFarber @USJLiban | Interested in Oncology
Britt 🖖 @BrittGratreak
7K Followers 8K Following 🌈♿ Very stubborn #FirstGen/low-income MD/PhD student, proud community college alum, open book. All posts reflect personal values & ethics, not my institution's
🇺🇦Brian May @thebrianmay
290 Followers 1K Following Passionate about photography & racecyclism. Digital content manager & CM for Amnesty International Belgium. Usual disclaimers.
Ruidong Xiang @RXiang5
273 Followers 325 Following Research Leader Computational Biology @DEECA_Vic @VicGovAg | visiting researcher @CamBakerSGI | @BakerResearchAu | @UniMelb
Joe Matty @JoeMattyM
31 Followers 50 Following
Peter Miller @tgof137
1K Followers 234 Following
Mwana wa kwithu @Kamanga__
2K Followers 2K Following I write, I draw, I code, I set fire to the rain
Alpay Ariyak @AlpayAriyak
1K Followers 2K Following 𝗔𝗜 @RunPod_io | 𝗟𝗲𝗮𝗱: @OpenChatDev (𝟲𝟬𝟬𝗸+ 𝗱𝗼𝘄𝗻𝗹𝗼𝗮𝗱𝘀 on HuggingFace🤗)
Smol Bean Gesserit @mimeticmagic
832 Followers 3K Following Alex / perpetual student / critical neurodiversity, med-anthro, (bio)politics, philosophy, STS, fully automated Star Trek socialism, everything else inbetween
Cellular and Molecula.. @Cmmr_Journal
111 Followers 1K Following An international, open access and peer-reviewed journal. Editor-in-Chief: Prof. Consolato M. Sergi, University of Ottawa, Canada
Ps @pnts_s
33 Followers 134 Following
Tailcalled (@tailcall.. @tailcalled
2K Followers 526 Following ❤️ @aliceryhl ❤️. Programmer, psychometrics nerd, hobbyist gender researcher. Autistic.
Laura Ehrig 🌎🌻 .. @LauraEhrig
1K Followers 3K Following
guangya wang @wang_guangya
3 Followers 113 Following
Rebecca @Rebecca21951651
2K Followers 4K Following I like long walks on the beach and epistemic trespassing #RetractProximalOrigins
Jojo Joestar @Mohamed46483635
0 Followers 17 Following
Walkinginsanta @walkingincali
17 Followers 144 Following
Cecilia_A @clase_mi93386
5 Followers 62 Following
Hunyadi Belgradski @hunyadi23632
4 Followers 71 Following
KOL Pulse AI @KolPulseAI
413 Followers 3K Following KOL Pulse AI is a Healthcare Intelligence Application focused on the Social Conversations and Digital Signature of Key Opinion Leaders in Medicine.
tyiusiuwn @tyiusiuwn
26 Followers 187 Following
Jeffrey Pullin @jeffreypullin
172 Followers 475 Following PhD Student at the MRC Biostatistics Unit, University of Cambridge | Gates Cambridge Scholar | Bioinformatics, genetics, statistics
ehy123 @ehy123
7 Followers 3K Following
ahahahahasss @istisnaefendi
38 Followers 93 Following
Angela Duckworth @angeladuckw
119K Followers 168 Following Professor at @Penn. Author of Grit. Co-host of @NSQ_Show. Co-founder of @thecharacterlab.
Zhen Miao @ZhenMiao2
356 Followers 265 Following PHD student, genomics & computational biology @Pennmedicine @UPenn | single cell multi-omics in human complex diseases | statistical modeling of gene regulation
David Russler-Germain.. @dgermain21
3K Followers 1K Following Oncology Instructor @SitemanCenter @WUSTLmed | lymphoma/leukemia researcher @LabFehniger | all views 100% my own
Ruidong Xiang @RXiang5
273 Followers 325 Following Research Leader Computational Biology @DEECA_Vic @VicGovAg | visiting researcher @CamBakerSGI | @BakerResearchAu | @UniMelb
Mathias Rask-Andersen @MathiasRaskAnd1
3 Followers 5 Following
Roman Akyüz @AkyuzRoman
269 Followers 939 Following
Yassine Meskhout @ymeskhout
2K Followers 897 Following Public Defender. Saracen Invader. Host of The Bailey podcast. I write for Jesse Singal solely for immigration reasons, please send all criticism to his boss.
Lars Penke @LarsPenke
3K Followers 643 Following Professor of Biological Personality Psychology at the University of Göttingen @[email protected]
Chris Chatham @chchatham
2K Followers 4K Following Sorting the universe of possible medicines for the mind: I use computational, cognitive and developmental neuroscience in the service of therapeutic discovery.
Aleksander Molak (at .. @AleksanderMolak
2K Followers 1K Following Causality for Machine Learners: https://t.co/n5xASwzYSu Podcast: https://t.co/4FWOtSWRDj Best-Selling Author || Advisor Teaching Causality @ Oxford TLV/WAW
Kristof Kovacs @Kristof__Kovacs
110 Followers 33 Following
Maxim Raginsky @mraginsky
8K Followers 2K Following father, academic, raconteur, aging wannabe hipster blog: https://t.co/akk6LCvKw6
Natália 🔍 @natalia__coelho
2K Followers 497 Following Applied epistemology enthusiast, software engineer. Married to @MatthewJBar. Not an expert in any academic field.
Peter Miller @tgof137
1K Followers 234 Following
Giorgio Farace @giorgio_farace
132 Followers 184 Following to eat and to talk... // political economy phd'ing @uchicago
Francesca Procopio @Francesca_Pro5
107 Followers 261 Following PhD candidate (she/her) @SGDPCentreKCL @TedsProject 🇬🇧🇮🇹
rogier kievit @rogierK
7K Followers 2K Following Professor of Developmental Neuroscience @DondersInst @radboudumc. https://t.co/716vKLpMs6
Eran Segal @segal_eran
55K Followers 159 Following Scientist at the Weizmann Institute. Microbiome, Genetics, Nutrition, Machine learning. Marathon runner (2h 56m)
Dr Kimberley Kendall @DrKimMKendall
274 Followers 459 Following Psychiatrist 🧠, mental health clinical informatics 🖥️ and genetics researcher 🧬 @CNGGCardiff. #genetics #psychiatry #psychosis
Clint Miller @clintomics
2K Followers 588 Following Human genomicist, Assoc Prof @UVA. Deconvolving complex cardiovascular diseases using systems genetics and single-cell omics.
Margarita Rayzberg @MRayzberg
103 Followers 500 Following Asst Prof: Soc, STS, IntDev. Soviet Jew, gay woman, proud Hoosier. Am often addressed in Spanish. All views mine.
Larissa Werhnyak @larisimilitude
399 Followers 595 Following Legal historian, recovering lawyer, novice Texan, rock climber. I've been told I make an excellent arch-nemesis.
Theodore Morley @MorleyTheodore
225 Followers 460 Following Researcher at VUMC in the Ruderfer lab/Center for Digital Genomic Medicine. Predicting disease with EHR data and genetic information. Lots of ML. CS@mcgillu
Sina Booeshaghi @sinabooeshaghi
4K Followers 1K Following HHMI Hanna Gray Fellow at @UCBerkeley with @airstreet. PhD @caltech, Math & ME BS @mit. I enjoy drinking tea, riding bikes, taking photos, and exploring nature.
Tailcalled (@tailcall.. @tailcalled
2K Followers 526 Following ❤️ @aliceryhl ❤️. Programmer, psychometrics nerd, hobbyist gender researcher. Autistic.
Jae Young Choi @Choi_JaeY
1K Followers 1K Following Assistant Professor of evolutionary genomics @KU_EEB. Has a preschooler 🙃😀🙃😀🇰🇷🇨🇦🇺🇲
Rex "garbage in" Doug.. @RexDouglass
4K Followers 5K Following Applied Scientist in Industry. Previously UCSD. Princeton PhD.
Zamin Iqbal @ZaminIqbal
10K Followers 7K Following Professor of Algorithmic and Microbial Genomics at the University of Bath; Group Leader EMBL-EBI. Pathogens, genomics, genome graphs, antibiotic resistance
Grant Haines @GrantEHaines
424 Followers 700 Following evolutionary biologist postdoc at Hólar University. fish doctor (not that kind). past: McGill, W&M, Colgate @ https://t.co/wEnX5X2hsB
Zach B. Hancock @zachbbionerd
905 Followers 666 Following Evolutionary biologist. Postdoc at UMich with @gbradburd. he/him
Jenny van Dongen @jenny_vandongen
640 Followers 786 Following Assistant Professor, Netherlands Twin Register @VUamsterdam @NTRscience - 🧬epigenetics - DNA methylation -https://t.co/13JW15r03s
Devin @epidevin
319 Followers 848 Following @uclafsph epidemiology grad student • UC Davis psychology alum
Genís Garcia Erill @ErillGenis
223 Followers 525 Following Postdoc at @AarhusUni_int | Population genetics
Yuriy Baglaenko @YuriyBaglaenko
215 Followers 149 Following Assistant Professor, Division of Human Genetics. Immunologist, molecular biologist, CRISPR & scRNAseq enthusiast.
Greg Zilberg @NeuroStructure
332 Followers 645 Following Neuroscience PhD student @WackerLab @SinaiBrain | Structural neurobiologist in training, determining structure/function relationships in signal transduction.
Chris Ferguson @CJFerguson1111
8K Followers 399 Following PhD Psychologist, Author of Suicide Kings; Moral Combat: Why the War on Violent Video Games is Wrong & How Madness Shaped History. Member of an awesome family.
Kirsten Hilger @Kirsten_Hilger
895 Followers 364 Following Head of Junior Research Group "Networks of Behavior and Cognition" at University of Würzburg
Protzko @protzko.bsky.. @JProtzko
1K Followers 242 Following @protzko.bsky.soci cognitive development, social cognition, & metascience. Using Twitter to help get high quality research to the world.
Oscar L Olvera Astivi.. @oscar_olvera100
2K Followers 349 Following PhD in Psychometrics. Assistant Prof @UW in Measurement & Statistics. R enthusiast. ❤️Maths & Stats❤️. From 🇨🇦 originally. He/His/Him. 🏳️🌈
Gergely Bence @GergelyBence7
54 Followers 94 Following PhD student, psychological methods enthusiast with a touch of computational science and backend development. Especially zoomed in on adaptive learning systems.
Hudson Golino @GolinoHudson
2K Followers 861 Following Associate Professor of Quantitative Methods at the Department of Psychology - University of Virginia. Views are my own.
Sandy Student @sandy_student
254 Followers 404 Following Assistant Professor, Educ. Statistics and Research Methods @UDSOE. Resident faculty, UD Data Science Institute. Measurement and quant methods in education!
Nicholas Judd on fedi.. @nickkjudd
217 Followers 524 Following Postdoc @ Donder's --- formerly Karolinska @[email protected]
Bruno Sauce @brunosauce
138 Followers 98 Following Assistant professor in biological psychology at the Vrije University Amsterdam. Researching cognitive abilities and digital media @NTRscience
Ryutaro Uchiyama @uch.. @RyutaroUchiyama
2K Followers 1K Following 内山隆太郎🗾📎Cultural Ecology〜Human Evodevo〜Cognitive Plasticity 📎Postdoc Tübingen AI Center🇩🇪. Previously NTU Singapore🇸🇬. PhD London School of Economics🇬🇧
Sacha Epskamp | @sach.. @SachaEpskamp
5K Followers 667 Following Associate Professor at the Department of Psychology, National University of Singapore.
Kees-Jan Kan @KeesJanKan
148 Followers 98 Following
Eric Blair🔥🟧 @protecttruth_
7K Followers 2K Following “When fascism comes to America it will be wrapped in a flag and carrying a cross, and the New York Times Opinion section will say we are all overreacting.”
Leila Mechoui @leilamechoui
5K Followers 938 Following Writing for the @compactmag_ Interested in statistics, demography, political theory, and Canada’s real estate bubbleThe next two chapters will be -3.3 Inferring human prehistory from genetic data -3.4 Digging deeper into human history: Ancient DNA I do have drafts of these, and although I'm reworking them at present I'm willing to share the drafts for teaching etc (email me)
Chapter 3.1 covers estimation of population structure, including concepts of clustering, Structure/Admixture, PCA, fineStructure, and interpretations of structure for geneticists and in society.
Two new chapters from my open-access textbook in human population genetics are now online: - Population structure: I. Ancestry estimation - Population structure: II. More about admixture web.stanford.edu/group/pritchar…
I'm delighted to release the first half of my new open-access online textbook in human population genetics: web.stanford.edu/group/pritchar…
I'm delighted to release the first half of my new open-access online textbook in human population genetics: web.stanford.edu/group/pritchar…
The irritated replies she’s getting bc she’s trying to explain a distinct diff bw hype & reality is an example of how some of these fandoms make people less informed. When the trusted source makes people resist hearing info from elsewhere but also is regularly wrong.
Ok a lot of you think solving protein folding and protein structure prediction are the same thing. They're not. But, even then, AlphaFold has not solved protein structure prediction. It has become a useful tool to be incorporated into the process of protein structure discovery.
Downloaded some survey data once where the code book said missing data was coded a "9". Except it was actually coded as "99".
Teaching a methods class now where students have to analyze survey data for their final, my first thought was that the authors just forgot to recode "9s" as missing Reckless data cleaning is probably much more pervasive and problematic than p-hacking
Inspired by @lpachter and team's exploration of scRNA-seq pipelines, we face similar challenges in scATAC-seq, only magnified! After 5 years of tackling these inconsistencies with my advisor @JunhyongKim , Here is a summary (and some solutions😃) 1/n #Genomics #Bioinformatics
The choice of whether to use Seurat or Scanpy for single-cell RNA-seq analysis typically comes down to a preference of R vs. Python. But do they produce the same results? In biorxiv.org/content/10.110… w/ @Josephmrich et al. we take a close look. The results are 👀 1/🧵
Please see additional discussions from the following tweet by my advisor @JunhyongKim (x.com/JunhyongKim/st…). Lastly, thank you for reading, and happy to discuss anything about scATAC-seq! 15/15
A funny thing happened on the way to routine single nucleus ATAC-seq analysis…and after scratching at it for longer than we wanted, we wrote a paper about what we found. This is a 🧵 about our little paper...(sorry long) biorxiv.org/content/10.110… 1/
Glad to finally see this (it almost didn't happen even with a 9%ile. Don't ask.)! And it's a big boi, $$$-wise!
big day for parents of sleep-deprived teenaged girls
This is the far right’s trick: they go “where is the moderate middle, why can’t people be reasonable like they used to? because of the culture war no one can have respectful discourse anymore :( ” But then you check their history and it’s just, slurs slurs racism slurs
Call them what they are. Don’t let them play this game
They rely on this code-switching trick, where they can simultaneously be a concerned moderate who has been left behind by changing social norms, and a completely overt bigot
Ok a lot of you think solving protein folding and protein structure prediction are the same thing. They're not. But, even then, AlphaFold has not solved protein structure prediction. It has become a useful tool to be incorporated into the process of protein structure discovery.
Me engaging about research with my lab or faculty colleagues: “wow this job is amazing, how am I lucky enough to get paid for it?” With grant/department administration: “maybe they’re right and me just finding another job would make both of our lives easier?”
This fall, I got an e-mail from a guy named JM Simpson who'd read things I'd written about homelessness. He mentioned he was a photojournalist in Olympia and that he'd been photographing the unhoused population there. He wanted to share some work with me . . . (1)
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