Jonathan Pritchard @jkpritch
My lab at Stanford studies human population genetics and complex traits. pritchardlab.stanford.edu Stanford University Joined April 2012-
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I finally read the new preprint by @trevorcousins_ , @aylwyn_scally and @richard_durbin on inferring deep structure from human genomes. Fascinating and impressive work! To me, on a technical level surprising was the finding that the transition matrix 1/5
I finally read the new preprint by @trevorcousins_ , @aylwyn_scally and @richard_durbin on inferring deep structure from human genomes. Fascinating and impressive work! To me, on a technical level surprising was the finding that the transition matrix 1/5
A fantastic read so far! It's really making population genetics beautiful to me, and the layout and illustrations are superb. I know I'm not the target audience... but thank you!
A fantastic read so far! It's really making population genetics beautiful to me, and the layout and illustrations are superb. I know I'm not the target audience... but thank you!
The most intuitive and well written textbook out there. I use this extensively to teach basic principles of genetics and pop gen
The most intuitive and well written textbook out there. I use this extensively to teach basic principles of genetics and pop gen
Would you believe me if I told you that a single variant in a non-coding RNA explains ~0.5% of all undiagnosed individuals with neurodevelopmental disorders (NDD) in @GenomicsEngland ??? I didn’t initially either, but here is the story of RNU4-2 🧵1/9
Would you believe me if I told you that a single variant in a non-coding RNA explains ~0.5% of all undiagnosed individuals with neurodevelopmental disorders (NDD) in @GenomicsEngland ??? I didn’t initially either, but here is the story of RNU4-2 🧵1/9
My preprint with @pastramimachine of a new genome-wide model of background selection (and statistical methods) applied to humans is now on BioRxiv! biorxiv.org/content/10.110…
1/🚀 Introducing an identifiability theory for latent variable models that compare patterns across datasets. Can we identify salient variation that is specific to a data set, and under which conditions? With wonderful collaborators @jchuetter, @EhsanHRA, @jkpritch, and Aviv Regev
Sold out show! Congrats @RoshniAPatel on your PhD defense. You make the field of Human Genetics 🧬 a more just and equitable one through your scholarship and dedication to education
For those in the NY area, SAVE THE DATE (& register) for a Symposium on Human Genetics at Columbia University: Oct 10-11 2024. Talks will also be streamed.
Discussed Spence et al. [biorxiv.org/content/10.110…] for journal club. Very nicely draws the connection between estimating posterior GWAS effect sizes and many downstream parameters we care about: polygenic scores, genetic correlation, fine-mapping, etc.
In the latest @NakedGenetics podcast we discuss ancestry in the Roman Empire (via a fascinating recent paper by @antmarge, @jkpritch & colleagues), and an example of how genetic evidence can contribute to our understanding of ancient & medieval societies. thenakedscientists.com/podcasts/naked…
I have been following the discussion around how best to represent and label human genetic variation, and thought it might also be worth discussing an aspect of the broader context. 1/n
Anshul Kundaje (anshu.. @anshulkundaje
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Veera Rajagopal @doctorveera
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Lior Pachter @lpachter
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emr @lo_mbrd
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Michel "Mike" Choudal.. @MChoudalakis
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zé gotinha 💉 @joze_gota
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4K Followers 2K Following Pull apart the double helix like a wishbone || Ars longa, tweeta brevis
GWAS Stories @gwas_stories
595 Followers 1 Following A newsletter on the latest advances in human genetics and drug discovery. Subscribe to read the latest stories directly in your email.
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836 Followers 890 Following || Assistant Professor @StanfordEpiNews @StanfordCancer || Genetic and Cancer Epidemiology || Formerly @UCSF @UofT_dlsph @mcgillu Views my own 🇨🇦🇺🇦🇽🇰
Jessica Chong @jxchong
2K Followers 2K Following @[email protected],https://t.co/VQyyqpMf93. Assistant Professor. UW Center for Rare Disease Research, @MyGene2, Deputy Editor of @HGGAdvances. #raredisease geneticsCrazy to think the year I was born Simon Tavaré is publishing absolute bangers like this
@NIGMS When the MIRA mechanism started, there were all sorts of reasonable promises made it sensible: budget increases with inflation, bridge funding for borderline renewals, etc. What it's become, however, is a subinflationary boa constrictor to suffocate NIGMS labs
Oh no have I become serious
Most of the heritability come from urate transporters. The SLC2A9 locus alone explains ~20%. elifesciences.org/articles/58615
Awesome open-access resource on human genetics!
I'm delighted to release the first half of my new open-access online textbook in human population genetics: web.stanford.edu/group/pritchar…
@arjunrajlab Isn’t this the ostensible raison d’être for the Eisen eLife model?
@arjunrajlab Remember the backlash against eLife’s new model? Most publishers/editors aren’t sufficiently brave to try anything new, because scientists are so conservative and mean. :)
@jkpritch fantastic! this is great material for teaching. Thank you so much
Given the national return on investment from the NSF (both in economic value and improvement in lives) over the last half century+, underfunding it simply an epic own goal by congress
@breakliquid seems hard to argue that one edition of a language model that won’t last more than a year (they’re already training llama4, which will cost more), and is not unique in its capabilities, is more impactful than the largest portfolio of basic scientific research in the US
One of the best textbooks I have ever read. I just finished the second chapter on yesterday's flight and now have two more chapters to read! @jkpritch Thanks a lot for the contribution to the community!
Two new chapters from my open-access textbook in human population genetics are now online: - Population structure: I. Ancestry estimation - Population structure: II. More about admixture web.stanford.edu/group/pritchar…
@jkpritch @PathologyPat Great gift, many thanks!
Great 👏
Two new chapters from my open-access textbook in human population genetics are now online: - Population structure: I. Ancestry estimation - Population structure: II. More about admixture web.stanford.edu/group/pritchar…
Does anyone know of any bars in New York that are going to show the Xiamen Diamond League at 7AM tomorrow?
@jkpritch This is fantastic! Thanks for sharing. I must say, the chapters on drift were particularly insightful and educational. Congratulations!
amazing!!!
I'm delighted to release the first half of my new open-access online textbook in human population genetics: web.stanford.edu/group/pritchar…
So excited to be recognized as one of the 502 AAAS Fellows for 2023. Such an honor for me, that could not have happened without my lab members and collaborators!
AAAS is thrilled to announce our 2023 #AAASFellows! “This year’s class embodies scientific excellence, fosters trust in science throughout the communities they serve, and leads the next generation of scientists,” said AAAS CEO @sudipsparikh. Read more: brnw.ch/21wIWyv
The best marketing I've ever seen for a company! I love this!
If you've been using one of our Oxford University dropboxes, you may have spotted something unusual...!!!🦖🚲 Daily pickups at @Dunn_School, @OxfordBiology, @HumanGeneticsOx, and Old Road Campus Research. Huge shoutout to Dr Malcolm Sim, @mjwsim!
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